Anapc2 (anaphase promoting complex subunit 2)

Gene: Anapc2 (anaphase promoting complex subunit 2) Rattus norvegicus

Analyze

Symbol:

Anapc2

Name:

anaphase promoting complex subunit 2

RGD ID:

1305546

Description:

Predicted to enable ubiquitin protein ligase binding activity. Involved in negative regulation of gene expression; positive regulation of axon extension; and positive regulation of dendrite morphogenesis. Predicted to be part of anaphase-promoting complex. Orthologous to human ANAPC2 (anaphase promoting complex subunit 2); PARTICIPATES IN cell cycle pathway, mitotic; ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

anaphase-promoting complex subunit 2; LOC296558

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ANAPC2 (anaphase promoting complex subunit 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Anapc2 (anaphase promoting complex subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Anapc2 (anaphase promoting complex subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	ANAPC2 (anaphase promoting complex subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ANAPC2 (anaphase promoting complex subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Anapc2 (anaphase promoting complex subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ANAPC2 (anaphase promoting complex subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	ANAPC2 (anaphase promoting complex subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Anapc2 (anaphase promoting complex subunit 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SUGCT (succinyl-CoA:glutarate-CoA transferase)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	ANAPC2 (anaphase promoting complex subunit 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Anapc2 (anaphase promoting complex subunit 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	anapc2 (anaphase promoting complex subunit 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	APC2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	apc-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	mr	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	anapc2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Candidate Gene For:

Arunc3

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	28,484,590 - 28,496,338 (+)	NCBI		GRCr8
mRatBN7.2	3	8,086,434 - 8,098,182 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	8,086,462 - 8,098,178 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	11,190,969 - 11,202,704 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	19,777,199 - 19,788,934 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	17,967,042 - 17,978,777 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	2,490,496 - 2,502,247 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	2,490,518 - 2,502,248 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	2,471,951 - 2,483,660 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	3,436,569 - 3,448,278 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	3,436,404 - 3,448,589 (+)	NCBI
Celera	3	2,913,015 - 2,924,724 (+)	NCBI		Celera
Cytogenetic Map	3	p13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

Adams-Oliver Syndrome 5 (ISO)

aplastic anemia (ISO)

autosomal dominant intellectual developmental disorder 8 (ISO)

developmental and epileptic encephalopathy 14 (ISO)

epilepsy (ISO)

Fetal Growth Retardation (ISO)

genetic disease (ISO)

Joubert syndrome 1 (ISO)

Kleefstra syndrome 1 (ISO)

lung adenocarcinoma (ISO)

lung adenoma (ISO)

Memory Disorders (ISO)

primary angle-closure glaucoma (ISO)

primary coenzyme Q10 deficiency 7 (ISO)

Rafiq syndrome (ISO)

Sotos syndrome 3 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

acrolein (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

aristolochic acid A (ISO)

Benoxacor (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

caffeine (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

coumarin (ISO)

doxorubicin (ISO)

Echimidine (ISO)

elemental selenium (ISO)

ethanol (ISO)

fenthion (ISO)

finasteride (EXP)

folic acid (ISO)

FR900359 (ISO)

fulvestrant (ISO)

gentamycin (EXP)

ivermectin (ISO)

Lasiocarpine (ISO)

lead(0) (ISO)

methapyrilene (ISO)

methidathion (ISO)

monocrotaline (ISO)

nocodazole (ISO)

paracetamol (EXP)

phlorizin (ISO)

selenium atom (ISO)

senecionine (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

sunitinib (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anaphase-promoting complex-dependent catabolic process (ISO)

cell division (IEA)

metaphase/anaphase transition of mitotic cell cycle (IBA)

negative regulation of gene expression (IMP)

positive regulation of axon extension (IMP)

positive regulation of dendrite morphogenesis (IMP)

positive regulation of synapse maturation (ISO)

positive regulation of synaptic plasticity (ISO)

protein K11-linked ubiquitination (IBA,ISO)

protein K48-linked ubiquitination (ISO)

ubiquitin-dependent protein catabolic process (IEA)

