Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | AQP4 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | PMID:28492532 | intellectual disability | | ISO | AQP4 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Intellectual disability | ClinVar | | Megalencephalic Leukoencephalopathy with Subcortical Cysts 4 | | ISO | AQP4 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Megalencephalic leukoencephalopathy with subcortical cysts 4 and remitting | ClinVar | PMID:25741868 and PMID:37143309 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
 |
Welcome {{ username}}
Message Center
{{ messageCount }} Messages
Watched Genes
{{$index + 1}}. {{ watchedObject.symbol }} (RGD ID:{{watchedObject.rgdId}})
Watched Ontology Terms
{{gene.symbol}}: {{ gene.description }}
|
| You must be logged in to use this feature |
| {{ loginError }} |
|
|
Analyze GeneStrainQTL List |
 Gene Annotator (Functional Annotation) unavailable |
 Gene Annotator (Annotation Distribution) unavailable |
 Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable |
Gene Annotator (Functional Annotation) |
Gene Annotator (Annotation Distribution) |
Variant Visualizer (Genomic Variants) |
 InterViewer (Protein-Protein Interactions) unavailable |
 Gviewer (Genome Viewer) unavailable |
 Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable |
InterViewer (Protein-Protein Interactions) |
GViewer (Genome Viewer) |
Variant Visualizer (Damaging Variants) |
 Gene Annotator (Annotation Comparison) unavailable |
 OLGA (Gene List Generator) unavailable |
 |
Gene Annotator (Annotation Comparison) |
OLGA (Gene List Generator) |
Excel (Download) |
 MOET (Multi-Ontology Enrichement) unavailable |
 GOLF (Gene-Ortholog Location Finder) unavailable |
|
MOET (Multi-Ontology Enrichement) |
GOLF (Gene-Ortholog Location Finder) |
|
||||||||||
Imported Disease Annotations - CTD
Imported Disease Annotations - MGI
Imported Disease Annotations - OMIM
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Gene Ontology Annotations Click to see Annotation Detail View
Biological Process
Cellular Component
Molecular Function
Molecular Pathway Annotations Click to see Annotation Detail View
RGD Manual Annotations
Imported Annotations - KEGG (archival)
Phenotype Annotations Click to see Annotation Detail View
Mammalian Phenotype
Disease Annotations
Click to see Annotation Detail View
Gene-Chemical Interaction Annotations
Click to see Annotation Detail View
|
|
|
Gene Ontology Annotations
Click to see Annotation Detail View
Biological Process
|
|
|
Cellular Component
|
|
|
Molecular Function
|
|
Molecular Pathway Annotations
Click to see Annotation Detail View
|
|
Phenotype Annotations
Click to see Annotation Detail View
References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Quantitation of brain edema and localisation of aquaporin 4 expression in relation to susceptibility to experimental cerebral malaria. | Ampawong S, etal., Int J Clin Exp Pathol. 2011 Aug 15;4(6):566-74. Epub 2011 Jul 23. |
| 2. | Hypoalgesia in mice lacking aquaporin-4 water channels. | Bao F, etal., Brain Res Bull. 2010 Nov 20;83(6):298-303. doi: 10.1016/j.brainresbull.2010.08.015. Epub 2010 Sep 22. |
| 3. | Changes in the astrocytic aquaporin-4 and inwardly rectifying potassium channel expression in the brain of the amyotrophic lateral sclerosis SOD1(G93A) rat model. | Bataveljic D, etal., Glia. 2012 Dec;60(12):1991-2003. doi: 10.1002/glia.22414. Epub 2012 Sep 14. |
| 4. | An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes. | Benfenati V, etal., Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2563-8. doi: 10.1073/pnas.1012867108. Epub 2011 Jan 24. |
