Rab10 (RAB10, member RAS oncogene family) - Rat Genome Database

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Gene: Rab10 (RAB10, member RAS oncogene family) Rattus norvegicus
Analyze
Symbol: Rab10
Name: RAB10, member RAS oncogene family
RGD ID: 620879
Description: Enables GDP-dissociation inhibitor binding activity and myosin V binding activity. Involved in Golgi to plasma membrane transport; cellular response to antibiotic; and generation of neurons. Located in cilium; perinuclear region of cytoplasm; and trans-Golgi network. Is active in synaptic vesicle membrane. Orthologous to human RAB10 (RAB10, member RAS oncogene family); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrobenzenesulfonic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ac1075; ras-related protein Rab-10; ras-related protein rab10
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8631,974,858 - 32,039,554 (-)NCBIGRCr8
mRatBN7.2626,267,081 - 26,319,739 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl626,266,859 - 26,320,193 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx626,559,705 - 26,612,364 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0626,875,588 - 26,928,242 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0626,353,848 - 26,406,629 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0627,668,387 - 27,721,120 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl627,668,403 - 27,721,120 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0637,479,058 - 37,531,622 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1626,260,312 - 26,297,639NCBI
Celera625,743,962 - 25,796,212 (-)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
Rab10RatLiver Reperfusion Injury amelioratesISORab10 (Mus musculus)329902072 RGD 
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Original Reference(s)
Rab10RatTatton-Brown-Rahman syndrome  ISORAB10 (Homo sapiens)8554872ClinVar Annotator: match by term: Tatton-Brown-Rahman overgrowth syndromeClinVarPMID:28492532

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Original Reference(s)
Rab10Rat1,2-dichloroethane increases expressionISORab10 (Mus musculus)6480464ethylene dichloride results in increased expression of RAB10 mRNACTDPMID:28960355
Rab10Rat1,2-dimethylhydrazine decreases expressionISORab10 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of RAB10 mRNACTDPMID:22206623
Rab10Rat1,2-dimethylhydrazine multiple interactionsISORab10 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of RAB10 mRNACTDPMID:22206623
Rab10Rat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of RAB10 proteinCTDPMID:32145629
Rab10Rat17beta-estradiol decreases expressionISORab10 (Mus musculus)6480464Estradiol results in decreased expression of RAB10 mRNACTDPMID:39298647
Rab10Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISORab10 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of RAB10 mRNACTDPMID:15328365
Rab10Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of RAB10 mRNACTDPMID:20959002 and PMID:33387578
Rab10Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORab10 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of RAB10 mRNACTDPMID:21570461
Rab10Rat2,4,6-trinitrobenzenesulfonic acid decreases expressionEXP 6480464Trinitrobenzenesulfonic Acid results in decreased expression of RAB10 mRNACTDPMID:23537331
Rab10Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of RAB10 mRNACTDPMID:21346803
Rab10Rat2-methylcholine affects expressionISORAB10 (Homo sapiens)6480464beta-methylcholine affects the expression of RAB10 mRNACTDPMID:21179406
Rab10Rat3,3',5,5'-tetrabromobisphenol A increases expressionISORAB10 (Homo sapiens)6480464tetrabromobisphenol A results in increased expression of RAB10 proteinCTDPMID:31675489
Rab10Rat3H-1,2-dithiole-3-thione decreases expressionEXP 64804641 and 2-dithiol-3-thione results in decreased expression of RAB10 mRNACTDPMID:19162173