Cellular Component

anaphase-promoting complex (IBA,ISO)

Molecular Function

protein binding (ISO)

ubiquitin protein ligase binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

cell cycle pathway, mitotic (IEA)

ubiquitin/proteasome degradation pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Loss-of-Function Mutation in APC2 Causes Sotos Syndrome Features.	Almuriekhi M, etal., Cell Rep. 2015 Mar 3. pii: S2211-1247(15)00139-4. doi: 10.1016/j.celrep.2015.02.011.
2.	Molecular profiling of mouse lung tumors: association with tumor progression, lung development, and human lung adenocarcinomas.	Bonner AE, etal., Oncogene. 2004 Feb 5;23(5):1166-76.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons.	Gieffers C, etal., Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11317-22.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	Liprinalpha1 degradation by calcium/calmodulin-dependent protein kinase II regulates LAR receptor tyrosine phosphatase distribution and dendrite development.	Hoogenraad CC, etal., Dev Cell. 2007 Apr;12(4):587-602. doi: 10.1016/j.devcel.2007.02.006.
7.	Comparative evaluation of the aqueous humor proteome of primary angle closure and primary open angle glaucomas and age-related cataract eyes.	Kaur I, etal., Int Ophthalmol. 2019 Jan;39(1):69-104. doi: 10.1007/s10792-017-0791-0. Epub 2018 Jan 13.
8.	A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons.	Kim AH, etal., Cell. 2009 Jan 23;136(2):322-36.
9.	The anaphase promoting complex is required for memory function in mice.	Kuczera T, etal., Learn Mem. 2010 Dec 22;18(1):49-57. doi: 10.1101/lm.1998411. Print 2011 Jan.
10.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
11.	Laser capture microdissection and microarray expression analysis of lung adenocarcinoma reveals tobacco smoking- and prognosis-related molecular profiles.	Miura K, etal., Cancer Res. 2002 Jun 1;62(11):3244-50.
12.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
13.	The expression pattern of APC2 and APC7 in various cancer cell lines and AML patients.	Rahimi H, etal., Adv Med Sci. 2015 Sep;60(2):259-63. doi: 10.1016/j.advms.2015.04.007. Epub 2015 May 13.
14.	GOA pipeline	RGD automated data pipeline
15.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
16.	Comprehensive gene review and curation	RGD comprehensive gene curation
17.	Alterations of protein expression in serum of infants with intrauterine growth restriction and different gestational ages.	Ruis-González MD, etal., J Proteomics. 2015 Apr 24;119:169-82. doi: 10.1016/j.jprot.2015.02.003. Epub 2015 Feb 25.
18.	APC/C is essential for hematopoiesis and impaired in aplastic anemia.	Wang J, etal., Oncotarget. 2017 Jun 28;8(38):63360-63369. doi: 10.18632/oncotarget.18808. eCollection 2017 Sep 8.

Additional References at PubMed

PMID:12477932	PMID:16364912	PMID:18485873	PMID:19900895

Genomics

Comparative Map Data

Anapc2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	28,484,590 - 28,496,338 (+)	NCBI		GRCr8
mRatBN7.2	3	8,086,434 - 8,098,182 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	8,086,462 - 8,098,178 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	11,190,969 - 11,202,704 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	19,777,199 - 19,788,934 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	17,967,042 - 17,978,777 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	2,490,496 - 2,502,247 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	2,490,518 - 2,502,248 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	2,471,951 - 2,483,660 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	3,436,569 - 3,448,278 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	3,436,404 - 3,448,589 (+)	NCBI
Celera	3	2,913,015 - 2,924,724 (+)	NCBI		Celera
Cytogenetic Map	3	p13	NCBI

