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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (S)-amphetamine | decreases expression | EXP | | 6480464 | Dextroamphetamine results in decreased expression of MBL2 mRNA | CTD | PMID:16715494 | 17beta-estradiol | decreases expression | ISO | RGD:735547 | 6480464 | Estradiol results in decreased expression of MBL2 mRNA | CTD | PMID:20106945 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:735547 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of MBL2 mRNA | CTD | PMID:20106945 PMID:11489354 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of MBL2 mRNA | CTD | PMID:21215274 PMID:21724226 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:735547 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of MBL2 mRNA | CTD | PMID:11489354 more ... | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of MBL2 mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:735547 | 6480464 | Tetrachlorodibenzodioxin affects the expression of MBL2 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:735547 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of MBL2 mRNA | CTD | PMID:11489354 PMID:20106945 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:731472 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of MBL2 mRNA | CTD | PMID:16120747 | 2-acetamidofluorene | increases expression | ISO | RGD:731472 | 6480464 | 2-Acetylaminofluorene results in increased expression of MBL2 mRNA | CTD | PMID:21607683 | 3,3',4,4',5-pentachlorobiphenyl | increases expression | ISO | RGD:735547 | 6480464 | 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of MBL2 mRNA | CTD | PMID:19692669 | 3,3',4,4'-tetrachlorobiphenyl | multiple interactions | ISO | RGD:731472 | 6480464 | 3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of MBL2 mRNA] | CTD | PMID:19467301 | 3H-1,2-dithiole-3-thione | decreases expression | EXP | | 6480464 | 1,2-dithiol-3-thione results in decreased expression of MBL2 mRNA | CTD | PMID:19162173 | 4,4'-diaminodiphenylmethane | increases expression | ISO | RGD:731472 | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of MBL2 mRNA | CTD | PMID:18648102 | aflatoxin B1 | affects expression | ISO | RGD:735547 | 6480464 | Aflatoxin B1 affects the expression of MBL2 protein | CTD | PMID:20106945 | aflatoxin B1 | decreases expression | ISO | RGD:735547 | 6480464 | Aflatoxin B1 results in decreased expression of MBL2 mRNA | CTD | PMID:22100608 | all-trans-retinol | multiple interactions | ISO | RGD:735547 | 6480464 | MBL2 gene polymorphism affects the susceptibility to [Vitamin A co-treated with beta Carotene] | CTD | PMID:16960176 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of MBL2 mRNA | CTD | PMID:16483693 | benzo[a]pyrene | increases expression | ISO | RGD:735547 | 6480464 | Benzo(a)pyrene results in increased expression of MBL2 mRNA | CTD | PMID:20106945 | benzo[a]pyrene | increases expression | ISO | RGD:735547 | 6480464 | Benzo(a)pyrene results in increased expression of MBL2 mRNA | CTD | PMID:20106945 more ... | benzo[a]pyrene | increases expression | ISO | RGD:735547 | 6480464 | Benzo(a)pyrene results in increased expression of MBL2 mRNA | CTD | PMID:20106945 PMID:22316170 | beta-carotene | multiple interactions | ISO | RGD:735547 | 6480464 | MBL2 gene polymorphism affects the susceptibility to [Vitamin A co-treated with beta Carotene] | CTD | PMID:16960176 | clofibrate | multiple interactions | ISO | RGD:731472 | 6480464 | PPARA protein affects the reaction [Clofibrate results in decreased expression of MBL2 mRNA]; more ... | CTD | PMID:17585979 | clofibrate | decreases expression | ISO | RGD:731472 | 6480464 | Clofibrate results in decreased expression of MBL2 mRNA | CTD | PMID:17585979 | clofibric acid | affects expression | EXP | | 6480464 | Clofibric Acid affects the expression of MBL2 mRNA | CTD | PMID:17602206 | copper(2+) sulfate | decreases expression | ISO | RGD:735547 | 6480464 | Copper Sulfate results in decreased expression of MBL2 mRNA | CTD | PMID:19549813 | coumarin | decreases expression | EXP | | 6480464 | coumarin results in decreased expression of MBL2 mRNA | CTD | PMID:18480146 | cyclosporin A | decreases expression | ISO | RGD:735547 | 6480464 | Cyclosporine results in decreased expression of MBL2 mRNA | CTD | PMID:20106945 | cyclosporin A | decreases expression | ISO | RGD:735547 | 6480464 | Cyclosporine results in decreased expression of MBL2 mRNA | CTD | PMID:20106945 PMID:21632981 | dexamethasone | decreases expression | EXP | | 6480464 | Dexamethasone results in decreased expression of MBL2 mRNA | CTD | PMID:20032058 | dexamethasone | multiple interactions | EXP | | 6480464 | Testosterone inhibits the reaction [Dexamethasone results in decreased expression of MBL2 mRNA] | CTD | PMID:20032058 | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of MBL2 gene | CTD | PMID:22079235 | N-nitrosodiethylamine | decreases expression | EXP | | 6480464 | Diethylnitrosamine results in decreased expression of MBL2 mRNA | CTD | PMID:19638242 | N-nitrosodiethylamine | increases expression | ISO | RGD:731472 | 6480464 | Diethylnitrosamine results in increased expression of MBL2 mRNA | CTD | PMID:21607683 | nickel dichloride | affects expression | EXP | | 6480464 | nickel chloride affects the expression of MBL2 mRNA | CTD | PMID:22110744 | paracetamol | multiple interactions | ISO | RGD:731472 | 6480464 | PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MBL2 mRNA] | CTD | PMID:17585979 | paracetamol | affects expression | ISO | RGD:731472 | 6480464 | Acetaminophen affects the expression of MBL2 mRNA | CTD | PMID:17562736 | perfluorooctane-1-sulfonic acid | decreases expression | ISO | RGD:731472 | 6480464 | perfluorooctane sulfonic acid results in decreased expression of MBL2 mRNA | CTD | PMID:19429403 | perfluorooctane-1-sulfonic acid | decreases expression | ISO | RGD:731472 | 6480464 | perfluorooctane sulfonic acid results in decreased expression of MBL2 mRNA | CTD | PMID:19429403 PMID:20936131 | perfluorooctanoic acid | decreases expression | ISO | RGD:731472 | 6480464 | perfluorooctanoic acid results in decreased expression of MBL2 mRNA | CTD | PMID:19429403 PMID:18467677 | perfluorooctanoic acid | decreases expression | ISO | RGD:731472 | 6480464 | perfluorooctanoic acid results in decreased expression of MBL2 mRNA | CTD | PMID:18467677 more ... | perfluorooctanoic acid | decreases expression | ISO | RGD:731472 | 6480464 | perfluorooctanoic acid results in decreased expression of MBL2 mRNA | CTD | PMID:18467677 PMID:19429403 | perfluorooctanoic acid | multiple interactions | ISO | RGD:731472 | 6480464 | PPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of MBL2 mRNA] | CTD | PMID:18467677 | perfluorooctanoic acid | decreases expression | EXP | | 6480464 | perfluorooctanoic acid results in decreased expression of MBL2 mRNA | CTD | PMID:19162173 | phorbol 13-acetate 12-myristate | multiple interactions | ISO | RGD:735547 | 6480464 | [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of MBL2 mRNA | CTD | PMID:16979875 | pirinixic acid | multiple interactions | ISO | RGD:735547 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MBL2 mRNA | CTD | PMID:19710929 | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of MBL2 mRNA | CTD | PMID:19162173 | pirinixic acid | multiple interactions | ISO | RGD:731472 | 6480464 | PPARA protein promotes the reaction [pirinixic acid results in decreased expression of MBL2 mRNA] | CTD | PMID:18467677 | pirinixic acid | multiple interactions | ISO | RGD:731472 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of MBL2 mRNA | CTD | PMID:19710929 | pirinixic acid | decreases expression | ISO | RGD:731472 | 6480464 | pirinixic acid results in decreased expression of MBL2 mRNA | CTD | PMID:18467677 | rosiglitazone | decreases expression | EXP | | 6480464 | rosiglitazone results in decreased expression of MBL2 mRNA | CTD | PMID:21515302 | sodium dichromate | decreases expression | ISO | RGD:731472 | 6480464 | sodium bichromate results in decreased expression of MBL2 mRNA | CTD | PMID:22155349 | testosterone | multiple interactions | EXP | | 6480464 | Testosterone inhibits the reaction [Dexamethasone results in decreased expression of MBL2 mRNA] | CTD | PMID:20032058 | troglitazone | decreases expression | EXP | | 6480464 | troglitazone results in decreased