RGD Reference Report - Cyclin G: a new mammalian cyclin with homology to fission yeast Cig1. - Rat Genome Database

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Cyclin G: a new mammalian cyclin with homology to fission yeast Cig1.

Authors: Tamura, K  Kanaoka, Y  Jinno, S  Nagata, A  Ogiso, Y  Shimizu, K  Hayakawa, T  Nojima, H  Okayama, H 
Citation: Tamura K, etal., Oncogene 1993 Aug;8(8):2113-8.
RGD ID: 68222
Pubmed: PMID:8336937   (View Abstract at PubMed)

A new gene encoding a cyclin-like protein has been isolated from a rat fibroblast cDNA library by cross-hybridization with a mixture of c-src family proto-oncogene kinase domains as a probe. This putative cyclin, called cyclin G, contains a typical cyclin box at the N-terminus but no apparent 'destruction box' or 'PEST' sequence. Interestingly, in its C-terminus region, it has a sequence homologous with a tyrosine phosphorylation site of the epidermal growth factor receptor. Although this cyclin is phylogenetically related to HCS26 of Saccharomyces cerevisiae, it most resembles Cig1, a B-type cyclin, of Schizosaccharomyces pombe, which has been suggested to act at the G1/S phase of the cell cycle. Cyclin G mRNA is induced within 3 h after growth stimulation and remains elevated with no apparent cell cycle dependency, indicating its close association with growth stimuli but not with the cell cycle.

Objects referenced in this article
Gene Ccnb1 cyclin B1 Rattus norvegicus
Gene Ccnc cyclin C Rattus norvegicus
Gene Ccnd1 cyclin D1 Rattus norvegicus
Gene Ccne1 cyclin E1 Rattus norvegicus
Gene Ccng1 cyclin G1 Rattus norvegicus

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