| 5. | Urinary concentrating defect in hypothyroid rats: role of sodium, potassium, 2-chloride co-transporter, and aquaporins. | Cadnapaphornchai MA, etal., J Am Soc Nephrol 2003 Mar;14(3):566-74. |
| 6. | [The effects of ketamine pretreated on cerebral edema and AQP4 expression after transient focal cerebral ischemia/reperfusion in rats]. | Cai SN and Zhu SM, Zhonghua Yi Xue Za Zhi. 2010 Jun 15;90(23):1648-51. |
| 7. | Molecular analysis of aquaporin genes 1 to 4 in patients with Meniere's disease. | Candreia C, etal., Cell Physiol Biochem. 2010;26(4-5):787-92. doi: 10.1159/000322346. Epub 2010 Oct 29. |
| 8. | Aquaporin-4 water channel expression by thymoma of patients with and without myasthenia gravis. | Chan KH, etal., J Neuroimmunol. 2010 Oct 8;227(1-2):178-84. Epub 2010 Aug 21. |
| 9. | Novel role of aquaporin-4 in CD4+ CD25+ T regulatory cell development and severity of Parkinson's disease. | Chi Y, etal., Aging Cell. 2011 Jun;10(3):368-82. doi: 10.1111/j.1474-9726.2011.00677.x. Epub 2011 Mar 22. |
| 10. | Age-related hearing loss: aquaporin 4 gene expression changes in the mouse cochlea and auditory midbrain. | Christensen N, etal., Brain Res. 2009 Feb 9;1253:27-34. doi: 10.1016/j.brainres.2008.11.070. Epub 2008 Dec 3. |
| 11. | Aquaporin 4 knockdown exacerbates streptozotocin-induced diabetic retinopathy through aggravating inflammatory response. | Cui B, etal., Exp Eye Res. 2012 May;98:37-43. doi: 10.1016/j.exer.2012.02.013. Epub 2012 Mar 16. |
| 12. | Alleviation of brain injury by applying TGN-020 in the supraoptic nucleus via inhibiting vasopressin neurons in rats of focal ischemic stroke. | Cui D, etal., Life Sci. 2021 Jan 1;264:118683. doi: 10.1016/j.lfs.2020.118683. Epub 2020 Oct 28. |
| 13. | Anti-aquaporin-4 antibodies in the context of assorted immune-mediated diseases. | Dellavance A, etal., Eur J Neurol. 2011 Jul 19. doi: 10.1111/j.1468-1331.2011.03479.x. |
| 14. | Changes in ocular aquaporin-4 (AQP4) expression following retinal injury. | Dibas A, etal., Mol Vis. 2008 Sep 25;14:1770-83. |
| 15. | Changes in ocular aquaporin expression following optic nerve crush. | Dibas A, etal., Mol Vis. 2010 Mar 3;16:330-40. |
| 16. | Brain expression of the water channels Aquaporin-1 and -4 in mice with acute liver injury, hyperammonemia and brain edema. | Eefsen M, etal., Metab Brain Dis. 2010 Sep;25(3):315-23. Epub 2010 Oct 12. |
| 17. | Anti-aquaporin-4 IgG in Patients Presenting with Unilateral Optic Neuritis: A Cohort Study. | Etemadifar M, etal., Int J Prev Med. 2012 Sep;3(9):612-5. |
| 18. | Altered expression of aquaporins 1 and 4 coincides with neurodegenerative events in retinas of spontaneously diabetic Torii rats. | Fukuda M, etal., Exp Eye Res. 2010 Jan;90(1):17-25. Epub 2009 Sep 11. |
| 19. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 20. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
| 21. | Temporal profiles of aquaporin 4 expression and astrocyte response in the process of brain damage in fat embolism model in rats. | Gohara T, etal., J Anesth. 2010 Apr;24(2):225-33. Epub 2010 Jan 29. |
| 22. | Aquaporin-11: a channel protein lacking apparent transport function expressed in brain. | Gorelick DA, etal., BMC Biochem. 2006 May 1;7:14. |
| 23. | Rapamycin alleviates brain edema after focal cerebral ischemia reperfusion in rats. | Guo W, etal., Immunopharmacol Immunotoxicol. 2014 Jun;36(3):211-23. doi: 10.3109/08923973.2014.913616. Epub 2014 Apr 29. |
| 24. | Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues. | Hasegawa H, etal., J Biol Chem 1994 Feb 25;269(8):5497-500. |