ANAPC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	137,174,784 - 137,188,560 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	137,174,784 - 137,188,560 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	140,069,236 - 140,083,012 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	139,189,057 - 139,202,878 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	137,345,072 - 137,358,894	NCBI
Celera	9	110,583,566 - 110,597,088 (-)	NCBI		Celera
Cytogenetic Map	9	q34.3	NCBI
HuRef	9	109,529,253 - 109,543,074 (-)	NCBI		HuRef
CHM1_1	9	140,217,925 - 140,231,746 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	149,412,464 - 149,426,223 (-)	NCBI		T2T-CHM13v2.0

Anapc2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	25,162,469 - 25,175,928 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	25,162,490 - 25,175,927 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	25,272,466 - 25,285,916 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	25,272,478 - 25,285,915 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	25,127,986 - 25,141,436 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	25,094,508 - 25,107,924 (+)	NCBI		MGSCv36	mm8
Celera	2	25,000,157 - 25,013,426 (+)	NCBI		Celera
Cytogenetic Map	2	A3	NCBI
cM Map	2	17.12	NCBI

Anapc2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955513	5,183,472 - 5,194,253 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955513	5,183,472 - 5,194,253 (-)	NCBI	ChiLan1.0	ChiLan1.0

ANAPC2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	2,210,577 - 2,224,304 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	2,213,159 - 2,226,638 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	108,234,949 - 108,248,227 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	137,204,356 - 137,217,652 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	137,204,356 - 137,217,652 (-)	Ensembl	panpan1.1		panPan2

ANAPC2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	48,475,777 - 48,486,715 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	48,471,584 - 48,609,303 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	47,666,446 - 47,677,538 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	49,341,288 - 49,352,382 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	49,341,432 - 49,355,653 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	48,117,700 - 48,128,794 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	48,416,513 - 48,427,605 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	48,463,672 - 48,474,764 (+)	NCBI		UU_Cfam_GSD_1.0

Anapc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	202,566,104 - 202,577,692 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936669	797,318 - 811,721 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936669	797,475 - 808,952 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ANAPC2
(Sus scrofa - pig)

No map positions available.

ANAPC2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	1,000,885 - 1,014,710 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	1,000,952 - 1,016,261 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666058	4,290,548 - 4,304,375 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Anapc2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	760,749 - 772,855 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624760	760,815 - 772,116 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Anapc2
6 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	83
Count of miRNA genes:	67
Interacting mature miRNAs:	70
Transcripts:	ENSRNOT00000015099
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70202	Alc19	Alcohol consumption QTL 19	2.5		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	3	1	27494778	Rat
631679	Cm10	Cardiac mass QTL 10	7.34	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	1	31158234	Rat
631831	Alc8	Alcohol consumption QTL 8	2.7		consumption behavior trait (VT:0002069)	calculated ethanol drink intake rate (CMO:0001615)	3	1	33230976	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	diastolic blood pressure (CMO:0000005)	3	1	33278763	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	3	1	33278763	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	pulse pressure (CMO:0000292)	3	1	33278763	Rat
631545	Bp85	Blood pressure QTL 85	3.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	33278763	Rat
4889966	Bss95	Bone structure and strength QTL 95	4.4		tibia area (VT:1000281)	tibia-fibula cross-sectional area (CMO:0001718)	3	1	36847613	Rat
2312664	Scl62	Serum cholesterol level QTL 62		0.05	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	1	38710544	Rat
631568	Bp92	Blood pressure QTL 92	2.2	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	39874793	Rat
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
1358185	Ept6	Estrogen-induced pituitary tumorigenesis QTL 6	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6537645	10778823	Rat
2292615	Ept17	Estrogen-induced pituitary tumorigenesis QTL 17	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6537645	10778823	Rat

Markers in Region

RH128511

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	8,085,113 - 8,085,304 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	2,489,182 - 2,489,372	NCBI	Rnor6.0
Rnor_5.0	3	2,470,595 - 2,470,785	UniSTS	Rnor5.0
RGSC_v3.4	3	3,435,213 - 3,435,403	UniSTS	RGSC3.4
Celera	3	2,911,659 - 2,911,849	UniSTS
Cytogenetic Map	3	p13	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	36	56	40	19	40	2	5	74	35	41	11	2
Low		7	1	1		1	6	6					6
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001100532	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063283461	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC107471	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC166796	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ224461	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000015099 ⟹ ENSRNOP00000015099

