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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | decreases expression | ISO | RGD:1315763 | 6480464 | Estradiol results in decreased expression of PROX1 mRNA | CTD | PMID:20106945 | 17beta-estradiol | decreases expression | ISO | RGD:1315763 | 6480464 | Estradiol results in decreased expression of PROX1 mRNA | CTD | PMID:20106945 PMID:21632981 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1315763 | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PROX1 gene] | CTD | PMID:19574409 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1315764 | 6480464 | Tetrachlorodibenzodioxin affects the expression of PROX1 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of PROX1 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1315764 | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PROX1 promoter] | CTD | PMID:21889950 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:1315764 | 6480464 | Tetrachlorodibenzodioxin affects the reaction [AHR protein binds to PROX1 promoter] | CTD | PMID:19654925 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1315763 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PROX1 mRNA | CTD | PMID:19574409 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of PROX1 mRNA | CTD | PMID:21346803 | 2-methylcholine | affects expression | ISO | RGD:1315763 | 6480464 | beta-methylcholine affects the expression of PROX1 mRNA | CTD | PMID:21179406 | 5-aza-2'-deoxycytidine | increases expression | ISO | RGD:1315763 | 6480464 | decitabine results in increased expression of PROX1 mRNA | CTD | PMID:17415710 | 5-aza-2'-deoxycytidine | multiple interactions | ISO | RGD:1315763 | 6480464 | decitabine inhibits the reaction [Smoke results in decreased expression of PROX1 mRNA] | CTD | PMID:21095227 | aflatoxin B1 | affects expression | ISO | RGD:1315763 | 6480464 | Aflatoxin B1 affects the expression of PROX1 protein | CTD | PMID:20106945 | aflatoxin B1 | decreases expression | ISO | RGD:1315763 | 6480464 | Aflatoxin B1 results in decreased expression of PROX1 mRNA | CTD | PMID:22100608 | amiodarone | increases expression | ISO | RGD:1315763 | 6480464 | Amiodarone results in increased expression of PROX1 mRNA | CTD | PMID:19774075 | benzo[a]pyrene | multiple interactions | ISO | RGD:1315764 | 6480464 | Benzo(a)pyrene affects the reaction [AHR protein binds to PROX1 promoter] | CTD | PMID:19654925 | benzo[a]pyrene | decreases expression | ISO | RGD:1315764 | 6480464 | Benzo(a)pyrene results in decreased expression of PROX1 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | multiple interactions | ISO | RGD:1315764 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in increased expression of PROX1 mRNA; more ... | CTD | PMID:21715664 | benzo[a]pyrene | decreases expression | ISO | RGD:1315763 | 6480464 | Benzo(a)pyrene results in decreased expression of PROX1 mRNA | CTD | PMID:20106945 | C60 fullerene | decreases expression | EXP | | 6480464 | fullerene C60 results in decreased expression of PROX1 mRNA | CTD | PMID:19167457 | cyclosporin A | decreases expression | ISO | RGD:1315763 | 6480464 | Cyclosporine results in decreased expression of PROX1 mRNA | CTD | PMID:20106945 | cyclosporin A | decreases expression | ISO | RGD:1315763 | 6480464 | Cyclosporine results in decreased expression of PROX1 mRNA | CTD | PMID:20106945 PMID:21632981 | diazoxide | decreases expression | ISO | RGD:1315764 | 6480464 | Isoproterenol results in decreased expression of PROX1 mRNA | CTD | PMID:20003209 | disodium selenite | multiple interactions | ISO | RGD:1315764 | 6480464 | [ptaquiloside co-treated with Sodium Selenite] results in decreased expression of PROX1 mRNA | CTD | PMID:23274088 | hydrogen peroxide | affects expression | ISO | RGD:1315763 | 6480464 | Hydrogen Peroxide affects the expression of PROX1 mRNA | CTD | PMID:20044591 | isoprenaline | decreases expression | ISO | RGD:1315764 | 6480464 | Isoproterenol results in decreased expression of PROX1 mRNA | CTD | PMID:20003209 | ochratoxin A | decreases expression | ISO | RGD:1315763 | 6480464 | ochratoxin A results in decreased expression of PROX1 mRNA | CTD | PMID:19287073 | paracetamol | decreases expression | ISO | RGD:1315763 | 6480464 | Acetaminophen results in decreased expression of PROX1 mRNA | CTD | PMID:21420995 | phenobarbital | decreases expression | ISO | RGD:1315764 | 6480464 | Phenobarbital results in decreased expression