CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: pyrrolizidine
Accession: CHEBI:64950
browse the term
Definition: A bicyclic organonitrogen heterocyclic compound comprised of two ortho-fused pyrrolidine rings which share a common nitrogen atom.
Synonyms: exact_synonym: hexahydro-1H-pyrrolizine
related_synonym: 1-azabicyclo[3.3.0]octane; 2,3,5,6,7,8-hexahydro-1H-pyrrolizine; Formula=C7H13N; Hexahydropyrrolizine; InChI=1S/C7H13N/c1-3-7-4-2-6-8(7)5-1/h7H,1-6H2; InChIKey=ADRDEXBBJTUCND-UHFFFAOYSA-N; SMILES=C1CC2CCCN2C1
xref: CAS:643-20-9; Reaxys:103088; Wikipedia:Pyrrolizidine
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Abraxas1
abraxas 1, BRCA1 A complex subunit
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ABRAXAS1 mRNA
CTD
PMID:33884520
NCBI chr14:8,796,281...8,810,625
Ensembl chr14:8,796,266...8,810,622
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Ace
angiotensin I converting enzyme
increases expression multiple interactions
EXP
Monocrotaline results in increased expression of ACE mRNA; Monocrotaline results in increased expression of ACE protein angiotensin I (1-7) inhibits the reaction [Monocrotaline results in increased expression of ACE mRNA]; magnolol inhibits the reaction [Monocrotaline results in increased expression of ACE protein]
CTD
PMID:20581171 PMID:30466619
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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Ace2
angiotensin converting enzyme 2
decreases expression multiple interactions
EXP
Monocrotaline results in decreased expression of ACE2 protein [Monocrotaline co-treated with angiotensin I (1-7)] results in increased expression of ACE2 mRNA; magnolol inhibits the reaction [Monocrotaline results in decreased expression of ACE2 protein]
CTD
PMID:20581171 PMID:30466619
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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Acta2
actin alpha 2, smooth muscle
increases expression multiple interactions
EXP
Monocrotaline results in increased expression of ACTA2 protein 18alpha-glycyrrhetinic acid inhibits the reaction [Monocrotaline results in increased expression of ACTA2 protein]
CTD
PMID:31325423 PMID:31734320
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Actb
actin, beta
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ACTB mRNA
CTD
PMID:33884520
NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
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Agt
angiotensinogen
increases expression multiple interactions
EXP
Monocrotaline results in increased expression of AGT protein magnolol inhibits the reaction [Monocrotaline results in increased expression of AGT protein]
CTD
PMID:16936438 PMID:30466619
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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Agtr1a
angiotensin II receptor, type 1a
multiple interactions increases expression
EXP
magnolol inhibits the reaction [Monocrotaline results in increased expression of AGTR1A protein]
CTD
PMID:30466619
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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Akt1
AKT serine/threonine kinase 1
decreases phosphorylation increases phosphorylation multiple interactions
EXP
Monocrotaline results in decreased phosphorylation of AKT1 protein Monocrotaline results in increased phosphorylation of AKT1 protein magnolol inhibits the reaction [Monocrotaline results in increased phosphorylation of AKT1 protein]; Monocrotaline affects the expression of and affects the phosphorylation of AKT1 protein; Quercetin affects the reaction [Monocrotaline affects the expression of and affects the phosphorylation of AKT1 protein]; Quercetin inhibits the reaction [Monocrotaline results in increased phosphorylation of AKT1 protein]
CTD
PMID:18801959 PMID:25460361 PMID:30466619
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Anapc13
anaphase promoting complex subunit 13
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of ANAPC13 mRNA
CTD
PMID:33884520
NCBI chr 8:103,205,520...103,213,936
Ensembl chr 8:103,205,520...103,213,936
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Anapc2
anaphase promoting complex subunit 2
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ANAPC2 mRNA
CTD
PMID:33884520
NCBI chr 3:8,086,434...8,098,182
Ensembl chr 3:8,086,462...8,098,178
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Anxa5
annexin A5
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of ANXA5 mRNA
CTD
PMID:21224054
NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
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Arid1a
AT-rich interaction domain 1A
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ARID1A mRNA
CTD
PMID:33884520
NCBI chr 5:145,908,173...145,981,552
Ensembl chr 5:145,908,181...145,985,564
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Arid2
AT-rich interaction domain 2
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ARID2 mRNA
CTD
PMID:33884520
NCBI chr 7:127,447,192...127,565,987
Ensembl chr 7:127,447,278...127,563,512
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Atm
ATM serine/threonine kinase
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM protein [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of ATM mRNA
CTD
PMID:21224054 PMID:33884520
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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Atp6v0e2
ATPase, H+ transporting V0 subunit e2
increases expression
ISO
Monocrotaline results in increased expression of ATP6V0E2 mRNA
CTD
PMID:28818515
NCBI chr 4:77,484,868...77,488,016
Ensembl chr 4:77,482,226...77,488,777
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Aurka
aurora kinase A
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of AURKA mRNA
CTD
PMID:33884520
NCBI chr 3:161,128,309...161,144,524
Ensembl chr 3:161,128,313...161,144,390
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Babam2
BRISC and BRCA1 A complex member 2
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of BABAM2 mRNA
CTD
PMID:33884520
NCBI chr 6:24,369,021...24,788,416
Ensembl chr 6:24,369,022...24,833,951
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Bard1
BRCA1 associated RING domain 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BARD1 mRNA
CTD
PMID:33884520
NCBI chr 9:72,616,070...72,694,553
Ensembl chr 9:72,623,155...72,694,265
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions increases expression
ISO EXP
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BAX mRNA modafinil inhibits the reaction [monocrotaline increases expression of Bax protein in lung]
CTD RGD
PMID:21224054 PMID:26959484 PMID:26959484
RGD:329969898 , RGD:329969898
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2l1
Bcl2-like 1
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BCL2L1 mRNA
CTD
PMID:21224054
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Bdnf
brain-derived neurotrophic factor
affects expression
EXP
Monocrotaline affects the expression of BDNF mRNA
CTD
PMID:36336098
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Birc5
baculoviral IAP repeat-containing 5
increases expression multiple interactions
EXP
Monocrotaline results in increased expression of BIRC5 mRNA Quercetin inhibits the reaction [Monocrotaline results in increased expression of BIRC5 mRNA]
CTD
PMID:25460361
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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Blm
BLM RecQ like helicase
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BLM mRNA
CTD
PMID:33884520
NCBI chr 1:134,409,832...134,496,073
Ensembl chr 1:134,409,857...134,484,312
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Bmp7
bone morphogenetic protein 7
increases expression
EXP
monocrotaline increases expression of Bmp7 protein in rat lung, pulmonary artery
RGD
PMID:31542483
RGD:155888480
NCBI chr 3:161,639,915...161,716,938
Ensembl chr 3:161,516,462...161,716,788
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Bmpr2
bone morphogenetic protein receptor type 2
multiple interactions decreases expression
EXP
Fluoxetine inhibits the reaction [Monocrotaline results in decreased expression of BMPR2 mRNA] Monocrotaline results in decreased expression of BMPR2 mRNA; Monocrotaline results in decreased expression of BMPR2 protein
CTD
PMID:20522807 PMID:21619414 PMID:25460361
NCBI chr 9:61,192,718...61,307,280
Ensembl chr 9:61,190,566...61,301,809
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Brca2
BRCA2, DNA repair associated
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of BRCA2 mRNA
CTD
PMID:33884520
NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
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Brd7
bromodomain containing 7
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BRD7 mRNA
CTD
PMID:33884520
NCBI chr19:18,708,792...18,737,497
Ensembl chr19:18,709,022...18,737,494
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Brip1
BRCA1 interacting helicase 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BRIP1 mRNA
CTD
PMID:33884520
NCBI chr10:70,907,266...71,031,502
Ensembl chr10:70,907,371...71,030,324
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Casp3
caspase 3
increases expression decreases expression multiple interactions
EXP
Monocrotaline results in increased expression of CASP3 mRNA Monocrotaline results in decreased expression of CASP3 protein Fluoxetine inhibits the reaction [Monocrotaline results in decreased expression of CASP3 protein]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of CASP3 mRNA]
CTD
PMID:21619414 PMID:22022327
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
multiple interactions increases activity
EXP
Curcumin analog inhibits the reaction [Monocrotaline results in increased activity of CAT protein]
CTD
PMID:31407471
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cav1
caveolin 1
decreases expression multiple interactions
EXP
Monocrotaline results in decreased expression of CAV1 mRNA; Monocrotaline results in decreased expression of CAV1 protein NCP-2454 inhibits the reaction [Monocrotaline results in decreased expression of CAV1 protein]
CTD
PMID:24835767 PMID:25275723
NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
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Cav2
caveolin 2
decreases expression
EXP
Monocrotaline results in decreased expression of CAV2 mRNA; Monocrotaline results in decreased expression of CAV2 protein
CTD
PMID:24835767
NCBI chr 4:45,616,766...45,624,144
Ensembl chr 4:45,616,712...45,624,244
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Cavin1
caveolae associated protein 1
decreases expression
EXP
Monocrotaline results in decreased expression of CAVIN1 mRNA; Monocrotaline results in decreased expression of CAVIN1 protein
CTD
PMID:24835767
NCBI chr10:85,884,100...85,896,136
Ensembl chr10:85,889,036...85,896,120
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Ccl2
C-C motif chemokine ligand 2
increases expression multiple interactions
EXP
Monocrotaline results in increased expression of CCL2 mRNA; Monocrotaline results in increased expression of CCL2 protein liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of CCL2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in increased expression of CCL2 mRNA]
CTD
PMID:25051504 PMID:31589899 PMID:36336098
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccl5
C-C motif chemokine ligand 5
affects expression
EXP
Monocrotaline affects the expression of CCL5 protein
CTD
PMID:25051504
NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377
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Ccnb1
cyclin B1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CCNB1 mRNA
CTD
PMID:33884520
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Ccnb2
cyclin B2
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CCNB2 mRNA
CTD
PMID:33884520
NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
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Ccnd1
cyclin D1
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CCND1 mRNA
CTD
PMID:21224054
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Ccng1
cyclin G1
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CCNG1 mRNA
CTD
PMID:21224054
NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
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Cdc20
cell division cycle 20
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of CDC20 mRNA
CTD
PMID:33884520
NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
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Cdc25a
cell division cycle 25A
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC25A mRNA
CTD
PMID:33884520
NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
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Cdc25b
cell division cycle 25B
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC25B mRNA
CTD
PMID:33884520
NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272
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Cdc25c
cell division cycle 25C
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC25C mRNA
CTD
PMID:33884520
NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
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Cdc7
cell division cycle 7
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC7 mRNA
CTD
PMID:33884520
NCBI chr14:2,804,660...2,824,796
Ensembl chr14:2,804,661...2,824,778
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Cdh1
cadherin 1
multiple interactions decreases expression
ISO
Propylthiouracil inhibits the reaction [Monocrotaline results in decreased expression of CDH1 protein]
CTD
PMID:36942326
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Cdh2
cadherin 2
increases expression multiple interactions
EXP ISO
Monocrotaline results in increased expression of CDH2 protein Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of CDH2 protein]
CTD
PMID:31734320 PMID:36942326
NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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Cdh5
cadherin 5
decreases expression
EXP
Monocrotaline results in decreased expression of CDH5 protein
CTD
PMID:31734320
NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368
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Cdk1
cyclin-dependent kinase 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDK1 mRNA
CTD
PMID:33884520
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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Cdk2
cyclin dependent kinase 2
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDK2 mRNA
CTD
PMID:33884520
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A protein [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of CDKN1A mRNA
CTD
PMID:21224054 PMID:33884520
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Chek1
checkpoint kinase 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of CHEK1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CHEK1 mRNA
CTD
PMID:33884520
NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
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Chek2
checkpoint kinase 2
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CHEK2 mRNA
CTD
PMID:21224054
NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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Clspn
claspin
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CLSPN mRNA
CTD
PMID:33884520
NCBI chr 5:138,850,119...138,885,037
Ensembl chr 5:138,850,128...138,885,034
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Col1a1
collagen type I alpha 1 chain
multiple interactions
EXP
[Monocrotaline co-treated with LGALS3 protein] promotes the reaction [[Monocrotaline co-treated with TGFB1] results in increased expression of COL1A1 protein]; [Monocrotaline co-treated with LGALS3 protein] results in increased expression of COL1A1 protein; [Monocrotaline co-treated with TGFB1] results in increased expression of COL1A1 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[Monocrotaline co-treated with TGFB1] results in increased expression of COL1A1 protein]
CTD
PMID:27870162
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Col4a1
collagen type IV alpha 1 chain
increases expression
EXP
Monocrotaline results in increased expression of COL4A1 protein
CTD
PMID:36414118
NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
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Csrp2
cysteine and glycine-rich protein 2
increases expression
EXP
Monocrotaline results in increased expression of CSRP2 protein
CTD
PMID:36414118
NCBI chr 7:46,349,109...46,367,743
Ensembl chr 7:46,348,686...46,367,745
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Ctnnb1
catenin beta 1
multiple interactions increases expression decreases expression
EXP
Fluoxetine inhibits the reaction [Monocrotaline results in decreased expression of CTNNB1 protein]; magnolol inhibits the reaction [Monocrotaline results in increased expression of CTNNB1 protein]
CTD
PMID:21619414 PMID:30466619
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Cxcl10
C-X-C motif chemokine ligand 10
multiple interactions decreases expression
ISO EXP
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CXCL10 mRNA Monocrotaline results in decreased expression of CXCL10 protein
CTD
PMID:21224054 PMID:25051504
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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Cxcl16
C-X-C motif chemokine ligand 16
multiple interactions
ISO
[Lipopolysaccharides co-treated with Monocrotaline] results in increased expression of CXCL16 protein; [Monocrotaline co-treated with Lipopolysaccharides] results in decreased expression of CXCL16 protein
CTD
PMID:21279329 PMID:21327618
NCBI chr10:55,166,721...55,171,316
Ensembl chr10:55,166,723...55,171,592
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Cxcl3
C-X-C motif chemokine ligand 3
multiple interactions
ISO
[Monocrotaline co-treated with Lipopolysaccharides] results in increased expression of CXCL1 protein; F3 protein promotes the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased expression of CXCL1 protein]
CTD
PMID:22407844
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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Cybb
cytochrome b-245 beta chain
increases expression
EXP
Monocrotaline results in increased expression of CYBB mRNA; Monocrotaline results in increased expression of CYBB protein
CTD
PMID:24835767 PMID:24947524
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP1B1 mRNA
CTD
PMID:21224054
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP2B10 mRNA
CTD
PMID:21224054
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
multiple interactions
ISO
CYP2C19 protein results in increased metabolism of and results in increased activity of Monocrotaline
CTD
PMID:19818743
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases metabolic processing increases response to substance increases expression multiple interactions
ISO
CYP3A4 protein results in increased metabolism of Monocrotaline CYP3A4 protein results in increased susceptibility to Monocrotaline Monocrotaline results in increased expression of CYP3A4 mRNA [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of BRCA2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of CDC20 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of CHEK1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of E2F8 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of KIF11 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of KIF23 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of PLK2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of RFC5 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ABRAXAS1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ACTB mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ANAPC2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ARID1A mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ARID2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ATRIP mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of AURKA mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BARD1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BLM mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BRD7 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of BRIP1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CCNB1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CCNB2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC25A mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC25B mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC25C mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDC7 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDK1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CDK2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CHEK1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of CLSPN mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of E2F1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of E2F5 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ESPL1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCA mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCB mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCD2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCG mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FBXO5 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MDC1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MRE11 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MSH2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MSH6 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PHF10 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PKMYT1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PLK1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PLK4 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of POU2F1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PPM1J mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PPM1L mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PPP2R3B mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PRC1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PTTG1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RAD1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RAD21 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RBL1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC3 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC4 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SLC19A1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMARCB1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMARCC1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMC1A mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMC3 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of STAG2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of TLK1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of ANAPC13 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of ATM mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of BABAM2 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of CDKN1A mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of GADD45A mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of MLH1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PCNA mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PLK3 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PPP2CB mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PPP2R5E mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of STAT1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of TOPBP1 mRNA; [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of TP53 mRNA; [Monocrotaline results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; CYP3A4 protein results in increased metabolism of and results in increased activity of Monocrotaline; Dihydrotestosterone inhibits the reaction [[Monocrotaline results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA]; Flutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [[Monocrotaline results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA]]
CTD
PMID:19818743 PMID:32682830 PMID:32910235 PMID:33884520
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
G
Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
increases expression
EXP
Monocrotaline results in increased expression of CYP3A23-3A1 mRNA
CTD
PMID:32682830
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
G
Cyp7a1
cytochrome P450 family 7 subfamily A member 1
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNA
CTD
PMID:21224054
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
G
Ddit3
DNA-damage inducible transcript 3
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of DDIT3 mRNA
CTD
PMID:21224054
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
G
Dnaja1
DnaJ heat shock protein family (Hsp40) member A1
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of DNAJA1 mRNA
CTD
PMID:21224054
NCBI chr 5:55,842,414...55,853,326
Ensembl chr 5:55,842,426...55,853,967
G
E2f1
E2F transcription factor 1
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of E2F1 mRNA [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of E2F1 mRNA
CTD
PMID:21224054 PMID:33884520
NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
G
E2f5
E2F transcription factor 5
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of E2F5 mRNA
CTD
PMID:33884520
NCBI chr 2:86,997,331...87,012,908
Ensembl chr 2:86,997,332...87,012,990
G
E2f8
E2F transcription factor 8
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of E2F8 mRNA
CTD
PMID:33884520
NCBI chr 1:98,565,717...98,584,265
Ensembl chr 1:98,565,717...98,584,098
G
Edn1
endothelin 1
multiple interactions increases expression
EXP
4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]; 4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in increased expression of EDN1 protein]; Bosentan inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA]; magnolol inhibits the reaction [Monocrotaline results in increased expression of EDN1 protein]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of EDN1 mRNA] Monocrotaline results in increased expression of EDN1 mRNA; Monocrotaline results in increased expression of EDN1 protein
CTD
PMID:16225752 PMID:20967148 PMID:22022327 PMID:30466619
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
G
Ednra
endothelin receptor type A
multiple interactions increases expression
EXP
magnolol inhibits the reaction [Monocrotaline results in increased expression of EDNRA protein]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of EDNRA mRNA] Monocrotaline results in increased expression of EDNRA mRNA; Monocrotaline results in increased expression of EDNRA protein
CTD
PMID:20967148 PMID:22022327 PMID:30466619
NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
G
Egr1
early growth response 1
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of EGR1 mRNA
CTD
PMID:21224054
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
G
Espl1
extra spindle pole bodies like 1, separase
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of ESPL1 mRNA
CTD
PMID:33884520
NCBI chr 7:133,424,027...133,450,984
Ensembl chr 7:133,424,130...133,450,984
G
F3
coagulation factor III, tissue factor
multiple interactions
ISO
[Monocrotaline co-treated with Lipopolysaccharides] results in increased expression of F3 protein; F3 protein promotes the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased expression of CXCL1 protein]; F3 protein results in increased susceptibility to [Monocrotaline co-treated with Lipopolysaccharides]
CTD
PMID:22407844
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
G
Fanca
FA complementation group A
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCA mRNA
CTD
PMID:33884520
NCBI chr19:51,304,126...51,362,586
Ensembl chr19:51,304,021...51,362,527
G
Fancb
FA complementation group B
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCB mRNA
CTD
PMID:33884520
NCBI chr X:29,403,771...29,420,484
Ensembl chr X:29,403,771...29,420,192
G
Fancd2
FA complementation group D2
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCD2 mRNA
CTD
PMID:33884520
NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
G
Fancg
FA complementation group G
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FANCG mRNA
CTD
PMID:33884520
NCBI chr 5:57,230,287...57,240,067
Ensembl chr 5:57,231,685...57,240,029
G
Faslg
Fas ligand
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FASL mRNA
CTD
PMID:21224054
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
G
Fbxo32
F-box protein 32
increases expression multiple interactions decreases expression
EXP
Monocrotaline results in increased expression of FBXO32 mRNA resveratrol inhibits the reaction [Monocrotaline results in decreased expression of FBXO32 mRNA]
CTD
PMID:18801959 PMID:22146233
NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436
G
Fbxo5
F-box protein 5
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of FBXO5 mRNA
CTD
PMID:33884520
NCBI chr 1:42,196,068...42,202,437
Ensembl chr 1:42,196,068...42,202,437
G
Flt4
Fms related receptor tyrosine kinase 4
decreases expression multiple interactions
ISO
Monocrotaline results in decreased expression of FLT4 mRNA romiplostim inhibits the reaction [Monocrotaline results in decreased expression of FLT4 mRNA]; THPO protein inhibits the reaction [Monocrotaline results in decreased expression of FLT4 mRNA]
CTD
PMID:33122006
NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770
G
Fmo1
flavin containing dimethylaniline monoxygenase 1
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO1 mRNA
CTD
PMID:21224054
NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
G
Fmo4
flavin containing dimethylaniline monoxygenase 4
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO4 mRNA
CTD
PMID:21224054
NCBI chr13:75,154,683...75,172,874
Ensembl chr13:75,154,684...75,172,874
G
Fn1
fibronectin 1
increases expression multiple interactions
EXP ISO
Monocrotaline results in increased expression of FN1 protein Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of FN1 protein] [Monocrotaline co-treated with TGFB1] results in increased expression of FN1 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[Monocrotaline co-treated with TGFB1] results in increased expression of FN1 protein]
CTD
PMID:24947524 PMID:27870162 PMID:36414118 PMID:36942326
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
G
Foxo3
forkhead box O3
decreases phosphorylation
EXP
Monocrotaline results in decreased phosphorylation of FOXO3 protein
CTD
PMID:18801959
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
G
Gadd45a
growth arrest and DNA-damage-inducible, alpha
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GADD45A mRNA [CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of GADD45A mRNA
CTD
PMID:21224054 PMID:33884520
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
G
Gata3
GATA binding protein 3
increases expression multiple interactions
ISO
Monocrotaline results in increased expression of GATA3 protein Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of GATA3 protein]
CTD
PMID:36942326
NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
G
Gata4
GATA binding protein 4
multiple interactions increases expression
ISO
Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of GATA4 protein]
CTD
PMID:36942326
NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
G
Gata6
GATA binding protein 6
increases expression multiple interactions
ISO
Monocrotaline results in increased expression of GATA6 protein Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of GATA6 protein]
CTD
PMID:36942326
NCBI chr18:2,188,121...2,219,532
Ensembl chr18:2,188,121...2,219,532
G
Gclc
glutamate-cysteine ligase, catalytic subunit
multiple interactions decreases expression
EXP
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GCLC mRNA]
CTD
PMID:29908794
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
G
Gclm
glutamate cysteine ligase, modifier subunit
multiple interactions decreases expression
EXP
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GCLM mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GCLM mRNA]
CTD
PMID:29908794
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
G
Gfap
glial fibrillary acidic protein
affects expression
EXP
Monocrotaline affects the expression of GFAP protein
CTD
PMID:21781985
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
G
Gpt
glutamic--pyruvic transaminase
increases activity multiple interactions
EXP ISO
Monocrotaline results in increased activity of GPT protein liquiritigenin inhibits the reaction [Monocrotaline results in increased activity of GPT protein]; liquiritin inhibits the reaction [Monocrotaline results in increased activity of GPT protein] [TBXA2R protein affects the susceptibility to Monocrotaline] which results in increased expression of ALT protein
CTD
PMID:24418708 PMID:28818515 PMID:31470032 PMID:31589899
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
G
Gpx2
glutathione peroxidase 2
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GPX2 mRNA
CTD
PMID:21224054
NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
G
Gsk3b
glycogen synthase kinase 3 beta
increases phosphorylation multiple interactions
EXP
Monocrotaline results in increased phosphorylation of GSK3B protein magnolol inhibits the reaction [Monocrotaline results in increased phosphorylation of GSK3B protein]
CTD
PMID:30466619
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
G
Gsr
glutathione-disulfide reductase
multiple interactions increases activity decreases expression
EXP
Curcumin analog inhibits the reaction [Monocrotaline results in increased activity of GSR protein]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GSR mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of GSR protein]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GSR mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of GSR protein] Monocrotaline results in decreased expression of GSR mRNA; Monocrotaline results in decreased expression of GSR protein
CTD
PMID:29908794 PMID:31407471
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
G
Gstm1
glutathione S-transferase mu 1
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM1 protein
CTD
PMID:21224054
NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
G
Gstm5
glutathione S-transferase, mu 5
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM3 mRNA
CTD
PMID:21224054
NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553
G
H19
H19 imprinted maternally expressed transcript
increases expression multiple interactions decreases expression
EXP ISO
monocrotaline increases expression of H19 protein in lung melatonin inhibits the reaction [monocrotaline decreases expression of H19 RNA in pulmonary artery smooth muscle cells]
RGD
PMID:30547791 PMID:30240970 PMID:30240970 PMID:30547791
RGD:155882573 , RGD:156430315 , RGD:156430315 , RGD:155882573
NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134
G
H2ax
H2A.X variant histone
increases expression
ISO
Monocrotaline results in increased expression of H2AX protein
CTD
PMID:31154085
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
G
Hdgf
heparin binding growth factor
affects expression
EXP
Monocrotaline affects the expression of HDGF mRNA
CTD
PMID:36336098
NCBI chr 2:173,370,147...173,379,756
Ensembl chr 2:173,370,465...173,379,747
G
Hmgb1
high mobility group box 1
increases secretion
ISO EXP
Monocrotaline results in increased secretion of HMGB1 protein
CTD
PMID:31504964
NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
G
Hmox1
heme oxygenase 1
multiple interactions increases expression
ISO EXP
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HMOX1 mRNA Monocrotaline results in increased expression of HMOX1 mRNA liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of HMOX1 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in increased expression of HMOX1 mRNA]
CTD
PMID:21224054 PMID:29908794
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Hspa1l
heat shock protein family A (Hsp70) member 1 like
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA1L mRNA
CTD
PMID:21224054
NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
G
Hspa8
heat shock protein family A (Hsp70) member 8
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA8 mRNA
CTD
PMID:21224054
NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
G
Hspb1
heat shock protein family B (small) member 1
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPB1 mRNA
CTD
PMID:21224054
NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
G
Hspd1
heat shock protein family D (Hsp60) member 1
multiple interactions affects expression increases secretion
ISO EXP
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPD1 mRNA liquiritigenin inhibits the reaction [Monocrotaline affects the expression of HSPD1 protein]; liquiritin inhibits the reaction [Monocrotaline affects the expression of HSPD1 protein] Monocrotaline results in increased secretion of HSPD1 protein
CTD
PMID:21224054 PMID:31504964 PMID:31589899
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
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Hspe1
heat shock protein family E (Hsp10) member 1
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPE1 mRNA
CTD
PMID:21224054
NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089
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Htr2a
5-hydroxytryptamine receptor 2A
multiple interactions increases expression
EXP
Quercetin inhibits the reaction [Monocrotaline results in increased expression of HTR2A mRNA]
CTD
PMID:25460361
NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
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Icam1
intercellular adhesion molecule 1
multiple interactions
ISO
[Monocrotaline co-treated with 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] results in decreased expression of ICAM1 mRNA; [TBXA2R protein affects the susceptibility to Monocrotaline] which affects the expression of ICAM1 mRNA
CTD
PMID:31470032
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Id1
inhibitor of DNA binding 1
decreases expression multiple interactions
EXP
Monocrotaline results in decreased expression of ID1 mRNA treprostinil inhibits the reaction [Monocrotaline results in decreased expression of ID1 mRNA]
CTD
PMID:20522807
NCBI chr 3:141,210,666...141,212,420
Ensembl chr 3:141,211,267...141,212,419
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Igf1r
insulin-like growth factor 1 receptor
increases expression multiple interactions
EXP
monocrotaline increases expression of Igf1r RNA in pulmonary artery smooth muscle cells melatonin inhibits the reaction [monocrotaline increases expression of Igf1r RNA in pulmonary artery smooth muscle cells]
RGD
PMID:30240970 PMID:30240970
RGD:156430315 , RGD:156430315
NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
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Il10
interleukin 10
multiple interactions decreases expression
ISO EXP
[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of IL10 protein Monocrotaline results in decreased expression of IL10 protein
CTD
PMID:21327618 PMID:25051504
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il18
interleukin 18
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA
CTD
PMID:21224054
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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Il1a
interleukin 1 alpha
decreases expression
EXP
Monocrotaline results in decreased expression of IL1A protein
CTD
PMID:25051504
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Il1b
interleukin 1 beta
multiple interactions increases secretion increases expression affects expression
ISO EXP
[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of IL1B protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL1B mRNA Monocrotaline results in increased secretion of IL1B protein angiotensin I (1-7) inhibits the reaction [Monocrotaline results in increased expression of IL1B mRNA]; Curcumin analog inhibits the reaction [Monocrotaline results in increased expression of IL1B protein] Monocrotaline results in increased expression of IL1B mRNA; Monocrotaline results in increased expression of IL1B protein Monocrotaline affects the expression of IL1B mRNA
CTD
PMID:20581171 PMID:21224054 PMID:21327618 PMID:25051504 PMID:31407471 PMID:31504964 PMID:31734320 PMID:36336098 More...