Rab10Rat4,4'-sulfonyldiphenol multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of RAB10 mRNACTDPMID:36041667
Rab10Rat4-amino-2,6-dinitrotoluene affects expressionEXP 64804644-amino-2 and 6-dinitrotoluene affects the expression of RAB10 mRNACTDPMID:21346803
Rab10Rataconitine decreases expressionEXP 6480464Aconitine results in decreased expression of RAB10 proteinCTDPMID:33236894
Rab10Ratacrylamide increases phosphorylationISORab10 (Mus musculus)6480464Acrylamide results in increased phosphorylation of RAB10 proteinCTDPMID:37037409
Rab10Ratactinomycin D multiple interactionsISORAB10 (Homo sapiens)6480464[Dactinomycin co-treated with nutlin 3] results in increased secretion of RAB10 proteinCTDPMID:38460933
Rab10Rataflatoxin B1 increases expressionISORab10 (Mus musculus)6480464Aflatoxin B1 results in increased expression of RAB10 mRNACTDPMID:19770486
Rab10Rataflatoxin B1 increases methylationISORAB10 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of RAB10 intronCTDPMID:30157460

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Biological Process
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Rab10Ratantigen processing and presentation involved_inIEAUniProtKB:P61026 and ensembl:ENSP000002647101600115GO_REF:0000107EnsemblGO_REF:0000107
Rab10Ratantigen processing and presentation involved_inISORAB10 (Homo sapiens)1624291 PMID:19717423RGDPMID:19717423
Rab10Rataxonogenesis involved_inIMP 8553614PMID:21856246UniProt 
Rab10Ratcellular response to antibiotic  IEP 734514brefeldin ARGD 
Rab10Ratcellular response to insulin stimulus involved_inIEAUniProtKB:P61027 and ensembl:ENSMUSP000000210011600115GO_REF:0000107EnsemblGO_REF:0000107
Rab10Ratcellular response to insulin stimulus involved_inISORab10 (Mus musculus)1624291 PMID:17403373 and PMID:22908308RGDPMID:17403373 and PMID:22908308
Rab10Ratcellular response to insulin stimulus involved_inISSUniProtKB:P610271600115GO_REF:0000024UniProtGO_REF:0000024
Rab10Ratendoplasmic reticulum tubular network organization involved_inIEAUniProtKB:P61026 and ensembl:ENSP000002647101600115GO_REF:0000107EnsemblGO_REF:0000107
Rab10Ratendoplasmic reticulum tubular network organization involved_inISORAB10 (Homo sapiens)1624291 PMID:23263280 and PMID:24891604RGDPMID:23263280 and PMID:24891604
Rab10Ratendoplasmic reticulum tubular network organization involved_inISSUniProtKB:P610261600115GO_REF:0000024UniProtGO_REF:0000024
Rab10Ratendosomal transport involved_inISSUniProtKB:P610261600115GO_REF:0000024UniProtGO_REF:0000024
Rab10Ratendosomal transport involved_inISORAB10 (Homo sapiens)1624291 PMID:16641372RGDPMID:16641372
Rab10Ratendosomal transport involved_inIEAUniProtKB:P61026 and ensembl:ENSP000002647101600115GO_REF:0000107EnsemblGO_REF:0000107
Rab10Ratestablishment of neuroblast polarity involved_inIMP 8553614PMID:21856246UniProt 
Rab10Ratestablishment of protein localization to endoplasmic reticulum membrane involved_inIEAUniProtKB:P61026 and ensembl:ENSP000002647101600115GO_REF:0000107EnsemblGO_REF:0000107
Rab10Ratestablishment of protein localization to endoplasmic reticulum membrane involved_inISORAB10 (Homo sapiens)1624291 PMID:23263280RGDPMID:23263280
Rab10Ratestablishment of protein localization to endoplasmic reticulum membrane involved_inISSUniProtKB:P610261600115GO_REF:0000024UniProtGO_REF:0000024
Rab10Ratestablishment of protein localization to membrane involved_inISORAB10 (Homo sapiens)1624291 PMID:24006491RGDPMID:24006491
Rab10Ratestablishment of protein localization to membrane involved_inIEAUniProtKB:P61026 and ensembl:ENSP000002647101600115GO_REF:0000107EnsemblGO_REF:0000107
Rab10Ratexocytosis involved_inIBACGD:CAL0000186445 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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Cellular Component