| 25. | Variants of the genes encoding AQP4 and Kir4.1 are associated with subgroups of patients with temporal lobe epilepsy. | Heuser K, etal., Epilepsy Res. 2010 Jan;88(1):55-64. Epub 2009 Oct 28. |
| 26. | Implications of the aquaporin-4 structure on array formation and cell adhesion. | Hiroaki Y, etal., J Mol Biol. 2006 Jan 27;355(4):628-39. doi: 10.1016/j.jmb.2005.10.081. Epub 2005 Nov 17. |
| 27. | Retinal ectopias and mechanically weakened basement membrane in a mouse model of muscle-eye-brain (MEB) disease congenital muscular dystrophy. | Hu H, etal., Mol Vis. 2010 Jul 28;16:1415-28. |
| 28. | The relationship between aquaporin-4 expression and blood-brain and spinal cord barrier permeability following experimental autoimmune encephalomyelitis in the rat. | Huang XN, etal., Anat Rec (Hoboken). 2011 Jan;294(1):46-54. doi: 10.1002/ar.21286. Epub 2010 Nov 12. |
| 29. | Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. | Igarashi H, etal., Neurol Sci. 2011 Feb;32(1):113-6. Epub 2010 Oct 6. |
| 30. | Immunohistochemical localization and mRNA expression of aquaporins in the macula utriculi of patients with Meniere's disease and acoustic neuroma. | Ishiyama G, etal., Cell Tissue Res. 2010 Jun;340(3):407-19. doi: 10.1007/s00441-010-0975-7. Epub 2010 May 12. |
| 31. | Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance. | Jung JS, etal., Proc Natl Acad Sci U S A 1994 Dec 20;91(26):13052-6. |
| 32. | Aquaporin-4 water channel oligomers are associated with the transverse tubules of skeletal myofibers. | Kaakinen M, etal., Exp Cell Res. 2011 Jan 1;317(1):20-8. Epub 2010 Sep 21. |
| 33. | Relationship between NMO-antibody and anti-MOG antibody in optic neuritis. | Kezuka T, etal., J Neuroophthalmol. 2012 Jun;32(2):107-10. doi: 10.1097/WNO.0b013e31823c9b6c. |
| 34. | Decreased hemispheric Aquaporin-4 is linked to evolving brain edema following controlled cortical impact injury in rats. | Kiening KL, etal., Neurosci Lett 2002 May 17;324(2):105-8. |
| 35. | Astroglial loss and edema formation in the rat piriform cortex and hippocampus following pilocarpine-induced status epilepticus. | Kim JE, etal., J Comp Neurol. 2010 Nov 15;518(22):4612-28. |
| 36. | Protective role of aquaporin-4 water channels after contusion spinal cord injury. | Kimura A, etal., Ann Neurol. 2010 Jun;67(6):794-801. |
| 37. | Longitudinally extensive transverse myelitis with and without aquaporin 4 antibodies. | Kitley J, etal., JAMA Neurol. 2013 Nov;70(11):1375-81. doi: 10.1001/jamaneurol.2013.3890. |
| 38. | High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. | Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7 |
| 39. | Aquaporins in the kidney. | Kwon TH, etal., Handb Exp Pharmacol. 2009;(190):95-132. doi: 10.1007/978-3-540-79885-9_5. |
| 40. | Decreased expression of the glial water channel aquaporin-4 in the intrahippocampal kainic acid model of epileptogenesis. | Lee DJ, etal., Exp Neurol. 2012 May;235(1):246-55. doi: 10.1016/j.expneurol.2012.02.002. Epub 2012 Feb 14. |
| 41. | IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. | Lennon VA, etal., J Exp Med. 2005 Aug 15;202(4):473-7. Epub 2005 Aug 8. |
| 42. | Downregulation of renal aquaporins in response to unilateral ureteral obstruction. | Li C, etal., Am J Physiol Renal Physiol 2003 May;284(5):F1066-79. |
| 43. | Impaired hearing in mice lacking aquaporin-4 water channels. | Li J and Verkman AS, J Biol Chem 2001 Aug 17;276(33):31233-7. Epub 2001 Jun 13. |
| 44. | Greatly attenuated experimental autoimmune encephalomyelitis in aquaporin-4 knockout mice. | Li L, etal., BMC Neurosci. 2009 Aug 6;10:94. |
| 45. | [A aquaporin 4 expression and effects in rat hippocampus after microwave radiation]. | Li X, etal., Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2009 Sep;27(9):534-8. |