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	8,086,462 - 8,098,178 (+)	Ensembl
Rnor_6.0 Ensembl	3	2,490,518 - 2,502,248 (+)	Ensembl

RefSeq Acc Id:

NM_001100532 ⟹ NP_001094002

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	28,484,628 - 28,496,338 (+)	NCBI
mRatBN7.2	3	8,086,470 - 8,098,181 (+)	NCBI
Rnor_6.0	3	2,490,538 - 2,502,247 (+)	NCBI
Rnor_5.0	3	2,471,951 - 2,483,660 (+)	NCBI
RGSC_v3.4	3	3,436,569 - 3,448,278 (+)	RGD
Celera	3	2,913,015 - 2,924,724 (+)	RGD

Sequence:

show sequence

CAGTGATGGAGGCCGAGGGTGTGGCGGTATCGGTGGCGGCGGCGGCGGCGGCGACAACGACAAT
TGTCGCCACGGATGACTGCGACTCTAGGCCTGGACAGGAGCTCGTGGTTGCCTGGAATACTGTG
AGCACCGGTCTGGTGCCGCCGGCTGCGCTGGGGCTGGCATCTTCCCGGACCAGCGGTGCAGTTC
CACCAAAGGAGGAAGAGCTTCGTGCAGCGGTAGAAGTTCTGAGGGCCCACGGTCTGCACTCTGT
CCTGGAGGAGTGGTTCGTGGAAGTGCTGCAGAATGACCTTCAAGGCAACATTGCCACGGAGTTC
TGGAATGCCATCTCCCTTCGCGAAAACTCTGTCGATGAACCCCAATGCCTTGTGCTGCTCCTGG
ATGCGTTCGGTCTGCTGGAAAGCCGCTTGGATCCCTATCTGCATAGCCTAGAACTCCTAGAGAA
ATGGACTCGTCTGGGCTTGCTGATGGGCGCTGGAGCTCAGGGTCTTCGGGAGAAAGTTCACACT
ATGTTGCGGGGAGTCCTGTTTTTTTCCACCCCTAGGACATTCCAGGAGATGGTCCAGCGCCTCT
ATGGTCGTTTCCTGAGAGTCTATATGCAGAGCAAGAGAAAAGGAGAAGGGGGCACAGATCCAGA
ACTAGAGGGAGAGCTGGACAGCCGGTATGCCCGCCGCAGGTACTACCGACTTTTGCAGAGCCCT
CTGTGTGCAGGATGTGGCAGTGACAAGCAGCAGTGCTGGTGCCGGCAGGCCCTGGAGCAGTTCA
ACCAGCTCAGCCAGGTCCTGCATAGGCTCAGTCTGCTGGAGCGGGTTAGCGCTGAGGCCGTGAC
CACCACCCTGCATCAGGTGACCCGGGAAAGGATGGAAGACCGCTGCCGAGGAGAGTATGAGCGC
TCTTTCTTGCGTGAGTTCCACAAGTGGATCGAGAGAGTGGTTGGTTGGCTTGGCAAAGTGTTCC
TTCAGGACAACCCCAGCAGACCAACTTCTCCAGAAGCTGGGAACACACTGCGTCGTTGGCGCTG
TCACGTACAGAGATTCTTCTACCGAATCTATGCCAGCCTACGTATTGAGGAGCTTTTCAGCATC
ATCCGAGACTTCCCAGACTCTCGGCCAGCCATTGAGGACCTTAAGTACTGCTTGGAGAGGACGG
