Gene: Suclg2 (succinate-CoA ligase, GDP-forming, beta subunit)
Rattus norvegicus
Symbol:
Suclg2
Name:
succinate-CoA ligase, GDP-forming, beta subunit
Description:
ENCODES a protein that exhibits GDP binding; protein heterodimerization activity; succinate-CoA ligase (GDP-forming) activity; INVOLVED IN succinate metabolic process; succinyl-CoA metabolic process; tricarboxylic acid cycle; PARTICIPATES IN citric acid cycle pathway; propanoate metabolic pathway; FOUND IN mitochondrion; protein complex; succinate-CoA ligase complex (GDP-forming); INTERACTS WITH (R)-adrenaline; 2,4-dinitrotoluene; 2,6-dinitrotoluene
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
LOC362404; succinate-CoA ligase, GDP-forming beta subunit; succinate-Coenzyme A ligase, GDP-forming, beta subunit; succinate-Coenzyme A ligase, GDP-forming, beta subunit (predicted); succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial; Suclg2_predicted
Orthologs:
Homo sapiens : SUCLG2
(succinate-CoA ligase, GDP-forming, beta subunit)
HGNC
Mus musculus : Suclg2
(succinate-Coenzyme A ligase, GDP-forming, beta subunit)
MGI
Latest Assembly:
RGSC Genome Assembly v3.4
Position:
Map Chr Position Strand Source Rat Cytogenetic Map 4 q34 NCBI RGSC Genome Assembly v5.0 4 192,061,200 - 192,333,899 - NCBI RGSC Genome Assembly v3.4 4 129,995,856 - 130,276,182 - NCBI Rat Celera Assembly 4 116,961,947 - 117,231,527 - NCBI Genome Assembly 3.1 4 130,240,697 - 130,521,016 - NCBI
Model
Gene-Chemical Interaction Annotations
(R)-adrenaline increases expression EXP 6480464 Epinephrine results in increased expression of SUCLG2 protein CTD PMID:19464573 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1312780 6480464 Tetrachlorodibenzodioxin results in increased expression of SUCLG2 mRNA CTD PMID:19465110 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1312780 6480464 Tetrachlorodibenzodioxin affects the expression of SUCLG2 mRNA CTD PMID:21570461 2,4-dinitrotoluene affects expression EXP 6480464 2,4-dinitrotoluene affects the expression of SUCLG2 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2,6-dinitrotoluene affects the expression of SUCLG2 mRNA CTD PMID:21346803 7H-xanthine multiple interactions EXP 6480464 [Xanthine co-treated with XDH protein] results in decreased expression of SUCLG2 protein CTD PMID:19464573 9H-xanthine multiple interactions EXP 6480464 [Xanthine co-treated with XDH protein] results in decreased expression of SUCLG2 protein CTD PMID:19464573 aflatoxin B1 affects expression ISO RGD:1312779 6480464 Aflatoxin B1 affects the expression of SUCLG2 protein CTD PMID:20106945 aflatoxin B1 decreases expression ISO RGD:1312780 6480464 Aflatoxin B1 results in decreased expression of SUCLG2 mRNA CTD PMID:19770486 alpha-hexachlorocyclohexane increases expression EXP 6480464 alpha-hexachlorocyclohexane results in increased expression of SUCLG2 mRNA CTD PMID:16940010 benzo[a]pyrene increases expression ISO RGD:1312780 6480464 Benzo(a)pyrene results in increased expression of SUCLG2 mRNA CTD PMID:22228805 benzo[a]pyrene decreases expression ISO RGD:1312779 6480464 Benzo(a)pyrene results in decreased expression of SUCLG2 mRNA CTD PMID:21632981 choline multiple interactions ISO RGD:1312780 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SUCLG2 mRNA CTD PMID:20938992 clofibrate increases expression