Npl (N-acetylneuraminate pyruvate lyase) - Rat Genome Database

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Gene: Npl (N-acetylneuraminate pyruvate lyase) Rattus norvegicus
Analyze
Symbol: Npl
Name: N-acetylneuraminate pyruvate lyase
RGD ID: 1549702
Description: Predicted to enable N-acetylneuraminate lyase activity and identical protein binding activity. Predicted to be involved in N-acetylneuraminate catabolic process. Predicted to be located in cytoplasm. Orthologous to human NPL (N-acetylneuraminate pyruvate lyase); PARTICIPATES IN amino sugar metabolic pathway; french type sialuria pathway; sialic acid storage disease pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 3',5'-cyclic AMP.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC304860; N-acetylneuraminate lyase; N-acetylneuraminate pyruvate-lyase; N-acetylneuraminic acid aldolase; NALase; sialate lyase; sialate-pyruvate lyase; sialic acid aldolase; sialic acid lyase; similar to N-acetylneuraminate pyruvate lyase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81368,205,602 - 68,247,940 (-)NCBIGRCr8
mRatBN7.21365,655,099 - 65,697,464 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1365,655,118 - 65,697,372 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1368,258,125 - 68,300,390 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01369,546,594 - 69,588,750 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01366,798,071 - 66,840,251 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01370,938,073 - 70,981,179 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1370,938,082 - 70,980,913 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01375,903,277 - 75,946,223 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41368,524,023 - 68,567,312 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1365,558,454 - 65,600,109 (-)NCBICelera
Cytogenetic Map13q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
allethrin  (EXP)
amphetamine  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP)
endosulfan  (ISO)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
formaldehyde  (ISO)
isotretinoin  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propanal  (ISO)
pyrethrins  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
Soman  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:11737202   PMID:15489334   PMID:22692205   PMID:25416956  


Genomics

Comparative Map Data
Npl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81368,205,602 - 68,247,940 (-)NCBIGRCr8
mRatBN7.21365,655,099 - 65,697,464 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1365,655,118 - 65,697,372 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1368,258,125 - 68,300,390 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01369,546,594 - 69,588,750 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01366,798,071 - 66,840,251 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01370,938,073 - 70,981,179 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1370,938,082 - 70,980,913 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01375,903,277 - 75,946,223 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41368,524,023 - 68,567,312 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1365,558,454 - 65,600,109 (-)NCBICelera
Cytogenetic Map13q21NCBI
NPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381182,789,773 - 182,830,384 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1182,789,293 - 182,830,384 (+)EnsemblGRCh38hg38GRCh38
GRCh371182,758,908 - 182,799,519 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361181,028,017 - 181,065,211 (+)NCBINCBI36Build 36hg18NCBI36
Build 341179,493,050 - 179,530,245NCBI
Celera1155,872,543 - 155,909,737 (+)NCBICelera
Cytogenetic Map1q25.3NCBI
HuRef1153,994,259 - 154,035,194 (+)NCBIHuRef
CHM1_11184,181,835 - 184,222,761 (+)NCBICHM1_1
T2T-CHM13v2.01182,148,939 - 182,189,548 (+)NCBIT2T-CHM13v2.0
Npl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391153,378,762 - 153,425,460 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1153,378,761 - 153,425,791 (-)EnsemblGRCm39 Ensembl
GRCm381153,503,016 - 153,549,714 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1153,503,015 - 153,550,045 (-)EnsemblGRCm38mm10GRCm38
MGSCv371155,350,146 - 155,396,844 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361155,265,234 - 155,311,932 (-)NCBIMGSCv36mm8
Celera1155,927,936 - 155,974,856 (-)NCBICelera
Cytogenetic Map1G3NCBI
cM Map165.38NCBI
Npl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540621,633,032 - 21,670,958 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540621,633,979 - 21,670,279 (+)NCBIChiLan1.0ChiLan1.0
NPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2166,901,458 - 66,944,704 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1166,584,984 - 66,626,297 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01158,305,203 - 158,346,531 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11161,957,118 - 161,997,635 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1161,958,896 - 161,997,222 (+)Ensemblpanpan1.1panPan2
NPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1716,186,693 - 16,226,658 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl716,192,005 - 16,224,033 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha715,773,528 - 15,812,293 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0715,916,535 - 15,955,524 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl715,915,242 - 15,952,901 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1715,828,310 - 15,866,959 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0715,937,498 - 15,975,727 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0716,066,339 - 16,105,552 (+)NCBIUU_Cfam_GSD_1.0
Npl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934489,095,379 - 89,129,855 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364816,942,282 - 6,972,775 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364816,942,128 - 6,977,042 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9124,093,604 - 124,132,860 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19124,093,579 - 124,132,862 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NPL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12546,543,645 - 46,582,700 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2546,541,401 - 46,581,767 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605547,760,165 - 47,800,243 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Npl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462481410,968,329 - 10,994,001 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462481410,968,218 - 11,006,637 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Npl
339 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:518
Count of miRNA genes:258
Interacting mature miRNAs:318
Transcripts:ENSRNOT00000003713
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132369296968692969Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132369296968692969Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
2303028Bp329Blood pressure QTL 329arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)135849787273485113Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)135949252277046890Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat

