Ccng1 (cyclin G1) - Rat Genome Database

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Gene: Ccng1 (cyclin G1) Rattus norvegicus
Analyze
Symbol: Ccng1
Name: cyclin G1
RGD ID: 2295
Description: Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Involved in several processes, including mitotic G2 DNA damage checkpoint signaling; response to gravity; and syncytium formation by cell-cell fusion. Located in dendrite; neuronal cell body; and perinuclear region of cytoplasm. Used to study hepatocellular carcinoma. Biomarker of breast cancer; hepatocellular carcinoma; muscular atrophy; and traumatic brain injury. Human ortholog(s) of this gene implicated in endocrine gland cancer (multiple); ovarian cancer (multiple); and sarcoma (multiple). Orthologous to human CCNG1 (cyclin G1); PARTICIPATES IN p53 signaling pathway; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ccng; CYCG; cyclin-G; cyclin-G1; MGC93642
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81025,678,503 - 25,684,876 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1025,677,885 - 25,683,766 (-)EnsemblGRCr8
mRatBN7.21025,176,231 - 25,182,604 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1025,176,234 - 25,181,641 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1029,938,596 - 29,945,089 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01029,427,123 - 29,433,616 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01024,913,784 - 24,920,277 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1028,602,345 - 28,608,838 (-)NCBI
Lyon_Normotensive1029,257,126 - 29,263,619 (-)NCBI
Lyon_Hypertensive1030,952,481 - 30,958,974 (-)NCBI
F344_StmMcwi1030,931,426 - 30,937,919 (-)NCBI
Rnor_6.01025,903,925 - 25,910,298 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1025,903,911 - 25,910,325 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01025,754,109 - 25,760,482 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41025,776,380 - 25,782,754 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1024,735,527 - 24,741,900 (-)NCBICelera
RGSC_v3.11025,777,429 - 25,783,775 (-)NCBI
RH 3.4 Map10255.21RGD
Cytogenetic Map10q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(+/-)-Aegeline  (ISO)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(RS)-coclaurine  (ISO)
(RS)-norcoclaurine  (ISO)
(S)-coclaurine  (ISO)
(S)-naringenin  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,4-dioxane  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropropane  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-diaminotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-nitro-p-phenylenediamine  (EXP)
2-nitrofluorene  (EXP)
2-nitropropane  (EXP)
2-nitrotoluene  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-acetylaminofluorene  (EXP)
4-hydroxynon-2-enal  (ISO)
4-nitro-1,2-phenylenediamine  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acetamiprid  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
aniline  (ISO)
anthracen-2-amine  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
azoxystrobin  (ISO)
bacitracin  (EXP)
benzene  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bleomycin A2  (ISO)
Bufotalin  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
calycosin  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
CGP 52608  (ISO)
chloroform  (EXP)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cylindrospermopsin  (ISO)
cytarabine  (EXP)
D-glucose  (ISO)
deguelin  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (EXP)
diazinon  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
diclofenac  (EXP)
dicrotophos  (ISO)
dicyclanil  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
doxorubicin  (EXP,ISO)
ellagic acid  (EXP)
enniatin  (EXP)
estrogen  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
fenamidone  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
fructose  (ISO)
furan  (EXP,ISO)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (EXP)
graphite  (EXP)
GSK-J4  (ISO)
Heliotrine  (EXP)
hydroxyurea  (ISO)
ionomycin  (ISO)
ketoconazole  (EXP)
kojic acid  (EXP,ISO)
L-ascorbic acid  (EXP,ISO)
Lasiocarpine  (EXP)
lead nitrate  (ISO)
limonene  (EXP)
lipopolysaccharide  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
menadione  (ISO)
metformin  (EXP,ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury(1+)  (EXP)
miconazole  (ISO)
microcystin-LR  (ISO)
mitomycin C  (ISO)
monocrotaline  (ISO)
monosodium L-glutamate  (ISO)
N-ethyl-N-nitrosourea  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nickel dichloride  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
oleanolic acid  (ISO)
ortho-Aminoazotoluene  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorobutyric acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pifithrin-alpha hydrobromide  (EXP)
piperonyl butoxide  (EXP,ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
pyrimidifen  (ISO)
pyrrolidine dithiocarbamate  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rimonabant  (ISO)
rotenone  (ISO)
seliciclib  (EXP)
senecionine  (EXP)
Senkirkine  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulfasalazine  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (EXP)
yohimbine  (ISO)
zinc dichloride  (ISO)
zinc pyrithione  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Increased expression of cyclin G1 in leiomyoma compared with normal myometrium. Baek WK, etal., Am J Obstet Gynecol. 2003 Mar;188(3):634-9.