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Rab10Ratcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
Rab10Ratcilium located_inISORAB10 (Homo sapiens)1624291 PMID:20576682RGDPMID:20576682
Rab10Ratcilium located_inISORab10 (Mus musculus)1624291 PMID:20576682RGDPMID:20576682
Rab10Ratcilium located_inIEAUniProtKB-SubCell:SL-00661600115GO_REF:0000044UniProtGO_REF:0000044
Rab10Ratcilium located_inIEAUniProtKB:P61027 and ensembl:ENSMUSP000000210011600115GO_REF:0000107EnsemblGO_REF:0000107
Rab10Ratcilium located_inIDA 8553613PMID:20576682UniProt 
Rab10Ratcilium located_inIEAUniProtKB:P61026 and ensembl:ENSP000002647101600115GO_REF:0000107EnsemblGO_REF:0000107
Rab10Ratcilium located_inISORAB10 (Canis lupus familiaris)1624291 PMID:20576682RGDPMID:20576682
Rab10Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Rab10Ratcytoplasmic vesicle located_inIEAUniProtKB-KW:KW-09681600115GO_REF:0000043UniProtGO_REF:0000043
Rab10Ratcytoplasmic vesicle membrane located_inIEAUniProtKB-SubCell:SL-00891600115GO_REF:0000044UniProtGO_REF:0000044
Rab10Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Rab10Ratendoplasmic reticulum membrane located_inIEAUniProtKB:P61026 and ensembl:ENSP000002647101600115GO_REF:0000107EnsemblGO_REF:0000107
Rab10Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Rab10Ratendoplasmic reticulum membrane located_inISORAB10 (Homo sapiens)1624291 PMID:23263280RGDPMID:23263280
Rab10Ratendoplasmic reticulum membrane located_inISSUniProtKB:P610261600115GO_REF:0000024UniProtGO_REF:0000024
Rab10Ratendoplasmic reticulum tubular network located_inIEAUniProtKB:P61026 and ensembl:ENSP000002647101600115GO_REF:0000107EnsemblGO_REF:0000107
Rab10Ratendoplasmic reticulum tubular network located_inISORAB10 (Homo sapiens)1624291 PMID:23263280RGDPMID:23263280
Rab10Ratendoplasmic reticulum tubular network located_inISSUniProtKB:P610261600115GO_REF:0000024UniProtGO_REF:0000024
Rab10Ratendosome located_inISSUniProtKB:P610261600115GO_REF:0000024UniProtGO_REF:0000024
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Molecular Function
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Rab10RatG protein activity enablesIEAEC:3.6.5.21600115GO_REF:0000003UniProtGO_REF:0000003
Rab10RatGDP binding enablesISSUniProtKB:P610261600115GO_REF:0000024UniProtGO_REF:0000024
Rab10RatGDP binding enablesISORAB10 (Homo sapiens)1624291 PMID:20937701RGDPMID:20937701
Rab10RatGDP binding enablesIEAUniProtKB:P61026 and ensembl:ENSP000002647101600115GO_REF:0000107EnsemblGO_REF:0000107
Rab10RatGDP-dissociation inhibitor binding  IPIGdi1 (Rattus norvegicus)8553614 RGD 
Rab10RatGTP binding enablesIEAUniProtKB:P61026 and ensembl:ENSP000002647101600115GO_REF:0000107EnsemblGO_REF:0000107
Rab10RatGTP binding enablesIEAUniProtKB-KW:KW-03421600115GO_REF:0000043UniProtGO_REF:0000043
Rab10RatGTP binding enablesIEAInterPro:IPR001806 and InterPro:IPR0052251600115GO_REF:0000002InterProGO_REF:0000002
Rab10RatGTP binding enablesISORAB10 (Homo sapiens)1624291 PMID:20937701RGDPMID:20937701
Rab10RatGTP binding enablesISSUniProtKB:P610261600115GO_REF:0000024UniProtGO_REF:0000024
Rab10RatGTPase activity enablesIEAInterPro:IPR0018061600115GO_REF:0000002InterProGO_REF:0000002
Rab10RatGTPase activity enablesIEARHEA:196691600115GO_REF:0000116RHEAGO_REF:0000116
Rab10Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Rab10Ratmyosin V binding  IPIMyo5b (Rattus norvegicus)11533641 RGD 
Rab10Ratmyosin V binding enablesISORAB10 (Homo sapiens)1624291UniProtKB:Q99104 and PMID:22908308RGDPMID:22908308
Rab10Ratmyosin V binding enablesIEAUniProtKB:P61026 and ensembl:ENSP000002647101600115GO_REF:0000107EnsemblGO_REF:0000107
Rab10Ratmyosin V binding enablesIBAPANTHER:PTN008479061 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Rab10Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Rab10Ratprotein binding enablesISORab10 (Mus musculus)1624291PR:Q99NE5 more ...RGDPMID:12578829 more ...