ATCAGAGGCAGCAGCTCCTCGTGTCCCTCAAAGTGGCCCTAGAGACTCGACTCCTCCACCCAGG
TGTCAACACGTGTGACATCATCACACTCTACATTTCTGCCATCAAGGCATTACGTGTGCTAGAT
CCCTCTATGGTCATCCTGGAGGTGGCCTGTGAGCCCATCCGTCGCTACCTGAGGACACGGGAGG
ACACAGTACGGCAGATTGTGGCTGGGCTAACCGGGGACTCGGATGGGACTGGGGACTTGGCTGT
TGAGCTGTCTAAGACTGACCCGGCCTGCCTGGAGACCGGCCAGGACAGTGAGGATGACTCTGGC
GAGCCCGAGGACTGGGTCCCTGACCCTGTGGATGCTGATCCAGCAAAGTCAAGTTCCAAGCGAC
GCTCTTCAGACATCATCAGCCTGCTGGTCAGCATCTATGGCAGCAAAGACCTGTTTATCAATGA
GTACCGCTCCCTCCTGGCCGATCGCCTCCTCCACCAGTTCAGCTTCAGTCCGGAGAGGGAGATT
CGTAATGTGGAGCTGTTGAAGCTGCGCTTTGGAGAAGCCCCCATGCACTTCTGTGAGGTCATGC
TCAAGGACATGGCAGATTCCCGCCGCATCAATGCCAATATCCGTGAGGAGGATGAGAAGCGGCC
TGTGGAAGAACAGCCACCATTTGGGGTCTATGCCGTCATATTGTCCAGTGAATTTTGGCCTCCC
TTCAAAGATGAGAAGCTGGAGGTCCCTGAGGACATCAGGGCAGCCCTGGATGTTTACTGCAAGA
AGTATGAGAAACTGAAGGCTATGCGGACACTCAGTTGGAAGCATACCCTGGGCCTGGTGACGAT
GGACGTGGAGCTGGCTGACCGCACCCTGTCTGTTGCGGTCACCCCAGTGCAGGCAGTGGTTTTG
CTGTATTTCCAGGACCAAGCCAGCTGGACCTTGGAGGAGCTGAGCAAGGTGGTGAAGATGCCCG
TGGCACTCCTACGAAGACGCATGTCAGTGTGGCTGCAGCAGGGTGTGCTGCGGGAGGAGCCTCC
CGGCACTTTCTCTGTCATTGAGGAAGAGCGGCCTCAGGATAGGGACAACATGGTGCTGATTGAC
AGTGATGATGAAAGTGACTCGGGCATGGCCTCCCAGGCTGACCAGAAGGAAGAGGAGCTACTGC
TCTTTTGGACATACATCCAGGCCATGTTGACCAACCTAGAGAGCCTCTCTCTGGAGCGCATCTA
CAGCATGCTCCGAATGTTTGTAATGACTGGCCCTGCACTGGCTGAGATTGACCTGCAGGAACTA
CAGGGCTACTTGCAGAAGAAGGTCCGAGACCAGCAGCTCATCTACTCTGCAGGTGTCTACCGCC
TGCCTAAGAACTGCAACTGATGTTCCCCTTCCAGGCTCTGACCTGCAGCATTCATGCCTGTGCA
ACCCCTGGATGGACAGCTAGGGTACCTTCTGTCCCCATGTTCCTGTGCCCAGCCCCTACCTGTT
CCCTGCCTAACACCTAAAGAACAAATTAAAGCATATTAGCTCAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063283461 ⟹ XP_063139531