2. Phase I/II and phase II studies of targeted gene delivery in vivo: intravenous Rexin-G for chemotherapy-resistant sarcoma and osteosarcoma. Chawla SP, etal., Mol Ther. 2009 Sep;17(9):1651-7. doi: 10.1038/mt.2009.126. Epub 2009 Jun 16.
3. Retroviral vector-mediated transfer of an antisense cyclin G1 construct inhibits osteosarcoma tumor growth in nude mice. Chen DS, etal., Hum Gene Ther. 1997 Sep 20;8(14):1667-74. doi: 10.1089/hum.1997.8.14-1667.
4. The relationship between Cyclin G1 and survival in patients treated surgically for HCC. Cui X, etal., Hepatogastroenterology. 2013 Jan-Feb;60(121):153-9. doi: 10.5754/hge12549.
5. Differential gene expression in mouse mammary adenocarcinomas in the presence and absence of wild type p53. Cui XS and Donehower LA, Oncogene. 2000 Dec 7;19(52):5988-96.
6. Structure and chromosomal assignment of the human cyclin G gene. Endo Y, etal., Genomics 1996 Nov 15;38(1):92-5.
7. MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells. Fornari F, etal., Cancer Res. 2009 Jul 15;69(14):5761-7. doi: 10.1158/0008-5472.CAN-08-4797. Epub 2009 Jul 7.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Suppression of p53 by Notch3 is mediated by Cyclin G1 and sustained by MDM2 and miR-221 axis in hepatocellular carcinoma. Giovannini C, etal., Oncotarget. 2014 Nov 15;5(21):10607-20. doi: 10.18632/oncotarget.2523.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Inhibition of metastatic tumor growth in nude mice by portal vein infusions of matrix-targeted retroviral vectors bearing a cytocidal cyclin G1 construct. Gordon EM, etal., Cancer Res. 2000 Jul 1;60(13):3343-7.
12. Systemic administration of a matrix-targeted retroviral vector is efficacious for cancer gene therapy in mice. Gordon EM, etal., Hum Gene Ther. 2001 Jan 20;12(2):193-204. doi: 10.1089/104303401750061258.
13. MicroRNA-488 inhibits ovarian cancer cell metastasis through regulating CCNG1 and p53 expression. Guo JY, etal., Eur Rev Med Pharmacol Sci. 2020 Mar;24(6):2902-2910. doi: 10.26355/eurrev_202003_20654.
14. Current concepts in pathophysiology and management of hepatocellular carcinoma. Hamza AH, etal., Acta Biochim Pol. 2015;62(3):573-80. doi: 10.18388/abp.2015_1030. Epub 2015 Sep 8.
15. Roscovitine reduces neuronal loss, glial activation, and neurologic deficits after brain trauma. Hilton GD, etal., J Cereb Blood Flow Metab. 2008 Nov;28(11):1845-59. doi: 10.1038/jcbfm.2008.75. Epub 2008 Jul 9.
16. Changes in expression of cell cycle regulators after G1 progression upon repetitive thioacetamide treatment in rat liver. Hong SH, etal., Exp Mol Med. 2002 Nov 30;34(5):361-6.
17. Alcohol facilitates HCV RNA replication via up-regulation of miR-122 expression and inhibition of cyclin G1 in human hepatoma cells. Hou W, etal., Alcohol Clin Exp Res. 2013 Apr;37(4):599-608. doi: 10.1111/acer.12005. Epub 2012 Nov 5.
18. The role of Cyclin G1 in cellular proliferation and apoptosis of human epithelial ovarian cancer. Jiang L, etal., J Mol Histol. 2015 Jun;46(3):291-302. doi: 10.1007/s10735-015-9622-7. Epub 2015 May 17.