Rab10Ratprotein binding enablesISORAB10 (Canis lupus familiaris)1624291UniProtKB:A0A8C0N5P9 and PMID:20576682RGDPMID:20576682
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Reference Title
Reference Citation
1. Rab10 associates with primary cilia and the exocyst complex in renal epithelial cells. Babbey CM, etal., Am J Physiol Renal Physiol. 2010 Sep;299(3):F495-506. doi: 10.1152/ajprenal.00198.2010. Epub 2010 Jun 24.
2. Expression and localization of two low molecular weight GTP-binding proteins, Rab8 and Rab10, by epitope tag. Chen YT, etal., Proc Natl Acad Sci U S A 1993 Jul 15;90(14):6508-12.
3. rab15, a novel low molecular weight GTP-binding protein specifically expressed in rat brain. Elferink LA, etal., J Biol Chem 1992 Mar 25;267(9):5768-75.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rab proteins in endocytosis and Glut4 trafficking. Kaddai V, etal., Acta Physiol (Oxf). 2008 Jan;192(1):75-88.
6. Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation. Klip A, etal., Am J Physiol Cell Physiol. 2014 May 15;306(10):C879-86. doi: 10.1152/ajpcell.00069.2014. Epub 2014 Mar 5.
7. The GLUT4 code. Larance M, etal., Mol Endocrinol. 2008 Feb;22(2):226-33. Epub 2007 Aug 23.
8. Myosin Vb controls biogenesis of post-Golgi Rab10 carriers during axon development. Liu Y, etal., Nat Commun. 2013;4:2005. doi: 10.1038/ncomms3005.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis. Pavlos NJ, etal., J Neurosci. 2010 Oct 6;30(40):13441-53. doi: 10.1523/JNEUROSCI.0907-10.2010.
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Comprehensive gene review and curation RGD comprehensive gene curation
15. Hepatic interferon regulatory factor 8 expression mediates liver ischemia/reperfusion injury in mice. Shi G, etal., Biochem Pharmacol. 2021 Oct;192:114728. doi: 10.1016/j.bcp.2021.114728. Epub 2021 Aug 13.
16. Lgl1 activation of rab10 promotes axonal membrane trafficking underlying neuronal polarization. Wang T, etal., Dev Cell. 2011 Sep 13;21(3):431-44. doi: 10.1016/j.devcel.2011.07.007.
17. GLUT4 translocation: the last 200 nanometers. Watson RT and Pessin JE, Cell Signal. 2007 Nov;19(11):2209-17. Epub 2007 Jun 21.
18. Insulin action on glucose transporters through molecular switches, tracks and tethers. Zaid H, etal., Biochem J. 2008 Jul 15;413(2):201-15.
