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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,4,6-trinitrobenzenesulfonic acid | increases expression | ISO | RGD:10330 | 6480464 | Trinitrobenzenesulfonic Acid results in increased expression of CEL mRNA | CTD | PMID:17982090 | 2-ethoxyethanol | increases expression | EXP | | 6480464 | 2-ethoxyethanol results in increased expression of CEL mRNA | CTD | PMID:19643169 | 2-methoxyethanol | increases expression | EXP | | 6480464 | methyl cellosolve results in increased expression of CEL mRNA | CTD | PMID:19643169 | actinomycin D | increases expression | ISO | RGD:737498 | 6480464 | Dactinomycin results in increased expression of CEL mRNA | CTD | PMID:21527772 | aflatoxin B1 | increases expression | ISO | RGD:737498 | 6480464 | Aflatoxin B1 results in increased expression of CEL protein | CTD | PMID:21527772 | aflatoxin B1 | increases expression | ISO | RGD:737498 | 6480464 | Aflatoxin B1 results in increased expression of CEL mRNA | CTD | PMID:21632981 PMID:22100608 | aflatoxin B1 | affects expression | ISO | RGD:737498 | 6480464 | Aflatoxin B1 affects the expression of CEL protein | CTD | PMID:20106945 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of CEL mRNA | CTD | PMID:16483693 | arsenic atom | affects expression | ISO | RGD:737498 | 6480464 | Arsenic affects the expression of CEL mRNA | CTD | PMID:18414638 | benzo[a]pyrene | increases expression | ISO | RGD:737498 | 6480464 | Benzo(a)pyrene results in increased expression of CEL mRNA | CTD | PMID:20106945 | benzo[a]pyrene | increases expression | ISO | RGD:737498 | 6480464 | Benzo(a)pyrene results in increased expression of CEL mRNA | CTD | PMID:20106945 PMID:21632981 | calcitriol | decreases expression | ISO | RGD:737498 | 6480464 | Calcitriol results in decreased expression of CEL mRNA | CTD | PMID:21592394 | calcitriol | multiple interactions | ISO | RGD:737498 | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of CEL mRNA | CTD | PMID:21592394 | cyclophosphamide | increases expression | ISO | RGD:737498 | 6480464 | Cyclophosphamide results in increased expression of CEL mRNA | CTD | PMID:21527772 | elemental selenium | increases expression | ISO | RGD:737498 | 6480464 | Selenium results in increased expression of CEL mRNA | CTD | PMID:19244175 | etoposide | increases expression | ISO | RGD:737498 | 6480464 | Etoposide results in increased expression of CEL mRNA | CTD | PMID:21527772 | ferroheme b | decreases expression | EXP | | 6480464 | Heme results in decreased expression of CEL mRNA | CTD | PMID:15539406 | ferroheme b | multiple interactions | EXP | | 6480464 | [Heme co-treated with Calcium, Dietary] results in decreased expression of CEL mRNA | CTD | PMID:15539406 | hydralazine | multiple interactions | ISO | RGD:737498 | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of CEL mRNA | CTD | PMID:17183730 | iron atom | increases expression | EXP | | 6480464 | Iron deficiency results in increased expression of CEL mRNA | CTD | PMID:19821111 | isotretinoin | increases expression | ISO | RGD:737498 | 6480464 | Isotretinoin results in increased expression of CEL mRNA | CTD | PMID:18769122 | lead diacetate | increases expression | ISO | RGD:10330 | 6480464 | lead acetate results in increased expression of CEL mRNA | CTD | PMID:20542052 | methyl methanesulfonate | increases expression | ISO | RGD:737498 | 6480464 | Methyl Methanesulfonate results in increased expression of CEL mRNA | CTD | PMID:21527772 | N-methyl-N-nitrosurea | increases expression | ISO | RGD:10330 | 6480464 | Methylnitrosourea results in increased expression of CEL mRNA | CTD | PMID:15240709 | paracetamol | increases expression | ISO | RGD:737498 | 6480464 | Acetaminophen results in increased expression of CEL mRNA | CTD | PMID:22230336 | pirinixic acid | increases expression | ISO | RGD:10330 | 6480464 | pirinixic acid results in increased expression of CEL mRNA | CTD | PMID:17426115 | quercetin | increases expression | ISO | RGD:737498 | 6480464 | Quercetin results in increased expression of CEL mRNA | CTD | PMID:21632981 | resveratrol | decreases expression | EXP | | 6480464 | resveratrol results in decreased expression of CEL mRNA | CTD | PMID:16099206 | resveratrol | decreases activity | ISO | RGD:737498 | 6480464 | resveratrol results in decreased activity of CEL protein | CTD | PMID:16099206 | resveratrol | multiple interactions | EXP | | 6480464 | resveratrol results in decreased expression of and results in decreased secretion of and results in decreased activity of CEL protein | CTD | PMID:16099206 | selenium atom | increases expression | ISO | RGD:737498 | 6480464 | Selenium results in increased expression of CEL mRNA | CTD | PMID:19244175 | taurocholic acid | multiple interactions | ISO | RGD:737498 | 6480464 | Taurocholic Acid inhibits the reaction [Polyphenols results in decreased activity of CEL protein] | CTD | PMID:16099206 | testosterone | multiple interactions | ISO | RGD:737498 | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of CEL mRNA | CTD | PMID:21592394 | testosterone | decreases expression | ISO | RGD:737498 | 6480464 | Testosterone results in decreased expression of CEL mRNA | CTD | PMID:21592394 | trans-resveratrol | decreases expression | EXP | | 6480464 | resveratrol results in decreased expression of CEL mRNA | CTD | PMID:16099206 | trans-resveratrol | decreases activity | ISO | RGD:737498 | 6480464 | resveratrol results in decreased activity of CEL protein | CTD | PMID:16099206 | trans-resveratrol | multiple interactions | EXP | | 6480464 | resveratrol results in decreased expression of and results in decreased secretion of and results in decreased activity of CEL protein | CTD | PMID:16099206 | valproic acid | multiple interactions | ISO | RGD:737498 | 6480464 | [Hydralazine co-treated with Valproic Acid] results in increased expression of CEL mRNA | CTD | PMID:17183730 | zinc atom | decreases expression | EXP | | 6480464 | Zinc deficiency results in decreased expression of CEL mRNA | CTD | PMID:15671213 | zinc(0) | decreases expression | EXP | | 6480464 | Zinc deficiency results in decreased expression of CEL mRNA | CTD | PMID:15671213 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Fat digestion and absorption |
| Glycerolipid metabolism | |
| Metabolic pathways | |
| Pancreatic secretion | |
| Steroid biosynthesis | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Fat digestion and absorption |
| Glycerolipid metabolism | |
| Metabolic pathways | |
| Pancreatic secretion | |
| Steroid biosynthesis | |
References - curated| 1. |
Aubert-Jousset E, etal., Structure. 2004 Aug;12(8):1437-47. |
| 2. |
Bruneau N, etal., J Cell Sci. 1998 Sep;111 ( Pt 17):2665-79. |
| 3. |
Caillol N, etal., Clin Sci (Lond). 1998 Feb;94(2):181-8. |
| 4. |
DiPersio LP, etal., J Biol Chem 1991 Mar 5;266(7):4033-6. |
| 5. |
Duan RD and Sternby B, Scand J Gastroenterol. 1993 Mar;28(3):256-60. |
| 6. |
GOA data from the GO Consortium |
| 7. |
Han JH, etal., Biochemistry 1987 Mar 24;26(6):1617-25. |
| 8. |
Harrison EH, etal., Biochim Biophys Acta. 1997 Aug 16;1347(2-3):177-82. |
| 9. |
KEGG |
| 10. |
Kissel JA, etal., Biochim Biophys Acta 1989 Nov 28;1006(2):227-36. |
| 11. |
Le Petit-Thevenin J, etal., Biochim Biophys Acta. 2001 Feb 26;1530(2-3):184-98. |
| 12. |
Liang Y, etal., J Biol Chem. 2000 Aug 4;275(31):24040-6. |
| 13. |
MGD data from the GO Consortium |
| 14. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 15. |
Panicot L, etal., Diabetes. 1999 Dec;48(12):2316-23. |
| 16. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 17. |
Raeder H, etal., Diabetes. 2007 Feb;56(2):444-9. |
| 18. |
Raeder H, etal., Nat Genet. 2006 Jan;38(1):54-62. Epub 2005 Dec 20. |
| 19. |
RGD automated data pipeline |
| 20. |
RGD automated import pipeline for gene-chemical interactions |
| 21. |
RGD Automated Pipelines |
| 22. |
RGD comprehensive gene curation |
References - uncuratedRGD Disease Portals| Cel has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Cel (Rattus norvegicus) |
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| CEL (Homo sapiens) |
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| Cel (Mus musculus) |
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Position Markers| D3Wox12 |
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| D3Arb3 |
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| RH132776 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_016997 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06022086 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06022087 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01020588 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01020589 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01020590 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474001 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M15893 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M69157 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X16054 | (Get FASTA) | Search GEO for Microarray Profiles | |
| Z22803 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_016997 | ||||||||||||||||||||
| RefSeq Status: | VALIDATED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_058693 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_058693 | (Get FASTA) |
| GenBank Protein | AAA41540 | (Get FASTA) |
| AAB46376 | (Get FASTA) | |
| CAA34189 | (Get FASTA) | |
| CAA80460 | (Get FASTA) | |
| EDL93407 | (Get FASTA) | |
| EDL93408 | (Get FASTA) | |
| P07882 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000010406 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000014572 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000014572 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 24254 | ENTREZGENE |
| Germonline | ENSRNOG00000010406 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 37529 | ENTREZGENE |
| InterPro | CarbesteraseB | UniProtKB/Swiss-Prot |
| Carboxylesterase_B_AS | UniProtKB/Swiss-Prot | |
| Carboxylesterase_B_CS | UniProtKB/Swiss-Prot | |
| IPI | IPI00211548 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:24254 | ENTREZGENE, UniProtKB/TrEMBL |
| Pfam | COesterase | UniProtKB/Swiss-Prot |
| PROSITE | CARBOXYLESTERASE_B_1 | UniProtKB/Swiss-Prot |
| CARBOXYLESTERASE_B_2 | UniProtKB/Swiss-Prot | |
| UniGene | Rn.91234 | ENTREZGENE |
| UniProt | CEL_RAT | UniProtKB/Swiss-Prot |
| G3V7G2_RAT | UniProtKB/TrEMBL | |
| Q64571_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2002-06-10 | Cel | Carboxyl ester lipase | Symbol and Name status set to approved | 1490 | APPROVED |
| More on Cel | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 2331 |
| Created: | 2000-05-25 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.