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
multiple interactions treatment increases expression increases secretion decreases expression
ISO EXP
[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of IL6 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of IL6 mRNA; TF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of IL6 protein] modafinil inhibits the reaction [monocrotaline increases expression of Il6 protein in lung] angiotensin I (1-7) inhibits the reaction [Monocrotaline results in increased expression of IL6 mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of IL6 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in increased expression of IL6 mRNA]; NCP-2454 inhibits the reaction [Monocrotaline results in increased expression of IL6 protein] Monocrotaline results in increased expression of IL6 mRNA; Monocrotaline results in increased expression of IL6 protein Monocrotaline results in increased secretion of IL6 protein Monocrotaline results in decreased expression of IL6 protein
CTD RGD
PMID:20581171 PMID:21224054 PMID:21327618 PMID:25051504 PMID:25275723 PMID:31504964 PMID:31589899 PMID:26959484 PMID:26959484 More...
RGD:329969898 , RGD:329969898
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Itgb1
integrin subunit beta 1
increases expression
ISO
Monocrotaline results in increased expression of ITGB1 mRNA
CTD
PMID:28818515
NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
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Jag1
jagged canonical Notch ligand 1
increases expression multiple interactions
ISO
Monocrotaline results in increased expression of JAG1 protein Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of JAG1 protein]
CTD
PMID:36942326
NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209
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Jag2
jagged canonical Notch ligand 2
increases expression multiple interactions
ISO
Monocrotaline results in increased expression of JAG2 protein Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of JAG2 protein]
CTD
PMID:36942326
NCBI chr 6:131,983,059...132,005,665
Ensembl chr 6:131,983,056...132,005,818
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Kcna5
potassium voltage-gated channel subfamily A member 5
decreases expression
EXP
Monocrotaline results in decreased expression of KCNA5 mRNA
CTD
PMID:25460361
NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697
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Kcnb1
potassium voltage-gated channel subfamily B member 1
decreases expression
EXP
Monocrotaline results in decreased expression of KCNB1 mRNA
CTD
PMID:25460361
NCBI chr 3:155,820,255...155,913,383
Ensembl chr 3:155,822,963...155,916,194
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Kcnn4
potassium calcium-activated channel subfamily N member 4
increases expression multiple interactions
EXP
monocrotaline increases expression of Kcnn4 protein in lung and smooth muscle cell of the pulmonary artery modafinil inhibits the reaction [monocrotaline increases expression of Kcnn4 protein in lung and smooth muscle cell of the pulmonary artery]
RGD
PMID:26959484 PMID:26959484
RGD:329969898 , RGD:329969898
NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340
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Kdr
kinase insert domain receptor
multiple interactions decreases expression
ISO
romiplostim inhibits the reaction [Monocrotaline results in decreased expression of KDR mRNA]; THPO protein inhibits the reaction [Monocrotaline results in decreased expression of KDR mRNA]
CTD
PMID:33122006
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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Kif11
kinesin family member 11
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of KIF11 mRNA
CTD
PMID:33884520
NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766
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Kif23
kinesin family member 23
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of KIF23 mRNA
CTD
PMID:33884520
NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072
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Lep
leptin
multiple interactions affects expression
ISO EXP
[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein; TF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein] Monocrotaline affects the expression of LEP protein
CTD
PMID:21327618 PMID:25051504
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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Lgals3
galectin 3
multiple interactions
EXP
[Monocrotaline co-treated with LGALS3 protein] inhibits the reaction [[Monocrotaline co-treated with TGFB1] results in decreased expression of MMP9 protein]; [Monocrotaline co-treated with LGALS3 protein] promotes the reaction [[Monocrotaline co-treated with TGFB1] results in increased expression of COL1A1 protein]; [Monocrotaline co-treated with LGALS3 protein] results in decreased expression of MMP9 protein; [Monocrotaline co-treated with LGALS3 protein] results in increased expression of COL1A1 protein; [Monocrotaline co-treated with TGFB1] results in increased expression of LGALS3 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[Monocrotaline co-treated with TGFB1] results in increased expression of LGALS3 protein]
CTD
PMID:27870162
NCBI chr15:20,620,083...20,632,019
Ensembl chr15:20,607,692...20,632,025
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Limd2
LIM domain containing 2
increases expression
ISO
Monocrotaline results in increased expression of LIMD2 mRNA
CTD
PMID:28818515
NCBI chr10:91,090,279...91,092,772
Ensembl chr10:91,090,280...91,092,775
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Ltbp2
latent transforming growth factor beta binding protein 2
increases expression
EXP
Monocrotaline increases expression of Ltbp2 mRNA in the heart right ventricle
RGD
PMID:30213070
RGD:156451373
NCBI chr 6:104,429,947...104,530,498
Ensembl chr 6:104,429,947...104,526,208
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Lyve1
lymphatic vessel endothelial hyaluronan receptor 1
decreases expression
ISO
Monocrotaline results in decreased expression of LYVE1 protein
CTD
PMID:31470032
NCBI chr 1:164,962,872...164,976,309
Ensembl chr 1:164,962,872...164,976,309
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Map3k7
mitogen activated protein kinase kinase kinase 7
increases phosphorylation multiple interactions
EXP
Monocrotaline increases phosphorylation of Map3k7 protein in the lung Paeoniflorin inhibits the reaction [monocrotaline increases phosphorylation of Map3k7 protein in the lung]
RGD
PMID:22388934 PMID:35582418 PMID:35582418
RGD:155791648 , RGD:155804297 , RGD:155804297
NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
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Mapk1
mitogen activated protein kinase 1
increases phosphorylation multiple interactions
EXP
Monocrotaline results in increased phosphorylation of MAPK1 protein magnolol inhibits the reaction [Monocrotaline results in increased phosphorylation of MAPK1 protein]
CTD
PMID:30466619
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
increases phosphorylation multiple interactions
EXP
Monocrotaline results in increased phosphorylation of MAPK3 protein magnolol inhibits the reaction [Monocrotaline results in increased phosphorylation of MAPK3 protein]
CTD
PMID:30466619
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mdc1
mediator of DNA damage checkpoint 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MDC1 mRNA
CTD
PMID:33884520
NCBI chr20:2,893,693...2,912,394
Ensembl chr20:2,895,505...2,910,240
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Mdm2
MDM2 proto-oncogene
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA
CTD
PMID:21224054
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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Mgat5b
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B
increases expression
ISO
Monocrotaline results in increased expression of MGAT5B mRNA
CTD
PMID:28818515
NCBI chr10:102,120,757...102,190,235
Ensembl chr10:102,120,445...102,190,233
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Mir122
microRNA 122
increases expression
ISO
Monocrotaline results in increased expression of MIR122 mRNA
CTD
PMID:28844483
NCBI chr18:58,758,703...58,758,787
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Mir132
microRNA 132
decreases expression
ISO
Monocrotaline results in decreased expression of MIR132 mRNA
CTD
PMID:28818515
NCBI chr10:60,023,696...60,023,796
Ensembl chr10:60,023,696...60,023,796
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Mir138-1
microRNA 138-1
decreases expression
ISO
Monocrotaline results in decreased expression of MIR138-1 mRNA
CTD
PMID:28818515
NCBI chr 8:122,300,966...122,301,064
Ensembl chr 8:122,300,966...122,301,064
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Mir200a
microRNA 200a
increases expression multiple interactions
EXP
monocrotaline increases expression of Mir200a RNA in pulmonary artery smooth muscle cells melatonin inhibits the reaction [monocrotaline increases expression of Mir200a RNA in pulmonary artery smooth muscle cells]
RGD
PMID:30240970 PMID:30240970
RGD:156430315 , RGD:156430315
NCBI chr 5:166,648,494...166,648,582
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Mir200b
microRNA 200b
multiple interactions decreases expression
ISO
Propylthiouracil inhibits the reaction [Monocrotaline results in decreased expression of MIR200B]
CTD
PMID:36942326
NCBI chr 5:166,649,272...166,649,366
Ensembl chr 5:166,649,272...166,649,366
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Mir200c
microRNA 200c
decreases expression multiple interactions
ISO
Monocrotaline results in decreased expression of MIR200C Propylthiouracil inhibits the reaction [Monocrotaline results in decreased expression of MIR200C]
CTD
PMID:36942326
NCBI chr 4:157,523,679...157,523,747
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Mir2964
microRNA 2964
decreases expression
ISO
Monocrotaline results in decreased expression of MIR219B mRNA
CTD
PMID:28818515
NCBI chr 3:13,118,623...13,118,722
Ensembl chr 3:13,118,623...13,118,722
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Mir301b
microRNA 301b
decreases expression
ISO
Monocrotaline results in decreased expression of MIR301B mRNA
CTD
PMID:28818515
NCBI chr11:83,879,816...83,879,893
Ensembl chr11:83,879,816...83,879,893
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Mir370
microRNA 370
decreases expression
ISO
Monocrotaline results in decreased expression of MIR370 mRNA
CTD
PMID:28818515
NCBI chr 6:128,572,257...128,572,335
Ensembl chr 6:128,572,257...128,572,335
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Mir410
microRNA 410
decreases expression
ISO
Monocrotaline results in decreased expression of MIR410 mRNA
CTD
PMID:28818515
NCBI chr 6:128,758,358...128,758,433
Ensembl chr 6:128,758,354...128,758,434
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Mir489
microRNA 489
decreases expression
ISO
Monocrotaline results in decreased expression of MIR489 mRNA
CTD
PMID:28818515
NCBI chr 4:31,693,355...31,693,460
Ensembl chr 4:31,693,355...31,693,460
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Mir500
microRNA 500
decreases expression
ISO
Monocrotaline results in decreased expression of MIR500 mRNA
CTD
PMID:28818515
NCBI chr X:15,258,778...15,258,857
Ensembl chr X:15,258,768...15,258,859
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Mir551b
microRNA 551b
decreases expression
ISO
Monocrotaline results in decreased expression of MIR551B mRNA
CTD
PMID:28818515
NCBI chr 2:113,989,203...113,989,300
Ensembl chr 2:113,989,203...113,989,300
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Mir675
microRNA 675
decreases expression multiple interactions
EXP
monocrotaline decreases expression of Mir675 RNA in pulmonary artery smooth muscle cells melatonin inhibits the reaction [monocrotaline decreases expression of Mir675 RNA in pulmonary artery smooth muscle cells]
RGD
PMID:30240970 PMID:30240970
RGD:156430315 , RGD:156430315
NCBI chr 1:197,732,275...197,732,358
Ensembl chr 1:197,732,275...197,732,358
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Mir93
microRNA 93
decreases expression
ISO
Monocrotaline results in decreased expression of MIR93 mRNA
CTD
PMID:28818515
NCBI chr12:17,043,135...17,043,221
Ensembl chr12:17,043,135...17,043,221
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Mir98
microRNA 98
decreases expression
ISO
Monocrotaline results in decreased expression of MIR98 mRNA
CTD
PMID:28818515
NCBI chr X:20,981,235...20,981,342
Ensembl chr X:20,981,235...20,981,342
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Mirlet7b
microRNA let-7b
decreases expression
ISO
Monocrotaline results in decreased expression of MIRLET7B mRNA
CTD
PMID:28818515
NCBI chr 7:116,804,186...116,804,270
Ensembl chr 7:116,804,186...116,804,270
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Mki67
marker of proliferation Ki-67
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC gene mutant form] results in increased expression of MKI67 protein
CTD
PMID:21224054
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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Mlh1
mutL homolog 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of MLH1 mRNA
CTD
PMID:33884520
NCBI chr 8:111,196,468...111,233,721
Ensembl chr 8:111,196,468...111,233,617
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Mmp2
matrix metallopeptidase 2
increases expression multiple interactions
EXP ISO
Monocrotaline results in increased expression of MMP2 mRNA [Monocrotaline co-treated with 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] results in decreased expression of MMP2 mRNA; [TBXA2R protein affects the susceptibility to Monocrotaline] which affects the expression of MMP2 mRNA Simvastatin inhibits the reaction [Monocrotaline results in increased expression of MMP2 mRNA]
CTD
PMID:22022327 PMID:31470032
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Mmp9
matrix metallopeptidase 9
multiple interactions increases expression
EXP ISO
[Monocrotaline co-treated with LGALS3 protein] inhibits the reaction [[Monocrotaline co-treated with TGFB1] results in decreased expression of MMP9 protein]; [Monocrotaline co-treated with LGALS3 protein] results in decreased expression of MMP9 protein; [Monocrotaline co-treated with TGFB1] results in decreased expression of MMP9 protein; liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein]; liquiritin inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein] Monocrotaline results in increased expression of MMP9 mRNA; Monocrotaline results in increased expression of MMP9 protein [TBXA2R protein affects the susceptibility to Monocrotaline] which affects the expression of MMP9 mRNA; romiplostim inhibits the reaction [Monocrotaline results in increased expression of MMP9 mRNA]; THPO protein inhibits the reaction [Monocrotaline results in increased expression of MMP9 mRNA]; TLR4 gene mutant form inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein]
CTD
PMID:27870162 PMID:29908794 PMID:31470032 PMID:31504964 PMID:31589899 PMID:33122006 More...
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mpo
myeloperoxidase
increases activity multiple interactions
EXP ISO
Monocrotaline results in increased activity of MPO protein liquiritigenin inhibits the reaction [Monocrotaline results in increased activity of MPO protein]; liquiritin inhibits the reaction [Monocrotaline results in increased activity of MPO protein] TLR4 gene mutant form inhibits the reaction [Monocrotaline results in increased activity of MPO protein]
CTD
PMID:31504964 PMID:31589899
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Mre11
MRE11 homolog, double strand break repair nuclease
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MRE11 mRNA
CTD
PMID:33884520
NCBI chr 8:11,618,876...11,680,451
Ensembl chr 8:11,632,354...11,678,279
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Msh2
mutS homolog 2
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MSH2 mRNA
CTD
PMID:33884520
NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938
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Msh6
mutS homolog 6
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of MSH6 mRNA
CTD
PMID:33884520
NCBI chr 6:6,562,631...6,579,995
Ensembl chr 6:6,562,632...6,579,956
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Myd88
MYD88, innate immune signal transduction adaptor
decreases response to substance
ISO
MYD88 gene mutant form results in decreased susceptibility to Monocrotaline
CTD
PMID:31504964
NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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Myh6
myosin heavy chain 6
decreases expression
EXP
Monocrotaline results in decreased expression of MYH6 mRNA
CTD
PMID:16936438
NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
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Myh7
myosin heavy chain 7
increases expression
EXP
Monocrotaline results in increased expression of MYH7 mRNA
CTD
PMID:16936438
NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
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Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions affects response to substance decreases expression
EXP ISO
liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of NFE2L2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of NFE2L2 mRNA] NFE2L2 gene mutant form affects the susceptibility to Monocrotaline
CTD
PMID:29908794 PMID:31504964
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nos2
nitric oxide synthase 2
multiple interactions increases expression
ISO EXP
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of NOS2 mRNA 4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA]; magnolol inhibits the reaction [Monocrotaline results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA] Monocrotaline results in increased expression of NOS2 mRNA; Monocrotaline results in increased expression of NOS2 protein
CTD
PMID:16225752 PMID:21224054 PMID:22022327 PMID:25460361 PMID:30466619 PMID:31589899 More...
