RGD Reference Report - GLUT4 translocation: the last 200 nanometers. - Rat Genome Database

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GLUT4 translocation: the last 200 nanometers.

Authors: Watson, RT  Pessin, JE 
Citation: Watson RT and Pessin JE, Cell Signal. 2007 Nov;19(11):2209-17. Epub 2007 Jun 21.
RGD ID: 2302395
Pubmed: PMID:17629673   (View Abstract at PubMed)
DOI: DOI:10.1016/j.cellsig.2007.06.003   (Journal Full-text)

Insulin regulates circulating glucose levels by suppressing hepatic glucose production and increasing glucose transport into muscle and adipose tissues. Defects in these processes are associated with elevated vascular glucose levels and can lead to increased risk for the development of Type 2 diabetes mellitus and its associated disease complications. At the cellular level, insulin stimulates glucose uptake by inducing the translocation of the glucose transporter 4 (GLUT4) from intracellular storage sites to the plasma membrane, where the transporter facilitates the diffusion of glucose into striated muscle and adipocytes. Although the immediate downstream molecules that function proximal to the activated insulin receptor have been relatively well-characterized, it remains unknown how the distal insulin-signaling cascade interfaces with and recruits GLUT4 to the cell surface. New biochemical assays and imaging techniques, however, have focused attention on the plasma membrane as a potential target of insulin action leading to GLUT4 translocation. Indeed, it now appears that insulin specifically regulates the docking and/or fusion of GLUT4-vesicles with the plasma membrane. Future work will focus on identifying the key insulin targets that regulate the GLUT4 docking/fusion processes.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
insulin responsive facilitative sugar transporter mediated glucose transport pathway   TAS 2302395; 2302395; 2302395; 2302395; 2302395; 2302395; 2302395; 2302395; 2302395; 2302395; 2302395 RGD 
insulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOAKT2 (Homo sapiens)2302395; 2302395 RGD 
insulin responsive facilitative sugar transporter mediated glucose transport pathway   ISORAB10 (Homo sapiens)2302395; 2302395 RGD 
insulin responsive facilitative sugar transporter mediated glucose transport pathway   ISORAB11A (Homo sapiens)2302395; 2302395 RGD 
insulin responsive facilitative sugar transporter mediated glucose transport pathway   ISORAB14 (Homo sapiens)2302395; 2302395 RGD 
insulin responsive facilitative sugar transporter mediated glucose transport pathway   ISORAB2A (Homo sapiens)2302395; 2302395 RGD 
insulin responsive facilitative sugar transporter mediated glucose transport pathway   ISORAB4A (Homo sapiens)2302395; 2302395 RGD 
insulin responsive facilitative sugar transporter mediated glucose transport pathway   ISORAB5A (Homo sapiens)2302395; 2302395 RGD 
insulin responsive facilitative sugar transporter mediated glucose transport pathway   ISORAB8A (Homo sapiens)2302395; 2302395 RGD 
insulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOSLC2A4 (Homo sapiens)2302395; 2302395 RGD 
insulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOSTXBP4 (Homo sapiens)2302395; 2302395 RGD 
Rab family mediated signaling pathway  TAS 2302395; 2302395; 2302395; 2302395; 2302395; 2302395; 2302395; 2302395 RGD 
Rab family mediated signaling pathway  ISORAB10 (Homo sapiens)2302395; 2302395 RGD 
Rab family mediated signaling pathway  ISORAB11A (Homo sapiens)2302395; 2302395 RGD 
Rab family mediated signaling pathway  ISORAB14 (Homo sapiens)2302395; 2302395 RGD 
Rab family mediated signaling pathway  ISORAB2A (Homo sapiens)2302395; 2302395 RGD 
Rab family mediated signaling pathway  ISORAB4A (Homo sapiens)2302395; 2302395 RGD 
Rab family mediated signaling pathway  ISORAB5A (Homo sapiens)2302395; 2302395 RGD 
Rab family mediated signaling pathway  ISORAB8A (Homo sapiens)2302395; 2302395 RGD 
Rab family mediated signaling pathway  ISOTBC1D4 (Homo sapiens)2302395; 2302395 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Akt2  (AKT serine/threonine kinase 2)
Rab10  (RAB10, member RAS oncogene family)
Rab11a  (RAB11a, member RAS oncogene family)
Rab14  (RAB14, member RAS oncogene family)
Rab2a  (RAB2A, member RAS oncogene family)
Rab4a  (RAB4A, member RAS oncogene family)
Rab5a  (RAB5A, member RAS oncogene family)
Rab8a  (RAB8A, member RAS oncogene family)
Slc2a4  (solute carrier family 2 member 4)
Stxbp4  (syntaxin binding protein 4)
Tbc1d4  (TBC1 domain family, member 4)

Genes (Mus musculus)
Akt2  (thymoma viral proto-oncogene 2)
Rab10  (RAB10, member RAS oncogene family)
Rab11a  (RAB11A, member RAS oncogene family)
Rab14  (RAB14, member RAS oncogene family)
Rab2a  (RAB2A, member RAS oncogene family)
Rab4a  (RAB4A, member RAS oncogene family)
Rab5a  (RAB5A, member RAS oncogene family)
Rab8a  (RAB8A, member RAS oncogene family)
Slc2a4  (solute carrier family 2 (facilitated glucose transporter), member 4)
Stxbp4  (syntaxin binding protein 4)
Tbc1d4  (TBC1 domain family, member 4)

Genes (Homo sapiens)
AKT2  (AKT serine/threonine kinase 2)
RAB10  (RAB10, member RAS oncogene family)
RAB11A  (RAB11A, member RAS oncogene family)
RAB14  (RAB14, member RAS oncogene family)
RAB2A  (RAB2A, member RAS oncogene family)
RAB4A  (RAB4A, member RAS oncogene family)
RAB5A  (RAB5A, member RAS oncogene family)
RAB8A  (RAB8A, member RAS oncogene family)
SLC2A4  (solute carrier family 2 member 4)
STXBP4  (syntaxin binding protein 4)
TBC1D4  (TBC1 domain family member 4)


Additional Information