Gene: Nox4 (NADPH oxidase 4) Rattus norvegicus
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Symbol: Nox4
Name: NADPH oxidase 4
Description: ENCODES a protein that exhibits NAD(P)H oxidase activity; oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor; modified amino acid binding (ortholog); INVOLVED IN aging; cellular response to cAMP; cellular response to gamma radiation; PARTICIPATES IN thyroid hormone biosynthetic pathway; ASSOCIATED WITH Aneurysm; Diabetes Mellitus, Experimental; Diabetic Nephropathies; FOUND IN apical plasma membrane; focal adhesion; mitochondrion; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: kidney oxidase-1; kidney superoxide-producing NADPH oxidase; kox-1
Orthologs:
Homo sapiens (human) : NOX4 (NADPH oxidase 4)  HGNC  AGR
Mus musculus (house mouse) : Nox4 (NADPH oxidase 4)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Nox4 (NADPH oxidase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : NOX4 (NADPH oxidase 4)
Canis lupus familiaris (dog) : NOX4 (NADPH oxidase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nox4 (NADPH oxidase 4)
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Allele / Splice: Nox4em2Mcwi   Nox4em1Mcwi  
Genetic Models: SS-Nox4em1Mcwi SS-Nox4em2Mcwi
Is Marker For: Strains:   FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01150,796,359 - 150,976,186 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01157,106,652 - 157,196,482 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01157,246,099 - 157,285,107 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41143,415,816 - 143,603,554 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11143,494,221 - 143,681,960 (+)NCBI
Celera1139,242,883 - 139,407,667 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Nox4
AGR Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620600
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2017-11-28
Status: ACTIVE