RGD Reference Report - Effect of cardamonin on hepatic ischemia reperfusion induced in rats: Role of nitric oxide. - Rat Genome Database

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Effect of cardamonin on hepatic ischemia reperfusion induced in rats: Role of nitric oxide.

Authors: Atef, Yara  El-Fayoumi, Hassan M  Abdel-Mottaleb, Yousra  Mahmoud, Mona F 
Citation: Atef Y, etal., Eur J Pharmacol. 2017 Nov 15;815:446-453. doi: 10.1016/j.ejphar.2017.09.037. Epub 2017 Sep 28.
RGD ID: 13450941
Pubmed: PMID:28966130   (View Abstract at PubMed)
DOI: DOI:10.1016/j.ejphar.2017.09.037   (Journal Full-text)

Ischemia reperfusion (I/R) injury is a cellular damage in a hypoxic organ following the restoration of oxygen delivery. It may occur during organ transplantation, trauma and hepatectomies. Nitric oxide (NO) effects during hepatic I/R are complicated. The iNOS-derived NO has a deleterious effect, whereas eNOS-derived NO has a protective effect in liver I/R. Cardamonin (CDN) is an anti-inflammatory molecule and a novel iNOS inhibitor, and N¿-Nitro-L-arginine (L-NNA) is a NOS inhibitor. L-Arginine is a precursor of NOS. This study was designed to investigate the possible protective effects of CDN on hepatic I/R and the role of NO. Wistar rats were randomly divided into 5 groups (Sham, I/R, CDN, L-NNA and L-arginine). Liver ischemia was induced for 45min then reperfusion was allowed for 1h. L-Arginine and CDN ameliorated the deleterious effects of I/R through reducing the oxidative stress and hepatocyte degeneration. Both molecules decreased the elevated inflammatory cytokines and increased the antiapoptotic marker, Bcl2. Both agents increased NO and eNOS expression and decreased iNOS expression. In conclusion, increased NO/eNOS and suppression of iNOS expression have protective effects on I/R injury. While inhibition of eNOS and reduction of NO have deleterious effects on I/R injury. For the first time, we demonstrated that cardamonin improved functional and structural abnormalities of the liver following I/R by improving oxidative stress and inflammation and increasing the availability of NO produced by eNOS. Treatment with cardamonin could be a promising strategy in patients with hepatic I/R injury in different clinical situations.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Liver Reperfusion Injury treatmentISONos3 (Rattus norvegicus)13450941; 13450941 RGD 
Liver Reperfusion Injury treatmentIEP 13450941 RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to L-arginine  IEP 13450941 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nos3  (nitric oxide synthase 3)

Genes (Mus musculus)
Nos3  (nitric oxide synthase 3, endothelial cell)

Genes (Homo sapiens)
NOS3  (nitric oxide synthase 3)


Additional Information