| 46. | The Involvement of Aquaporin-4 in the Interstitial Fluid Drainage Impairment Following Subarachnoid Hemorrhage. | Liu E, etal., Front Aging Neurosci. 2021 Jan 26;12:611494. doi: 10.3389/fnagi.2020.611494. eCollection 2020. |
| 47. | Arginine-vasopressin V1 but not V2 receptor antagonism modulates infarct volume, brain water content, and aquaporin-4 expression following experimental stroke. | Liu X, etal., Neurocrit Care. 2010 Feb;12(1):124-31. |
| 48. | Calcitonin gene-related peptide prevents blood-brain barrier injury and brain edema induced by focal cerebral ischemia reperfusion. | Liu Z, etal., Regul Pept. 2011 Nov 10;171(1-3):19-25. Epub 2011 Jun 28. |
| 49. | [The effect of AQP4 gene on the activation of retinal glial cells in chronic high intraocular pressure mice]. | Luo SS, etal., Zhonghua Yan Ke Za Zhi. 2012 Jul;48(7):598-603. |
| 50. | Preliminary study on the association of AQP4 promoter polymorphism with anti-aquaporin-4 antibody positivity in southern Han Chinese patients with idiopathic demyelinating disorders of central nervous system. | Mai W, etal., J Neuroimmunol. 2013 Feb 15;255(1-2):75-80. doi: 10.1016/j.jneuroim.2012.10.004. Epub 2012 Oct 29. |
| 51. | Sulphoraphane enhances aquaporin-4 expression and decreases spinal cord oedema following spinal cord injury. | Mao L, etal., Brain Inj. 2011;25(3):300-6. Epub 2011 Jan 31. |
| 52. | Aquaporin 4 regulation during acute and long-term experimental Herpes simplex virus encephalitis. | Martinez Torres FJ, etal., J Neurovirol. 2007;13(1):38-46. |
| 53. | Aquaporin-4 astrocytopathy in Balo's disease. | Matsuoka T, etal., Acta Neuropathol. 2010 Nov;120(5):651-60. Epub 2010 Aug 3. |
| 54. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
| 55. | Aquaporin expression in the brains of patients with or without cerebral amyloid angiopathy. | Moftakhar P, etal., J Neuropathol Exp Neurol. 2010 Dec;69(12):1201-9. |
| 56. | Aquaporin expression in blood-retinal barrier cells during experimental autoimmune uveitis. | Motulsky E, etal., Mol Vis. 2010 Apr 3;16:602-10. |
| 57. | Relative CO2/NH3 selectivities of AQP1, AQP4, AQP5, AmtB, and RhAG. | Musa-Aziz R, etal., Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5406-11. doi: 10.1073/pnas.0813231106. Epub 2009 Mar 9. |
| 58. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 59. | Compensatory increase in AQP2, p-AQP2, and AQP3 expression in rats with diabetes mellitus. | Nejsum LN, etal., Am J Physiol Renal Physiol 2001 Apr;280(4):F715-26. |
| 60. | Functional requirement of aquaporin-5 in plasma membranes of sweat glands. | Nejsum LN, etal., Proc Natl Acad Sci U S A 2002 Jan 8;99(1):511-516. |
| 61. | Transcriptional profiling of spinal cord injury-induced central neuropathic pain. | Nesic O, etal., J Neurochem. 2005 Nov;95(4):998-1014. Epub 2005 Oct 10. |
| 62. | Aquaporin 1 - a novel player in spinal cord injury. | Nesic O, etal., J Neurochem. 2008 May;105(3):628-40. Epub 2008 Jan 28. |
| 63. | Aquaporin-4 overexpression in rat ALS model. | Nicaise C, etal., Anat Rec (Hoboken). 2009 Feb;292(2):207-13. |
| 64. | Higher order structure of aquaporin-4. | Nicchia GP, etal., Neuroscience. 2010 Jul 28;168(4):903-14. Epub 2010 Feb 11. |
| 65. | Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis. | Papadopoulos MC and Verkman AS, J Biol Chem. 2005 Apr 8;280(14):13906-12. Epub 2005 Feb 4. |
| 66. | Expression of aquaporin 1 and 4 in a congenital hydrocephalus rat model. | Paul L, etal., Neurosurgery. 2011 Feb;68(2):462-73. |
| 67. | Experimental autoimmune encephalomyelitis (EAE) IN C57Bl/6 mice is not associated with astrogliosis. | Pham H, etal., J Neuroimmunol. 2011 Mar;232(1-2):51-62. Epub 2010 Nov 6. |