19. Increased Cyclin G1 Immunoreactivity During Alzheimer's Disease. Jordan-Sciutto KL, etal., J Alzheimers Dis. 1999 Dec;1(6):409-417.
20. CR8, a novel inhibitor of CDK, limits microglial activation, astrocytosis, neuronal loss, and neurologic dysfunction after experimental traumatic brain injury. Kabadi SV, etal., J Cereb Blood Flow Metab. 2014 Mar;34(3):502-13. doi: 10.1038/jcbfm.2013.228. Epub 2014 Jan 8.
21. Panax ginseng exerts antiproliferative effects on rat hepatocarcinogenesis. Kim H, etal., Nutr Res. 2013 Sep;33(9):753-60. doi: 10.1016/j.nutres.2013.07.005. Epub 2013 Aug 15.
22. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
23. Relationship between cyclin G1 and human papilloma virus infection in cervical intraepithelial neoplasia and cervical carcinoma. Liang J, etal., Chin Med Sci J. 2006 Jun;21(2):81-5.
24. Long non‑coding RNA OIP5‑AS1 facilitates the progression of ovarian cancer via the miR‑128‑3p/CCNG1 axis. Liu Y, etal., Mol Med Rep. 2021 May;23(5). pii: 388. doi: 10.3892/mmr.2021.12027. Epub 2021 Mar 24.
25. MicroRNA 'signature' during estrogen-mediated mammary carcinogenesis and its reversal by ellagic acid intervention. Munagala R, etal., Cancer Lett. 2013 Oct 10;339(2):175-84. doi: 10.1016/j.canlet.2013.06.012. Epub 2013 Jun 18.
26. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
27. Comprehensive phenotypic analysis of knockout mice deficient in cyclin G1 and cyclin G2. Ohno S, etal., Sci Rep. 2016 Dec 16;6:39091. doi: 10.1038/srep39091.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
30. GOA pipeline RGD automated data pipeline
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Cyclin G1 regulates the outcome of taxane-induced mitotic checkpoint arrest. Russell P, etal., Oncogene. 2012 May 10;31(19):2450-60. doi: 10.1038/onc.2011.431. Epub 2011 Nov 7.
33. CyclinG contributes to G2/M arrest of cells in response to DNA damage. Shimizu A, etal., Biochem Biophys Res Commun. 1998 Jan 26;242(3):529-33.
34. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
35. Cyclin G: a new mammalian cyclin with homology to fission yeast Cig1. Tamura K, etal., Oncogene 1993 Aug;8(8):2113-8.
36. Alteration of gene expression profiles in skeletal muscle of rats exposed to microgravity during a spaceflight. Taylor WE, etal., J Gravit Physiol. 2002 Dec;9(2):61-70.
37. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
38. Tumor-suppressor p53 is expressed in proliferating and newly formed neurons of the embryonic and postnatal rat brain: comparison with expression of the cell cycle regulators p21Waf1/Cip1, p27Kip1, p57Kip2, p16Ink4a, cyclin G1, and the proto-oncogene Bax. van Lookeren Campagne M and Gill R, J Comp Neurol. 1998 Jul 27;397(2):181-98.
39. Increased expression of cyclin G1 and p21WAF1/CIP1 in neurons following transient forebrain ischemia: comparison with early DNA damage. van Lookeren Campagne M and Gill R, J Neurosci Res. 1998 Aug 1;53(3):279-96.
40. Developmental expression and co-localization of cyclin G1 and the B' subunits of protein phosphatase 2a in neurons. van Lookeren Campagne M, etal., Brain Res Mol Brain Res. 1999 Jan 22;64(1):1-10.
41. Cyclin G1 expands liver tumor-initiating cells by Sox2 induction via Akt/mTOR signaling. Wen W, etal., Mol Cancer Ther. 2013 Sep;12(9):1796-804. doi: 10.1158/1535-7163.MCT-13-0099. Epub 2013 Jun 26.
42. Silencing the Expression of Cyclin G1 Enhances the Radiosensitivity of Hepatocellular Carcinoma In Vitro and In Vivo by Inducing Apoptosis. Xu G, etal., Radiat Res. 2021 Apr 1;195(4):378-384. doi: 10.1667/RADE-20-00180.1.