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nos3
nitric oxide synthase 3
decreases activity multiple interactions decreases expression increases expression
EXP
Monocrotaline results in decreased activity of NOS3 protein 4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in decreased activity of NOS3 protein]; 4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in increased expression of NOS3 mRNA]; magnolol inhibits the reaction [Monocrotaline results in decreased expression of NOS3 protein]; Quercetin inhibits the reaction [Monocrotaline results in decreased expression of NOS3 mRNA]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of NOS3 mRNA] Monocrotaline results in decreased expression of NOS3 mRNA; Monocrotaline results in decreased expression of NOS3 protein
CTD
PMID:16225752 PMID:22022327 PMID:25460361 PMID:30466619
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Notch1
notch receptor 1
increases expression multiple interactions
ISO
Monocrotaline results in increased expression of NOTCH1 protein Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of NOTCH1 protein]
CTD
PMID:36942326
NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
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Notch2
notch receptor 2
increases expression multiple interactions
ISO
Monocrotaline results in increased expression of NOTCH2 protein Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of NOTCH2 protein]
CTD
PMID:36942326
NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088
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Nox1
NADPH oxidase 1
increases expression
EXP
Monocrotaline results in increased expression of NOX1 mRNA
CTD
PMID:24947524
NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236
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Nox4
NADPH oxidase 4
increases expression
EXP
Monocrotaline results in increased expression of NOX4 mRNA; Monocrotaline results in increased expression of NOX4 protein
CTD
PMID:24835767 PMID:24947524
NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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Nppa
natriuretic peptide A
increases expression
EXP
Monocrotaline results in increased expression of NPPA mRNA
CTD
PMID:16936438
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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Nppb
natriuretic peptide B
increases expression multiple interactions
EXP
Monocrotaline results in increased expression of NPPB mRNA; Monocrotaline results in increased expression of NPPB protein Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of NPPB protein]
CTD
PMID:16936438 PMID:36942326
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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Nqo1
NAD(P)H quinone dehydrogenase 1
decreases expression increases expression multiple interactions
EXP
Monocrotaline results in decreased expression of NQO1 mRNA Monocrotaline results in increased expression of NQO1 protein liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of NQO1 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of NQO1 mRNA]
CTD
PMID:29908794
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity multiple interactions
ISO
Monocrotaline results in increased activity of NR1I2 protein [Monocrotaline results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Dihydrotestosterone inhibits the reaction [[Monocrotaline results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA]; Dihydrotestosterone inhibits the reaction [Monocrotaline results in increased activity of NR1I2 protein]; Flutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [[Monocrotaline results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA]]; Flutamide inhibits the reaction [Dihydrotestosterone inhibits the reaction [Monocrotaline results in increased activity of NR1I2 protein]]
CTD
PMID:32682830
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Pcna
proliferating cell nuclear antigen
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PCNA mRNA
CTD
PMID:33884520
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Pdcd4
programmed cell death 4
decreases expression multiple interactions
EXP
monocrotaline decreases expression of Pdcd4 mRNA in pulmonary artery smooth muscle cells melatonin inhibits the reaction [monocrotaline decreases expression of Pdcd4 mRNA in pulmonary artery smooth muscle cells]
RGD
PMID:30240970 PMID:30240970
RGD:156430315 , RGD:156430315
NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
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Pecam1
platelet and endothelial cell adhesion molecule 1
decreases expression multiple interactions
ISO
Monocrotaline results in decreased expression of PECAM1 mRNA; Monocrotaline results in decreased expression of PECAM1 protein romiplostim inhibits the reaction [Monocrotaline results in decreased expression of PECAM1 mRNA]; TBXA2R protein affects the reaction [Monocrotaline results in decreased expression of PECAM1 protein]; THPO protein inhibits the reaction [Monocrotaline results in decreased expression of PECAM1 mRNA]
CTD
PMID:31470032 PMID:33122006
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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Phf10
PHD finger protein 10
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PHF10 mRNA
CTD
PMID:33884520
NCBI chr 1:55,952,249...55,968,994
Ensembl chr 1:55,952,253...55,969,038
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Pigl
phosphatidylinositol glycan anchor biosynthesis, class L
decreases expression
ISO
Monocrotaline results in decreased expression of PIGL mRNA
CTD
PMID:28818515
NCBI chr10:47,142,160...47,199,892
Ensembl chr10:47,141,780...47,200,145
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Pkmyt1
protein kinase, membrane associated tyrosine/threonine 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PKMYT1 mRNA
CTD
PMID:33884520
NCBI chr10:12,748,221...12,758,995
Ensembl chr10:12,748,237...12,758,995
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Pknox1
PBX/knotted 1 homeobox 1
decreases expression
ISO
Monocrotaline results in decreased expression of PKNOX1 mRNA
CTD
PMID:28818515
NCBI chr20:9,662,866...9,705,030
Ensembl chr20:9,662,899...9,703,727
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Plk1
polo-like kinase 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PLK1 mRNA
CTD
PMID:33884520
NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
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Plk2
polo-like kinase 2
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of PLK2 mRNA
CTD
PMID:33884520
NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947
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Plk3
polo-like kinase 3
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PLK3 mRNA
CTD
PMID:33884520
NCBI chr 5:130,607,142...130,612,317
Ensembl chr 5:130,607,142...130,612,317
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Plk4
polo-like kinase 4
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PLK4 mRNA
CTD
PMID:33884520
NCBI chr 2:123,802,527...123,820,942
Ensembl chr 2:123,802,512...123,820,942
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Plvap
plasmalemma vesicle associated protein
decreases expression
EXP
Monocrotaline results in decreased expression of PLVAP mRNA
CTD
PMID:24835767
NCBI chr16:18,184,985...18,197,301
Ensembl chr16:18,184,975...18,197,301
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Por
cytochrome p450 oxidoreductase
affects metabolic processing
ISO
POR protein affects the metabolism of Monocrotaline
CTD
PMID:33033841
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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Postn
periostin
increases expression
EXP
Monocrotaline results in increased expression of POSTN protein
CTD
PMID:24947524
NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
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Pou2f1
POU class 2 homeobox 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of POU2F1 mRNA
CTD
PMID:33884520
NCBI chr13:78,120,617...78,263,306
Ensembl chr13:78,130,685...78,263,363
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Ppm1j
protein phosphatase, Mg2+/Mn2+ dependent, 1J
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PPM1J mRNA
CTD
PMID:33884520
NCBI chr 2:192,278,597...192,283,883
Ensembl chr 2:192,278,517...192,283,882
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Ppm1l
protein phosphatase, Mg2+/Mn2+ dependent, 1L
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PPM1L mRNA
CTD
PMID:33884520
NCBI chr 2:153,566,653...153,839,434
Ensembl chr 2:153,566,653...153,839,434
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Ppp2cb
protein phosphatase 2 catalytic subunit beta
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PPP2CB mRNA
CTD
PMID:33884520
NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
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Ppp2r3b
protein phosphatase 2, regulatory subunit B'', beta
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PPP2R3B mRNA
CTD
PMID:33884520
NCBI chr14:88,507...95,750
Ensembl chr14:89,176...95,750
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Ppp2r5e
protein phosphatase 2 regulatory subunit B', epsilon
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of PPP2R5E mRNA
CTD
PMID:33884520
NCBI chr 6:94,168,846...94,317,872
Ensembl chr 6:94,168,846...94,317,872
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Prc1
protein regulator of cytokinesis 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PRC1 mRNA
CTD
PMID:33884520
NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
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Prkar2a
protein kinase cAMP-dependent type II regulatory subunit alpha
increases expression
ISO
Monocrotaline results in increased expression of PRKAR2A mRNA
CTD
PMID:28818515
NCBI chr 8:109,393,189...109,458,832
Ensembl chr 8:109,395,833...109,455,628
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Prkdc
protein kinase, DNA-activated, catalytic subunit
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC gene mutant form] results in increased expression of MKI67 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of ATM protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CCND1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CHEK2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP1B1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2A5 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP2B9 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP4A10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP4A14 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP7A1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of DNAJA1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of EGR1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FASL mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of FMO4 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPD1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPE1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL18 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of IL1B mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of RAD50 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TNFSF10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TRADD mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of XRCC4 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of ANXA5 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BAX mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of BCL2L1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CCNG1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CDKN1A protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CXCL10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP2B10 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A11 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of CYP3A4 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of DDIT3 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of E2F1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GADD45A mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GPX2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM1 protein; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM3 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HMOX1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA1L mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPA8 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of HSPB1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of IL6 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of MDM2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of NOS2 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of SERPINE1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of UNG mRNA; PRKDC gene mutant form results in increased susceptibility to [Rifampin co-treated with Phenytoin co-treated with Monocrotaline]
CTD
PMID:21224054
NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
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Prkg1
protein kinase cGMP-dependent 1
decreases expression multiple interactions
EXP
Monocrotaline results in decreased expression of PRKG1 protein Fluoxetine inhibits the reaction [Monocrotaline results in decreased expression of PRKG1 protein]
CTD
PMID:21619414
NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080
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Psma1
proteasome 20S subunit alpha 1
increases expression multiple interactions
EXP
Monocrotaline results in increased expression of PSMA1 mRNA Pentoxifylline inhibits the reaction [Monocrotaline results in increased expression of PSMA1 mRNA]
CTD
PMID:18801959
NCBI chr 1:168,442,421...168,453,440
Ensembl chr 1:168,440,936...168,453,472
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Psma3
proteasome 20S subunit alpha 3
increases expression multiple interactions
EXP
Monocrotaline results in increased expression of PSMA3 mRNA Pentoxifylline inhibits the reaction [Monocrotaline results in increased expression of PSMA3 mRNA]
CTD
PMID:18801959
NCBI chr 6:89,483,741...89,503,775
Ensembl chr 6:89,483,727...89,504,965
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Psmc2
proteasome 26S subunit, ATPase 2
increases expression
EXP
Monocrotaline results in increased expression of PSMC2 mRNA
CTD
PMID:18801959
NCBI chr 4:13,255,850...13,270,160
Ensembl chr 4:13,255,856...13,270,185
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Psmc6
proteasome 26S subunit, ATPase 6
increases expression multiple interactions
EXP
Monocrotaline results in increased expression of PSMC6 mRNA Pentoxifylline inhibits the reaction [Monocrotaline results in increased expression of PSMC6 mRNA]
CTD
PMID:18801959
NCBI chr15:18,542,585...18,564,057
Ensembl chr15:18,542,563...18,564,055
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Ptgis
prostaglandin I2 synthase
increases expression
EXP
Monocrotaline increases expression of Ptgis mRNA in lung
RGD
PMID:18612919
RGD:401901264
NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451
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Pttg1
PTTG1 regulator of sister chromatid separation, securin
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of PTTG1 mRNA
CTD
PMID:33884520
NCBI chr10:27,893,466...27,904,965
Ensembl chr10:27,893,689...27,904,837
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Rad1
RAD1 checkpoint DNA exonuclease
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RAD1 mRNA
CTD
PMID:33884520
NCBI chr 2:59,461,597...59,469,707
Ensembl chr 2:59,461,607...59,469,689
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Rad21
RAD21 cohesin complex component
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RAD21 mRNA
CTD
PMID:33884520
NCBI chr 7:83,287,867...83,314,810
Ensembl chr 7:83,287,870...83,314,817
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Rad50
RAD50 double strand break repair protein
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of RAD50 mRNA
CTD
PMID:21224054
NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396
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Rbl1
RB transcriptional corepressor like 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RBL1 mRNA
CTD
PMID:33884520
NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330
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Rela
RELA proto-oncogene, NF-kB subunit
increases localization multiple interactions increases expression
EXP ISO
Monocrotaline results in increased localization of RELA protein liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of RELA protein]; liquiritin inhibits the reaction [Monocrotaline results in increased expression of RELA protein] TLR4 gene mutant form inhibits the reaction [Monocrotaline results in increased localization of RELA protein]
CTD
PMID:31504964 PMID:31589899
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Rfc1
replication factor C subunit 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC1 mRNA
CTD
PMID:33884520
NCBI chr14:42,966,279...43,041,372
Ensembl chr14:42,966,324...43,041,370
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Rfc2
replication factor C subunit 2
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC2 mRNA
CTD
PMID:33884520
NCBI chr12:22,120,449...22,133,576
Ensembl chr12:22,120,010...22,133,557
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Rfc3
replication factor C subunit 3
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC3 mRNA
CTD
PMID:33884520
NCBI chr12:1,000,987...1,011,778
Ensembl chr12:1,000,994...1,011,778
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Rfc4
replication factor C subunit 4
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of RFC4 mRNA
CTD
PMID:33884520
NCBI chr11:77,749,642...77,764,123
Ensembl chr11:77,749,638...77,764,122
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Rfc5
replication factor C subunit 5
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which affects the expression of RFC5 mRNA
CTD
PMID:33884520
NCBI chr12:39,207,484...39,217,041
Ensembl chr12:39,207,484...39,217,312
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Rps6
ribosomal protein S6
increases phosphorylation multiple interactions
EXP
Monocrotaline results in increased phosphorylation of RPS6 protein Quercetin inhibits the reaction [Monocrotaline results in increased phosphorylation of RPS6 protein]
CTD
PMID:25460361
NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
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Serpine1
serpin family E member 1
multiple interactions
ISO
[Monocrotaline co-treated with 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] results in decreased expression of SERPINE1 mRNA; [Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of SERPINE1 mRNA; [TBXA2R protein affects the susceptibility to Monocrotaline] which affects the expression of SERPINE1 mRNA
CTD
PMID:21224054 PMID:31470032
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Slc19a1
solute carrier family 19 member 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SLC19A1 mRNA
CTD
PMID:33884520
NCBI chr20:11,584,410...11,602,429
Ensembl chr20:11,584,411...11,601,972
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Slc22a1
solute carrier family 22 member 1
multiple interactions increases uptake
ISO
Monocrotaline inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Quinidine inhibits the reaction [SLC22A1 protein results in increased uptake of Monocrotaline]; tetrahydropalmatine inhibits the reaction [SLC22A1 protein results in increased uptake of Monocrotaline]
CTD
PMID:23831208
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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Slc6a4
solute carrier family 6 member 4
multiple interactions increases expression
ISO EXP
Sertraline inhibits the reaction [Monocrotaline results in increased expression of SLC6A4 mRNA] Monocrotaline results in increased expression of SLC6A4 protein Atorvastatin inhibits the reaction [Monocrotaline results in increased expression of SLC6A4 protein]
CTD
PMID:17042913 PMID:17575010
NCBI chr10:61,824,208...61,858,924
Ensembl chr10:61,826,123...61,858,384
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Smad1
SMAD family member 1
multiple interactions decreases phosphorylation decreases expression
EXP
Fluoxetine inhibits the reaction [Monocrotaline results in decreased expression of SMAD1 mRNA]; Fluoxetine inhibits the reaction [Monocrotaline results in decreased phosphorylation of SMAD1 protein]
CTD
PMID:21619414
NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651
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Smad3
SMAD family member 3
increases phosphorylation multiple interactions
ISO
Monocrotaline results in increased phosphorylation of SMAD3 protein Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of SMAD3 protein]
CTD
PMID:36942326
NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
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Smarcb1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMARCB1 mRNA
CTD
PMID:33884520
NCBI chr20:12,741,164...12,763,616
Ensembl chr20:12,741,477...12,763,620
G
Smarcc1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMARCC1 mRNA
CTD
PMID:33884520
NCBI chr 8:110,111,097...110,214,734
Ensembl chr 8:110,111,122...110,214,720
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Smc1a
structural maintenance of chromosomes 1A
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMC1A mRNA
CTD
PMID:33884520
NCBI chr X:21,103,323...21,148,053
Ensembl chr X:21,103,282...21,148,056
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Smc3
structural maintenance of chromosomes 3
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of SMC3 mRNA
CTD
PMID:33884520
NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522
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Snai1
snail family transcriptional repressor 1
multiple interactions increases expression
ISO
Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of SNAI1 protein]
CTD
PMID:36942326
NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
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Sox17
SRY-box transcription factor 17
decreases expression
EXP
Monocrotaline decreases expression of Sox17 protein in the lung
RGD
PMID:36913491
RGD:329853317
NCBI chr 5:15,016,660...15,022,228
Ensembl chr 5:15,016,731...15,022,228
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Sqstm1
sequestosome 1
increases expression multiple interactions
EXP
Monocrotaline results in increased expression of SQSTM1 protein liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of SQSTM1 protein]; liquiritin inhibits the reaction [Monocrotaline results in increased expression of SQSTM1 protein]
CTD
PMID:29908794
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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Stag2
STAG2 cohesin complex component
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of STAG2 mRNA
CTD
PMID:33884520
NCBI chr X:120,974,687...121,105,677
Ensembl chr X:120,974,857...121,105,677
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Stat1
signal transducer and activator of transcription 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of STAT1 mRNA
CTD
PMID:33884520
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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Stat3
signal transducer and activator of transcription 3
multiple interactions increases phosphorylation
EXP
[Monocrotaline co-treated with TGFB1] results in increased phosphorylation of STAT3 protein; NCP-2454 inhibits the reaction [Monocrotaline results in increased phosphorylation of STAT3 protein]
CTD
PMID:25275723 PMID:27870162
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Tbxa2r
thromboxane A2 receptor
multiple interactions affects response to substance increases expression
ISO
[TBXA2R protein affects the susceptibility to Monocrotaline] which affects the expression of ICAM1 mRNA; [TBXA2R protein affects the susceptibility to Monocrotaline] which affects the expression of MMP2 mRNA; [TBXA2R protein affects the susceptibility to Monocrotaline] which affects the expression of MMP9 mRNA; [TBXA2R protein affects the susceptibility to Monocrotaline] which affects the expression of SERPINE1 mRNA; [TBXA2R protein affects the susceptibility to Monocrotaline] which results in increased expression of ALT protein; TBXA2R protein affects the reaction [Monocrotaline results in decreased expression of PECAM1 protein]; TBXA2R protein affects the reaction [Monocrotaline results in increased expression of TBXA2R mRNA]
CTD
PMID:31470032
NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176
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Tbxas1
thromboxane A synthase 1
increases expression
ISO
Monocrotaline results in increased expression of TBXAS1 mRNA
CTD
PMID:31470032
NCBI chr 4:67,664,963...67,837,096
Ensembl chr 4:67,665,007...67,837,096
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Tf
transferrin
multiple interactions
ISO
[Lipopolysaccharides co-treated with Monocrotaline] results in increased expression of TF protein; [Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of TF protein; TF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of IL6 protein]; TF mRNA affects the reaction [[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of LEP protein]
CTD
PMID:21279329 PMID:21327618
NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
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Tfrc
transferrin receptor
increases expression
ISO
Monocrotaline results in increased expression of TFRC mRNA
CTD
PMID:28818515
NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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Tgfb1
transforming growth factor, beta 1
multiple interactions increases expression
EXP
[Monocrotaline co-treated with LGALS3 protein] inhibits the reaction [[Monocrotaline co-treated with TGFB1] results in decreased expression of MMP9 protein]; [Monocrotaline co-treated with LGALS3 protein] promotes the reaction [[Monocrotaline co-treated with TGFB1] results in increased expression of COL1A1 protein]; [Monocrotaline co-treated with TGFB1] results in decreased expression of MMP9 protein; [Monocrotaline co-treated with TGFB1] results in increased expression of COL1A1 protein; [Monocrotaline co-treated with TGFB1] results in increased expression of FN1 protein; [Monocrotaline co-treated with TGFB1] results in increased expression of LGALS3 protein; [Monocrotaline co-treated with TGFB1] results in increased phosphorylation of STAT3 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[Monocrotaline co-treated with TGFB1] results in increased expression of COL1A1 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[Monocrotaline co-treated with TGFB1] results in increased expression of FN1 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [[Monocrotaline co-treated with TGFB1] results in increased expression of LGALS3 protein]; NCP-2454 inhibits the reaction [Monocrotaline results in increased expression of TGFB1 protein]
CTD
PMID:25275723 PMID:27870162 PMID:31734320
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Thpo
thrombopoietin
decreases response to substance multiple interactions
ISO
THPO protein results in decreased susceptibility to Monocrotaline THPO protein inhibits the reaction [Monocrotaline results in decreased expression of FLT4 mRNA]; THPO protein inhibits the reaction [Monocrotaline results in decreased expression of KDR mRNA]; THPO protein inhibits the reaction [Monocrotaline results in decreased expression of PECAM1 mRNA]; THPO protein inhibits the reaction [Monocrotaline results in increased expression of MMP9 mRNA]
CTD
PMID:33122006
Ensembl chr11:80,182,820...80,188,167
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Thy1
Thy-1 cell surface antigen
increases expression
EXP
Monocrotaline results in increased expression of THY1 protein
CTD
PMID:24947524
NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659
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Ticam1
TIR domain containing adaptor molecule 1
decreases response to substance
ISO
TICAM1 gene mutant form results in decreased susceptibility to Monocrotaline
CTD
PMID:31504964
NCBI chr 9:1,102,559...1,111,023
Ensembl chr 9:1,102,366...1,123,147
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Timp1
TIMP metallopeptidase inhibitor 1
increases expression multiple interactions
EXP
Monocrotaline results in increased expression of TIMP1 mRNA Simvastatin inhibits the reaction [Monocrotaline results in increased expression of TIMP1 mRNA]
CTD
PMID:22022327
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
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Tlk1
tousled-like kinase 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in decreased expression of TLK1 mRNA
CTD
PMID:33884520
NCBI chr 3:55,520,559...55,627,580
Ensembl chr 3:55,503,358...55,691,968
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Tlr4
toll-like receptor 4
increases expression multiple interactions decreases response to substance
EXP ISO
Monocrotaline results in increased expression of TLR4 protein liquiritigenin inhibits the reaction [Monocrotaline results in increased expression of TLR4 protein]; liquiritin inhibits the reaction [Monocrotaline results in increased expression of TLR4 protein] TLR4 gene mutant form results in decreased susceptibility to Monocrotaline TLR4 gene mutant form inhibits the reaction [Monocrotaline results in increased activity of MPO protein]; TLR4 gene mutant form inhibits the reaction [Monocrotaline results in increased expression of MMP9 protein]; TLR4 gene mutant form inhibits the reaction [Monocrotaline results in increased localization of RELA protein]
CTD
PMID:31504964 PMID:31589899
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tmed2
transmembrane p24 trafficking protein 2
increases expression
ISO
Monocrotaline results in increased expression of TMED2 mRNA
CTD
PMID:28818515
NCBI chr12:32,052,542...32,061,628
Ensembl chr12:32,052,543...32,071,903
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Tnf
tumor necrosis factor
multiple interactions increases expression affects expression increases secretion decreases expression
ISO EXP
[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of TNF protein modafinil inhibits the reaction [monocrotaline increases expression of Tnf protein in lung] Monocrotaline affects the expression of TNF mRNA angiotensin I (1-7) inhibits the reaction [Monocrotaline results in increased expression of TNF mRNA]; Curcumin analog inhibits the reaction [Monocrotaline results in increased expression of TNF protein] Monocrotaline results in increased expression of TNF mRNA; Monocrotaline results in increased expression of TNF protein Monocrotaline results in increased secretion of TNF protein Monocrotaline results in decreased expression of TNF protein
CTD RGD
PMID:20581171 PMID:21327618 PMID:25051504 PMID:31407471 PMID:31504964 PMID:31734320 PMID:36336098 PMID:26959484 PMID:26959484 More...
