RGD Reference Report - Insulin action on glucose transporters through molecular switches, tracks and tethers. - Rat Genome Database

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Insulin action on glucose transporters through molecular switches, tracks and tethers.

Authors: Zaid, H  Antonescu, CN  Randhawa, VK  Klip, A 
Citation: Zaid H, etal., Biochem J. 2008 Jul 15;413(2):201-15.
RGD ID: 2302397
Pubmed: PMID:18570632   (View Abstract at PubMed)
DOI: DOI:10.1042/BJ20080723   (Journal Full-text)

Glucose entry into muscle cells is precisely regulated by insulin, through recruitment of GLUT4 (glucose transporter-4) to the membrane of muscle and fat cells. Work done over more than two decades has contributed to mapping the insulin signalling and GLUT4 vesicle trafficking events underpinning this response. In spite of this intensive scientific research, there are outstanding questions that continue to challenge us today. The present review summarizes the knowledge in the field, with emphasis on the latest breakthroughs in insulin signalling at the level of AS160 (Akt substrate of 160 kDa), TBC1D1 (tre-2/USP6, BUB2, cdc16 domain family member 1) and their target Rab proteins; in vesicle trafficking at the level of vesicle mobilization, tethering, docking and fusion with the membrane; and in the participation of the cytoskeleton to achieve optimal temporal and spatial location of insulin-derived signals and GLUT4 vesicles.

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
insulin responsive facilitative sugar transporter mediated glucose transport pathway   TAS 2302397; 2302397; 2302397; 2302397; 2302397; 2302397; 2302397; 2302397; 2302397; 2302397; 2302397; 2302397; 2302397; 2302397 RGD 
insulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOAKT2 (Homo sapiens)2302397; 2302397 RGD 
insulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOMYO5A (Homo sapiens)2302397; 2302397 RGD 
insulin responsive facilitative sugar transporter mediated glucose transport pathway   ISORAB10 (Homo sapiens)2302397; 2302397 RGD 
insulin responsive facilitative sugar transporter mediated glucose transport pathway   ISORAB11A (Homo sapiens)2302397; 2302397 RGD 
insulin responsive facilitative sugar transporter mediated glucose transport pathway   ISORAB14 (Homo sapiens)2302397; 2302397 RGD 
insulin responsive facilitative sugar transporter mediated glucose transport pathway   ISORAB2A (Homo sapiens)2302397; 2302397 RGD 
insulin responsive facilitative sugar transporter mediated glucose transport pathway   ISORAB4A (Homo sapiens)2302397; 2302397 RGD 
insulin responsive facilitative sugar transporter mediated glucose transport pathway   ISORAB8A (Homo sapiens)2302397; 2302397 RGD 
insulin responsive facilitative sugar transporter mediated glucose transport pathway   ISORAB8B (Homo sapiens)2302397; 2302397 RGD 
insulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOSLC2A4 (Homo sapiens)2302397; 2302397 RGD 
insulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOSNAP23 (Homo sapiens)2302397; 2302397 RGD 
insulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOSTX4 (Homo sapiens)2302397; 2302397 RGD 
insulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOSTXBP3 (Homo sapiens)2302397; 2302397 RGD 
insulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOTBC1D4 (Homo sapiens)2302397 RGD 
insulin responsive facilitative sugar transporter mediated glucose transport pathway   ISOVAMP2 (Homo sapiens)2302397; 2302397 RGD 
Rab family mediated signaling pathway  TAS 2302397; 2302397; 2302397; 2302397; 2302397; 2302397; 2302397; 2302397 RGD 
Rab family mediated signaling pathway  ISORAB10 (Homo sapiens)2302397; 2302397 RGD 
Rab family mediated signaling pathway  ISORAB11A (Homo sapiens)2302397; 2302397 RGD 
Rab family mediated signaling pathway  ISORAB14 (Homo sapiens)2302397; 2302397 RGD 
Rab family mediated signaling pathway  ISORAB2A (Homo sapiens)2302397; 2302397 RGD 
Rab family mediated signaling pathway  ISORAB4A (Homo sapiens)2302397; 2302397 RGD 
Rab family mediated signaling pathway  ISORAB8A (Homo sapiens)2302397; 2302397 RGD 
Rab family mediated signaling pathway  ISORAB8B (Homo sapiens)2302397; 2302397 RGD 
Rab family mediated signaling pathway  ISOTBC1D4 (Homo sapiens)2302397; 2302397 RGD 
Objects Annotated

Genes (Rattus norvegicus)
Akt2  (AKT serine/threonine kinase 2)
Myo5a  (myosin VA)
Rab10  (RAB10, member RAS oncogene family)
Rab11a  (RAB11a, member RAS oncogene family)
Rab14  (RAB14, member RAS oncogene family)
Rab2a  (RAB2A, member RAS oncogene family)
Rab4a  (RAB4A, member RAS oncogene family)
Rab8a  (RAB8A, member RAS oncogene family)
Rab8b  (RAB8B, member RAS oncogene family)
Slc2a4  (solute carrier family 2 member 4)
Snap23  (synaptosome associated protein 23)
Stx4  (syntaxin 4)
Stxbp3  (syntaxin binding protein 3)
Tbc1d4  (TBC1 domain family, member 4)
Vamp2  (vesicle-associated membrane protein 2)

Genes (Mus musculus)
Akt2  (thymoma viral proto-oncogene 2)
Myo5a  (myosin VA)
Rab10  (RAB10, member RAS oncogene family)
Rab11a  (RAB11A, member RAS oncogene family)
Rab14  (RAB14, member RAS oncogene family)
Rab2a  (RAB2A, member RAS oncogene family)
Rab4a  (RAB4A, member RAS oncogene family)
Rab8a  (RAB8A, member RAS oncogene family)
Rab8b  (RAB8B, member RAS oncogene family)
Slc2a4  (solute carrier family 2 (facilitated glucose transporter), member 4)
Snap23  (synaptosomal-associated protein 23)
Stx4a  (syntaxin 4A (placental))
Stxbp3  (syntaxin binding protein 3)
Tbc1d4  (TBC1 domain family, member 4)
Vamp2  (vesicle-associated membrane protein 2)

Genes (Homo sapiens)
AKT2  (AKT serine/threonine kinase 2)
MYO5A  (myosin VA)
RAB10  (RAB10, member RAS oncogene family)
RAB11A  (RAB11A, member RAS oncogene family)
RAB14  (RAB14, member RAS oncogene family)
RAB2A  (RAB2A, member RAS oncogene family)
RAB4A  (RAB4A, member RAS oncogene family)
RAB8A  (RAB8A, member RAS oncogene family)
RAB8B  (RAB8B, member RAS oncogene family)
SLC2A4  (solute carrier family 2 member 4)
SNAP23  (synaptosome associated protein 23)
STX4  (syntaxin 4)
TBC1D4  (TBC1 domain family member 4)
VAMP2  (vesicle associated membrane protein 2)


Additional Information