43. CCNG1 (Cyclin G1) regulation by mutant-P53 via induction of Notch3 expression promotes high-grade serous ovarian cancer (HGSOC) tumorigenesis and progression. Xu Y, etal., Cancer Med. 2019 Jan;8(1):351-362. doi: 10.1002/cam4.1812. Epub 2018 Dec 18.
44. MiR-23b targets cyclin G1 and suppresses ovarian cancer tumorigenesis and progression. Yan J, etal., J Exp Clin Cancer Res. 2016 Feb 13;35:31. doi: 10.1186/s13046-016-0307-1.
45. Oleanolic acid suppresses the proliferation of lung carcinoma cells by miR-122/Cyclin G1/MEF2D axis. Zhao X, etal., Mol Cell Biochem. 2015 Feb;400(1-2):1-7. doi: 10.1007/s11010-014-2228-7. Epub 2014 Dec 4.
46. Downregulation of cyclin G1 expression by retrovirus-mediated antisense gene transfer inhibits vascular smooth muscle cell proliferation and neointima formation. Zhu NL, etal., Circulation. 1997 Jul 15;96(2):628-35.
Additional References at PubMed
PMID:7784084   PMID:11983168   PMID:15489334  


Genomics

Comparative Map Data
Ccng1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81025,678,503 - 25,684,876 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1025,677,885 - 25,683,766 (-)EnsemblGRCr8
mRatBN7.21025,176,231 - 25,182,604 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1025,176,234 - 25,181,641 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1029,938,596 - 29,945,089 (-)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01029,427,123 - 29,433,616 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01024,913,784 - 24,920,277 (-)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1028,602,345 - 28,608,838 (-)NCBI
Lyon_Normotensive1029,257,126 - 29,263,619 (-)NCBI
Lyon_Hypertensive1030,952,481 - 30,958,974 (-)NCBI
F344_StmMcwi1030,931,426 - 30,937,919 (-)NCBI
Rnor_6.01025,903,925 - 25,910,298 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1025,903,911 - 25,910,325 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01025,754,109 - 25,760,482 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41025,776,380 - 25,782,754 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1024,735,527 - 24,741,900 (-)NCBICelera
RGSC_v3.11025,777,429 - 25,783,775 (-)NCBI
RH 3.4 Map10255.21RGD
Cytogenetic Map10q12NCBI
CCNG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385163,437,571 - 163,457,640 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5163,437,569 - 163,457,635 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh375162,864,577 - 162,875,205 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365162,797,155 - 162,804,600 (+)NCBIBuild 36Build 36hg18NCBI36
Build 345162,797,154 - 162,804,598NCBI
Celera5158,898,684 - 158,906,130 (+)NCBICelera
Cytogenetic Map5q34NCBI
HuRef5157,964,260 - 157,971,705 (+)NCBIHuRef
CHM1_15162,297,037 - 162,304,482 (+)NCBICHM1_1
T2T-CHM13v2.05163,972,739 - 163,983,375 (+)NCBIT2T-CHM13v2.0
Ccng1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391140,639,379 - 40,646,044 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1140,639,377 - 40,646,148 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381140,748,552 - 40,755,309 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1140,748,552 - 40,755,311 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv371140,562,054 - 40,568,788 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361140,591,975 - 40,598,709 (-)NCBIMGSCv36mm8
Celera1144,600,600 - 44,607,334 (-)NCBICelera
Cytogenetic Map11A5NCBI
cM Map1124.42NCBI
Ccng1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540816,847,336 - 16,850,343 (+)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_00495540816,846,050 - 16,850,365 (+)NCBIChiLan1.0ChiLan1.0
CCNG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24158,610,583 - 158,624,484 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15156,750,429 - 156,757,885 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05158,814,563 - 158,822,019 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15165,591,279 - 165,598,728 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5165,592,971 - 165,598,728 (+)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