RGD:329969898 , RGD:329969898
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfsf10
TNF superfamily member 10
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TNFSF10 mRNA
CTD
PMID:21224054
NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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Tnn
tenascin N
increases expression
EXP
Monocrotaline results in increased expression of TNN protein
CTD
PMID:24947524
NCBI chr13:72,319,160...72,386,362
Ensembl chr13:72,319,155...72,408,156
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Topbp1
DNA topoisomerase II binding protein 1
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of TOPBP1 mRNA
CTD
PMID:33884520
NCBI chr 8:103,887,805...103,931,662
Ensembl chr 8:103,887,865...103,931,674
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Tp53
tumor protein p53
multiple interactions
ISO
[CYP3A4 protein results in increased metabolism of Monocrotaline] which results in increased expression of TP53 mRNA
CTD
PMID:33884520
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tradd
TNFRSF1A-associated via death domain
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of TRADD mRNA
CTD
PMID:21224054
NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
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Tubb3
tubulin, beta 3 class III
decreases expression
EXP
Monocrotaline results in decreased expression of TUBB3 protein
CTD
PMID:21781985
NCBI chr19:51,457,187...51,466,243
Ensembl chr19:51,457,184...51,466,243
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Txn2
thioredoxin 2
decreases expression multiple interactions
EXP
Monocrotaline results in decreased expression of TXN2 mRNA; Monocrotaline results in decreased expression of TXN2 protein liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 protein]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXN2 protein]
CTD
PMID:29908794
NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359
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Txnrd1
thioredoxin reductase 1
decreases expression
EXP
Monocrotaline results in decreased expression of TXNRD1 mRNA
CTD
PMID:29908794
NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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Txnrd2
thioredoxin reductase 2
decreases expression multiple interactions
EXP
Monocrotaline results in decreased expression of TXNRD2 mRNA; Monocrotaline results in decreased expression of TXNRD2 protein liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 mRNA]; liquiritigenin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 protein]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 mRNA]; liquiritin inhibits the reaction [Monocrotaline results in decreased expression of TXNRD2 protein]
CTD
PMID:29908794
NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156
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Ube2b
ubiquitin-conjugating enzyme E2B
increases expression
EXP
Monocrotaline results in increased expression of UBE2B mRNA
CTD
PMID:18801959
NCBI chr10:36,248,434...36,263,379
Ensembl chr10:36,248,438...36,264,665
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Ube2g1
ubiquitin-conjugating enzyme E2G 1
increases expression
EXP
Monocrotaline results in increased expression of UBE2G1 mRNA
CTD
PMID:18801959
NCBI chr10:57,225,963...57,306,748
Ensembl chr10:57,225,952...57,308,568
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Ung
uracil-DNA glycosylase
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of UNG mRNA
CTD
PMID:21224054
NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206
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Vcam1
vascular cell adhesion molecule 1
increases expression
EXP
Monocrotaline results in increased expression of VCAM1 protein
CTD
PMID:25051504
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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Vegfa
vascular endothelial growth factor A
multiple interactions increases expression
ISO EXP
[Monocrotaline co-treated with Lipopolysaccharides] results in increased secretion of VEGFA protein monocrotaline increases expression of Vegfa protein in lung Monocrotaline results in increased expression of VEGFA protein
CTD RGD
PMID:21327618 PMID:25051504 PMID:26959484
RGD:329969898
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Vim
vimentin
increases expression multiple interactions
EXP ISO
Monocrotaline results in increased expression of VIM protein Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of VIM protein]
CTD
PMID:24947524 PMID:36942326
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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Xrcc4
X-ray repair cross complementing 4
multiple interactions
ISO
[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of XRCC4 mRNA
CTD
PMID:21224054
NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808
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Zeb1
zinc finger E-box binding homeobox 1
multiple interactions increases expression
ISO
Propylthiouracil inhibits the reaction [Monocrotaline results in increased expression of ZEB1 protein]
CTD
PMID:36942326
NCBI chr17:51,948,948...52,116,018
Ensembl chr17:51,948,948...52,115,214
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Abca3
ATP binding cassette subfamily A member 3
decreases expression
ISO
senecionine results in decreased expression of ABCA3 protein
CTD
PMID:35357534
NCBI chr10:13,382,439...13,439,748
Ensembl chr10:13,382,540...13,439,745
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Abcb11
ATP binding cassette subfamily B member 11
decreases expression
ISO
senecionine results in decreased expression of ABCB11 mRNA
CTD
PMID:26100227 PMID:31606820
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Abcb1a
ATP binding cassette subfamily B member 1A
decreases expression
ISO
senecionine results in decreased expression of ABCB1 mRNA
CTD
PMID:31606820
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcb1b
ATP-binding cassette, sub-family B member 1B
increases expression
EXP
senecionine results in increased expression of ABCB1B mRNA
CTD
PMID:32419051
NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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Abcb4
ATP binding cassette subfamily B member 4
decreases expression
ISO
senecionine results in decreased expression of ABCB4 mRNA
CTD
PMID:31606820
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Abcc1
ATP binding cassette subfamily C member 1
increases expression
ISO
senecionine results in increased expression of ABCC1 mRNA
CTD
PMID:31606820
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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Abcc2
ATP binding cassette subfamily C member 2
decreases expression
ISO
senecionine results in decreased expression of ABCC2 mRNA
CTD
PMID:26100227 PMID:31606820
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Abcc3
ATP binding cassette subfamily C member 3
increases expression decreases expression
EXP ISO
senecionine results in increased expression of ABCC3 mRNA senecionine results in decreased expression of ABCC3 mRNA
CTD
PMID:24641316 PMID:26100227 PMID:31606820
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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Abcc4
ATP binding cassette subfamily C member 4
decreases expression
ISO
senecionine results in decreased expression of ABCC4 mRNA
CTD
PMID:31606820
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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Abcc6
ATP binding cassette subfamily C member 6
decreases expression
ISO
senecionine results in decreased expression of ABCC6 mRNA
CTD
PMID:26100227
NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
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Abhd11
abhydrolase domain containing 11
increases expression
ISO
senecionine results in increased expression of ABHD11 protein
CTD
PMID:35357534
NCBI chr12:21,682,206...21,685,331
Ensembl chr12:21,682,202...21,685,398
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Abtb2
ankyrin repeat and BTB domain containing 2
increases expression
ISO
senecionine results in increased expression of ABTB2 protein
CTD
PMID:35357534
NCBI chr 3:89,954,726...90,108,549
Ensembl chr 3:89,954,713...90,108,548
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Acaa1a
acetyl-CoA acyltransferase 1A
increases expression
ISO
senecionine results in increased expression of ACAA1A protein
CTD
PMID:35357534
NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624
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Acaa1b
acetyl-Coenzyme A acyltransferase 1B
increases expression
ISO
senecionine results in increased expression of ACAA1B protein
CTD
PMID:35357534
NCBI chr 8:118,872,996...118,881,852
Ensembl chr 8:118,872,997...118,881,825
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Acot13
acyl-CoA thioesterase 13
increases expression
ISO
senecionine results in increased expression of ACOT13 protein
CTD
PMID:35357534
NCBI chr17:40,240,378...40,252,851
Ensembl chr17:40,240,378...40,252,851
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Acot2
acyl-CoA thioesterase 2
increases expression
ISO
senecionine results in increased expression of ACOT2 protein
CTD
PMID:35357534
NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245
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Acot3
acyl-CoA thioesterase 3
increases expression
ISO
senecionine results in increased expression of ACOT3 protein
CTD
PMID:35357534
NCBI chr 6:103,682,518...103,688,735
Ensembl chr 6:103,682,596...103,688,427 Ensembl chr 6:103,682,596...103,688,427
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Acot4
acyl-CoA thioesterase 4
increases expression
ISO
senecionine results in increased expression of ACOT4 protein
CTD
PMID:35357534
NCBI chr 6:103,668,699...103,674,037
Ensembl chr 6:103,668,753...103,673,917
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Acsl3
acyl-CoA synthetase long-chain family member 3
decreases expression
ISO
senecionine results in decreased expression of ACSL3 mRNA
CTD
PMID:26100227
NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627
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Acsl4
acyl-CoA synthetase long-chain family member 4
decreases expression
ISO
senecionine results in decreased expression of ACSL4 protein
CTD
PMID:35357534
NCBI chr X:105,942,794...106,006,573
Ensembl chr X:105,942,799...106,006,427
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Acsm3
acyl-CoA synthetase medium-chain family member 3
decreases expression
ISO
senecionine results in decreased expression of ACSM3 mRNA
CTD
PMID:26100227
NCBI chr 1:174,133,260...174,159,966
Ensembl chr 1:174,133,288...174,160,184
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Acss3
acyl-CoA synthetase short-chain family member 3
increases expression
ISO
senecionine results in increased expression of ACSS3 protein
CTD
PMID:35357534
NCBI chr 7:42,241,261...42,450,209
Ensembl chr 7:42,242,652...42,450,230
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Actg2
actin gamma 2, smooth muscle
decreases expression
EXP
senecionine results in decreased expression of ACTG2 mRNA
CTD
PMID:34185104
NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465
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Adam8
ADAM metallopeptidase domain 8
increases expression
EXP
senecionine results in increased expression of ADAM8 mRNA
CTD
PMID:32419051
NCBI chr 1:194,776,559...194,789,330
Ensembl chr 1:194,770,060...194,788,801
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Adh1c
alcohol dehydrogenase 1C (class I), gamma polypeptide
increases expression
ISO
senecionine results in increased expression of ADH1 protein
CTD
PMID:35357534
NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
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Aff3
ALF transcription elongation factor 3
decreases expression
ISO
senecionine results in decreased expression of AFF3 mRNA
CTD
PMID:26100227
NCBI chr 9:40,399,099...40,856,716
Ensembl chr 9:40,404,375...40,857,247
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Agxt
alanine--glyoxylate aminotransferase
decreases expression
ISO
senecionine results in decreased expression of AGXT mRNA
CTD
PMID:26100227
NCBI chr 9:93,675,384...93,685,337
Ensembl chr 9:93,675,384...93,685,336
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Aif1
allograft inflammatory factor 1
decreases expression
ISO
senecionine results in decreased expression of AIF1 protein
CTD
PMID:35357534
NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668
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Akap12
A-kinase anchoring protein 12
increases expression
ISO
senecionine results in increased expression of AKAP12 protein
CTD
PMID:35357534
NCBI chr 1:40,730,123...40,819,863
Ensembl chr 1:40,730,123...40,819,886
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Aldh1a1
aldehyde dehydrogenase 1 family, member A1
increases expression
EXP
senecionine results in increased expression of ALDH1A1 mRNA
CTD
PMID:32419051
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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Aldh1b1
aldehyde dehydrogenase 1 family, member B1
increases expression
ISO
senecionine results in increased expression of ALDH1B1 protein
CTD
PMID:35357534
NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378
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Aldh6a1
aldehyde dehydrogenase 6 family, member A1
increases expression
ISO
senecionine results in increased expression of ALDH6A1 mRNA
CTD
PMID:26100227
NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656
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Aldh8a1
aldehyde dehydrogenase 8 family, member A1
decreases expression
ISO
senecionine results in decreased expression of ALDH8A1 mRNA
CTD
PMID:26100227
NCBI chr 1:16,183,940...16,203,385
Ensembl chr 1:16,183,940...16,203,385
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Anapc2
anaphase promoting complex subunit 2
increases expression
ISO
senecionine results in increased expression of ANAPC2 protein
CTD
PMID:35357534
NCBI chr 3:8,086,434...8,098,182
Ensembl chr 3:8,086,462...8,098,178
G
Ankrd1
ankyrin repeat domain 1
decreases expression
EXP
senecionine results in decreased expression of ANKRD1 mRNA
CTD
PMID:34185104
NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919
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Anxa1
annexin A1
increases expression
ISO
senecionine results in increased expression of ANXA1 protein
CTD
PMID:35357534
NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
G
Apcs
amyloid P component, serum
decreases expression
ISO
senecionine results in decreased expression of APCS protein
CTD
PMID:35357534
NCBI chr13:85,373,219...85,374,195
Ensembl chr13:85,373,220...85,374,298
G
Apob
apolipoprotein B
decreases expression
ISO
senecionine results in decreased expression of APOB protein
CTD
PMID:35357534
NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
G
Apoc1
apolipoprotein C1
decreases expression
ISO
senecionine results in decreased expression of APOC1 protein
CTD
PMID:35357534
NCBI chr 1:79,347,057...79,350,340
Ensembl chr 1:79,346,136...79,350,375
G
Apoh
apolipoprotein H
decreases expression
ISO
senecionine results in decreased expression of APOH protein
CTD
PMID:35357534
NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329
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Apom
apolipoprotein M
decreases expression
ISO
senecionine results in decreased expression of APOM protein
CTD
PMID:35357534
NCBI chr20:3,690,950...3,693,550
Ensembl chr20:3,688,413...3,693,550
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Aqp4
aquaporin 4
decreases expression
ISO
senecionine results in decreased expression of AQP4 protein
CTD
PMID:35357534
NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
G
Aqp8
aquaporin 8
increases expression
ISO
senecionine results in increased expression of AQP8 protein
CTD
PMID:35357534
NCBI chr 1:177,993,313...177,999,158
Ensembl chr 1:177,993,305...177,999,158
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Areg
amphiregulin
increases expression
ISO
senecionine results in increased expression of AREG mRNA
CTD
PMID:26100227
NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
G
Arhgap11a
Rho GTPase activating protein 11A
increases expression
EXP
senecionine results in increased expression of ARHGAP11A mRNA
CTD
PMID:32419051
NCBI chr 3:100,590,865...100,607,146
Ensembl chr 3:100,590,865...100,607,559
G
Arl6ip1
ADP-ribosylation factor like GTPase 6 interacting protein 1
decreases expression
ISO
senecionine results in decreased expression of ARL6IP1 protein
CTD
PMID:35357534
NCBI chr 1:172,430,475...172,439,990
Ensembl chr 1:172,430,489...172,439,994
G
Arl6ip4
ADP-ribosylation factor like GTPase 6 interacting protein 4
decreases expression
ISO
senecionine results in decreased expression of ARL6IP4 protein
CTD
PMID:35357534
NCBI chr12:32,479,623...32,481,768
Ensembl chr12:32,479,625...32,481,799
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Atad2
ATPase family, AAA domain containing 2
increases expression
EXP
senecionine results in increased expression of ATAD2 mRNA
CTD
PMID:32419051
NCBI chr 7:89,634,123...89,676,738
Ensembl chr 7:89,634,123...89,676,738
G
Atf3
activating transcription factor 3
increases expression
ISO
senecionine results in increased expression of ATF3 protein
CTD
PMID:35357534
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
G
Atp13a2
ATPase cation transporting 13A2
decreases expression
ISO
senecionine results in decreased expression of ATP13A2 protein
CTD
PMID:35357534
NCBI chr 5:153,292,722...153,312,143
Ensembl chr 5:153,292,751...153,312,139
G
Atp2a3
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
increases expression
ISO
senecionine results in increased expression of ATP2A3 protein
CTD
PMID:35357534
NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748
G
Atp5if1
ATP synthase inhibitory factor subunit 1
decreases expression
ISO
senecionine results in decreased expression of ATP5IF1 protein
CTD
PMID:35357534
NCBI chr 5:144,738,950...144,742,668
Ensembl chr 5:144,738,950...144,742,668
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Atp6v1h
ATPase H+ transporting V1 subunit H
increases expression
ISO
senecionine results in increased expression of ATP6V1H protein
CTD
PMID:35357534
NCBI chr 5:14,379,029...14,484,703
Ensembl chr 5:14,378,257...14,537,962
G
Atpaf2
ATP synthase mitochondrial F1 complex assembly factor 2
increases expression
ISO
senecionine results in increased expression of ATPAF2 protein
CTD
PMID:35357534
NCBI chr10:45,205,658...45,221,891
Ensembl chr10:45,197,441...45,221,026
G
Axin2
axin 2
decreases expression
ISO
senecionine results in decreased expression of AXIN2 mRNA
CTD
PMID:31606820
NCBI chr10:93,893,830...93,927,042
Ensembl chr10:93,899,245...93,926,231
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B3galt1
Beta-1,3-galactosyltransferase 1
decreases expression
ISO
senecionine results in decreased expression of B3GALT1 protein
CTD
PMID:35357534
NCBI chr 3:52,253,413...52,826,508
Ensembl chr 3:52,253,618...52,825,313
G
Baat
bile acid CoA:amino acid N-acyltransferase
decreases expression
EXP ISO
senecionine results in decreased expression of BAAT mRNA
CTD
PMID:24641316 PMID:26100227
NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685
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Bcl2l1
Bcl2-like 1
decreases expression
ISO
senecionine results in decreased expression of BCL2L1 protein
CTD
PMID:29458164
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Bcl3
BCL3, transcription coactivator
increases expression
ISO
senecionine results in increased expression of BCL3 protein
CTD
PMID:35357534
NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
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Bnip3
BCL2 interacting protein 3
decreases expression
ISO
senecionine results in decreased expression of BNIP3 protein
CTD
PMID:35357534
NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
G
Bod1l1
biorientation of chromosomes in cell division 1-like 1
decreases expression
ISO
senecionine results in decreased expression of BOD1L protein
CTD
PMID:35357534
NCBI chr14:69,108,483...69,163,255
Ensembl chr14:69,108,491...69,162,490
G
Bpgm
bisphosphoglycerate mutase
increases expression
ISO
senecionine results in increased expression of BPGM protein
CTD
PMID:35357534
NCBI chr 4:63,139,730...63,168,581
Ensembl chr 4:63,140,018...63,168,581
G
Btc
betacellulin
increases expression
ISO
senecionine results in increased expression of BTC protein
CTD
PMID:35357534
NCBI chr14:16,708,447...16,746,961
Ensembl chr14:16,707,982...16,747,049
G
C3
complement C3
decreases expression
ISO
senecionine results in decreased expression of C3 protein
CTD
PMID:35357534
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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C3ar1
complement C3a receptor 1
increases expression
EXP
senecionine results in increased expression of C3AR1 mRNA
CTD
PMID:34185104
NCBI chr 4:156,074,747...156,084,680
Ensembl chr 4:156,075,389...156,084,701
G
C4b
complement C4B
decreases expression
ISO
senecionine results in decreased expression of C4B protein
CTD
PMID:35357534
NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
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C5
complement C5
decreases expression
ISO
senecionine results in decreased expression of C5 protein
CTD
PMID:35357534
NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
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Camp
cathelicidin antimicrobial peptide
increases expression
ISO
senecionine results in increased expression of CAMP protein
CTD
PMID:35357534
NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543
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Car1
carbonic anhydrase 1
increases expression
ISO
senecionine results in increased expression of CA1 protein
CTD
PMID:35357534
NCBI chr 2:86,829,436...86,872,209
Ensembl chr 2:86,861,897...86,872,208
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Car2
carbonic anhydrase 2
increases expression
ISO
senecionine results in increased expression of CA2 protein
CTD
PMID:35357534
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
G
Car5a
carbonic anhydrase 5A
increases expression
ISO
senecionine results in increased expression of CA5A protein
CTD
PMID:35357534
NCBI chr19:49,973,092...50,002,948
Ensembl chr19:49,973,107...50,002,906
G
Car5b
carbonic anhydrase 5B
increases expression
ISO
senecionine results in increased expression of CA5B protein
CTD
PMID:35357534
NCBI chr X:30,474,697...30,534,797
Ensembl chr X:30,474,784...30,533,837
G
Casp12
caspase 12
increases expression
EXP
senecionine results in increased expression of CASP12 mRNA
CTD
PMID:32419051
NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
G
Casp3
caspase 3
multiple interactions
ISO
senecionine results in increased activity of and results in increased cleavage of CASP3 protein
CTD
PMID:29458164
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casp8
caspase 8
multiple interactions
ISO
senecionine results in increased activity of and results in increased cleavage of CASP8 protein
CTD
PMID:29458164
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
G
Casp9
caspase 9
increases activity
ISO
senecionine results in increased activity of CASP9 protein
CTD
PMID:29458164
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
G
Cav1
caveolin 1
decreases expression
ISO
senecionine results in decreased expression of CAV1 protein
CTD
PMID:35357534
NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
G
Cavin3
caveolae associated protein 3
decreases expression
ISO
senecionine results in decreased expression of CAVIN3 protein
CTD
PMID:35357534
NCBI chr 1:159,826,549...159,828,138
Ensembl chr 1:159,826,549...159,828,161
G
Ccdc137
coiled-coil domain containing 137
decreases expression
ISO
senecionine results in decreased expression of CCDC137 protein
CTD
PMID:35357534
NCBI chr10:105,730,776...105,737,158
Ensembl chr10:105,730,739...105,737,158
G
Ccna2
cyclin A2
increases expression
EXP
senecionine results in increased expression of CCNA2 mRNA
CTD
PMID:32419051
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
G
Ccne2
cyclin E2
increases expression
EXP
senecionine results in increased expression of CCNE2 mRNA
CTD
PMID:32419051
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
G
Ccng1
cyclin G1
increases expression
EXP
senecionine results in increased expression of CCNG1 mRNA
CTD
PMID:32419051
NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