| 68. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
| 69. | Evidence of aquaporin involvement in human central pontine myelinolysis. | Popescu BF, etal., Acta Neuropathol Commun. 2013 Jul 25;1(1):40. doi: 10.1186/2051-5960-1-40. |
| 70. | Loss of AQP4 polarized localization with loss of beta-dystroglycan immunoreactivity may induce brain edema following intracerebral hemorrhage. | Qiu GP, etal., Neurosci Lett. 2015 Feb 19;588:42-8. doi: 10.1016/j.neulet.2014.12.053. Epub 2014 Dec 27. |
| 71. | Brain aquaporin-4 in experimental acute liver failure. | Rama Rao KV, etal., J Neuropathol Exp Neurol. 2010 Sep;69(9):869-79. |
| 72. | Involvement of antibody-dependent cell-mediated cytotoxicity in inflammatory demyelination in a mouse model of neuromyelitis optica. | Ratelade J, etal., Acta Neuropathol. 2013 Nov;126(5):699-709. doi: 10.1007/s00401-013-1172-z. Epub 2013 Aug 31. |
| 73. | Effects of intravitreal triamcinolone acetonide on retinal gene expression in a rat model of central retinal vein occlusion. | Rehak M, etal., Graefes Arch Clin Exp Ophthalmol. 2011 Aug;249(8):1175-83. Epub 2011 Apr 13. |
| 74. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 75. | Supramolecular aggregation of aquaporin-4 is different in muscle and brain: correlation with tissue susceptibility in neuromyelitis optica. | Rosito S, etal., J Cell Mol Med. 2018 Feb;22(2):1236-1246. doi: 10.1111/jcmm.13401. Epub 2017 Oct 20. |
| 76. | Effects of estradiol on ischemic factor-induced astrocyte swelling and AQP4 protein abundance. | Rutkowsky JM, etal., Am J Physiol Cell Physiol. 2011 Jul;301(1):C204-12. Epub 2011 Apr 6. |
| 77. | Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice. | Saadoun S, etal., Brain. 2010 Feb;133(Pt 2):349-61. Epub 2010 Jan 4. |
| 78. | [Deficiency of water channel AQP4 aggravates NMDA-induced brain injury in mice]. | Shi WZ, etal., Zhejiang Da Xue Xue Bao Yi Xue Ban. 2011 Mar;40(2):145-9. |
| 79. | Expression of aquaporin 1 and aquaporin 4 water channels in rat choroid plexus. | Speake T, etal., Biochim Biophys Acta 2003 Jan 10;1609(1):80-6. |
| 80. | Intractable hiccup and nausea in neuromyelitis optica with anti-aquaporin-4 antibody: a herald of acute exacerbations. | Takahashi T, etal., J Neurol Neurosurg Psychiatry. 2008 Sep;79(9):1075-8. doi: 10.1136/jnnp.2008.145391. Epub 2008 Apr 17. |
| 81. | Select types of supporting cell in the inner ear express aquaporin-4 water channel protein. | Takumi Y, etal., Eur J Neurosci. 1998 Dec;10(12):3584-95. |
| 82. | Anti-aquaporin 4 antibody in selected Japanese multiple sclerosis patients with long spinal cord lesions. | Tanaka K, etal., Mult Scler. 2007 Aug;13(7):850-5. Epub 2007 Apr 27. |
| 83. | Anti-aquaporin 4 antibody in Japanese multiple sclerosis: the presence of optic spinal multiple sclerosis without long spinal cord lesions and anti-aquaporin 4 antibody. | Tanaka M, etal., J Neurol Neurosurg Psychiatry. 2007 Sep;78(9):990-2. |
| 84. | Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. | Thrane AS, etal., Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):846-51. Epub 2010 Dec 27. |
| 85. | [Changes of VEGF and AQPs gene and protein expression in rat brain tissue during hypoxic encephaledema]. | Tian YM, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2011 Feb;27(1):7-11. |
| 86. | Expression of aquaporins 1 and 4 in the brain of spontaneously hypertensive rats. | Tomassoni D, etal., Brain Res. 2010 Apr 14;1325:155-63. Epub 2010 Feb 12. |
| 87. | Effect of decompressive craniectomy on aquaporin-4 expression after lateral fluid percussion injury in rats. | Tomura S, etal., J Neurotrauma. 2011 Feb;28(2):237-43. |