CCNG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1447,800,697 - 47,808,259 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl447,801,575 - 47,808,211 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha447,693,783 - 47,701,354 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0448,231,625 - 48,239,215 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl448,231,625 - 48,238,937 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1448,014,780 - 48,022,368 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0448,173,025 - 48,180,607 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0448,692,928 - 48,700,530 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ccng1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap11173,959,471 - 173,966,428 (+)NCBImIctTri1.hap1
HiC_Itri_2NW_024407213102,164,944 - 102,171,907 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936515614,290 - 619,963 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936515614,287 - 621,213 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCNG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1660,349,258 - 60,356,738 (-)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.11660,349,255 - 60,356,737 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21665,189,603 - 65,197,085 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CCNG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap12318,988,520 - 18,995,257 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_0236662714,928 - 12,088 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.12365,709,759 - 65,716,913 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2365,709,786 - 65,714,711 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
ChlSab1.1 Ensembl2365,709,786 - 65,714,711 (+)NCBIChlSab1.1 EnsemblchlSab2Vervet-AGM
Ccng1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473326,366,448 - 26,378,062 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_00462473326,367,200 - 26,376,664 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl419,661,584 - 19,665,541 (+)Ensembl
Ccng1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1923,681,440 - 23,687,856 (-)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in Ccng1
28 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:833
Count of miRNA genes:329
Interacting mature miRNAs:420
Transcripts:ENSRNOT00000065633
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10589381150893811Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10589381150893811Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10687714251877142Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135730538Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10130004247Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1092219745922197Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)10210370847103708Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10589381150893811Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138832698Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)102342212132490778Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10666111835509383Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10589381150893811Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat

Markers in Region
RH138781  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21025,178,618 - 25,178,780 (+)MAPPERmRatBN7.2
Rnor_6.01025,906,313 - 25,906,474NCBIRnor6.0
Rnor_5.01025,756,497 - 25,756,658UniSTSRnor5.0
RGSC_v3.41025,778,768 - 25,778,929UniSTSRGSC3.4
Celera1024,737,915 - 24,738,076UniSTS
RH 3.4 Map10255.01UniSTS
Cytogenetic Map10q12UniSTS
RH140678  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21025,176,620 - 25,176,828 (+)MAPPERmRatBN7.2
Rnor_6.01025,904,315 - 25,904,522NCBIRnor6.0
Rnor_5.01025,754,499 - 25,754,706UniSTSRnor5.0
RGSC_v3.41025,776,770 - 25,776,977UniSTSRGSC3.4
Celera1024,735,917 - 24,736,124UniSTS
RH 3.4 Map10254.41UniSTS
Cytogenetic Map10q12UniSTS
Ccng1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81025,680,558 - 25,681,058 (+)Marker Load Pipeline
mRatBN7.21025,178,286 - 25,178,786 (+)MAPPERmRatBN7.2
Rnor_6.01025,905,981 - 25,906,480NCBIRnor6.0
Rnor_5.01025,756,165 - 25,756,664UniSTSRnor5.0
RGSC_v3.41025,778,436 - 25,778,935UniSTSRGSC3.4
Celera1024,737,583 - 24,738,082UniSTS
RH 3.4 Map10255.21UniSTS
Cytogenetic Map10q12UniSTS
BE096914  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21025,179,493 - 25,179,693 (+)MAPPERmRatBN7.2