G
Ccpg1
cell cycle progression 1
decreases expression
ISO
senecionine results in decreased expression of CCPG1 protein
CTD
PMID:35357534
NCBI chr 8:73,719,960...73,752,437
Ensembl chr 8:73,719,955...73,752,430
G
Cd163
CD163 molecule
decreases expression
ISO
senecionine results in decreased expression of CD163 protein
CTD
PMID:35357534
NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878
G
Cd177
CD177 molecule
increases expression
ISO
senecionine results in increased expression of CD177 protein
CTD
PMID:35357534
NCBI chr 1:80,340,034...80,360,599
Ensembl chr 1:80,340,034...80,360,621
G
Cd300lg
Cd300 molecule-like family member G
decreases expression
ISO
senecionine results in decreased expression of CD300LG protein
CTD
PMID:35357534
NCBI chr10:86,991,886...87,009,248
Ensembl chr10:86,991,921...87,008,733
G
Cd47
Cd47 molecule
increases expression
ISO
senecionine results in increased expression of CD47 mRNA; senecionine results in increased expression of CD47 protein
CTD
PMID:35357534
NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425
G
Cdadc1
cytidine and dCMP deaminase domain containing 1
decreases expression
ISO
senecionine results in decreased expression of CDADC1 protein
CTD
PMID:35357534
NCBI chr15:33,726,590...33,755,611
Ensembl chr15:33,723,435...33,755,576
G
Cdkal1
CDK5 regulatory subunit associated protein 1-like 1
decreases expression
ISO
senecionine results in decreased expression of CDKAL1 protein
CTD
PMID:35357534
NCBI chr17:34,718,701...35,271,276
Ensembl chr17:34,718,687...35,407,524
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
EXP ISO
senecionine results in increased expression of CDKN1A mRNA senecionine results in increased expression of CDKN1A protein
CTD
PMID:32419051 PMID:35357534
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
G
Cel
carboxyl ester lipase
decreases expression
ISO
senecionine results in decreased expression of CEL protein
CTD
PMID:35357534
NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035
G
Cenpq
centromere protein Q
increases expression
EXP
senecionine results in increased expression of CENPQ mRNA
CTD
PMID:32419051
NCBI chr 9:19,957,122...19,972,807
Ensembl chr 9:19,957,048...19,972,789
G
Cenpw
centromere protein W
increases expression
EXP
senecionine results in increased expression of CENPW mRNA
CTD
PMID:32419051
NCBI chr 1:27,525,324...27,530,464
Ensembl chr 1:27,525,324...27,530,464
G
Cep97
centrosomal protein 97
increases expression
ISO
senecionine results in increased expression of CEP97 protein
CTD
PMID:35357534
NCBI chr11:44,683,503...44,711,471
Ensembl chr11:44,683,506...44,711,471
G
Cfh
complement factor H
decreases expression
ISO
senecionine results in decreased expression of CFH protein
CTD
PMID:35357534
NCBI chr13:51,512,376...51,613,829
Ensembl chr13:51,511,828...51,613,838
G
Cgnl1
cingulin-like 1
decreases expression
ISO
senecionine results in decreased expression of CGNL1 protein
CTD
PMID:35357534
NCBI chr 8:72,273,401...72,424,842
Ensembl chr 8:72,275,645...72,422,917
G
Champ1
chromosome alignment maintaining phosphoprotein 1
increases expression
ISO
senecionine results in increased expression of CHAMP1 protein
CTD
PMID:35357534
NCBI chr16:75,733,958...75,744,931
Ensembl chr16:75,733,805...75,744,984
G
Chtop
chromatin target of PRMT1
decreases expression
ISO
senecionine results in decreased expression of CHTOP protein
CTD
PMID:35357534
NCBI chr 2:175,981,266...175,992,820
Ensembl chr 2:175,981,271...175,992,748
G
Cib1
calcium and integrin binding 1
increases expression
ISO
senecionine results in increased expression of CIB1 protein
CTD
PMID:35357534
NCBI chr 1:134,178,331...134,183,895
Ensembl chr 1:134,178,331...134,213,423
G
Cir1
corepressor interacting with RBPJ, 1
decreases expression
ISO
senecionine results in decreased expression of CIR1 protein
CTD
PMID:35357534
NCBI chr 3:58,158,923...58,188,799
Ensembl chr 3:58,158,951...58,188,789
G
Ckap2
cytoskeleton associated protein 2
increases expression
EXP
senecionine results in increased expression of CKAP2 mRNA
CTD
PMID:32419051
NCBI chr16:69,839,668...69,864,852
Ensembl chr16:69,839,630...69,864,913
G
Ckmt1
creatine kinase, mitochondrial 1
decreases expression
ISO
senecionine results in decreased expression of CKMT1 protein
CTD
PMID:35357534
NCBI chr 3:108,329,859...108,335,760
Ensembl chr 3:108,330,705...108,335,758
G
Ckmt2
creatine kinase, mitochondrial 2
decreases expression
EXP
senecionine results in decreased expression of CKMT2 mRNA
CTD
PMID:34185104
NCBI chr 2:23,079,918...23,110,518
Ensembl chr 2:23,079,918...23,110,430
G
Clec3b
C-type lectin domain family 3, member B
decreases expression
ISO
senecionine results in decreased expression of CLEC3B protein
CTD
PMID:35357534
NCBI chr 8:122,810,120...122,815,837
Ensembl chr 8:122,810,149...122,815,835
G
Clec4a1
C-type lectin domain family 4, member A1
increases expression
EXP
senecionine results in increased expression of CLEC4A1 mRNA
CTD
PMID:34185104
NCBI chr 4:156,173,894...156,186,009
Ensembl chr 4:156,173,894...156,186,008
G
Clec4f
C-type lectin domain family 4, member F
decreases expression
EXP ISO
senecionine results in decreased expression of CLEC4F mRNA senecionine results in decreased expression of CLEC4F protein
CTD
PMID:32419051 PMID:35357534
NCBI chr 4:116,129,023...116,138,744
Ensembl chr 4:116,129,023...116,138,775
G
Cnbp
CCHC-type zinc finger, nucleic acid binding protein
decreases expression
ISO
senecionine results in decreased expression of CNBP protein
CTD
PMID:35357534
NCBI chr 4:120,302,768...120,311,694
Ensembl chr 4:120,302,771...120,311,637
G
Cntrl
centriolin
decreases expression
ISO
senecionine results in decreased expression of CNTRL protein
CTD
PMID:35357534
NCBI chr 3:18,428,147...18,500,362
Ensembl chr 3:18,428,103...18,500,380
G
Col18a1
collagen type XVIII alpha 1 chain
decreases expression
ISO
senecionine results in decreased expression of COL18A1 protein
CTD
PMID:35357534
NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593
G
Cops3
COP9 signalosome subunit 3
increases expression
ISO
senecionine results in increased expression of COPS3 protein
CTD
PMID:35357534
NCBI chr10:44,618,115...44,652,807
Ensembl chr10:44,618,115...44,641,597
G
Coro1a
coronin 1A
increases expression
ISO
senecionine results in increased expression of CORO1A protein
CTD
PMID:35357534
NCBI chr 1:181,295,561...181,300,566
Ensembl chr 1:181,295,562...181,300,534
G
Cpa1
carboxypeptidase A1
decreases expression
ISO
senecionine results in decreased expression of CPA1 protein
CTD
PMID:35357534
NCBI chr 4:59,257,417...59,263,544
Ensembl chr 4:59,257,417...59,263,544
G
Cpb2
carboxypeptidase B2
decreases expression
ISO
senecionine results in decreased expression of CPB2 protein
CTD
PMID:35357534
NCBI chr15:50,557,722...50,606,569
Ensembl chr15:50,557,717...50,606,556
G
Creld1
cysteine-rich with EGF-like domains 1
decreases expression
ISO
senecionine results in decreased expression of CRELD1 protein
CTD
PMID:35357534
NCBI chr 4:146,631,883...146,641,493
Ensembl chr 4:146,631,883...146,641,499
G
Creld2
cysteine-rich with EGF-like domains 2
decreases expression
ISO
senecionine results in decreased expression of CRELD2 protein
CTD
PMID:35357534
NCBI chr 7:119,909,626...119,916,556
Ensembl chr 7:119,909,633...119,916,543
G
Crip1
cysteine rich protein 1
decreases expression
ISO
senecionine results in decreased expression of CRIP1 protein
CTD
PMID:35357534
NCBI chr 6:132,226,746...132,234,620
Ensembl chr 6:132,226,746...132,234,620
G
Csf1r
colony stimulating factor 1 receptor
decreases expression
EXP
senecionine results in decreased expression of CSF1R mRNA
CTD
PMID:32419051
NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415
G
Ctdnep1
CTD nuclear envelope phosphatase 1
increases expression
ISO
senecionine results in increased expression of CTDNEP1 protein
CTD
PMID:35357534
NCBI chr10:54,704,367...54,713,781
Ensembl chr10:54,704,148...54,713,781
G
Ctrl
chymotrypsin-like
decreases expression
ISO
senecionine results in decreased expression of CTRB1 protein
CTD
PMID:35357534
NCBI chr19:33,827,279...33,829,129
Ensembl chr19:33,827,229...33,833,626
G
Ctsg
cathepsin G
increases expression
ISO
senecionine results in increased expression of CTSG protein
CTD
PMID:35357534
NCBI chr15:29,930,988...29,937,353
Ensembl chr15:29,931,003...29,937,353
G
Cxcl12
C-X-C motif chemokine ligand 12
decreases expression
ISO
senecionine results in decreased expression of CXCL12 protein
CTD
PMID:35357534
NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
G
Cxcr4
C-X-C motif chemokine receptor 4
increases expression
ISO
senecionine results in increased expression of CXCR4 mRNA
CTD
PMID:35357534
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
G
Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
increases expression
ISO
senecionine results in increased expression of CYP11A1 mRNA
CTD
PMID:26100227
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
ISO
senecionine results in increased expression of CYP1A1 mRNA
CTD
PMID:26100227
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
G
Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression decreases expression
ISO
senecionine results in increased expression of CYP1A2 mRNA senecionine results in decreased expression of CYP1A2 mRNA
CTD
PMID:26100227 PMID:31606820
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
increases expression
ISO
senecionine results in increased expression of CYP1B1 mRNA
CTD
PMID:26100227
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
G
Cyp2a1
cytochrome P450, family 2, subfamily a, polypeptide 1
increases expression
ISO
senecionine results in increased expression of CYP2A13 mRNA
CTD
PMID:26100227
NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
G
Cyp2a3
cytochrome P450, family 2, subfamily a, polypeptide 3
increases expression
ISO
senecionine results in increased expression of CYP2A4 protein
CTD
PMID:35357534
NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979
G
Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases expression affects expression
ISO
senecionine results in increased expression of CYP2B6 mRNA senecionine affects the expression of CYP2B10 mRNA
CTD
PMID:26100227 PMID:31606820
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
G
Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
decreases expression
ISO
senecionine results in decreased expression of CYP2C18 mRNA
CTD
PMID:26100227
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases expression decreases expression
ISO
senecionine results in increased expression of CYP2E1 mRNA senecionine results in decreased expression of CYP2E1 mRNA
CTD
PMID:26100227 PMID:31606820
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
G
Cyp3a18
cytochrome P450, family 3, subfamily a, polypeptide 18
increases expression
ISO
senecionine results in increased expression of CYP3A43 mRNA
CTD
PMID:26100227
NCBI chr12:8,880,509...8,930,382
Ensembl chr12:8,880,528...8,930,381
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases expression increases response to substance
ISO
senecionine results in increased expression of CYP3A4 mRNA CYP3A4 protein results in increased susceptibility to senecionine
CTD
PMID:26100227 PMID:32910235
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
G
Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
decreases expression
ISO
senecionine results in decreased expression of CYP3A5 mRNA
CTD
PMID:26100227
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
G
Cyp4f1
cytochrome P450, family 4, subfamily f, polypeptide 1
decreases expression
ISO
senecionine results in decreased expression of CYP4F12 mRNA
CTD
PMID:26100227
NCBI chr 7:12,010,850...12,022,497
Ensembl chr 7:12,010,852...12,022,046
G
Cyp4f40
cytochrome P450, family 4, subfamily f, polypeptide 40
increases expression
ISO
senecionine results in increased expression of CYP4F11 mRNA
CTD
PMID:26100227
NCBI chr 7:11,691,648...11,707,437
Ensembl chr 7:11,692,086...11,706,229
G
Cyp7a1
cytochrome P450 family 7 subfamily A member 1
decreases expression
EXP ISO
senecionine results in decreased expression of CYP7A1 mRNA
CTD
PMID:24641316 PMID:26100227 PMID:31606820
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
G
Cyp8b1
cytochrome P450 family 8 subfamily B member 1
decreases expression
ISO
senecionine results in decreased expression of CYP8B1 mRNA
CTD
PMID:26100227
NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
G
Cyria
CYFIP related Rac1 interactor A
increases expression
EXP
senecionine results in increased expression of CYRIA mRNA
CTD
PMID:32419051
NCBI chr 6:35,045,208...35,150,669
Ensembl chr 6:35,045,208...35,150,668
G
Dbr1
debranching RNA lariats 1
increases expression
ISO
senecionine results in increased expression of DBR1 protein
CTD
PMID:35357534
NCBI chr 8:100,139,039...100,150,768
Ensembl chr 8:100,139,034...100,151,030
G
Ddias
DNA damage-induced apoptosis suppressor
increases expression
EXP
senecionine results in increased expression of DDIAS mRNA
CTD
PMID:32419051
NCBI chr 1:146,906,150...146,930,462
Ensembl chr 1:146,906,154...146,930,462
G
Dedd
death effector domain-containing
decreases expression
ISO
senecionine results in decreased expression of DEDD protein
CTD
PMID:35357534
NCBI chr13:83,755,874...83,769,982
Ensembl chr13:83,756,108...83,769,332
G
Dguok
deoxyguanosine kinase
increases expression
ISO
senecionine results in increased expression of DGUOK protein
CTD
PMID:35357534
NCBI chr 4:115,987,101...116,014,733
Ensembl chr 4:115,979,094...116,014,733
G
Dhrs2
dehydrogenase/reductase 2
increases expression
ISO
senecionine results in increased expression of DHRS2 mRNA
CTD
PMID:26100227
NCBI chr15:28,688,881...28,703,646
Ensembl chr15:28,688,940...28,703,644
G
Dhrs9
dehydrogenase/reductase 9
increases expression
ISO
senecionine results in increased expression of DHRS9 mRNA
CTD
PMID:26100227
NCBI chr 3:54,147,834...54,170,052
Ensembl chr 3:54,147,803...54,220,241
G
Diaph3
diaphanous-related formin 3
increases expression
EXP
senecionine results in increased expression of DIAPH3 mRNA
CTD
PMID:32419051
NCBI chr15:62,543,375...63,013,060
Ensembl chr15:62,543,375...63,012,975
G
Dip2a
disco-interacting protein 2 homolog A
decreases expression
ISO
senecionine results in decreased expression of DIP2A protein
CTD
PMID:35357534
NCBI chr20:12,284,566...12,371,068
Ensembl chr20:12,284,654...12,370,217
G
Dlgap5
DLG associated protein 5
increases expression
EXP
senecionine results in increased expression of DLGAP5 mRNA
CTD
PMID:32419051
NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518
G
Dmbt1
deleted in malignant brain tumors 1
decreases expression
ISO
senecionine results in decreased expression of DMBT1 protein
CTD
PMID:35357534
NCBI chr 1:185,617,469...185,696,476
Ensembl chr 1:185,617,294...185,696,478
G
Dnajb9
DnaJ heat shock protein family (Hsp40) member B9
increases expression
ISO
senecionine results in increased expression of DNAJB9 protein
CTD
PMID:35357534
NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
G
Dnajc12
DnaJ heat shock protein family (Hsp40) member C12
decreases expression
ISO
senecionine results in decreased expression of DNAJC12 protein
CTD
PMID:35357534
NCBI chr20:25,246,744...25,267,508
Ensembl chr20:25,223,144...25,267,521
G
Dnajc15
DnaJ heat shock protein family (Hsp40) member C15
decreases expression
ISO
senecionine results in decreased expression of DNAJC15 protein
CTD
PMID:35357534
NCBI chr15:53,182,060...53,249,675
Ensembl chr15:53,184,855...53,249,675
G
Dph5
diphthamide biosynthesis 5
increases expression
ISO
senecionine results in increased expression of DPH5 protein
CTD
PMID:35357534
NCBI chr 2:203,804,620...203,858,196
Ensembl chr 2:203,804,936...203,840,433
G
Dpyd
dihydropyrimidine dehydrogenase
decreases expression
ISO
senecionine results in decreased expression of DPYD mRNA
CTD
PMID:26100227
NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982
G
Dtl
denticleless E3 ubiquitin protein ligase homolog
increases expression
EXP
senecionine results in increased expression of DTL mRNA
CTD
PMID:32419051
NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890
G
Dusp1
dual specificity phosphatase 1
increases expression
ISO
senecionine results in increased expression of DUSP1 protein
CTD
PMID:35357534
NCBI chr10:16,680,478...16,683,275
G
Dynll2
dynein light chain LC8-type 2
decreases expression
ISO
senecionine results in decreased expression of DYNLL2 protein
CTD
PMID:35357534
NCBI chr10:72,767,035...72,785,824
Ensembl chr10:72,767,035...72,785,805
G
Eda2r
ectodysplasin A2 receptor
increases expression
EXP
senecionine results in increased expression of EDA2R mRNA
CTD
PMID:32419051
NCBI chr X:62,224,763...62,269,333
Ensembl chr X:62,228,229...62,269,268
G
Egfr
epidermal growth factor receptor
decreases expression
ISO
senecionine results in decreased expression of EGFR protein
CTD
PMID:35357534
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
G
Eif3g
eukaryotic translation initiation factor 3, subunit G
decreases expression
ISO
senecionine results in decreased expression of EIF3G protein
CTD
PMID:35357534
NCBI chr 8:19,429,728...19,433,760
Ensembl chr 8:19,429,643...19,433,808
G
Eif4b
eukaryotic translation initiation factor 4B
decreases expression
ISO
senecionine results in decreased expression of EIF4B protein
CTD
PMID:35357534
NCBI chr 7:133,206,637...133,228,436
G
Elf1
E74 like ETS transcription factor 1
decreases expression
ISO
senecionine results in decreased expression of ELF1 protein
CTD
PMID:35357534
NCBI chr15:54,890,644...54,986,721
Ensembl chr15:54,865,616...54,986,699
G
Elovl1
ELOVL fatty acid elongase 1
decreases expression
ISO
senecionine results in decreased expression of ELOVL1 protein
CTD
PMID:35357534
NCBI chr 5:131,961,478...131,965,961
Ensembl chr 5:131,961,322...131,965,958
G
Emilin2
elastin microfibril interfacer 2
increases expression
EXP
senecionine results in increased expression of EMILIN2 mRNA
CTD
PMID:34185104
NCBI chr 9:111,160,708...111,220,463
Ensembl chr 9:111,160,712...111,220,352
G
Eng
endoglin
decreases expression
ISO
senecionine results in decreased expression of ENG protein
CTD
PMID:35357534
NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
G
Eno3
enolase 3
increases expression
ISO
senecionine results in increased expression of ENO3 protein
CTD
PMID:35357534
NCBI chr10:55,370,531...55,375,921
Ensembl chr10:55,366,975...55,375,921
G
Entpd5
ectonucleoside triphosphate diphosphohydrolase 5
increases expression
ISO
senecionine results in increased expression of ENTPD5 protein
CTD
PMID:35357534
NCBI chr 6:104,019,095...104,055,311
Ensembl chr 6:104,019,185...104,055,530
G
Epha2
Eph receptor A2
increases expression
ISO
senecionine results in increased expression of EPHA2 protein
CTD
PMID:35357534
NCBI chr 5:153,605,644...153,634,115
Ensembl chr 5:153,605,644...153,634,117
G
Ephx2
epoxide hydrolase 2
decreases expression
ISO
senecionine results in decreased expression of EPHX2 mRNA
CTD
PMID:26100227
NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615
G
Epm2a
EPM2A glucan phosphatase, laforin
increases expression
ISO
senecionine results in increased expression of EPM2A protein
CTD
PMID:35357534
NCBI chr 1:5,727,111...5,845,338
Ensembl chr 1:5,727,066...5,920,555
G
Erp29
endoplasmic reticulum protein 29
increases expression
ISO
senecionine results in increased expression of ERP29 protein
CTD
PMID:35357534
NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376
G
Esco2
establishment of sister chromatid cohesion N-acetyltransferase 2
increases expression
EXP
senecionine results in increased expression of ESCO2 mRNA
CTD
PMID:32419051
NCBI chr15:40,034,566...40,052,295
Ensembl chr15:40,034,568...40,055,306
G
Esrra
estrogen related receptor, alpha
decreases expression
ISO
senecionine results in decreased expression of ESRRA protein
CTD
PMID:35357534
NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
G
Ethe1
ETHE1, persulfide dioxygenase
decreases expression
EXP
senecionine results in decreased expression of ETHE1 mRNA
CTD
PMID:32419051
NCBI chr 1:80,184,037...80,199,092
Ensembl chr 1:80,183,894...80,199,052
G
Etnppl
ethanolamine-phosphate phospho-lyase
increases expression
ISO
senecionine results in increased expression of ETNPPL protein
CTD
PMID:35357534
NCBI chr 2:219,173,048...219,194,646
Ensembl chr 2:219,172,978...219,192,212
G
Ets2
ETS proto-oncogene 2, transcription factor
increases expression
ISO
senecionine results in increased expression of ETS2 protein
CTD
PMID:35357534
NCBI chr11:35,021,536...35,038,322
Ensembl chr11:35,021,596...35,038,319
G
Etv6
ETS variant transcription factor 6
decreases expression
ISO
senecionine results in decreased expression of ETV6 protein
CTD
PMID:35357534
NCBI chr 4:166,849,031...167,085,211
Ensembl chr 4:166,847,686...167,084,992
G
Ext1
exostosin glycosyltransferase 1
decreases expression
ISO
senecionine results in decreased expression of EXT1 protein
CTD
PMID:35357534
NCBI chr 7:84,375,769...84,654,625
Ensembl chr 7:84,375,784...84,655,357
G
F13a1
coagulation factor XIII A1 chain
increases expression
ISO
senecionine results in increased expression of F13A1 protein
CTD
PMID:35357534
NCBI chr17:27,815,723...27,992,494
Ensembl chr17:27,815,702...27,992,700
G
Fancd2
FA complementation group D2
increases expression
EXP
senecionine results in increased expression of FANCD2 mRNA
CTD
PMID:32419051
NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
G
Fas
Fas cell surface death receptor
increases expression
ISO EXP
senecionine metabolite results in increased expression of FAS mRNA senecionine results in increased expression of FAS mRNA
CTD
PMID:30465738 PMID:32419051
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
G
Fbxo21
F-box protein 21
increases expression
ISO
senecionine results in increased expression of FBXO21 protein
CTD
PMID:35357534
NCBI chr12:38,570,878...38,605,133
Ensembl chr12:38,571,023...38,605,133
G
Fcgr3a
Fc gamma receptor 3A
increases expression
EXP
senecionine results in increased expression of FCGR3A mRNA
CTD
PMID:34185104
NCBI chr13:83,249,905...83,259,921
Ensembl chr13:83,249,872...83,259,921
G
Fdft1
farnesyl diphosphate farnesyl transferase 1
decreases expression
ISO
senecionine results in decreased expression of FDFT1 protein
CTD
PMID:35357534
NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
G
Fgl1
fibrinogen-like 1
decreases expression
ISO
senecionine results in decreased expression of FGL1 protein
CTD
PMID:35357534
NCBI chr16:51,120,652...51,150,907
Ensembl chr16:51,120,694...51,151,093
G
Fis1
fission, mitochondrial 1
decreases expression
ISO
senecionine results in decreased expression of FIS1 protein
CTD
PMID:35357534
NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377
G
Fmo3
flavin containing dimethylaniline monoxygenase 3
increases expression
ISO
senecionine results in increased expression of FMO3 protein
CTD
PMID:35357534
NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
G
Fmo4
flavin containing dimethylaniline monoxygenase 4
decreases expression
ISO
senecionine results in decreased expression of FMO4 mRNA
CTD
PMID:26100227
NCBI chr13:75,154,683...75,172,874
Ensembl chr13:75,154,684...75,172,874
G
Fmo5
flavin containing dimethylaniline monoxygenase 5
decreases expression
ISO
senecionine results in decreased expression of FMO5 mRNA
CTD
PMID:26100227
NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693
G
Fmr1
fragile X messenger ribonucleoprotein 1
decreases expression
ISO
senecionine results in decreased expression of FMR1 protein
CTD
PMID:35357534
NCBI chr X:147,240,239...147,278,057
Ensembl chr X:147,240,301...147,278,050
G
Fndc3b
fibronectin type III domain containing 3B
decreases expression
ISO
senecionine results in decreased expression of FNDC3B protein
CTD
PMID:35357534
NCBI chr 2:110,311,439...110,617,504
Ensembl chr 2:110,312,694...110,547,830
G
Folr2
folate receptor beta
decreases expression
ISO
senecionine results in decreased expression of FOLR2 protein
CTD
PMID:35357534
NCBI chr 1:156,200,044...156,218,380
Ensembl chr 1:156,200,060...156,205,724
G
Frmd4b
FERM domain containing 4B
decreases expression
ISO
senecionine results in decreased expression of FRMD4B protein
CTD
PMID:35357534
NCBI chr 4:129,895,401...130,222,070
Ensembl chr 4:129,895,708...130,084,197
G
Ftsj3
FtsJ RNA 2'-O-methyltransferase 3
decreases expression
ISO
senecionine results in decreased expression of FTSJ3 protein
CTD
PMID:35357534
NCBI chr10:91,180,945...91,187,389
Ensembl chr10:91,180,696...91,187,397
G
Fyb2
FYN binding protein 2
decreases expression
ISO
senecionine results in decreased expression of FYB2 protein
CTD
PMID:35357534
NCBI chr 5:119,677,116...119,800,911
Ensembl chr 5:119,677,204...119,800,910