| 88. | Anti-aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica. | Tradtrantip L, etal., Ann Neurol. 2012 Mar;71(3):314-22. doi: 10.1002/ana.22657. Epub 2012 Jan 23. |
| 89. | Beneficial effect of agmatine on brain apoptosis, astrogliosis, and edema after rat transient cerebral ischemia. | Wang CC, etal., BMC Pharmacol. 2010 Sep 6;10:11. doi: 10.1186/1471-2210-10-11. |
| 90. | 2-Methoxyestradiol inhibits the up-regulation of AQP4 and AQP1 expression after spinal cord injury. | Wang YF, etal., Brain Res. 2011 Jan 25;1370:220-6. Epub 2010 Nov 16. |
| 91. | Regional expression of aquaporin 1, 4, and 9 in the brain during pregnancy. | Wiegman MJ, etal., Reprod Sci. 2008 May;15(5):506-16. |
| 92. | Role of aquaporin-4 in the development of brain oedema in liver failure. | Wright G, etal., J Hepatol. 2010 Jul;53(1):91-7. Epub 2010 Apr 1. |
| 93. | Time course of upregulation of inflammatory mediators in the hemorrhagic brain in rats: correlation with brain edema. | Wu H, etal., Neurochem Int. 2010 Oct;57(3):248-53. Epub 2010 Jun 10. |
| 94. | Myelin oligodendrocyte glycoprotein induces aquaporin-4 autoantibodies in mouse experimental autoimmune encephalomyelitis. | Wu X, etal., J Neuroimmunol. 2013 Aug 15;261(1-2):1-6. doi: 10.1016/j.jneuroim.2013.03.008. Epub 2013 May 22. |
| 95. | Water permeability and characterization of aquaporin-11. | Yakata K, etal., J Struct Biol. 2011 May;174(2):315-20. doi: 10.1016/j.jsb.2011.01.003. Epub 2011 Jan 18. |
| 96. | Clinical features and sera anti-aquaporin 4 antibody positivity in patients with demyelinating disorders of the central nervous system from Tianjin, China. | Yang CS, etal., CNS Neurosci Ther. 2014 Jan;20(1):32-9. doi: 10.1111/cns.12156. Epub 2013 Jul 27. |
| 97. | Temporal changes in expression of aquaporin-3, -4, -5 and -8 in rat brains after permanent focal cerebral ischemia. | Yang M, etal., Brain Res. 2009 Sep 22;1290:121-32. Epub 2009 Jul 16. |
| 98. | Differential Regulations of AQP4 and Kir4.1 by Triamcinolone Acetonide and Dexamethasone in the Healthy and Inflamed Retina. | Zhao M, etal., Invest Ophthalmol Vis Sci. 2011 Aug 11;52(9):6340-7. Print 2011 Sep. |
| 99. | Favorable effects of MMP-9 knockdown in murine herpes simplex encephalitis using small interfering RNA. | Zhou Y, etal., Neurol Res. 2010 Oct;32(8):801-9. doi: 10.1179/016164110X12644252260556. Epub 2010 May 18. |
Additional References at PubMed
| PMID:1373524 | PMID:1510932 | PMID:7530250 | PMID:8601457 | PMID:8660998 | PMID:9369468 | PMID:9405233 | PMID:9806845 | PMID:9829975 | PMID:10021464 | PMID:10318966 | PMID:10510269 |
| PMID:10564231 | PMID:10613915 | PMID:10662735 | PMID:10795927 | PMID:11001937 | PMID:11034202 | PMID:11076974 | PMID:11573934 | PMID:11717465 | PMID:11726686 | PMID:12034763 | PMID:12081649 |
| PMID:12084581 | PMID:12359252 | PMID:12504879 | PMID:12650429 | PMID:12673830 | PMID:12692561 | PMID:12944406 | PMID:14627352 | PMID:14663195 | PMID:14701836 | PMID:14752829 | PMID:14753448 |
| PMID:15010203 | PMID:15090052 | PMID:15149973 | PMID:15466140 | PMID:15488478 | PMID:15948717 | PMID:16103109 | PMID:16461188 | PMID:16582023 | PMID:16596446 | PMID:16641100 | PMID:16646408 |
| PMID:16814974 | PMID:16895520 | PMID:16987239 | PMID:16997459 | PMID:17178220 | PMID:17184078 | PMID:17266129 | PMID:17356517 | PMID:17416972 | PMID:17566653 | PMID:17593398 | PMID:17622964 |
| PMID:17645239 | PMID:17970725 | PMID:18179769 | PMID:18202181 | PMID:18206860 | PMID:18255256 | PMID:18284610 | PMID:18286643 | PMID:18392839 | PMID:18487486 | PMID:18501347 | PMID:18510734 |
