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Lgl1 activation of rab10 promotes axonal membrane trafficking underlying neuronal polarization.

Authors: Wang, T  Liu, Y  Xu, XH  Deng, CY  Wu, KY  Zhu, J  Fu, XQ  He, M  Luo, ZG 
Citation: Wang T, etal., Dev Cell. 2011 Sep 13;21(3):431-44. doi: 10.1016/j.devcel.2011.07.007.
Pubmed: (View Article at PubMed) PMID:21856246
DOI: Full-text: DOI:10.1016/j.devcel.2011.07.007

Directed membrane trafficking is believed to be crucial for axon development during neuronal morphogenesis. However, the underlying mechanisms are poorly understood. Here, we report a role of Lgl1, the mammalian homolog of Drosophila tumor suppressor Lethal giant larvae, in controlling membrane trafficking underlying axonal growth. We find that Lgl1 is associated with plasmalemmal precursor vesicles and enriched in developing axons. Lgl1 upregulation promoted axonal growth, whereas downregulation attenuated it as well as directional membrane insertion. Interestingly, Lgl1 interacted with and activated Rab10, a small GTPase that mediates membrane protein trafficking, by releasing GDP dissociation inhibitor (GDI) from Rab10. Furthermore, Rab10 lies downstream of Lgl1 in axon development and directional membrane insertion. Finally, both Lgl1 and Rab10 are required for neocortical neuronal polarization in vivo. Thus, the Lgl1 regulation of Rab10 stimulates the trafficking of membrane precursor vesicles, whose fusion with the plasmalemma is crucial for axonal growth.

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RGD Object Information
RGD ID: 8553614
Created: 2014-05-08
Species: All species
Last Modified: 2014-05-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.