RGD Reference Report - Rab10 associates with primary cilia and the exocyst complex in renal epithelial cells. - Rat Genome Database

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Rab10 associates with primary cilia and the exocyst complex in renal epithelial cells.

Authors: Babbey, CM  Bacallao, RL  Dunn, KW 
Citation: Babbey CM, etal., Am J Physiol Renal Physiol. 2010 Sep;299(3):F495-506. doi: 10.1152/ajprenal.00198.2010. Epub 2010 Jun 24.
RGD ID: 8553613
Pubmed: PMID:20576682   (View Abstract at PubMed)
PMCID: PMC2944301   (View Article at PubMed Central)
DOI: DOI:10.1152/ajprenal.00198.2010   (Journal Full-text)

Rab10, a mammalian homolog of the yeast Sec4p protein, has previously been associated with endocytic recycling and biosynthetic membrane transport in cultured epithelia and with Glut4 translocation in adipocytes. Here, we report that Rab10 associates with primary cilia in renal epithelia in culture and in vivo. In addition, we find that Rab10 also colocalizes with exocyst proteins at the base of nascent cilia, and physically interacts with the exocyst complex, as detected with anti-Sec8 antibodies. These data suggest that membrane transport to the primary cilum may be mediated by interactions between Rab10 and an exocyst complex located at the cilium base.




Cellular Component

  
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Original Reference(s)
Rab10Ratcilium located_inIDA PMID:20576682UniProt 


Genes (Rattus norvegicus)
Rab10  (RAB10, member RAS oncogene family)