Markers in Region
RH133413  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21365,655,378 - 65,655,572 (+)MAPPERmRatBN7.2
Rnor_6.01370,938,335 - 70,938,528NCBIRnor6.0
Rnor_5.01375,903,539 - 75,903,732UniSTSRnor5.0
RGSC_v3.41368,524,285 - 68,524,478UniSTSRGSC3.4
Celera1365,558,716 - 65,558,909UniSTS
RH 3.4 Map13301.2UniSTS
Cytogenetic Map13q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 4 11 4 6 29 31 9
Low 3 43 53 37 8 37 8 11 68 6 10 2 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003713   ⟹   ENSRNOP00000003713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1365,655,118 - 65,697,372 (-)Ensembl
Rnor_6.0 Ensembl1370,938,082 - 70,980,913 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102662   ⟹   ENSRNOP00000076598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1365,655,118 - 65,684,851 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109291   ⟹   ENSRNOP00000097337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1365,655,118 - 65,697,232 (-)Ensembl
RefSeq Acc Id: NM_001013984   ⟹   NP_001014006
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,205,602 - 68,247,707 (-)NCBI
mRatBN7.21365,655,117 - 65,697,232 (-)NCBI
Rnor_6.01370,938,073 - 70,980,852 (-)NCBI
Rnor_5.01375,903,277 - 75,946,223 (-)NCBI
RGSC_v3.41368,524,023 - 68,567,312 (-)RGD
Celera1365,558,454 - 65,600,109 (-)RGD
Sequence:
RefSeq Acc Id: XM_006249997   ⟹   XP_006250059
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81368,205,602 - 68,247,940 (-)NCBI
mRatBN7.21365,655,099 - 65,697,464 (-)NCBI
Rnor_6.01370,938,073 - 70,981,179 (-)NCBI
Rnor_5.01375,903,277 - 75,946,223 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001014006   ⟸   NM_001013984
- UniProtKB: Q66H59 (UniProtKB/Swiss-Prot),   A0A8L2Q119 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250059   ⟸   XM_006249997
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q119 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003713   ⟸   ENSRNOT00000003713
RefSeq Acc Id: ENSRNOP00000097337   ⟸   ENSRNOT00000109291
RefSeq Acc Id: ENSRNOP00000076598   ⟸   ENSRNOT00000102662

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q66H59-F1-model_v2 AlphaFold Q66H59 1-320 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698898
Promoter ID:EPDNEW_R9423
Type:single initiation site
Name:Npl_1
Description:N-acetylneuraminate pyruvate lyase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01370,980,871 - 70,980,931EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1549702 AgrOrtholog
BioCyc Gene G2FUF-17880 BioCyc
Ensembl Genes ENSRNOG00000002775 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055018453 UniProtKB/Swiss-Prot
  ENSRNOG00060014268 UniProtKB/Swiss-Prot
  ENSRNOG00065023674 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003713.7 UniProtKB/TrEMBL
  ENSRNOT00000102662.1 UniProtKB/TrEMBL
  ENSRNOT00000109291 ENTREZGENE
  ENSRNOT00000109291.1 UniProtKB/Swiss-Prot
  ENSRNOT00055031349 UniProtKB/Swiss-Prot
  ENSRNOT00060024431 UniProtKB/Swiss-Prot
  ENSRNOT00065040562 UniProtKB/Swiss-Prot
Gene3D-CATH 3.20.20.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7131519 IMAGE-MGC_LOAD
InterPro Aldolase_TIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DapA-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:304860 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94250 IMAGE-MGC_LOAD
NCBI Gene 304860 ENTREZGENE
PANTHER N-ACETYLNEURAMINATE LYASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12128 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DHDPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Npl PhenoGen
PIRSF DHDPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS DHPICSNTHASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002775 RatGTEx
  ENSRNOG00055018453 RatGTEx
  ENSRNOG00060014268 RatGTEx
  ENSRNOG00065023674 RatGTEx
SMART DHDPS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Aldolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZK42_RAT UniProtKB/TrEMBL
  A0A8L2Q119 ENTREZGENE, UniProtKB/TrEMBL
  NPL_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Npl  N-acetylneuraminate pyruvate lyase  LOC304860  similar to N-acetylneuraminate pyruvate lyase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-15 LOC304860  similar to N-acetylneuraminate pyruvate lyase      Symbol and Name status set to provisional 70820 PROVISIONAL