G
Fyttd1
forty-two-three domain containing 1
decreases expression
ISO
senecionine results in decreased expression of FYTTD1 protein
CTD
PMID:35357534
NCBI chr11:67,877,967...67,907,500
Ensembl chr11:67,877,967...67,907,511
G
G0s2
G0/G1switch 2
increases expression
ISO
senecionine results in increased expression of G0S2 protein
CTD
PMID:35357534
NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451
G
G6pd
glucose-6-phosphate dehydrogenase
increases expression
ISO
senecionine results in increased expression of G6PDX protein
CTD
PMID:35357534
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
G
Gc
GC, vitamin D binding protein
decreases expression
ISO
senecionine results in decreased expression of GC protein
CTD
PMID:35357534
NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567
G
Gckr
glucokinase regulator
increases expression
ISO
senecionine results in increased expression of GCKR protein
CTD
PMID:35357534
NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654
G
Gcsh
glycine cleavage system protein H
increases expression
ISO
senecionine results in increased expression of GCSH protein
CTD
PMID:35357534
NCBI chr19:45,036,013...45,046,770
Ensembl chr19:45,036,011...45,046,792
G
Gem
GTP binding protein overexpressed in skeletal muscle
increases expression
ISO
senecionine results in increased expression of GEM mRNA
CTD
PMID:26100227
NCBI chr 5:25,214,309...25,225,222
Ensembl chr 5:25,214,309...25,225,222
G
Ghr
growth hormone receptor
decreases expression
ISO
senecionine results in decreased expression of GHR protein
CTD
PMID:35357534
NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735
G
Gls
glutaminase
increases expression
ISO
senecionine results in increased expression of GLS mRNA
CTD
PMID:26100227
NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900
G
Glyat
glycine-N-acyltransferase
decreases expression
ISO
senecionine results in decreased expression of GLYAT mRNA
CTD
PMID:26100227
NCBI chr 1:209,704,213...209,724,949
Ensembl chr 1:209,704,268...209,724,942
G
Gnmt
glycine N-methyltransferase
increases expression
ISO
senecionine results in increased expression of GNMT mRNA
CTD
PMID:26100227
NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434
G
Gpatch4
G patch domain containing 4
increases expression
ISO
senecionine results in increased expression of GPATCH4 protein
CTD
PMID:35357534
NCBI chr 2:173,499,700...173,520,346
Ensembl chr 2:173,509,897...173,518,684
G
Gpc1
glypican 1
decreases expression
EXP
senecionine results in decreased expression of GPC1 mRNA
CTD
PMID:34185104
NCBI chr 9:93,396,234...93,424,047
Ensembl chr 9:93,396,234...93,424,047
G
Gpcpd1
glycerophosphocholine phosphodiesterase 1
increases expression
ISO
senecionine results in increased expression of GPCPD1 protein
CTD
PMID:35357534
NCBI chr 3:119,787,681...119,832,550
Ensembl chr 3:119,787,682...119,832,517
G
Gphn
gephyrin
decreases expression
ISO
senecionine results in decreased expression of GPHN mRNA
CTD
PMID:26100227
NCBI chr 6:96,954,365...97,483,617
Ensembl chr 6:96,892,148...97,483,612
G
Gprc5a
G protein-coupled receptor, class C, group 5, member A
increases expression
ISO
senecionine results in increased expression of GPRC5A mRNA
CTD
PMID:26100227
NCBI chr 4:167,903,542...167,922,276
Ensembl chr 4:167,903,542...167,922,260
G
Gpsm3
G-protein signaling modulator 3
increases expression
ISO
senecionine results in increased expression of GPSM3 protein
CTD
PMID:35357534
NCBI chr20:4,157,123...4,158,984
Ensembl chr20:4,157,123...4,159,035
G
Gpt
glutamic--pyruvic transaminase
increases activity multiple interactions increases expression
EXP ISO
senecionine results in increased activity of GPT protein POR protein affects the reaction [senecionine results in increased expression of GPT protein]
CTD
PMID:24641316 PMID:31606820
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
G
Gria3
glutamate ionotropic receptor AMPA type subunit 3
increases expression
EXP
senecionine results in increased expression of GRIA3 mRNA
CTD
PMID:32419051
NCBI chr X:120,238,515...120,504,106
Ensembl chr X:120,238,534...120,504,096
G
Grn
granulin precursor
decreases expression
ISO
senecionine results in decreased expression of GRN protein
CTD
PMID:35357534
NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
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Grpel1
GrpE-like 1, mitochondrial
increases expression
ISO
senecionine results in increased expression of GRPEL1 protein
CTD
PMID:35357534
NCBI chr14:74,292,023...74,298,243
Ensembl chr14:74,292,023...74,298,200
G
Gsta4
glutathione S-transferase alpha 4
decreases expression
ISO
senecionine results in decreased expression of GSTA4 mRNA
CTD
PMID:26100227
NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182
G
Gstt1
glutathione S-transferase theta 1
decreases expression
ISO
senecionine results in decreased expression of GSTT1 mRNA
CTD
PMID:26100227
NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
G
Gzma
granzyme A
decreases expression
EXP
senecionine results in decreased expression of GZMA mRNA
CTD
PMID:32419051
NCBI chr 2:44,740,569...44,752,502
Ensembl chr 2:44,740,569...44,752,493
G
H1f4
H1.4 linker histone, cluster member
decreases expression
ISO
senecionine results in decreased expression of H1-4 protein
CTD
PMID:35357534
NCBI chr17:41,486,574...41,487,355
Ensembl chr17:41,486,560...41,487,403
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H2ax
H2A.X variant histone
increases expression
ISO
senecionine results in increased expression of H2AX protein
CTD
PMID:31154085
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
G
Haus2
HAUS augmin like complex subunit 2
decreases expression
ISO
senecionine results in decreased expression of HAUS2 protein
CTD
PMID:35357534
NCBI chr 3:107,553,146...107,565,982
Ensembl chr 3:107,553,161...107,565,157
G
Hba-a1
hemoglobin alpha, adult chain 1
increases expression
ISO
senecionine results in increased expression of HBA protein
CTD
PMID:35357534
NCBI chr10:15,337,265...15,338,121
Ensembl chr10:15,307,815...15,338,392
G
Hbb
hemoglobin subunit beta
increases expression
ISO
senecionine results in increased expression of HBB-B1 protein
CTD
PMID:35357534
NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012
G
Hdlbp
high density lipoprotein binding protein
decreases expression
ISO
senecionine results in decreased expression of HDLBP protein
CTD
PMID:35357534
NCBI chr 9:93,948,099...94,018,040
Ensembl chr 9:93,949,913...94,018,048
G
Herc6
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
increases expression
EXP
senecionine results in increased expression of HERC6 mRNA
CTD
PMID:32419051
NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744
G
Hic2
HIC ZBTB transcriptional repressor 2
decreases expression
ISO
senecionine results in decreased expression of HIC2 protein
CTD
PMID:35357534
NCBI chr11:83,737,075...83,789,554
Ensembl chr11:83,738,874...83,767,484
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
decreases expression
ISO
senecionine results in decreased expression of HMGCR protein
CTD
PMID:35357534
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
G
Hmmr
hyaluronan-mediated motility receptor
increases expression
EXP
senecionine results in increased expression of HMMR mRNA
CTD
PMID:32419051
NCBI chr10:25,132,933...25,163,029
Ensembl chr10:25,132,977...25,163,060
G
Hnf1a
HNF1 homeobox A
decreases expression
ISO
senecionine results in decreased expression of HNF1A protein
CTD
PMID:35357534
NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104
G
Hnmt
histamine N-methyltransferase
decreases expression
ISO
senecionine results in decreased expression of HNMT mRNA
CTD
PMID:26100227
NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012
G
Hoga1
4-hydroxy-2-oxoglutarate aldolase 1
increases expression
ISO
senecionine results in increased expression of HOGA1 protein
CTD
PMID:35357534
NCBI chr 1:240,856,991...240,884,243
Ensembl chr 1:240,857,126...240,884,568
G
Hp
haptoglobin
decreases expression
ISO
senecionine results in decreased expression of HP protein
CTD
PMID:35357534
NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
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Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
increases expression
ISO
senecionine results in increased expression of HSD3B1 protein
CTD
PMID:35357534
NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
G
Hsf1
heat shock transcription factor 1
increases activity
ISO
senecionine results in increased activity of HSF1 protein
CTD
PMID:34170685
NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
G
Hypk
Huntingtin interacting protein K
decreases expression
ISO
senecionine results in decreased expression of HYPK protein
CTD
PMID:35357534
NCBI chr 3:108,434,997...108,436,370
Ensembl chr 3:108,432,539...108,436,370
G
Icam1
intercellular adhesion molecule 1
increases expression
ISO
senecionine results in increased expression of ICAM1 mRNA
CTD
PMID:35357534
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Ifit2
interferon-induced protein with tetratricopeptide repeats 2
increases expression
EXP
senecionine results in increased expression of IFIT2 mRNA
CTD
PMID:32419051
NCBI chr 1:232,102,570...232,108,638
Ensembl chr 1:232,102,570...232,108,635
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Ift25
intraflagellar transport 25
increases expression
ISO
senecionine results in increased expression of IFT25 protein
CTD
PMID:35357534
NCBI chr 5:122,035,588...122,062,421
Ensembl chr 5:122,035,581...122,062,421
G
Igfbp4
insulin-like growth factor binding protein 4
decreases expression
ISO
senecionine results in decreased expression of IGFBP4 protein
CTD
PMID:35357534
NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225
G
Ighg1
immunoglobulin heavy constant gamma 1
increases expression
ISO
senecionine results in increased expression of IGHG1 protein
CTD
PMID:35357534
Ensembl chr 6:132,389,370...132,393,397
G
Il11
interleukin 11
increases expression
ISO
senecionine metabolite results in increased expression of IL11 mRNA
CTD
PMID:30465738
NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
G
Il13ra1
interleukin 13 receptor subunit alpha 1
decreases expression
ISO
senecionine results in decreased expression of IL13RA1 protein
CTD
PMID:35357534
NCBI chr X:115,348,822...115,408,682
Ensembl chr X:115,348,860...115,408,681 Ensembl chr11:115,348,860...115,408,681
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Il17rd
interleukin 17 receptor D
increases expression
EXP
senecionine results in increased expression of IL17RD mRNA
CTD
PMID:32419051
NCBI chr16:2,228,438...2,295,122
Ensembl chr16:2,228,287...2,292,556
G
Il1b
interleukin 1 beta
increases expression
ISO
senecionine metabolite results in increased expression of IL1B mRNA
CTD
PMID:30465738
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il6st
interleukin 6 cytokine family signal transducer
decreases expression
ISO
senecionine results in decreased expression of IL6ST protein
CTD
PMID:35357534
NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
G
Impdh2
inosine monophosphate dehydrogenase 2
increases expression
ISO
senecionine results in increased expression of IMPDH2 protein
CTD
PMID:35357534
NCBI chr 8:109,256,705...109,261,365
Ensembl chr 8:109,256,728...109,261,359
G
Inip
INTS3 and NABP interacting protein
decreases expression
ISO
senecionine results in decreased expression of INIP protein
CTD
PMID:35357534
NCBI chr 5:74,648,392...74,662,628
Ensembl chr 5:74,648,392...74,662,628
G
Inmt
indolethylamine N-methyltransferase
decreases expression
EXP
senecionine results in decreased expression of INMT mRNA
CTD
PMID:32419051
NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493
G
Isca1
iron-sulfur cluster assembly 1
increases expression
ISO
senecionine results in increased expression of ISCA1 protein
CTD
PMID:35357534
NCBI chr17:4,905,291...4,917,955
Ensembl chr17:4,905,287...4,917,955
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Isg15
ISG15 ubiquitin-like modifier
increases expression
ISO
senecionine results in increased expression of ISG15 protein
CTD
PMID:35357534
NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
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Isg20
interferon stimulated exonuclease gene 20
increases expression
ISO
senecionine results in increased expression of ISG20 mRNA
CTD
PMID:26100227
NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027
G
Itgam
integrin subunit alpha M
increases expression
ISO
senecionine results in increased expression of ITGAM protein
CTD
PMID:35357534
NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
G
Itih2
inter-alpha-trypsin inhibitor heavy chain 2
decreases expression
ISO
senecionine results in decreased expression of ITIH2 protein
CTD
PMID:35357534
NCBI chr17:68,375,574...68,411,849
Ensembl chr17:68,375,567...68,411,841
G
Itih3
inter-alpha trypsin inhibitor, heavy chain 3
decreases expression
ISO
senecionine results in decreased expression of ITIH3 protein
CTD
PMID:35357534
NCBI chr16:6,101,922...6,117,154
Ensembl chr16:6,101,930...6,116,924
G
Itm2b
integral membrane protein 2B
decreases expression
ISO
senecionine results in decreased expression of ITM2B protein
CTD
PMID:35357534
NCBI chr15:48,545,998...48,568,904
Ensembl chr15:48,546,001...48,568,917
G
Jam3
junctional adhesion molecule 3
increases expression
EXP
senecionine results in increased expression of JAM3 mRNA
CTD
PMID:32419051
NCBI chr 8:25,508,461...25,569,306
Ensembl chr 8:25,507,057...25,569,355
G
Jchain
joining chain of multimeric IgA and IgM
decreases expression
ISO
senecionine results in decreased expression of JCHAIN protein
CTD
PMID:35357534
NCBI chr14:19,538,927...19,547,023
Ensembl chr14:19,538,952...19,546,298
G
Jmjd6
jumonji domain containing 6, arginine demethylase and lysine hydroxylase
increases expression
ISO
senecionine results in increased expression of JMJD6 protein
CTD
PMID:35357534
NCBI chr10:102,041,131...102,047,182
Ensembl chr10:102,041,120...102,047,182
G
Junb
JunB proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
senecionine results in increased expression of JUNB protein
CTD
PMID:35357534
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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Kif11
kinesin family member 11
increases expression
EXP
senecionine results in increased expression of KIF11 mRNA
CTD
PMID:32419051
NCBI chr 1:235,124,371...235,176,760
Ensembl chr 1:235,124,316...235,176,766
G
Kif18a
kinesin family member 18A
increases expression
EXP
senecionine results in increased expression of KIF18A mRNA
CTD
PMID:32419051
NCBI chr 3:95,764,388...95,824,756
Ensembl chr 3:95,764,388...95,824,582
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Knl1
kinetochore scaffold 1
increases expression
EXP
senecionine results in increased expression of KNL1 mRNA
CTD
PMID:32419051
NCBI chr 3:106,029,627...106,091,915
Ensembl chr 3:106,029,661...106,091,915
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Kntc1
kinetochore associated 1
increases expression
EXP
senecionine results in increased expression of KNTC1 mRNA
CTD
PMID:32419051
NCBI chr12:32,769,020...32,839,617
Ensembl chr12:32,769,020...32,839,561
G
Krt19
keratin 19
decreases expression
ISO
senecionine results in decreased expression of KRT19 protein
CTD
PMID:35357534
NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799
G
Ktn1
kinectin 1
decreases expression
ISO
senecionine results in decreased expression of KTN1 protein
CTD
PMID:35357534
NCBI chr15:20,913,665...21,002,588
Ensembl chr15:20,914,642...21,002,578
G
Kyat1
kynurenine aminotransferase 1
decreases expression
ISO
senecionine results in decreased expression of KYAT1 mRNA
CTD
PMID:26100227
NCBI chr 3:13,459,598...13,493,308
Ensembl chr 3:13,459,591...13,493,355
G
Larp4
La ribonucleoprotein 4
decreases expression
ISO
senecionine results in decreased expression of LARP4 protein
CTD
PMID:35357534
NCBI chr 7:131,104,470...131,152,692
Ensembl chr 7:131,101,564...131,150,811
G
Lbp
lipopolysaccharide binding protein
increases expression
EXP
senecionine results in increased expression of LBP mRNA
CTD
PMID:32419051
NCBI chr 3:146,953,889...146,981,032
Ensembl chr 3:146,954,015...146,981,586
G
Lcn2
lipocalin 2
increases expression
ISO
senecionine results in increased expression of LCN2 mRNA
CTD
PMID:31606820
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
G
Lgals2
galectin 2
decreases expression
ISO
senecionine results in decreased expression of LGALS2 protein
CTD
PMID:35357534
NCBI chr 7:110,403,171...110,410,046
Ensembl chr 7:110,403,173...110,404,802
G
Lgr5
leucine rich repeat containing G protein coupled receptor 5
decreases expression
ISO
senecionine results in decreased expression of LGR5 mRNA
CTD
PMID:31606820
NCBI chr 7:51,087,059...51,221,882
Ensembl chr 7:51,088,239...51,222,446
G
Lin37
lin-37 DREAM MuvB core complex component
decreases expression
ISO
senecionine results in decreased expression of LIN37 protein
CTD
PMID:35357534
NCBI chr 1:85,809,065...85,813,235
Ensembl chr 1:85,809,074...85,812,991
G
Lonp1
lon peptidase 1, mitochondrial
increases expression
ISO
senecionine results in increased expression of LONP1 protein
CTD
PMID:35357534
NCBI chr 9:1,447,444...1,459,771
Ensembl chr 9:1,447,447...1,459,771
G
Lrp1
LDL receptor related protein 1
decreases expression
ISO
senecionine results in decreased expression of LRP1 protein
CTD
PMID:35357534
NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
G
Lrrc59
leucine rich repeat containing 59
decreases expression
ISO
senecionine results in decreased expression of LRRC59 protein
CTD
PMID:35357534
NCBI chr10:79,572,295...79,586,953
Ensembl chr10:79,572,317...79,602,533
G
Ltf
lactotransferrin
increases expression
ISO
senecionine results in increased expression of LTF protein
CTD
PMID:35357534
NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795
G
Lyz2
lysozyme 2
increases expression
ISO
senecionine results in increased expression of LYZ2 protein
CTD
PMID:35357534
NCBI chr 7:52,906,810...52,912,154
Ensembl chr 7:52,906,811...52,912,106
G
Maco1
macoilin 1
decreases expression
ISO
senecionine results in decreased expression of MACO1 protein
CTD
PMID:35357534
NCBI chr 5:147,012,416...147,075,265
Ensembl chr 5:147,012,867...147,075,001
G
Mad2l1
mitotic arrest deficient 2 like 1
increases expression
EXP
senecionine results in increased expression of MAD2L1 mRNA
CTD
PMID:32419051
NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470
G
Maff
MAF bZIP transcription factor F
increases expression
ISO
senecionine results in increased expression of MAFF mRNA senecionine results in increased expression of MAFF protein
CTD
PMID:26100227 PMID:35357534
NCBI chr 7:110,912,367...110,923,711
Ensembl chr 7:110,912,499...110,923,851
G
Mafk
MAF bZIP transcription factor K
increases expression
ISO
senecionine results in increased expression of MAFK protein
CTD
PMID:35357534
NCBI chr12:14,834,628...14,856,414
Ensembl chr12:14,833,984...14,837,048 Ensembl chr12:14,833,984...14,837,048
G
Mal
mal, T-cell differentiation protein
increases expression
EXP
senecionine results in increased expression of MAL mRNA
CTD
PMID:34185104
NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136
G
Maoa
monoamine oxidase A
decreases expression
ISO
senecionine results in decreased expression of MAOA mRNA
CTD
PMID:26100227
NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593
G
Map2k3
mitogen activated protein kinase kinase 3
increases expression
ISO
senecionine results in increased expression of MAP2K3 protein
CTD
PMID:35357534
NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492
G
Map7
microtubule-associated protein 7
decreases expression
ISO
senecionine results in decreased expression of MAP7 protein
CTD
PMID:35357534
NCBI chr 1:14,910,433...15,037,574
Ensembl chr 1:14,910,551...15,037,574
G
Mapre2
microtubule-associated protein, RP/EB family, member 2
decreases expression
ISO
senecionine results in decreased expression of MAPRE2 protein
CTD
PMID:35357534
NCBI chr18:15,028,675...15,169,553
Ensembl chr18:15,029,041...15,168,044
G
Mastl
microtubule associated serine/threonine kinase-like
increases expression
EXP
senecionine results in increased expression of MASTL mRNA
CTD
PMID:32419051
NCBI chr17:85,250,512...85,287,479
Ensembl chr17:85,251,997...85,287,353
G
Mbl2
mannose binding lectin 2
increases expression
ISO
senecionine results in increased expression of MBL2 protein
CTD
PMID:35357534
NCBI chr 1:228,016,439...228,024,736
G
Mcm3
minichromosome maintenance complex component 3
increases expression
EXP
senecionine results in increased expression of MCM3 mRNA
CTD
PMID:32419051
NCBI chr 9:23,219,169...23,237,314
Ensembl chr 9:23,219,169...23,237,314
G
Mcm5
minichromosome maintenance complex component 5
increases expression
EXP
senecionine results in increased expression of MCM5 mRNA
CTD
PMID:32419051
NCBI chr19:13,483,030...13,504,389
Ensembl chr19:13,483,066...13,504,389
G
Mettl21a
methyltransferase 21A, HSPA lysine
increases expression
ISO
senecionine results in increased expression of METTL21A protein
CTD
PMID:35357534
NCBI chr 9:65,934,253...65,999,964
Ensembl chr 9:65,978,051...65,987,550
G
Mgat5
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase
decreases expression
ISO
senecionine results in decreased expression of MGAT5 protein
CTD
PMID:35357534
NCBI chr13:38,675,776...38,959,697
Ensembl chr13:38,676,119...38,959,513
G
Mgme1
mitochondrial genome maintenance exonuclease 1
increases expression
ISO
senecionine results in increased expression of MGME1 protein
CTD
PMID:35357534
NCBI chr 3:131,640,770...131,649,933
Ensembl chr 3:131,640,944...131,649,932
G
Mgmt
O-6-methylguanine-DNA methyltransferase
increases expression
EXP
senecionine results in increased expression of MGMT mRNA
CTD
PMID:32419051
NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
G
Mib2
MIB E3 ubiquitin protein ligase 2
decreases expression
ISO
senecionine results in decreased expression of MIB2 protein
CTD
PMID:35357534
NCBI chr 5:166,243,776...166,259,944
Ensembl chr 5:166,243,776...166,259,650
G
Micos10
mitochondrial contact site and cristae organizing system subunit 10
decreases expression
ISO
senecionine results in decreased expression of MICOS10 protein
CTD
PMID:35357534
NCBI chr 5:151,341,124...151,367,403
Ensembl chr 5:151,339,176...151,367,485
G
Mki67
marker of proliferation Ki-67
increases expression
EXP
senecionine results in increased expression of MKI67 mRNA
CTD
PMID:32419051
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
G
Mmp1
matrix metallopeptidase 1
increases expression
ISO
senecionine results in increased expression of MMP1 mRNA
CTD
PMID:26100227
NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
G
Mmp9
matrix metallopeptidase 9
increases expression multiple interactions
ISO
senecionine results in increased expression of MMP9 mRNA senecionine results in increased expression of MMP9 mRNA; senecionine results in increased expression of MMP9 protein Leu-Ser-Lys-Leu peptide inhibits the reaction [senecionine results in increased expression of MMP9 mRNA]
CTD
PMID:35357534
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
G
Mmrn1
multimerin 1
increases expression
ISO
senecionine results in increased expression of MMRN1 protein
CTD
PMID:35357534
NCBI chr 4:89,875,408...89,950,814
Ensembl chr 4:89,903,174...89,950,474
G
Mpdu1
mannose-P-dolichol utilization defect 1
decreases expression
ISO
senecionine results in decreased expression of MPDU1 protein
CTD
PMID:35357534
NCBI chr10:54,374,719...54,380,301
Ensembl chr10:54,374,725...54,380,447
G
Mpo
myeloperoxidase
increases expression
ISO
senecionine results in increased expression of MPO protein
CTD
PMID:35357534
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
G
Mpst
mercaptopyruvate sulfurtransferase
increases expression
ISO
senecionine results in increased expression of MPST protein
CTD
PMID:35357534
NCBI chr 7:109,955,581...109,963,155
Ensembl chr 7:109,955,675...109,963,141
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Mrpl42
mitochondrial ribosomal protein L42
increases expression
ISO
senecionine results in increased expression of MRPL42 protein
CTD
PMID:35357534
NCBI chr 7:30,117,977...30,141,757
Ensembl chr 7:30,117,977...30,141,639
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Msmo1
methylsterol monooxygenase 1
decreases expression
ISO
senecionine results in decreased expression of MSMO1 protein
CTD
PMID:35357534
NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
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Mt-co3
mitochondrially encoded cytochrome c oxidase III
increases expression
ISO
senecionine results in increased expression of COX3 protein
