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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-alpha-tocopherol | affects activity | ISO | RGD:737269 | 6480464 | alpha-Tocopherol affects the activity of HP protein polymorphism | CTD | PMID:19769483 | (+)-alpha-tocopherol | multiple interactions | ISO | RGD:10728 | 6480464 | Ascorbic Acid inhibits the reaction [alpha-Tocopherol affects the activity of HP protein polymorphism] | CTD | PMID:19769483 | 1,1-dichloroethene | increases expression | EXP | | 6480464 | vinylidene chloride results in increased expression of HP protein | CTD | PMID:14565772 | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of HP mRNA | CTD | PMID:16940010 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:10728 | 6480464 | [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of HP mRNA]; more ... | CTD | PMID:16054899 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of HP protein | CTD | PMID:15822908 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:10728 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of HP mRNA | CTD | PMID:16114106 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:10728 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of HP mRNA | CTD | PMID:16054899 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:10728 | 6480464 | Tetrachlorodibenzodioxin affects the expression of HP mRNA | CTD | PMID:18343893 | 3',5'-cyclic AMP | multiple interactions | ISO | RGD:10728 | 6480464 | Cyclic AMP inhibits the reaction [IL1B protein results in increased expression of HP mRNA] | CTD | PMID:22117073 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | RGD:10728 | 6480464 | [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of HP mRNA; more ... | CTD | PMID:16054899 | aflatoxin B1 | decreases expression | ISO | RGD:737269 | 6480464 | Aflatoxin B1 results in decreased expression of HP mRNA | CTD | PMID:21641981 | alclofenac | decreases expression | ISO | RGD:737269 | 6480464 | alclofenac results in decreased expression of HP protein | CTD | PMID:241598 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of HP mRNA | CTD | PMID:16483693 | andrographolide | multiple interactions | ISO | RGD:10728 | 6480464 | [andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of HP mRNA | CTD | PMID:19737545 | azathioprine | multiple interactions | EXP | | 6480464 | [Carbon Tetrachloride co-treated with Azathioprine] results in increased expression of HP protein | CTD | PMID:8614026 | benzene | increases expression | ISO | RGD:10728 | 6480464 | Benzene results in increased expression of HP mRNA | CTD | PMID:15122651 PMID:15120971 | benzene | increases expression | ISO | RGD:10728 | 6480464 | Benzene results in increased expression of HP mRNA | CTD | PMID:15120971 PMID:15122651 | benzo[a]pyrene | decreases expression | ISO | RGD:737269 | 6480464 | Benzo(a)pyrene results in decreased expression of HP mRNA | CTD | PMID:19737606 | bis(2-ethylhexyl) phthalate | increases expression | ISO | RGD:10728 | 6480464 | Diethylhexyl Phthalate results in increased expression of HP mRNA | CTD | PMID:19850644 | bis(2-ethylhexyl) phthalate | multiple interactions | ISO | RGD:10728 | 6480464 | PPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of HP mRNA] | CTD | PMID:19850644 | bisphenol A | increases expression | ISO | RGD:737269 | 6480464 | bisphenol A results in increased expression of HP mRNA | CTD | PMID:17989879 | calciol | increases expression | ISO | RGD:10728 | 6480464 | Cholecalciferol results in increased expression of HP mRNA | CTD | PMID:16508948 | clofibrate | decreases expression | EXP | | 6480464 | Clofibrate results in decreased expression of HP mRNA | CTD | PMID:12851107 | copper(2+) sulfate | decreases expression | ISO | RGD:737269 | 6480464 | Copper Sulfate results in decreased expression of HP mRNA | CTD | PMID:19549813 | cyclosporin A | affects expression | ISO | RGD:737269 | 6480464 | Cyclosporine affects the expression of HP mRNA | CTD | PMID:20106945 | cyclosporin A | increases expression | ISO | RGD:737269 | 6480464 | Cyclosporine results in increased expression of HP mRNA | CTD | PMID:21632981 | D-penicillamine | decreases expression | ISO | RGD:737269 | 6480464 | Penicillamine results in decreased expression of HP protein | CTD | PMID:241598 | Delta(9)-tetrahydrocannabinol | increases expression | ISO | RGD:10728 | 6480464 | Tetrahydrocannabinol results in increased expression of HP mRNA | CTD | PMID:21542829 | dexamethasone | multiple interactions | ISO | RGD:10728 | 6480464 | [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of HP mRNA; more ... | CTD | PMID:16054899 | dexamethasone | increases expression | ISO | RGD:737269 | 6480464 | Dexamethasone results in increased expression of HP mRNA | CTD | PMID:19853017 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of HP mRNA | CTD | PMID:21525395 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of HP mRNA | CTD | PMID:19299419 PMID:21525395 | hexachlorobenzene | increases expression | EXP | | 6480464 | Hexachlorobenzene results in increased expression of HP mRNA | CTD | PMID:15159207 | hydrogen peroxide | multiple interactions | ISO | RGD:737269 | 6480464 | [HP gene polymorphism co-treated with GSTM1 gene polymorphism] affects the susceptibility to Hydrogen Peroxide; more ... | CTD | PMID:20444272 | L-ascorbic acid | affects activity | ISO | RGD:737269 | 6480464 | Ascorbic Acid affects the activity of HP protein polymorphism | CTD | PMID:19769483 | L-ascorbic acid | affects response to substance | ISO | RGD:737269 | 6480464 | HP gene polymorphism affects the susceptibility to Ascorbic Acid deficiency | CTD | PMID:20926521 | L-ascorbic acid | multiple interactions | ISO | RGD:10728 | 6480464 | Ascorbic Acid inhibits the reaction [alpha-Tocopherol affects the activity of HP protein polymorphism] | CTD | PMID:19769483 | menadione | affects expression | ISO | RGD:737269 | 6480464 | Vitamin K 3 affects the expression of HP mRNA | CTD | PMID:20044591 | methimazole | increases expression | ISO | RGD:737269 | 6480464 | Methimazole results in increased expression of HP mRNA | CTD | PMID:20144635 | morphine | decreases expression | EXP | | 6480464 | Morphine results in decreased expression of HP protein | CTD | PMID:23056601 | N-nitrosodimethylamine | decreases expression | EXP | | 6480464 | Dimethylnitrosamine results in decreased expression of HP protein | CTD | PMID:17719030 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of HP protein | CTD | PMID:16687475 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of HP mRNA; more ... | CTD | PMID:15800402 | paracetamol | affects expression | ISO | RGD:10728 | 6480464 | Acetaminophen affects the expression of HP mRNA | CTD | PMID:17562736 | perfluorooctane-1-sulfonic acid | decreases expression | EXP | | 6480464 | perfluorooctane sulfonic acid results in decreased expression of HP mRNA | CTD | PMID:18692542 | pirinixic acid | multiple interactions | ISO | RGD:10728 | 6480464 | [pirinixic acid co-treated with PPARA] results in decreased expression of HP mRNA | CTD | PMID:20813756 | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of HP mRNA | CTD | PMID:16940010 | pirinixic acid | decreases expression | ISO | RGD:10728 | 6480464 | pirinixic acid results in decreased expression of HP mRNA | CTD | PMID:20813756 | profenofos | increases expression | EXP | | 6480464 | profenofos results in increased expression of HP mRNA | CTD | PMID:17569032 | progesterone | affects expression | ISO | RGD:10728 | 6480464 | Progesterone affects the expression of HP mRNA | CTD | PMID:17251523 | quartz | increases expression | EXP | | 6480464 | Quartz results in increased expression of HP mRNA | CTD | PMID:19836432 | quercetin | decreases expression | ISO | RGD:737269 | 6480464 | Quercetin results in decreased expression of HP mRNA | CTD | PMID:21632981 | rosiglitazone | multiple interactions | ISO | RGD:10728 | 6480464 | [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of HP mRNA; more ... | CTD | PMID:16054899 | tetrachloromethane | affects expression | ISO | RGD:10728 | 6480464 | Carbon Tetrachloride affects the expression of HP mRNA | CTD | PMID:17484886 | tetrachloromethane | multiple interactions | EXP | | 6480464 | [Carbon Tetrachloride co-treated with Azathioprine] results in increased expression of HP protein | CTD | PMID:8614026 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsDisease AnnotationsGene-Chemical Interaction Annotations
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Gene Ontology Annotations
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References - uncuratedRGD Disease Portals| Hp has been annotated in the following RGD Disease Portals. |
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Candidate Gene StatusComparative Map Data| Hp (Rattus norvegicus) |
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| HP (Homo sapiens) |
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| Hp (Mus musculus) |
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Position Markers| D19Mgh5 |
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| D19Arb2 |
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| D19Wox9 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_012582 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06098651 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01098339 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF476963 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY325231 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC089816 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473972 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ209575 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ209592 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ209684 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ211144 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ219122 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ219413 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ219443 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ219547 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ219598 | (Get FASTA) | Search GEO for Microarray Profiles | |
| K01933 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M34230 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M34231 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M34232 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_012582 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_036714 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_036714 | (Get FASTA) |
| GenBank Protein | AAA41348 | (Get FASTA) |
| AAA41349 | (Get FASTA) | |
| AAH89816 | (Get FASTA) | |
| AAP92632 | (Get FASTA) | |
| EDL92502 | (Get FASTA) | |
| EDL92503 | (Get FASTA) | |
| P06866 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000014964 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000020196 | ENTREZGENE, UniProtKB/Swiss-Prot |
| ENSRNOP00000049003 | UniProtKB/Swiss-Prot | |
| Ensembl Transcript | ENSRNOT00000020197 | ENTREZGENE, UniProtKB/Swiss-Prot |
| ENSRNOT00000050989 | UniProtKB/Swiss-Prot | |
| Entrez Gene | 24464 | ENTREZGENE |
| Germonline | ENSRNOG00000014964 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 121756 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7321960 | IMAGE-MGC_LOAD |
| InterPro | Haptoglobin | UniProtKB/Swiss-Prot |
| Peptidase_S1_S6 | UniProtKB/Swiss-Prot | |
| Peptidase_S1A | UniProtKB/Swiss-Prot | |
| Ser/Cys_Pept_Trypsin-like | UniProtKB/Swiss-Prot | |
| Sushi_SCR_CCP | UniProtKB/Swiss-Prot | |
| IPI | IPI00382202 | UniProtKB/Swiss-Prot |
| IPI00565708 | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:24464 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGC_CLONE | MGC:108751 | IMAGE-MGC_LOAD |
| Pfam | Trypsin | UniProtKB/Swiss-Prot |
| PIRSF | Haptoglobin | UniProtKB/Swiss-Prot |
| PRINTS | CHYMOTRYPSIN | UniProtKB/Swiss-Prot |
| PROSITE | SUSHI | UniProtKB/Swiss-Prot |
| TRYPSIN_DOM | UniProtKB/Swiss-Prot | |
| SMART | CCP | UniProtKB/Swiss-Prot |
| Tryp_SPc | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Complement_control_module | UniProtKB/Swiss-Prot |
| Pept_Ser_Cys | UniProtKB/Swiss-Prot | |
| TIGR | TC210914 | |
| UniGene | Rn.10950 | ENTREZGENE |
| UniProt | HPT_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2002-06-10 | Hp | Haptoglobin | Symbol and Name status set to approved | 1490 | APPROVED |
| More on Hp | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2825 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.