of PROX1 mRNA | CTD | PMID:23091169 | pirinixic acid | multiple interactions | ISO | RGD:1315763 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PROX1 mRNA | CTD | PMID:19710929 | propiconazole | decreases expression | ISO | RGD:1315764 | 6480464 | propiconazole results in decreased expression of PROX1 mRNA | CTD | PMID:21278054 | quercetin | decreases expression | ISO | RGD:1315763 | 6480464 | Quercetin results in decreased expression of PROX1 mRNA | CTD | PMID:21632981 | testosterone enanthate | affects expression | ISO | RGD:1315763 | 6480464 | testosterone enanthate affects the expression of PROX1 mRNA | CTD | PMID:17440010 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of PROX1 mRNA | CTD | PMID:16770575 | trimellitic anhydride | decreases expression | ISO | RGD:1315764 | 6480464 | trimellitic anhydride results in decreased expression of PROX1 mRNA | CTD | PMID:19042947 | valproic acid | affects expression | ISO | RGD:1315764 | 6480464 | Valproic Acid affects the expression of PROX1 mRNA | CTD | PMID:17292431 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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References - curated| 1. |
Dudas J, etal., Histochem Cell Biol. 2006 Nov;126(5):549-62. Epub 2006 Jun 13. |
| 2. |
Galeeva A, etal., Neuroscience. 2007 May 11;146(2):604-16. Epub 2007 Mar 26. |
| 3. |
GOA data from the GO Consortium |
| 4. |
Laszlo V, etal., Histochem Cell Biol. 2008 Nov;130(5):1005-14. Epub 2008 Jul 29. |
| 5. |
McCloskey DP, etal., Eur J Neurosci. 2006 Oct;24(8):2203-10. Epub 2006 Oct 17. |
| 6. |
MGD data from the GO Consortium |
| 7. |
RGD automated import pipeline for gene-chemical interactions |
| 8. |
RGD comprehensive gene curation |
| 9. |
Welham SJ, etal., Physiol Genomics. 2005 Jun 16;22(1):48-56. Epub 2005 Apr 12. |
References - uncurated
RGD Disease Portals| Prox1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Prox1 (Rattus norvegicus) |
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| PROX1 (Homo sapiens) |
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| Prox1 (Mus musculus) |
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Position Markers| D13Rat162 |
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| BG373964 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001107201 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06076839 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06076840 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06076841 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06076842 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06076843 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06076844 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01077478 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01077479 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01077480 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01077481 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01077482 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473985 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001107201 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001100671 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001100671 | (Get FASTA) |
| GenBank Protein | EDL94973 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000003694 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000004905 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000004905 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 305066 | ENTREZGENE |
| HomoloGene Group ID | 2069 | ENTREZGENE |
| InterPro | Prox1 | UniProtKB/TrEMBL |
| KEGG Report | rno:305066 | ENTREZGENE, UniProtKB/TrEMBL |
| PANTHER | Prox1 | UniProtKB/TrEMBL |
| Pfam | Prox1 | UniProtKB/TrEMBL |
| UniGene | Rn.26557 | ENTREZGENE |
| UniProt | D3ZU00_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2008-10-24 | Prox1 | prospero homeobox 1 | Prox1 | prospero-related homeobox 1 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-04-30 | Prox1 | prospero-related homeobox 1 | Prox1_predicted | prospero-related homeobox 1 (predicted) | 'predicted' is removed | 24709 | APPROVED |
| 2005-01-12 | Prox1_predicted | prospero-related homeobox 1 (predicted) | Symbol and Name status set to approved | 1724 | APPROVED |
| More on Prox1 | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1306890 |
| Created: | 2005-01-12 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