CTD
PMID:35357534
NCBI chr MT:8,599...9,382 NCBI chr MT:8,599...9,382 NCBI chr MT:8,599...9,382 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
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Mt-nd3
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3
decreases expression
ISO
senecionine results in decreased expression of ND3 protein
CTD
PMID:35357534
NCBI chr MT:9,451...9,798 NCBI chr MT:9,451...9,798 NCBI chr MT:9,451...9,798 NCBI chr MT:9,451...9,798 NCBI chr MT:9,451...9,798
Ensembl chr MT:9,451...9,798
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Mt2A
metallothionein 2A
increases expression
ISO
senecionine results in increased expression of MT2 mRNA
CTD
PMID:31606820
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
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Mthfd1l
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
increases expression
ISO
senecionine results in increased expression of MTHFD1L protein
CTD
PMID:35357534
NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905
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Mtss1
MTSS I-BAR domain containing 1
decreases expression
ISO
senecionine results in decreased expression of MTSS1 protein
CTD
PMID:35357534
NCBI chr 7:90,488,751...90,628,007
Ensembl chr 7:90,488,754...90,627,968
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Mtus1
microtubule associated scaffold protein 1
decreases expression
ISO
senecionine results in decreased expression of MTUS1 protein
CTD
PMID:35357534
NCBI chr16:51,202,497...51,347,794
Ensembl chr16:51,253,562...51,347,793
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Mybl1
MYB proto-oncogene like 1
increases expression
EXP
senecionine results in increased expression of MYBL1 mRNA
CTD
PMID:32419051
NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183
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Mybl2
MYB proto-oncogene like 2
increases expression
EXP
senecionine results in increased expression of MYBL2 mRNA
CTD
PMID:32419051
NCBI chr 3:151,705,254...151,733,714
Ensembl chr 3:151,705,288...151,733,708
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Mybpc3
myosin binding protein C3
decreases expression
EXP
senecionine results in decreased expression of MYBPC3 mRNA
CTD
PMID:34185104
NCBI chr 3:77,095,165...77,113,406
Ensembl chr 3:77,095,252...77,113,405
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Myoz2
myozenin 2
decreases expression
EXP
senecionine results in decreased expression of MYOZ2 mRNA
CTD
PMID:34185104
NCBI chr 2:211,141,463...211,168,187
Ensembl chr 2:211,141,463...211,168,221
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N4bp2l1
NEDD4 binding protein 2-like 1
decreases expression
ISO
senecionine results in decreased expression of N4BP2L1 protein
CTD
PMID:35357534
NCBI chr12:102,572...128,352
Ensembl chr12:102,573...127,257
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Napsa
napsin A aspartic peptidase
increases expression
ISO
senecionine results in increased expression of NAPSA protein
CTD
PMID:35357534
NCBI chr 1:95,064,726...95,077,101
Ensembl chr 1:95,064,900...95,077,094
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Ncaph
non-SMC condensin I complex, subunit H
increases expression
EXP
senecionine results in increased expression of NCAPH mRNA
CTD
PMID:32419051
NCBI chr 3:114,371,937...114,399,178
Ensembl chr 3:114,371,941...114,399,180
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Ncf4
neutrophil cytosolic factor 4
increases expression
ISO
senecionine results in increased expression of NCF4 protein
CTD
PMID:35357534
NCBI chr 7:109,825,420...109,843,389
Ensembl chr 7:109,826,020...109,843,389
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Ndc80
NDC80 kinetochore complex component
increases expression
EXP
senecionine results in increased expression of NDC80 mRNA
CTD
PMID:32419051
NCBI chr 9:111,407,191...111,440,921
Ensembl chr 9:111,407,191...111,440,924
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Neb
nebulin
decreases expression
ISO
senecionine results in decreased expression of NEB mRNA
CTD
PMID:26100227
NCBI chr 3:36,613,677...36,811,618
Ensembl chr 3:36,613,716...36,811,574
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Nfia
nuclear factor I/A
decreases expression
ISO
senecionine results in decreased expression of NFIA protein
CTD
PMID:35357534
NCBI chr 5:112,436,655...112,781,878
Ensembl chr 5:112,436,644...112,775,885
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Nifk
nucleolar protein interacting with the FHA domain of MKI67
decreases expression
ISO
senecionine results in decreased expression of NIFK protein
CTD
PMID:35357534
NCBI chr13:29,393,303...29,403,387
Ensembl chr13:29,393,286...29,405,896
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Nnmt
nicotinamide N-methyltransferase
decreases expression
ISO
senecionine results in decreased expression of NNMT mRNA
CTD
PMID:26100227
NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...48,946,655
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Nop16
NOP16 nucleolar protein
decreases expression
ISO
senecionine results in decreased expression of NOP16 protein
CTD
PMID:35357534
NCBI chr17:10,022,950...10,027,867
Ensembl chr17:10,022,932...10,027,867
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Nos2
nitric oxide synthase 2
increases expression
ISO
senecionine results in increased expression of NOS2 mRNA
CTD
PMID:35357534
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Npl
N-acetylneuraminate pyruvate lyase
increases expression
ISO
senecionine results in increased expression of NPL protein
CTD
PMID:35357534
NCBI chr13:65,655,099...65,697,464
Ensembl chr13:65,655,118...65,697,372
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
ISO
senecionine results in increased expression of NQO1 mRNA
CTD
PMID:26100227
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nr0b2
nuclear receptor subfamily 0, group B, member 2
decreases expression
EXP ISO
senecionine results in decreased expression of NR0B2 mRNA
CTD
PMID:24641316 PMID:31606820
NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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Nr1d1
nuclear receptor subfamily 1, group D, member 1
increases expression
ISO
senecionine results in increased expression of NR1D1 protein
CTD
PMID:35357534
NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
decreases expression
EXP ISO
senecionine results in decreased expression of NR1H4 mRNA senecionine results in decreased expression of NR1H4 protein
CTD
PMID:24641316 PMID:35357534
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
decreases expression
ISO
senecionine results in decreased expression of NR1I3 mRNA
CTD
PMID:31606820
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
decreases expression
EXP
senecionine results in decreased expression of NR3C1 mRNA
CTD
PMID:32419051
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Nrcam
neuronal cell adhesion molecule
increases expression
EXP
senecionine results in increased expression of NRCAM mRNA
CTD
PMID:32419051
NCBI chr 6:61,402,813...61,698,536
Ensembl chr 6:61,329,863...61,702,992
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Nrg1
neuregulin 1
increases expression
EXP
senecionine results in increased expression of NRG1 mRNA
CTD
PMID:32419051
NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884
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Nrp1
neuropilin 1
decreases expression
ISO
senecionine results in decreased expression of NRP1 protein
CTD
PMID:35357534
NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633
G
Ntm
neurotrimin
decreases expression
ISO
senecionine results in decreased expression of NTM protein
CTD
PMID:35357534
NCBI chr 8:27,376,582...28,366,604
Ensembl chr 8:27,377,773...28,366,595
G
Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
decreases expression
ISO
senecionine results in decreased expression of NUCKS1 protein
CTD
PMID:35357534
NCBI chr13:43,345,091...43,374,316
Ensembl chr13:43,345,115...43,370,229
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Nudt7
nudix hydrolase 7
increases expression
ISO
senecionine results in increased expression of NUDT7 protein
CTD
PMID:35357534
NCBI chr19:42,125,679...42,151,198
Ensembl chr19:42,125,711...42,151,081
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Nusap1
nucleolar and spindle associated protein 1
increases expression
EXP
senecionine results in increased expression of NUSAP1 mRNA
CTD
PMID:32419051
NCBI chr 3:106,603,273...106,633,428
Ensembl chr 3:106,603,289...106,633,624
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Orm1
orosomucoid 1
decreases expression
ISO
senecionine results in decreased expression of ORM1 protein
CTD
PMID:35357534
NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154
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Oxsm
3-oxoacyl-ACP synthase, mitochondrial
increases expression
ISO
senecionine results in increased expression of OXSM protein
CTD
PMID:35357534
NCBI chr15:9,210,443...9,215,852
Ensembl chr15:9,210,547...9,214,558
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Pabpc1
poly(A) binding protein, cytoplasmic 1
decreases expression
ISO
senecionine results in decreased expression of PABPC1 protein
CTD
PMID:35357534
NCBI chr 7:67,777,438...67,789,731
Ensembl chr 7:67,777,381...67,789,744
G
Parp1
poly (ADP-ribose) polymerase 1
decreases expression
ISO
senecionine results in decreased expression of PARP1 protein
CTD
PMID:29458164 PMID:35357534
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pclaf
PCNA clamp associated factor
increases expression
EXP
senecionine results in increased expression of PCLAF mRNA
CTD
PMID:32419051
NCBI chr 8:66,420,606...66,432,994
Ensembl chr 8:66,420,587...66,432,994 Ensembl chr 8:66,420,587...66,432,994
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Pcsk9
proprotein convertase subtilisin/kexin type 9
decreases expression
ISO
senecionine results in decreased expression of PCSK9 protein
CTD
PMID:35357534
NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688
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Pdcl
phosducin like
increases expression
ISO
senecionine results in increased expression of PDCL protein
CTD
PMID:35357534
NCBI chr 3:21,110,165...21,119,763
Ensembl chr 3:21,110,167...21,119,715
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Pde12
phosphodiesterase 12
increases expression
ISO
senecionine results in increased expression of PDE12 protein
CTD
PMID:35357534
NCBI chr16:1,920,062...1,925,638
Ensembl chr16:1,915,386...1,925,887
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Pde7b
phosphodiesterase 7B
decreases expression
ISO
senecionine results in decreased expression of PDE7B protein
CTD
PMID:35357534
NCBI chr 1:15,174,001...15,493,267
Ensembl chr 1:15,182,704...15,492,900
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Pdia2
protein disulfide isomerase family A, member 2
decreases expression
ISO
senecionine results in decreased expression of PDIA2 protein
CTD
PMID:35357534
NCBI chr10:15,215,824...15,218,937
Ensembl chr10:15,215,824...15,220,931
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Pdzrn3
PDZ domain containing RING finger 3
decreases expression
ISO
senecionine results in decreased expression of PDZRN3 protein
CTD
PMID:35357534
NCBI chr 4:133,770,736...133,996,959
Ensembl chr 4:133,770,736...133,996,959
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Per3
period circadian regulator 3
decreases expression
ISO
senecionine results in decreased expression of PER3 protein
CTD
PMID:35357534
NCBI chr 5:161,460,228...161,495,404
Ensembl chr 5:161,459,533...161,495,607
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Phf14
PHD finger protein 14
decreases expression
ISO
senecionine results in decreased expression of PHF14 protein
CTD
PMID:35357534
NCBI chr 4:40,009,691...40,195,877
Ensembl chr 4:40,009,264...40,195,885
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Pid1
phosphotyrosine interaction domain containing 1
decreases expression
ISO
senecionine results in decreased expression of PID1 protein
CTD
PMID:35357534
NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044
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Piezo1
piezo-type mechanosensitive ion channel component 1
increases expression
ISO
senecionine results in increased expression of PIEZO1 protein
CTD
PMID:35357534
NCBI chr19:50,544,580...50,606,812
Ensembl chr19:50,544,582...50,606,501
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Pigr
polymeric immunoglobulin receptor
decreases expression
ISO
senecionine results in decreased expression of PIGR protein
CTD
PMID:35357534
NCBI chr13:42,298,905...42,326,877
Ensembl chr13:42,298,914...42,326,875
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Pkd2
polycystin 2, transient receptor potential cation channel
decreases expression
ISO
senecionine results in decreased expression of PKD2 protein
CTD
PMID:35357534
NCBI chr14:5,237,135...5,280,455
Ensembl chr14:5,237,135...5,280,825
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Plcg2
phospholipase C, gamma 2
increases expression
ISO
senecionine results in increased expression of PLCG2 protein
CTD
PMID:35357534
NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930
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Pld1
phospholipase D1
decreases expression
ISO
senecionine results in decreased expression of PLD1 protein
CTD
PMID:35357534
NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692
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Pld4
phospholipase D family, member 4
increases expression
EXP
senecionine results in increased expression of PLD4 mRNA
CTD
PMID:34185104
NCBI chr 6:131,818,860...131,827,457
Ensembl chr 6:131,818,860...131,826,376
G
Plg
plasminogen
decreases expression
ISO
senecionine results in decreased expression of PLG protein
CTD
PMID:35357534
NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786
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Plin2
perilipin 2
increases expression
ISO
senecionine results in increased expression of PLIN2 protein
CTD
PMID:35357534
NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319
G
Plk4
polo-like kinase 4
increases expression
EXP
senecionine results in increased expression of PLK4 mRNA
CTD
PMID:32419051
NCBI chr 2:123,802,527...123,820,942
Ensembl chr 2:123,802,512...123,820,942
G
Pln
phospholamban
decreases expression
EXP
senecionine results in decreased expression of PLN mRNA
CTD
PMID:34185104
NCBI chr20:32,629,537...32,639,559
G
Pml
PML nuclear body scaffold
decreases expression
ISO
senecionine results in decreased expression of PML protein
CTD
PMID:35357534
NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
G
Pnpla2
patatin-like phospholipase domain containing 2
increases expression
ISO
senecionine results in increased expression of PNPLA2 protein
CTD
PMID:35357534
NCBI chr 1:196,552,723...196,557,805
Ensembl chr 1:196,552,723...196,557,805
G
Polr1g
RNA polymerase I subunit G
increases expression
ISO
senecionine results in increased expression of POLR1G protein
CTD
PMID:35357534
NCBI chr 1:79,007,490...79,010,766
Ensembl chr 1:79,007,490...79,010,766
G
Por
cytochrome p450 oxidoreductase
multiple interactions affects response to substance
ISO
POR protein affects the reaction [senecionine results in increased expression of GPT protein] POR protein affects the susceptibility to senecionine
CTD
PMID:31606820
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
G
Ppif
peptidylprolyl isomerase F
increases expression
ISO
senecionine results in increased expression of PPIF protein
CTD
PMID:35357534
NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913
G
Ppp1r3b
protein phosphatase 1, regulatory subunit 3B
decreases expression
ISO
senecionine results in decreased expression of PPP1R3B protein
CTD
PMID:35357534
NCBI chr16:56,830,011...56,842,395
Ensembl chr16:56,829,660...56,842,406
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Prc1
protein regulator of cytokinesis 1
increases expression
EXP
senecionine results in increased expression of PRC1 mRNA
CTD
PMID:32419051
NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
G
Prdx3
peroxiredoxin 3
increases expression
ISO
senecionine results in increased expression of PRDX3 protein
CTD
PMID:35357534
NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111
G
Prg4
proteoglycan 4
decreases expression
ISO
senecionine results in decreased expression of PRG4 protein
CTD
PMID:35357534
NCBI chr13:62,487,257...62,504,657
Ensembl chr13:62,487,257...62,504,119
G
Prlr
prolactin receptor
decreases expression
ISO
senecionine results in decreased expression of PRLR protein
CTD
PMID:35357534
NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718
G
Prox1
prospero homeobox 1
decreases expression
ISO
senecionine results in decreased expression of PROX1 protein
CTD
PMID:35357534
NCBI chr13:101,669,184...101,719,804
Ensembl chr13:101,669,184...101,711,183
G
Prr12
proline rich 12
decreases expression
ISO
senecionine results in decreased expression of PRR12 protein
CTD
PMID:35357534
NCBI chr 1:95,510,015...95,534,002
Ensembl chr 1:95,509,931...95,533,652
G
Psap
prosaposin
decreases expression
ISO
senecionine results in decreased expression of PSAP protein
CTD
PMID:35357534
NCBI chr20:28,214,229...28,240,501
Ensembl chr20:28,214,271...28,240,498
G
Psip1
PC4 and SRSF1 interacting protein 1
decreases expression
ISO
senecionine results in decreased expression of PSIP1 protein
CTD
PMID:35357534
NCBI chr 5:97,847,010...97,879,280
Ensembl chr 5:97,847,015...97,879,257
G
Psmd10
proteasome 26S subunit, non-ATPase 10
increases expression
ISO
senecionine results in increased expression of PSMD10 protein
CTD
PMID:35357534
NCBI chr X:104,656,809...104,665,122
Ensembl chr X:104,656,812...104,665,097
G
Ptgis
prostaglandin I2 synthase
decreases expression
ISO
senecionine metabolite results in decreased expression of PTGIS mRNA; senecionine metabolite results in decreased expression of PTGIS protein
CTD
PMID:30465738
NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451
G
Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression
ISO
senecionine metabolite results in increased expression of PTGS2 mRNA; senecionine metabolite results in increased expression of PTGS2 protein
CTD
PMID:30465738
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Ptprd
protein tyrosine phosphatase, receptor type, D
decreases expression
ISO
senecionine results in decreased expression of PTPRD mRNA senecionine results in decreased expression of PTPRD protein
CTD
PMID:26100227 PMID:35357534
NCBI chr 5:90,046,993...90,698,977 NCBI chr 5:91,122,354...91,641,754
Ensembl chr 5:90,048,966...92,369,396
G
Rab11a
RAB11a, member RAS oncogene family
decreases expression
ISO
senecionine results in decreased expression of RAB11A protein
CTD
PMID:35357534
NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525
G
Rapgef4
Rap guanine nucleotide exchange factor 4
decreases expression
ISO
senecionine results in decreased expression of RAPGEF4 mRNA
CTD
PMID:26100227
NCBI chr 3:56,809,388...57,101,332
Ensembl chr 3:56,809,270...57,102,316
G
Rassf1
Ras association domain family member 1
increases expression
ISO
senecionine results in increased expression of RASSF1 protein
CTD
PMID:35357534
NCBI chr 8:108,225,023...108,236,164
Ensembl chr 8:108,225,023...108,236,164
G
Rbis
ribosomal biogenesis factor
decreases expression
ISO
senecionine results in decreased expression of RBIS protein
CTD
PMID:35357534
NCBI chr 2:86,981,314...86,997,352
Ensembl chr 2:86,991,315...87,041,339
G
Rbm3
RNA binding motif protein 3
decreases expression
ISO
senecionine results in decreased expression of RBM3 protein
CTD
PMID:35357534
NCBI chr X:14,348,909...14,352,387
Ensembl chr X:14,348,910...14,353,580
G
Rc3h1
ring finger and CCCH-type domains 1
increases expression
ISO
senecionine results in increased expression of RC3H1 protein
CTD
PMID:35357534
NCBI chr13:73,174,075...73,245,762
Ensembl chr13:73,173,946...73,238,839
G
Rcl1
RNA terminal phosphate cyclase-like 1
decreases expression
ISO
senecionine results in decreased expression of RCL1 protein
CTD
PMID:35357534
NCBI chr 1:226,824,561...226,869,046
Ensembl chr 1:226,824,534...226,902,315
G
Rexo4
REX4 homolog, 3'-5' exonuclease
decreases expression
ISO
senecionine results in decreased expression of REXO4 protein
CTD
PMID:35357534
NCBI chr 3:10,280,654...10,291,003
Ensembl chr 3:10,280,654...10,290,996
G
Ring1
ring finger protein 1
decreases expression
ISO
senecionine results in decreased expression of RING1 protein
CTD
PMID:35357534
NCBI chr20:4,830,120...4,833,623
Ensembl chr20:4,830,053...4,833,620
G
Rpl34
ribosomal protein L34
decreases expression
ISO
senecionine results in decreased expression of RPL34 protein
CTD
PMID:35357534
NCBI chr 2:219,284,373...219,288,108
Ensembl chr 2:219,284,382...219,288,111
G
Rpl36
ribosomal protein L36
decreases expression
ISO
senecionine results in decreased expression of RPL36 protein
CTD
PMID:35357534
NCBI chr 9:1,441,986...1,447,397
Ensembl chr 6:98,809,534...98,809,897
G
Rplp1
ribosomal protein lateral stalk subunit P1
increases expression
ISO
senecionine results in increased expression of RPLP1 protein
CTD
PMID:35357534
NCBI chr 8:62,394,008...62,395,341
Ensembl chr 8:62,393,177...62,395,339
G
Rps27
ribosomal protein S27
decreases expression
ISO
senecionine results in decreased expression of RPS27 protein
CTD
PMID:35357534
NCBI chr 2:175,665,858...175,666,963
Ensembl chr 2:175,665,853...175,666,964
G
Rrad
RRAD, Ras related glycolysis inhibitor and calcium channel regulator
increases expression
ISO
senecionine results in increased expression of RRAD mRNA
CTD
PMID:26100227
NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417
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RragB
Ras-related GTP binding B
increases expression
ISO
senecionine results in increased expression of RRAGB protein
CTD
PMID:35357534
NCBI chr X:18,184,619...18,234,639
Ensembl chr X:18,184,992...18,234,639
G
Rrbp1
ribosome binding protein 1
decreases expression
ISO
senecionine results in decreased expression of RRBP1 protein
CTD
PMID:35357534
NCBI chr 3:131,314,996...131,376,930
Ensembl chr 3:131,314,998...131,376,981
G
Rrm1
ribonucleotide reductase catalytic subunit M1
increases expression
EXP
senecionine results in increased expression of RRM1 mRNA
CTD
PMID:32419051
NCBI chr 1:156,823,960...156,848,262
Ensembl chr 1:156,823,960...156,848,261
G
Rrn3
RRN3 homolog, RNA polymerase I transcription factor
increases expression
ISO
senecionine results in increased expression of RRN3 protein
CTD
PMID:35357534
NCBI chr10:2,129,949...2,165,381
Ensembl chr10:2,129,978...2,165,663
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Rsad2
radical S-adenosyl methionine domain containing 2
increases expression
ISO
senecionine results in increased expression of RSAD2 protein
CTD
PMID:35357534
NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699
G
Rsl24d1
ribosomal L24 domain containing 1
decreases expression
ISO
senecionine results in decreased expression of RSL24D1 protein
CTD
PMID:35357534
NCBI chr 8:73,852,991...73,861,996
Ensembl chr 8:73,852,996...73,862,001
G
Rxra
retinoid X receptor alpha
decreases expression
ISO
senecionine results in decreased expression of RXRA protein
CTD
PMID:35357534
NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
G
S100a4
S100 calcium-binding protein A4
increases expression
ISO
senecionine results in increased expression of S100A4 protein
CTD
PMID:35357534
NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
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S100a6
S100 calcium binding protein A6
increases expression
ISO
senecionine results in increased expression of S100A6 protein
CTD
PMID:35357534
NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180
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S100a9
S100 calcium binding protein A9
increases expression
ISO
senecionine results in increased expression of S100A9 protein
CTD
PMID:35357534
NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
G
Saa4
serum amyloid A4
decreases expression
ISO
senecionine results in decreased expression of SAA4 protein
CTD
PMID:35357534
NCBI chr 1:97,247,580...97,251,882
G
Sarnp
SAP domain containing ribonucleoprotein
decreases expression
ISO
senecionine results in decreased expression of SARNP protein
CTD
PMID:35357534
NCBI chr 7:1,251,096...1,305,335
Ensembl chr 7:1,251,098...1,305,332
G
Sat1
spermidine/spermine N1-acetyl transferase 1
increases expression
ISO
senecionine results in increased expression of SAT1 mRNA