| PMID:18511455 | PMID:18572411 | PMID:18649401 | PMID:18718702 | PMID:18762715 | PMID:18951883 | PMID:19114109 | PMID:19170255 | PMID:19229993 | PMID:19236167 | PMID:19240114 | PMID:19285541 |
| PMID:19297454 | PMID:19383790 | PMID:19406128 | PMID:19429018 | PMID:19451651 | PMID:19596320 | PMID:19705963 | PMID:19800950 | PMID:19831719 | PMID:19843522 | PMID:19843787 | PMID:19928950 |
| PMID:19948131 | PMID:19962432 | PMID:20017335 | PMID:20026178 | PMID:20071343 | PMID:20109536 | PMID:20461024 | PMID:20484841 | PMID:20617879 | PMID:20625331 | PMID:20709083 | PMID:20806048 |
| PMID:20877385 | PMID:21178974 | PMID:21204635 | PMID:21208160 | PMID:21212277 | PMID:21468722 | PMID:21519634 | PMID:21621589 | PMID:21682559 | PMID:21700703 | PMID:21705333 | PMID:21713710 |
| PMID:21850708 | PMID:22011386 | PMID:22069320 | PMID:22146847 | PMID:22322923 | PMID:22381744 | PMID:22420318 | PMID:22528459 | PMID:22554469 | PMID:22590566 | PMID:22610042 | PMID:22676888 |
| PMID:22718347 | PMID:22728101 | PMID:22802001 | PMID:22871113 | PMID:22896675 | PMID:22902770 | PMID:22903516 | PMID:22922737 | PMID:22967487 | PMID:23022607 | PMID:23040263 | PMID:23142737 |
| PMID:23180003 | PMID:23199918 | PMID:23357720 | PMID:23441695 | PMID:23505074 | PMID:23510922 | PMID:23520529 | PMID:23592763 | PMID:23616425 | PMID:23622727 | PMID:23651078 | PMID:24238521 |
| PMID:24282821 | PMID:24657265 | PMID:24817288 | PMID:24828425 | PMID:24912027 | PMID:25013167 | PMID:25146699 | PMID:25223087 | PMID:25231107 | PMID:25373717 | PMID:25441658 | PMID:25479407 |
| PMID:25770057 | PMID:25800444 | PMID:25907740 | PMID:26013827 | PMID:26385393 | PMID:26459070 | PMID:26583111 | PMID:26617791 | PMID:26724742 | PMID:27181510 | PMID:27188736 | PMID:27236300 |
| PMID:27435677 | PMID:27525904 | PMID:27706789 | PMID:27726111 | PMID:27751903 | PMID:27788222 | PMID:27886057 | PMID:27930615 | PMID:28206694 | PMID:28303331 | PMID:28341892 | PMID:28461494 |
| PMID:28549966 | PMID:28567523 | PMID:28572712 | PMID:28826498 | PMID:28978666 | PMID:29057271 | PMID:29066483 | PMID:29178911 | PMID:29351212 | PMID:29520011 | PMID:29921834 | PMID:29956781 |
| PMID:30293570 | PMID:30628716 | PMID:30919512 | PMID:31063681 | PMID:31218751 | PMID:31242419 | PMID:31407064 | PMID:31454080 | PMID:31556577 | PMID:31626131 | PMID:32131375 | PMID:32450187 |
| PMID:32664509 | PMID:32726124 | PMID:32920036 | PMID:32985231 | PMID:33373887 | PMID:33862142 | PMID:33978309 | PMID:33991463 | PMID:34099798 | PMID:34232129 | PMID:34657253 | PMID:35189787 |
| PMID:35961528 | PMID:36036510 | PMID:36115513 | PMID:36195691 | PMID:36293145 | PMID:37208490 | PMID:37316571 | PMID:37351177 | PMID:37357177 | PMID:37992974 | PMID:38237380 |
Genomics
Comparative Map Data
| Aqp4 (Rattus norvegicus - Norway rat) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| AQP4 (Homo sapiens - human) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Aqp4 (Mus musculus - house mouse) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Aqp4 (Chinchilla lanigera - long-tailed chinchilla) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| AQP4 (Pan paniscus - bonobo/pygmy chimpanzee) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| AQP4 (Canis lupus familiaris - dog) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Aqp4 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| AQP4 (Sus scrofa - pig) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| AQP4 (Chlorocebus sabaeus - green monkey) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Aqp4 (Heterocephalus glaber - naked mole-rat) |
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Variants
.
Variants in Aqp4
26 total Variants 
|