expression of MBL2 mRNA | CTD | PMID:21515302 | vincristine | increases response to substance | ISO | RGD:735547 | 6480464 | MBL2 gene SNP results in increased susceptibility to Vincristine | CTD | PMID:20864405 | zinc atom | multiple interactions | ISO | RGD:735547 | 6480464 | [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of MBL2 mRNA | CTD | PMID:16979875 | zinc(0) | multiple interactions | ISO | RGD:735547 | 6480464 | [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of MBL2 mRNA | CTD | PMID:16979875 | | 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Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Complement and coagulation cascades |
| Phagosome | |
| Staphylococcus aureus infection | |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Complement and coagulation cascades |
| Phagosome | |
| Staphylococcus aureus infection | |
References - curated| 1. |
Ampel NM, etal., Mycopathologia. 2009 Apr;167(4):173-80. Epub 2008 Dec 14. |
| 2. |
Biezeveld MH, etal., Arthritis Rheum. 2006 Jan;54(1):369-76. |
| 3. |
Capparelli R, etal., J Infect Dis. 2009 Mar 1;199(5):666-72. |
| 4. |
Cedzynski M, etal., Mol Immunol. 2009 Dec;47(2-3):415-9. Epub 2009 Sep 19. |
| 5. |
Cervera C, etal., Transplant Proc. 2009 Jul-Aug;41(6):2259-61. |
| 6. |
Chen CB and Wallis R, J Biol Chem. 2001 Jul 13;276(28):25894-902. Epub 2001 May 3. |
| 7. |
Chen J, etal., Eur J Pediatr. 2009 Nov;168(11):1305-13. Epub 2009 Jan 24. |
| 8. |
Cheung YF, etal., Pediatr Res. 2004 Oct;56(4):591-6. Epub 2004 Aug 4. |
| 9. |
Crosdale DJ, etal., J Infect Dis. 2001 Sep 1;184(5):653-6. Epub 2001 Jul 24. |
| 10. |
Cui YH, etal., Rhinology. 2009 Jun;47(2):187-91. |
| 11. |
de Vries B, etal., Am J Pathol. 2004 Nov;165(5):1677-88. |
| 12. |
Drickamer K, etal., J Biol Chem 1986 May 25;261(15):6878-87. |
| 13. |
Endeman H, etal., Chest. 2008 Dec;134(6):1135-40. Epub 2008 Jul 18. |
| 14. |
Fernandez-Real JM, etal., Diabetologia. 2006 Oct;49(10):2402-11. Epub 2006 Aug 29. |
| 15. |
Fidler KJ, etal., Thorax. 2009 Feb;64(2):150-5. Epub 2008 Nov 6. |
| 16. |
Font J, etal., Rheumatology (Oxford). 2007 Jan;46(1):76-80. Epub 2006 Jun 26. |
| 17. |
Garcia-Laorden MI, etal., J Allergy Clin Immunol. 2008 Aug;122(2):368-74, 374.e1-2. Epub 2008 Jun 25. |
| 18. |
Garred P, etal., J Clin Invest. 1999 Aug;104(4):431-7. |
| 19. |
GOA data from the GO Consortium |
| 20. |
Gong MN, etal., Crit Care Med. 2007 Jan;35(1):48-56. |
| 21. |
Gregersen S, etal., Ann Allergy Asthma Immunol. 2010 Jun;104(6):503-10. |
| 22. |
Hodge S, etal., Am J Respir Cell Mol Biol. 2010 Feb;42(2):235-42. Epub 2009 May 1. |
| 23. |
Inanc N, etal., J Rheumatol. 2005 Feb;32(2):287-91. |
| 24. |
Ip WK, etal., J Infect Dis. 2005 May 15;191(10):1697-704. Epub 2005 Apr 11. |
| 25. |
Kuroki Y, etal., FEBS Lett. 1997 Sep 8;414(2):387-92. |
| 26. |
Lanzrein AS, etal., Neuroreport. 1998 May 11;9(7):1491-5. |
| 27. |
Lee RT, etal., Biosci Rep. 1999 Aug;19(4):283-92. |
| 28. |
Lin CL, etal., Chest. 2010 Aug 5. |
| 29. |
Litzman J, etal., Clin Exp Immunol. 2008 Sep;153(3):324-30. Epub 2008 Jul 11. |
| 30. |
McDougal KE, etal., Eur J Hum Genet. 2010 Jun;18(6):680-4. Epub 2010 Jan 13. |
| 31. |
MGD data from the GO Consortium |
| 32. |
Miranda KA, etal., Braz J Med Biol Res. 2009 Apr;42(4):353-7. |
| 33. |
Moller-Kristensen M, etal., Scand J Immunol. 2005 May;61(5):426-34. |
| 34. |
Muhlebach MS, etal., Clin Exp Immunol. 2006 Aug;145(2):302-7. |
| 35. |
Mullighan CG, etal., Scand J Immunol. 2000 Feb;51(2):111-22. |
| 36. |
Munster JM, etal., Transplantation. 2008 Dec 27;86(12):1857-63. |
| 37. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 38. |
Ned RM, etal., BMC Med Genet. 2010 Nov 5;11:155. |
| 39. |
Ng KK and Weis WI, Biochemistry. 1998 Dec 22;37(51):17977-89. |
| 40. |
Ng KK, etal., J Biol Chem. 1996 Jan 12;271(2):663-74. |
| 41. |
Nisihara RM, etal., Hum Immunol. 2010 Jan;71(1):63-6. Epub . |
| 42. |
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| 43. |
Oka S, etal., J Biochem (Tokyo) 1987 Jan;101(1):135-44. |
| 44. |
Olivo-Marston SE, etal., Cancer Epidemiol Biomarkers Prev. 2009 Dec;18(12):3375-83. |
| 45. |
Park KS, etal., Tissue Antigens. 2005 Mar;65(3):260-5. |