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PMID:2732579   PMID:11042173   PMID:12477932   PMID:16641372   PMID:17132146   PMID:17403373   PMID:18504258   PMID:19056867   PMID:19717423   PMID:20458337   PMID:20937701   PMID:21423176  
PMID:22908308   PMID:23263280   PMID:23533145   PMID:24006491   PMID:24478353   PMID:24662485   PMID:24891604   PMID:25468996   PMID:27354378   PMID:29476059   PMID:31505169  



Rab10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8631,974,858 - 32,039,554 (-)NCBIGRCr8
mRatBN7.2626,267,081 - 26,319,739 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl626,266,859 - 26,320,193 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx626,559,705 - 26,612,364 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0626,875,588 - 26,928,242 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0626,353,848 - 26,406,629 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0627,668,387 - 27,721,120 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl627,668,403 - 27,721,120 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0637,479,058 - 37,531,622 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.1626,260,312 - 26,297,639NCBI
Celera625,743,962 - 25,796,212 (-)NCBICelera
Cytogenetic Map6q14NCBI
RAB10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38226,033,285 - 26,137,454 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl226,034,084 - 26,137,454 (+)EnsemblGRCh38hg38GRCh38
GRCh37226,256,953 - 26,360,323 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36226,110,478 - 26,213,782 (+)NCBINCBI36Build 36hg18NCBI36
Build 34226,168,624 - 26,271,929NCBI
Celera226,097,002 - 26,200,567 (+)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef225,993,019 - 26,096,921 (+)NCBIHuRef
CHM1_1226,186,807 - 26,290,405 (+)NCBICHM1_1
T2T-CHM13v2.0226,069,400 - 26,172,749 (+)NCBIT2T-CHM13v2.0
Rab10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39123,297,428 - 3,359,969 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl123,297,428 - 3,359,969 (-)EnsemblGRCm39 Ensembl
GRCm38123,247,428 - 3,309,969 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl123,247,428 - 3,309,969 (-)EnsemblGRCm38mm10GRCm38
MGSCv37123,247,428 - 3,309,969 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36123,247,726 - 3,309,939 (-)NCBIMGSCv36mm8
Celera123,174,851 - 3,237,418 (-)NCBICelera
Cytogenetic Map12A1.1NCBI
cM Map121.71NCBI
Rab10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554698,057,235 - 8,138,983 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554698,057,235 - 8,138,983 (+)NCBIChiLan1.0ChiLan1.0
RAB10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v212100,381,221 - 100,485,143 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A100,385,189 - 100,488,306 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A26,034,046 - 26,132,658 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A26,125,984 - 26,228,505 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A26,125,985 - 26,228,505 (+)Ensemblpanpan1.1panPan2
RAB10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11720,181,363 - 20,264,927 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1720,181,363 - 20,264,927 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1720,077,187 - 20,160,857 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01720,503,635 - 20,587,796 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1720,503,607 - 20,589,813 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11720,190,180 - 20,274,283 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01720,200,321 - 20,284,230 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01720,247,131 - 20,331,947 (+)NCBIUU_Cfam_GSD_1.0
Rab10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629264,488,453 - 64,575,695 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364936,263,863 - 6,351,327 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364936,263,870 - 6,351,327 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAB10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3112,829,137 - 112,924,269 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13112,842,190 - 112,924,188 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23119,827,428 - 119,909,414 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAB10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11481,508,800 - 81,618,172 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1481,507,031 - 81,617,983 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604530,540,276 - 30,649,087 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rab10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247388,212,355 - 8,294,423 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247388,212,401 - 8,294,307 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Rab10