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	28,484,590 - 28,495,890 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001094002	(Get FASTA)	NCBI Sequence Viewer
	XP_063139531	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI07472	(Get FASTA)	NCBI Sequence Viewer
	AAI66796	(Get FASTA)	NCBI Sequence Viewer
	EDL93618	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000015099
	ENSRNOP00000015099.6

RefSeq Acc Id:

NP_001094002 ⟸ NM_001100532

- UniProtKB:

B2RYJ1 (UniProtKB/TrEMBL), F7EWF8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEAEGVAVSVAAAAAATTTIVATDDCDSRPGQELVVAWNTVSTGLVPPAALGLASSRTSGAVPP
KEEELRAAVEVLRAHGLHSVLEEWFVEVLQNDLQGNIATEFWNAISLRENSVDEPQCLVLLLDA
FGLLESRLDPYLHSLELLEKWTRLGLLMGAGAQGLREKVHTMLRGVLFFSTPRTFQEMVQRLYG
RFLRVYMQSKRKGEGGTDPELEGELDSRYARRRYYRLLQSPLCAGCGSDKQQCWCRQALEQFNQ
LSQVLHRLSLLERVSAEAVTTTLHQVTRERMEDRCRGEYERSFLREFHKWIERVVGWLGKVFLQ
DNPSRPTSPEAGNTLRRWRCHVQRFFYRIYASLRIEELFSIIRDFPDSRPAIEDLKYCLERTDQ
RQQLLVSLKVALETRLLHPGVNTCDIITLYISAIKALRVLDPSMVILEVACEPIRRYLRTREDT
VRQIVAGLTGDSDGTGDLAVELSKTDPACLETGQDSEDDSGEPEDWVPDPVDADPAKSSSKRRS
SDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHFCEVMLK
DMADSRRINANIREEDEKRPVEEQPPFGVYAVILSSEFWPPFKDEKLEVPEDIRAALDVYCKKY
EKLKAMRTLSWKHTLGLVTMDVELADRTLSVAVTPVQAVVLLYFQDQASWTLEELSKVVKMPVA
LLRRRMSVWLQQGVLREEPPGTFSVIEEERPQDRDNMVLIDSDDESDSGMASQADQKEEELLLF
WTYIQAMLTNLESLSLERIYSMLRMFVMTGPALAEIDLQELQGYLQKKVRDQQLIYSAGVYRLP
KNCN

hide sequence

RefSeq Acc Id:

ENSRNOP00000015099 ⟸ ENSRNOT00000015099

RefSeq Acc Id:	XP_063139531 ⟸ XM_063283461
- Peptide Label:	isoform X1

Protein Domains

Cullin family profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B2RYJ1-F1-model_v2	AlphaFold	B2RYJ1	1-836	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691867

Promoter ID:

EPDNEW_R2392

Type:

multiple initiation site

Name:

Anapc2_1

Description:

anaphase promoting complex subunit 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	2,490,528 - 2,490,588	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305546	AgrOrtholog
BioCyc Gene	G2FUF-50465	BioCyc
Ensembl Genes	ENSRNOG00000011295	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000015099	ENTREZGENE
	ENSRNOT00000015099.8	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
	Cullin Repeats	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7446651	IMAGE-MGC_LOAD
	IMAGE:7938000	IMAGE-MGC_LOAD
InterPro	APC2-like	UniProtKB/TrEMBL
	APC_su2_C	UniProtKB/TrEMBL
	Cullin_homology	UniProtKB/TrEMBL
	Cullin_homology_sf	UniProtKB/TrEMBL
	Cullin_N	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/TrEMBL
KEGG Report	rno:296558	UniProtKB/TrEMBL
MGC_CLONE	MGC:125206	IMAGE-MGC_LOAD
	MGC:188593	IMAGE-MGC_LOAD
NCBI Gene	296558	ENTREZGENE
PANTHER	ANAPHASE-PROMOTING COMPLEX SUBUNIT 2	UniProtKB/TrEMBL
	PTHR45957	UniProtKB/TrEMBL
Pfam	APC2	UniProtKB/TrEMBL
	Cullin	UniProtKB/TrEMBL
PhenoGen	Anapc2	PhenoGen
PROSITE	CULLIN_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000011295	RatGTEx
SMART	APC2	UniProtKB/TrEMBL
	CULLIN	UniProtKB/TrEMBL
Superfamily-SCOP	Cullin_homology	UniProtKB/TrEMBL
	SSF46785	UniProtKB/TrEMBL
UniProt	B2RYJ1	ENTREZGENE, UniProtKB/TrEMBL
	F7EWF8	ENTREZGENE, UniProtKB/TrEMBL
	Q3B7T7_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Anapc2	anaphase promoting complex subunit 2	Anapc2_predicted	anaphase promoting complex subunit 2 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Anapc2_predicted	anaphase promoting complex subunit 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

Send us a Message

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)