CTD
PMID:26100227
NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813
G
Scd
stearoyl-CoA desaturase
decreases expression
ISO
senecionine results in decreased expression of SCD1 protein
CTD
PMID:35357534
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
G
Sdc2
syndecan 2
decreases expression
ISO
senecionine results in decreased expression of SDC2 protein
CTD
PMID:35357534
NCBI chr 7:64,127,185...64,239,885
Ensembl chr 7:64,127,110...64,241,081
G
Sdc4
syndecan 4
decreases expression
ISO
senecionine results in decreased expression of SDC4 protein
CTD
PMID:35357534
NCBI chr 3:153,154,888...153,173,576
Ensembl chr 3:153,154,896...153,173,580
G
Sdr42e1
short chain dehydrogenase/reductase family 42E, member 1
increases expression
ISO
senecionine results in increased expression of SDR42E1 protein
CTD
PMID:35357534
NCBI chr19:45,715,366...45,727,901
Ensembl chr19:45,715,399...45,727,901
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Secisbp2l
SECIS binding protein 2-like
decreases expression
ISO
senecionine results in decreased expression of SECISBP2L protein
CTD
PMID:35357534
NCBI chr 3:112,989,613...113,036,060
Ensembl chr 3:112,991,908...113,035,884
G
Sema3e
semaphorin 3E
decreases expression
ISO
senecionine results in decreased expression of SEMA3E protein
CTD
PMID:35357534
NCBI chr 4:20,297,534...20,555,287
Ensembl chr 4:20,299,718...20,555,229
G
Sema4b
semaphorin 4B
decreases expression
ISO
senecionine results in decreased expression of SEMA4B protein
CTD
PMID:35357534
NCBI chr 1:134,136,646...134,177,777
Ensembl chr 1:134,149,536...134,177,775
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Serpina10
serpin family A member 10
decreases expression
ISO
senecionine results in decreased expression of SERPINA10 protein
CTD
PMID:35357534
NCBI chr 6:122,756,106...122,764,544
Ensembl chr 6:122,756,108...122,764,544
G
Serpina3n
serine (or cysteine) peptidase inhibitor, clade A, member 3N
decreases expression
ISO
senecionine results in decreased expression of SERPINA3N protein
CTD
PMID:35357534
NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433
G
Serpina7
serpin family A member 7
increases expression
ISO
senecionine results in increased expression of SERPINA7 protein
CTD
PMID:35357534
NCBI chr X:102,663,242...102,722,319
Ensembl chr X:102,663,405...102,669,040
G
Sft2d3
SFT2 domain containing 3
increases expression
ISO
senecionine results in increased expression of SFT2D3 protein
CTD
PMID:35357534
NCBI chr18:23,537,105...23,539,305
Ensembl chr18:23,537,105...23,539,305
G
Sgcb
sarcoglycan, beta
increases expression
EXP
senecionine results in increased expression of SGCB mRNA
CTD
PMID:32419051
NCBI chr14:34,563,614...34,578,614
Ensembl chr14:34,563,608...34,578,583
G
Sh3bp5
SH3-domain binding protein 5
decreases expression
ISO
senecionine results in decreased expression of SH3BP5 protein
CTD
PMID:35357534
NCBI chr16:6,583,462...6,678,344
Ensembl chr16:6,583,465...6,698,975
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Sh3pxd2a
SH3 and PX domains 2A
decreases expression
ISO
senecionine results in decreased expression of SH3PXD2A protein
CTD
PMID:35357534
NCBI chr 1:246,153,660...246,359,806
Ensembl chr 1:246,160,502...246,360,166
G
Slc10a1
solute carrier family 10 member 1
decreases expression
EXP ISO
senecionine results in decreased expression of SLC10A1 mRNA
CTD
PMID:24641316 PMID:31606820
NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
G
Slc16a12
solute carrier family 16, member 12
decreases expression
ISO
senecionine results in decreased expression of SLC16A12 protein
CTD
PMID:35357534
NCBI chr 1:232,184,004...232,262,170
Ensembl chr 1:232,185,907...232,262,141
G
Slc16a2
solute carrier family 16 member 2
increases expression
ISO
senecionine results in increased expression of SLC16A2 protein
CTD
PMID:35357534
NCBI chr X:68,725,365...68,848,572
Ensembl chr X:68,723,261...68,848,771
G
Slc22a1
solute carrier family 22 member 1
decreases expression
ISO
senecionine results in decreased expression of SLC22A1 mRNA
CTD
PMID:31606820
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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Slc22a25
solute carrier family 22, member 25
decreases expression
ISO
senecionine results in decreased expression of SLC22A9 mRNA
CTD
PMID:26100227
NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085
G
Slc22a7
solute carrier family 22 member 7
decreases expression
ISO
senecionine results in decreased expression of SLC22A7 mRNA
CTD
PMID:26100227 PMID:31606820
NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
G
Slc25a47
solute carrier family 25, member 47
increases expression
ISO
senecionine results in increased expression of SLC25A47 protein
CTD
PMID:35357534
NCBI chr 6:127,767,365...127,773,000
Ensembl chr 6:127,767,305...127,773,005
G
Slc2a3
solute carrier family 2 member 3
increases expression
ISO
senecionine results in increased expression of SLC2A3 protein
CTD
PMID:35357534
NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472
G
Slc30a10
solute carrier family 30, member 10
decreases expression
ISO
senecionine results in decreased expression of SLC30A10 protein
CTD
PMID:35357534
NCBI chr13:96,998,143...97,048,076
Ensembl chr13:96,998,143...97,009,103
G
Slc31a2
solute carrier family 31 member 2
decreases expression
ISO
senecionine results in decreased expression of SLC31A2 protein
CTD
PMID:35357534
NCBI chr 5:75,738,008...75,748,542
Ensembl chr 5:75,738,024...75,748,542
G
Slc38a4
solute carrier family 38, member 4
decreases expression
ISO
senecionine results in decreased expression of SLC38A4 protein
CTD
PMID:35357534
NCBI chr 7:128,142,866...128,203,000
Ensembl chr 7:128,144,807...128,202,995
G
Slc39a14
solute carrier family 39 member 14
decreases expression
ISO
senecionine results in decreased expression of SLC39A14 protein
CTD
PMID:35357534
NCBI chr15:45,376,806...45,423,549
Ensembl chr15:45,376,917...45,423,524
G
Slc3a1
solute carrier family 3 member 1
decreases expression
ISO
senecionine results in decreased expression of SLC3A1 protein
CTD
PMID:35357534
NCBI chr 6:9,608,169...9,641,881
Ensembl chr 6:9,608,178...9,641,907
G
Slc6a12
solute carrier family 6 member 12
decreases expression
ISO
senecionine results in decreased expression of SLC6A12 protein
CTD
PMID:35357534
NCBI chr 4:154,585,386...154,603,750
Ensembl chr 4:154,585,500...154,603,750
G
Slco1a4
solute carrier organic anion transporter family, member 1a4
decreases expression
EXP
senecionine results in decreased expression of SLCO1A2 mRNA
CTD
PMID:24641316
NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
G
Slco1b2
solute carrier organic anion transporter family member 1B2
decreases expression
EXP ISO
senecionine results in decreased expression of SLCO1B2 mRNA senecionine results in decreased expression of SLCO1B3 mRNA
CTD
PMID:24641316 PMID:26100227 PMID:31606820
NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
G
Smc2
structural maintenance of chromosomes 2
increases expression
EXP
senecionine results in increased expression of SMC2 mRNA
CTD
PMID:32419051
NCBI chr 5:66,806,882...66,853,478
Ensembl chr 5:66,807,011...66,853,242
G
Smc4
structural maintenance of chromosomes 4
increases expression
EXP
senecionine results in increased expression of SMC4 mRNA
CTD
PMID:32419051
NCBI chr 2:153,240,243...153,268,722
Ensembl chr 2:153,240,283...153,271,571
G
Smc6
structural maintenance of chromosomes 6
decreases expression
ISO
senecionine results in decreased expression of SMC6 protein
CTD
PMID:35357534
NCBI chr 6:33,978,730...34,033,201
Ensembl chr 6:33,978,716...34,031,746
G
Smoc1
SPARC related modular calcium binding 1
decreases expression
ISO
senecionine results in decreased expression of SMOC1 protein
CTD
PMID:35357534
NCBI chr 6:100,701,330...100,897,441
Ensembl chr 6:100,701,346...100,862,699
G
Smpx
small muscle protein, X-linked
decreases expression
EXP
senecionine results in decreased expression of SMPX mRNA
CTD
PMID:34185104
NCBI chr X:37,233,209...37,292,266
Ensembl chr X:37,234,294...37,276,708
G
Snd1
staphylococcal nuclease and tudor domain containing 1
decreases expression
ISO
senecionine results in decreased expression of SND1 protein
CTD
PMID:35357534
NCBI chr 4:57,095,205...57,494,501
Ensembl chr 4:57,095,208...57,530,843
G
Soat1
sterol O-acyltransferase 1
decreases expression
ISO
senecionine results in decreased expression of SOAT1 protein
CTD
PMID:35357534
NCBI chr13:68,552,274...68,597,529
Ensembl chr13:68,552,317...68,597,494
G
Sqle
squalene epoxidase
decreases expression
ISO
senecionine results in decreased expression of SQLE protein
CTD
PMID:35357534
NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
G
Srebf1
sterol regulatory element binding transcription factor 1
decreases expression
ISO
senecionine results in decreased expression of SREBF1 protein
CTD
PMID:35357534
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
G
Sri
sorcin
increases expression
ISO
senecionine results in increased expression of SRI protein
CTD
PMID:35357534
NCBI chr 4:25,973,493...25,997,879
Ensembl chr 4:25,966,750...25,998,077
G
Srl
sarcalumenin
decreases expression
EXP
senecionine results in decreased expression of SRL mRNA
CTD
PMID:34185104
NCBI chr10:11,033,976...11,078,103
Ensembl chr10:11,034,035...11,078,101
G
Stac3
SH3 and cysteine rich domain 3
decreases expression
EXP
senecionine results in decreased expression of STAC3 mRNA
CTD
PMID:32419051
NCBI chr 7:63,343,078...63,350,590
Ensembl chr 7:63,343,186...63,350,589
G
Stc1
stanniocalcin 1
increases expression
EXP
senecionine results in increased expression of STC1 mRNA
CTD
PMID:34185104
NCBI chr15:44,299,591...44,311,695
Ensembl chr15:44,299,621...44,310,264
G
Steap4
STEAP4 metalloreductase
increases expression decreases expression
EXP ISO
senecionine results in increased expression of STEAP4 mRNA senecionine results in decreased expression of STEAP4 protein
CTD
PMID:34185104 PMID:35357534
NCBI chr 4:26,077,182...26,099,859
Ensembl chr 4:26,054,671...26,099,859
G
Stil
STIL, centriolar assembly protein
increases expression
EXP
senecionine results in increased expression of STIL mRNA
CTD
PMID:32419051
NCBI chr 5:128,520,837...128,573,732
Ensembl chr 5:128,520,953...128,573,730
G
Stmn1
stathmin 1
increases expression
EXP
senecionine results in increased expression of STMN1 mRNA
CTD
PMID:32419051
NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154
G
Ston1
stonin 1
increases expression
ISO
senecionine results in increased expression of STON1 protein
CTD
PMID:35357534
NCBI chr 6:5,843,186...5,892,557
Ensembl chr 6:5,843,185...5,892,449
G
Suclg2
succinate-CoA ligase GDP-forming subunit beta
increases expression
ISO
senecionine results in increased expression of SUCLG2 protein
CTD
PMID:35357534
NCBI chr 4:128,067,031...128,337,146
Ensembl chr 4:128,067,033...128,337,170
G
Sult1e1
sulfotransferase family 1E member 1
decreases expression
ISO
senecionine results in decreased expression of SULT1E1 mRNA
CTD
PMID:26100227
NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
G
Sult2a1
sulfotransferase family 2A member 1
decreases expression
ISO
senecionine results in decreased expression of SULT2A1 mRNA
CTD
PMID:31606820
NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134
G
Surf2
surfeit 2
increases expression
ISO
senecionine results in increased expression of SURF2 protein
CTD
PMID:35357534
NCBI chr 3:10,244,654...10,248,502
Ensembl chr 3:10,244,654...10,250,077
G
Syf2
SYF2 pre-mRNA-splicing factor
decreases expression
ISO
senecionine results in decreased expression of SYF2 protein
CTD
PMID:35357534
NCBI chr 5:147,156,492...147,164,416
Ensembl chr 5:147,156,480...147,164,414
G
Tcf19
transcription factor 19
increases expression
EXP
senecionine results in increased expression of TCF19 mRNA
CTD
PMID:32419051
NCBI chr20:3,218,756...3,222,861
Ensembl chr20:3,218,693...3,223,271
G
Tdrd1
tudor domain containing 1
increases expression
ISO
senecionine results in increased expression of TDRD1 protein
CTD
PMID:35357534
NCBI chr 1:255,871,939...255,919,222
Ensembl chr 1:255,875,887...255,915,871
G
Tecpr1
tectonin beta-propeller repeat containing 1
increases expression
ISO
senecionine results in increased expression of TECPR1 protein
CTD
PMID:35357534
NCBI chr12:10,391,587...10,420,462
Ensembl chr12:10,391,696...10,419,611
G
Tenm1
teneurin transmembrane protein 1
decreases expression
ISO
senecionine results in decreased expression of TENM1 mRNA
CTD
PMID:26100227
NCBI chr X:121,400,466...122,289,877
Ensembl chr X:121,403,649...122,290,207
G
Tenm2
teneurin transmembrane protein 2
decreases expression
ISO
senecionine results in decreased expression of TENM2 mRNA
CTD
PMID:26100227
NCBI chr10:20,480,662...21,706,415
Ensembl chr10:20,481,854...21,705,597
G
Tgfb1
transforming growth factor, beta 1
increases expression
ISO
senecionine results in increased expression of TGFB1 mRNA; senecionine results in increased expression of TGFB1 protein
CTD
PMID:35357534
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
G
Thbs1
thrombospondin 1
increases expression multiple interactions
ISO
senecionine results in increased expression of THBS1 mRNA; senecionine results in increased expression of THBS1 protein Leu-Ser-Lys-Leu peptide inhibits the reaction [senecionine results in increased expression of THBS1 mRNA]; senecionine promotes the reaction [Pyrrolizidine Alkaloids binds to THBS1 protein]
CTD
PMID:35357534
NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
G
Tlr8
toll-like receptor 8
increases expression
EXP
senecionine results in increased expression of TLR8 mRNA
CTD
PMID:34185104
NCBI chr X:27,091,780...27,116,092
Ensembl chr X:27,091,778...27,116,549
G
Tma7
translation machinery associated 7 homolog
decreases expression
ISO
senecionine results in decreased expression of TMA7 protein
CTD
PMID:35357534
NCBI chr 8:109,726,213...109,730,902
Ensembl chr 8:109,726,196...109,735,474
G
Tmem144
transmembrane protein 144
increases expression
ISO
senecionine results in increased expression of TMEM144 protein
CTD
PMID:35357534
NCBI chr 2:164,960,649...164,993,562
Ensembl chr 2:164,961,247...164,992,368
G
Tmem176a
transmembrane protein 176A
decreases expression
ISO
senecionine results in decreased expression of TMEM176A protein
CTD
PMID:35357534
NCBI chr 4:77,774,940...77,778,620
Ensembl chr 4:77,774,843...77,778,620
G
Tmem176b
transmembrane protein 176B
decreases expression
ISO
senecionine results in decreased expression of TMEM176B protein
CTD
PMID:35357534
NCBI chr 4:77,766,928...77,774,740
Ensembl chr 4:77,766,928...77,774,384
G
Tmem208
transmembrane protein 208
decreases expression
ISO
senecionine results in decreased expression of TMEM208 protein
CTD
PMID:35357534
NCBI chr19:33,203,587...33,206,287
Ensembl chr19:33,203,587...33,212,183
G
Tmem35b
transmembrane protein 35B
increases expression
ISO
senecionine results in increased expression of TMEM35B protein
CTD
PMID:35357534
NCBI chr 5:139,446,317...139,449,947
Ensembl chr 5:139,444,399...139,449,947
G
Tmem87b
transmembrane protein 87B
decreases expression
ISO
senecionine results in decreased expression of TMEM87B protein
CTD
PMID:35357534
NCBI chr 3:116,061,933...116,097,421
Ensembl chr 3:116,062,204...116,097,367
G
Tnfrsf1b
TNF receptor superfamily member 1B
increases expression
EXP
senecionine results in increased expression of TNFRSF1B mRNA
CTD
PMID:34185104
NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
G
Tnip2
TNFAIP3 interacting protein 2
decreases expression
ISO
senecionine results in decreased expression of TNIP2 protein
CTD
PMID:35357534
NCBI chr14:76,228,350...76,245,553
Ensembl chr14:76,228,371...76,275,265
G
Tnnc1
troponin C1, slow skeletal and cardiac type
decreases expression
EXP
senecionine results in decreased expression of TNNC1 mRNA
CTD
PMID:34185104
NCBI chr16:6,400,801...6,405,634
Ensembl chr16:6,402,171...6,405,634
G
Top2a
DNA topoisomerase II alpha
increases expression
EXP
senecionine results in increased expression of TOP2A mRNA
CTD
PMID:32419051
NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874
G
Topors
TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
decreases expression
ISO
senecionine results in decreased expression of TOPORS protein
CTD
PMID:35357534
NCBI chr 5:55,388,033...55,399,937
Ensembl chr 5:55,387,632...55,399,937
G
Tox
thymocyte selection-associated high mobility group box
decreases expression
ISO
senecionine results in decreased expression of TOX protein
CTD
PMID:35357534
NCBI chr 5:19,874,994...20,171,272
Ensembl chr 5:19,874,467...20,171,272
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Tp53
tumor protein p53
increases expression
ISO
senecionine results in increased expression of TRP53 mRNA; senecionine results in increased expression of TRP53 protein senecionine results in increased expression of TP53 mRNA
CTD
PMID:35357534
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tpmt
thiopurine S-methyltransferase
increases expression
ISO
senecionine results in increased expression of TPMT mRNA
CTD
PMID:26100227
NCBI chr17:17,644,088...17,662,709
Ensembl chr17:17,644,173...17,662,709
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Tpx2
TPX2, microtubule nucleation factor
increases expression
EXP
senecionine results in increased expression of TPX2 mRNA
CTD
PMID:32419051
NCBI chr 3:141,318,428...141,360,684
Ensembl chr 3:141,318,455...141,360,468
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Treml1
triggering receptor expressed on myeloid cells-like 1
increases expression
ISO
senecionine results in increased expression of TREML1 protein
CTD
PMID:35357534
NCBI chr 9:12,635,584...12,642,324
Ensembl chr 9:12,635,590...12,642,347
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Tsr2
TSR2, ribosome maturation factor
decreases expression
ISO
senecionine results in decreased expression of TSR2 protein
CTD
PMID:35357534
NCBI chr X:20,064,102...20,072,673
Ensembl chr X:20,064,103...20,072,620
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Tstd3
thiosulfate sulfurtransferase like domain containing 3
increases expression
ISO
senecionine results in increased expression of TSTD3 protein
CTD
PMID:35357534
NCBI chr 5:35,294,652...35,304,093
Ensembl chr 5:35,294,645...35,304,101
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Ttk
Ttk protein kinase
increases expression
EXP
senecionine results in increased expression of TTK mRNA
CTD
PMID:32419051
NCBI chr 8:84,754,329...84,792,653
Ensembl chr 8:84,754,315...84,792,651
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Ttr
transthyretin
decreases expression
ISO
senecionine results in decreased expression of TTR protein
CTD
PMID:35357534
NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
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Tuft1
tuftelin 1
increases expression
ISO
senecionine results in increased expression of TUFT1 protein
CTD
PMID:35357534
NCBI chr 2:182,259,457...182,306,296
Ensembl chr 2:182,260,398...182,306,192
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Tyms
thymidylate synthetase
increases expression
EXP
senecionine results in increased expression of TYMS mRNA
CTD
PMID:32419051
NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
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Ubl3
ubiquitin-like 3
decreases expression
ISO
senecionine results in decreased expression of UBL3 protein
CTD
PMID:35357534
NCBI chr12:6,473,684...6,518,331
Ensembl chr12:6,473,460...6,518,862
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Uchl3
ubiquitin C-terminal hydrolase L3
increases expression
ISO
senecionine results in increased expression of UCHL3 mRNA
CTD
PMID:26100227
NCBI chr15:78,485,304...78,527,355
Ensembl chr15:78,485,315...78,527,355 Ensembl chr 3:78,485,315...78,527,355
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Uckl1
uridine-cytidine kinase 1-like 1
increases expression
ISO
senecionine results in increased expression of UCKL1 protein
CTD
PMID:35357534
NCBI chr 3:168,674,849...168,687,513
Ensembl chr 3:168,674,849...168,698,091
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Ugt1a5
UDP glucuronosyltransferase family 1 member A5
increases glycosylation multiple interactions
ISO
UGT1A4 protein results in increased glycosylation of senecionine [hecogenin results in decreased activity of UGT1A4 protein] which results in decreased glycosylation of senecionine
CTD
PMID:20092275
NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt2a3
UDP glucuronosyltransferase family 2 member A3
decreases expression
ISO
senecionine results in decreased expression of UGT2A3 mRNA
CTD
PMID:26100227
NCBI chr14:20,572,793...20,590,795
Ensembl chr14:20,572,808...20,590,729
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Ugt2b1
UDP glucuronosyltransferase 2 family, polypeptide B1
decreases expression
ISO
senecionine results in decreased expression of UGT2B1 mRNA
CTD
PMID:31606820
NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
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Utp11
UTP11, small subunit processome component
decreases expression
ISO
senecionine results in decreased expression of UTP11 protein
CTD
PMID:35357534
NCBI chr 5:136,931,279...136,946,164
Ensembl chr 5:136,931,008...136,946,191
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Vps13b
vacuolar protein sorting 13 homolog B
decreases expression
ISO
senecionine results in decreased expression of VPS13B mRNA
CTD
PMID:26100227
NCBI chr 7:66,557,862...67,128,429
Ensembl chr 7:66,558,471...67,128,429
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Vps36
vacuolar protein sorting 36 homolog
increases expression
ISO
senecionine results in increased expression of VPS36 protein
CTD
PMID:35357534
NCBI chr16:69,810,404...69,834,789
Ensembl chr16:69,808,193...69,834,810
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Wdr53
WD repeat domain 53
decreases expression
ISO
senecionine results in decreased expression of WDR53 protein
CTD
PMID:35357534
NCBI chr11:68,542,647...68,551,148
Ensembl chr11:68,542,650...68,551,112
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Wdr82
WD repeat domain 82
decreases expression
ISO
senecionine results in decreased expression of WDR82 protein
CTD
PMID:35357534
NCBI chr 8:106,814,569...106,834,535
Ensembl chr 8:106,814,569...106,834,438
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Xpa
XPA, DNA damage recognition and repair factor
increases expression
ISO
senecionine results in increased expression of XPA protein
CTD
PMID:35357534
NCBI chr 5:60,431,673...60,475,726
Ensembl chr 5:60,431,673...60,475,726
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Xylt2
xylosyltransferase 2
decreases expression
ISO
senecionine results in decreased expression of XYLT2 protein
CTD
PMID:35357534
NCBI chr10:79,605,910...79,619,482
Ensembl chr10:79,606,007...79,619,391
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Yipf5
Yip1 domain family, member 5
decreases expression
ISO
senecionine results in decreased expression of YIPF5 protein
CTD
PMID:35357534
NCBI chr18:32,123,814...32,136,947
Ensembl chr18:32,123,842...32,157,642
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Zcchc10
zinc finger CCHC-type containing 10
increases expression
ISO
senecionine results in increased expression of ZCCHC10 protein
CTD
PMID:35357534
NCBI chr10:37,470,628...37,481,027
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Zfp106
zinc finger protein 106
increases expression
ISO
senecionine results in increased expression of ZNF106 protein
CTD
PMID:35357534
NCBI chr 3:107,459,232...107,510,507
Ensembl chr 3:107,462,096...107,510,481
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Zfp367
zinc finger protein 367
increases expression
EXP
senecionine results in increased expression of ZFP367 mRNA
CTD
PMID:32419051
NCBI chr17:965,161...984,290
Ensembl chr17:965,161...984,287
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Zfp36l1
zinc finger protein 36, C3H type-like 1
increases expression
ISO
senecionine results in increased expression of ZFP36L1 protein
CTD
PMID:35357534
NCBI chr 6:98,930,705...98,935,748
Ensembl chr 6:98,930,718...98,935,748
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Zg16
zymogen granule protein 16
decreases expression
ISO
senecionine results in decreased expression of ZG16 protein
CTD
PMID:35357534
NCBI chr 1:181,657,722...181,660,079
Ensembl chr 1:181,657,722...181,660,079
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Zwilch
zwilch kinetochore protein
increases expression
EXP
senecionine results in increased expression of ZWILCH mRNA
CTD
PMID:32419051
NCBI chr 8:64,638,401...64,670,911
Ensembl chr 8:64,637,672...64,675,916
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