| 46. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 47. |
RGD automated data pipeline |
| 48. |
RGD automated import pipeline for gene-chemical interactions |
| 49. |
RGD Automated Pipelines |
| 50. |
Roy S, etal., Lancet. 2002 May 4;359(9317):1569-73. |
| 51. |
Rugonfalvi-Kiss S, etal., Stroke. 2005 May;36(5):944-8. Epub 2005 Mar 24. |
| 52. |
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| 53. |
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| 56. |
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References - uncurated| PubMed | 1607365 |
RGD Disease Portals| Mbl2 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Mbl2 (Rattus norvegicus) |
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| MBL2 (Homo sapiens) |
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| Mbl2 (Mus musculus) |
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Position Markers| AA893453 |
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| D11440 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_022704 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06010508 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01000048 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY325174 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY325178 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473953 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ210356 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M14103 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X05023 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_022704 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_073195 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_073195 | (Get FASTA) |
| GenBank Protein | AAA41554 | (Get FASTA) |
| AAP92575 | (Get FASTA) | |
| AAP92579 | (Get FASTA) | |
| CAA28687 | (Get FASTA) | |
| EDM13116 | (Get FASTA) | |
| EDM13117 | (Get FASTA) | |
| EDM13118 | (Get FASTA) | |
| P08661 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000011637 | UniProtKB/TrEMBL |
| ENSRNOG00000050305 | UniProtKB/Swiss-Prot | |
| Ensembl Protein | ENSRNOP00000047103 | UniProtKB/TrEMBL |
| ENSRNOP00000064876 | UniProtKB/Swiss-Prot | |
| Ensembl Transcript | ENSRNOT00000050984 | UniProtKB/TrEMBL |
| ENSRNOT00000072188 | UniProtKB/Swiss-Prot | |
| Entrez Gene | 64668 | ENTREZGENE |
| Gene3D-CATH | C-type_lectin-like | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000011637 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 110436 | ENTREZGENE |
| InterPro | C-type_lectin | UniProtKB/Swiss-Prot |
| C-type_lectin-like | UniProtKB/Swiss-Prot | |
| C-type_lectin_CS | UniProtKB/Swiss-Prot | |
| C-type_lectin_fold | UniProtKB/Swiss-Prot | |
| Collagen | UniProtKB/Swiss-Prot | |
| IPI | IPI00382128 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:100911854 | UniProtKB/Swiss-Prot |
| rno:64668 | ENTREZGENE, UniProtKB/Swiss-Prot | |
| Pfam | Collagen | UniProtKB/Swiss-Prot |
| Lectin_C | UniProtKB/Swiss-Prot | |
| PROSITE | C_TYPE_LECTIN_1 | UniProtKB/Swiss-Prot |
| C_TYPE_LECTIN_2 | UniProtKB/Swiss-Prot | |
| SMART | CLECT | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | C-type_lectin_fold | UniProtKB/Swiss-Prot |
| UniGene | Rn.9667 | ENTREZGENE |
| UniProt | MBL2_RAT | UniProtKB/Swiss-Prot |
| Q7TMC0_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2009-02-26 | Mbl2 | mannose-binding lectin (protein C) 2 | Mbl2 | mannose binding lectin 2 (protein C) | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2006-03-30 | Mbl2 | mannose binding lectin 2 (protein C) | mannose binding lectin 2, protein C | Name updated | 10779 | APPROVED | |
| 2005-09-12 | Mbl1 | mannose binding lectin 2, protein C | Mbl2 | mannose-binding protein C (liver) | Name updated | 10779 | APPROVED |
| 2002-06-10 | Mbl2 | Symbol and Name status set to approved | 1490 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_domains | contains a NH2-terminal cysteine rich region, a collagen-like domain and a COOH-terminal carbohydrate-binding domain | 633272 |
| More on Mbl2 | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 67380 |
| Created: | 2001-06-01 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