Rnor_6.01025,907,188 - 25,907,387NCBIRnor6.0
Rnor_5.01025,757,372 - 25,757,571UniSTSRnor5.0
RGSC_v3.41025,779,644 - 25,779,843UniSTSRGSC3.4
Celera1024,738,790 - 24,738,989UniSTS
RH 3.4 Map10256.73UniSTS
Cytogenetic Map10q12UniSTS
Ccng  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21025,178,358 - 25,178,479 (+)MAPPERmRatBN7.2
Rnor_6.01025,906,053 - 25,906,173NCBIRnor6.0
Rnor_5.01025,756,237 - 25,756,357UniSTSRnor5.0
RGSC_v3.41025,778,508 - 25,778,628UniSTSRGSC3.4
Celera1024,737,655 - 24,737,775UniSTS
Cytogenetic Map10q12UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
277 156 729 1591 4066 1010 1727 133 873 492 855 156 5392 2593 448 3979 38 1393 741 909 160 158

Sequence


Ensembl Acc Id: ENSRNOT00000065633   ⟹   ENSRNOP00000063905
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1025,678,227 - 25,683,766 (-)Ensembl
mRatBN7.2 Ensembl1025,176,234 - 25,181,641 (-)Ensembl
Rnor_6.0 Ensembl1025,903,925 - 25,910,298 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079646   ⟹   ENSRNOP00000073529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1025,903,911 - 25,910,325 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000164430   ⟹   ENSRNOP00000111727
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1025,677,885 - 25,683,766 (-)Ensembl
RefSeq Acc Id: NM_012923   ⟹   NP_037055
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81025,678,503 - 25,684,876 (-)NCBI
mRatBN7.21025,176,231 - 25,182,604 (-)NCBI
Dahl_SR_JrHsd1028,602,345 - 28,608,838 (-)NCBI
Lyon_Normotensive1029,257,126 - 29,263,619 (-)NCBI
Lyon_Hypertensive1030,952,481 - 30,958,974 (-)NCBI
F344_StmMcwi1030,931,426 - 30,937,919 (-)NCBI
Rnor_6.01025,903,925 - 25,910,298 (-)NCBI
Rnor_5.01025,754,109 - 25,760,482 (-)NCBI
RGSC_v3.41025,776,380 - 25,782,754 (-)RGD
Celera1024,735,527 - 24,741,900 (-)RGD
Sequence:
RefSeq Acc Id: NP_037055   ⟸   NM_012923
- UniProtKB: P39950 (UniProtKB/Swiss-Prot),   A0ABK0M3T9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073529   ⟸   ENSRNOT00000079646
Ensembl Acc Id: ENSRNOP00000063905   ⟸   ENSRNOT00000065633
Ensembl Acc Id: ENSRNOP00000111727   ⟸   ENSRNOT00000164430
Protein Domains
Cyclin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P39950-F1-model_v2 AlphaFold P39950 1-294 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697109
Promoter ID:EPDNEW_R7634
Type:multiple initiation site
Name:Ccng1_1
Description:cyclin G1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01025,910,281 - 25,910,341EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2295 AgrOrtholog
BioCyc Gene G2FUF-25489 BioCyc
Ensembl Genes ENSRNOG00000003256 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055003060 UniProtKB/Swiss-Prot
  ENSRNOG00060003052 UniProtKB/Swiss-Prot
  ENSRNOG00065001337 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000065633 ENTREZGENE
  ENSRNOT00000065633.5 UniProtKB/Swiss-Prot
  ENSRNOT00055004764 UniProtKB/Swiss-Prot
  ENSRNOT00060005017 UniProtKB/Swiss-Prot
  ENSRNOT00065001767 UniProtKB/Swiss-Prot
Gene3D-CATH Cyclin-like UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7105829 IMAGE-MGC_LOAD
InterPro Cyclin UniProtKB/Swiss-Prot
  Cyclin-like UniProtKB/Swiss-Prot
  Cyclin-like_sf UniProtKB/Swiss-Prot
  Cyclin_N UniProtKB/Swiss-Prot
KEGG Report rno:25405 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93642 IMAGE-MGC_LOAD
NCBI Gene 25405 ENTREZGENE
PANTHER PTHR10177 UniProtKB/Swiss-Prot
Pfam Cyclin_N UniProtKB/Swiss-Prot
PhenoGen Ccng1 PhenoGen
RatGTEx ENSRNOG00000003256 RatGTEx
  ENSRNOG00055003060 RatGTEx
  ENSRNOG00060003052 RatGTEx
  ENSRNOG00065001337 RatGTEx
SMART CYCLIN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47954 UniProtKB/Swiss-Prot
TIGR TC204012
UniProt A0ABK0M3T9 ENTREZGENE, UniProtKB/TrEMBL
  CCNG1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Ccng1  Cyclin G1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains N-terminal cyclin box, but no PEST sequence; contains C-terminal sequence similar to tyrosine phosphorylation site of epidermal growth factor receptor 68222
gene_homology phylogenetically related to HCS26 of S. cerevisiae; most closely resembles Cig1 B-type cyclin of S. pombe 68222
gene_process may be involved in cellular growth stimuli but appears not to be involved in cell cycle 68222
gene_protein 294 amino acids 634709