EXP 6480464 Clofibrate results in increased expression of SUCLG2 protein CTD PMID:16470657 clofibric acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SUCLG2 mRNA CTD PMID:17602206 cobalt dichloride decreases expression ISO RGD:1312779 6480464 cobaltous chloride results in decreased expression of SUCLG2 mRNA CTD PMID:19376846 cyclosporin A decreases expression ISO RGD:1312779 6480464 Cyclosporine results in decreased expression of SUCLG2 mRNA CTD PMID:20106945 dibutyl phthalate decreases expression ISO RGD:1312780 6480464 Dibutyl Phthalate results in decreased expression of SUCLG2 mRNA CTD PMID:21266533 dibutyl phthalate decreases expression ISO RGD:1312780 6480464 Dibutyl Phthalate results in decreased expression of SUCLG2 mRNA CTD PMID:17361019 PMID:21266533 dibutyl phthalate decreases expression EXP 6480464 Dibutyl Phthalate results in decreased expression of SUCLG2 mRNA CTD PMID:21266533 folic acid multiple interactions ISO RGD:1312780 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SUCLG2 mRNA CTD PMID:20938992 fumonisin B1 decreases expression ISO RGD:1312780 6480464 fumonisin B1 results in decreased expression of SUCLG2 mRNA CTD PMID:16221962 L-ascorbic acid affects expression ISO RGD:1312780 6480464 Ascorbic Acid affects the expression of SUCLG2 protein CTD PMID:19224539 L-methionine multiple interactions ISO RGD:1312780 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of SUCLG2 mRNA CTD PMID:20938992 methotrexate affects response to substance ISO RGD:1312779 6480464 SUCLG2 protein affects the susceptibility to Methotrexate CTD PMID:16217747 microcystin-LR decreases expression ISO RGD:1312780 6480464 cyanoginosin LR results in decreased expression of SUCLG2 mRNA CTD PMID:17383702 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SUCLG2 mRNA CTD PMID:17602206 paracetamol affects expression ISO RGD:1312780 6480464 Acetaminophen affects the expression of SUCLG2 mRNA CTD PMID:17562736 phenethyl isothiocyanate increases metabolic processing ISO RGD:1312779 6480464 phenethyl isothiocyanate results in increased metabolism of SUCLG2 protein CTD PMID:21838287 phenethyl isothiocyanate affects binding ISO RGD:1312779 6480464 SUCLG2 protein binds to phenethyl isothiocyanate CTD PMID:21838287 phlorizin decreases expression ISO RGD:1312780 6480464 Phlorhizin results in decreased expression of SUCLG2 mRNA CTD PMID:22538082 pirinixic acid increases expression ISO RGD:1312780 6480464 pirinixic acid results in increased expression of SUCLG2 mRNA CTD PMID:18301758 quercetin decreases expression ISO RGD:1312779 6480464 Quercetin results in decreased expression of SUCLG2 mRNA CTD PMID:21632981 rosiglitazone affects expression ISO RGD:1312780 6480464 rosiglitazone affects the expression of SUCLG2 mRNA CTD PMID:22013433
Gene Ontology Annotations
2303168 Bp330 Blood pressure QTL 330 4.25 .017 Blood pressure 4 456799 149181446 Rat 2316958 Gluco58 Glucose level QTL 58 10 Glucose level postprandial 4 6690606 185398530 Rat 1358352 Srcrt3 Stress Responsive Cort QTL 3 2.29 Hypothalamic-pituitary-adrenal axis corticosterone post-stress 4 8819982 149560340 Rat 1576305 Emca6 Estrogen-induced mammary cancer QTL 6 5.8 Mammary tumor susceptibility estradiol-induced 4 41729583 159115617 Rat 1354612 Foco1 Food consumption QTL 1 8.87 Consumption level food intake 4 41729771 