159 total Variants

Predicted Target Of
Summary Value
Count of predictions:275
Count of miRNA genes:171
Interacting mature miRNAs:219
Transcripts:ENSRNOT00000071425
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 33 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat

1 to 10 of 33 rows
BI283356  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2626,267,200 - 26,267,405 (+)MAPPERmRatBN7.2
Rnor_6.0627,668,507 - 27,668,711NCBIRnor6.0
Rnor_5.0637,479,178 - 37,479,382UniSTSRnor5.0
Celera625,744,082 - 25,744,286UniSTS
RH 3.4 Map6118.2UniSTS
Cytogenetic Map6q12UniSTS
BF393954  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2626,285,386 - 26,285,553 (+)MAPPERmRatBN7.2
Rnor_6.0627,686,682 - 27,686,848NCBIRnor6.0
Rnor_5.0637,497,184 - 37,497,350UniSTSRnor5.0
RGSC_v3.4626,257,916 - 26,258,082UniSTSRGSC3.4
Celera625,761,930 - 25,762,096UniSTS
RH 3.4 Map6118.19UniSTS
Cytogenetic Map6q12UniSTS
AU048675  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2626,313,990 - 26,314,190 (+)MAPPERmRatBN7.2
Rnor_6.0627,715,372 - 27,715,571NCBIRnor6.0
Rnor_5.0637,525,874 - 37,526,073UniSTSRnor5.0
RGSC_v3.4626,288,785 - 26,288,984UniSTSRGSC3.4
Celera625,790,473 - 25,790,661UniSTS
Cytogenetic Map6q12UniSTS
RAB10_1045  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2626,266,838 - 26,267,720 (+)MAPPERmRatBN7.2
Rnor_6.0627,668,145 - 27,669,026NCBIRnor6.0
Rnor_5.0637,478,816 - 37,479,697UniSTSRnor5.0
Celera625,743,720 - 25,744,601UniSTS
Cytogenetic Map6q12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000071425   ⟹   ENSRNOP00000065234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl626,266,859 - 26,320,193 (-)Ensembl
Rnor_6.0 Ensembl627,668,403 - 27,721,120 (-)Ensembl
RefSeq Acc Id: NM_017359   ⟹   NP_059055
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8631,986,905 - 32,039,554 (-)NCBI
mRatBN7.2626,267,081 - 26,319,739 (-)NCBI
Rnor_6.0627,668,387 - 27,721,120 (-)NCBI
Rnor_5.0637,479,058 - 37,531,622 (-)NCBI
Celera625,743,962 - 25,796,212 (-)RGD
Sequence:
RefSeq Acc Id: XM_063262358   ⟹   XP_063118428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8631,974,858 - 32,039,550 (-)NCBI
1 to 9 of 9 rows
Protein RefSeqs NP_059055 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118428 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41991 (Get FASTA)   NCBI Sequence Viewer  
  AAH85744 (Get FASTA)   NCBI Sequence Viewer  
  AAP78748 (Get FASTA)   NCBI Sequence Viewer  
  EDM03004 (Get FASTA)   NCBI Sequence Viewer  
  EDM03005 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065234
GenBank Protein P35281 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_059055   ⟸   NM_017359
- UniProtKB: P35281 (UniProtKB/Swiss-Prot),   Q5RKJ9 (UniProtKB/TrEMBL),   M0R717 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065234   ⟸   ENSRNOT00000071425
RefSeq Acc Id: XP_063118428   ⟸   XM_063262358
- Peptide Label: isoform X1
- UniProtKB: P35281 (UniProtKB/Swiss-Prot)

Name Modeler Protein Id AA Range Protein Structure
AF-P35281-F1-model_v2 AlphaFold P35281 1-200 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 27 of 27 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-38299 BioCyc
Ensembl Genes ENSRNOG00000047088 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000071425 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7191921 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/Swiss-Prot
  Small_GTP-bd_dom UniProtKB/Swiss-Prot
  Small_GTPase UniProtKB/Swiss-Prot
  Small_GTPase_Rab UniProtKB/Swiss-Prot
MGC_CLONE MGC:93509 IMAGE-MGC_LOAD
NCBI Gene 50993 ENTREZGENE
PANTHER LD44762P UniProtKB/Swiss-Prot
Pfam Ras UniProtKB/Swiss-Prot
PhenoGen Rab10 PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot
PROSITE RAB UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000047088 RatGTEx
SMART RAB UniProtKB/Swiss-Prot
  RAN UniProtKB/Swiss-Prot
  RAS UniProtKB/Swiss-Prot
  RHO UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A6HAF0_RAT UniProtKB/TrEMBL
  M0R717 ENTREZGENE, UniProtKB/TrEMBL
  P35281 ENTREZGENE
  Q5RKJ9 ENTREZGENE, UniProtKB/TrEMBL
  RAB10_RAT UniProtKB/Swiss-Prot
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Rab10  RAB10, member RAS oncogene family    ras-related protein rab10  Name updated 1299863 APPROVED
2002-08-07 Rab10  ras-related protein rab10      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_cellular_localization localized to membranes in the perinuclear region, possibly to the Golgi apparatus 734514