151158666 Rat 1354660 Salc1 Saline consumption QTL 1 11.26 Consumption level saline intake 4 41729771 151158666 Rat 2312567 Glom19 Glomerulus QTL 19 1.9 .006 Renal pathology 4 43686352 149560340 Rat 1298082 Stresp4 Stress response QTL 4 Hormone level corticosterone 4 47889730 149560340 Rat 70200 Alc18 Alcohol consumption QTL 18 9.2 Consumption level alcohol preference 4 54828166 152570244 Rat 738009 Sach4 Saccharine consumption QTL 4 4.9 .000016 Consumption level saccharin preference 4 58421110 158108528 Rat 738016 Alc16 Alcohol consumption QTL 16 3.6 .00015 Consumption level alcohol preference 4 58421110 158108528 Rat 738031 Alc14 Alcohol consumption QTL 14 7.6 .00003 Consumption level alcohol preference 4 58421110 158108528 Rat 61418 Pia5 Pristane induced arthritis QTL 5 4.5 Joint/bone inflammation inflammation score 4 60974346 130228614 Rat 631674 Iddm14 Insulin dependent diabetes mellitus QTL 14 Glucose level 4 63276741 160891592 Rat 61330 Eau1 Experimental allergic uveoretinitis QTL 1 .0003 Uvea inflammation score 4 69183301 134858710 Rat 631646 Stl4 Serum triglyceride level QTL 4 6.5 .0001 Lipid level triglyceride 4 72160227 134858710 Rat 61476 Aia3 Adjuvant induced arthritis QTL 3 3.9 Joint/bone inflammation arthritis severity 4 73972453 133939659 Rat 61406 Scwia1 Streptococcal cell wall induced arthritis QTL 1 2.3 Joint/bone inflammation streptococcal cell wall induced 4 73972453 154937227 Rat 631662 Hcar2 Hepatocarcinoma resistance QTL 2 3.1 .0003 Liver tumor resistance nodule volume 4 78035196 135074488 Rat 1576316 Ept5 Estrogen-induced pituitary tumorigenesis QTL 5 3.8 Gland mass pituitary 4 82700691 182307104 Rat 70177 Xhs1 X-ray hypersensitivity QTL 1 25.1 X-ray sensitivity 4 82861630 155893772 Rat 634334 Xhs3 X-ray hypersensitivity QTL 3 10 X-ray sensitivity 4 84355208 131969855 Rat 1582232 Gluco25 Glucose level QTL 25 3.6 .0023 Glucose level uptake 4 84886545 151158853 Rat 1358202 Gluco11 Glucose level QTL 11 2.4 .02 Glucose level uptake 4 85014031 171204531 Rat 1578662 Bss15 Bone structure and strength QTL 15 19.6 Bone structure femoral neck width 4 89539438 134539438 Rat 1578670 Bss14 Bone structure and strength QTL 14 16.4 Bone structure femoral neck trabecular area 4 89539438 134539438 Rat 1578655 Bmd11 Bone mineral density QTL 11 11 Bone mineral density femoral neck total vBMD 4 93201451 138201451 Rat 634335 Anxrr16 Anxiety related response QTL 16 7.22 Anxiety response 4 93498821 171204377 Rat 631689 Scl4 Serum cholesterol level QTL 4 1.9 .008 Lipid level cholesterol 4 96867443 141867443 Rat 61434 Cia3 Collagen induced arthritis QTL 3 4.8 Joint/bone inflammation type II collagen induced 4 104415843 149415843 Rat 737821 Hcar9 Hepatocarcinoma resistance QTL 9 3.7 Liver tumor resistance nodule number 4 106554769 171204531 Rat 6478680 Anxrr29 Anxiety related response QTL 29 .00092 Anxiety response open field inner locomotion 4 106808891 151808891 Rat 6478740 Anxrr39 Anxiety related response QTL 39 .07528 Anxiety response open field inner locomotion 4 106808891 151808891 Rat 2302049 Pia32 Pristane induced arthritis QTL 32 5.1 .001 Joint/bone inflammation pristane induced 4 107728559 152728559 Rat 731165 Uae21 Urinary albumin excretion QTL 21 2.4 .0001 Renal function urine albumin level 4 108641841 153641841 Rat 1331759 Hrtrt13 Heart rate QTL 13 3.54628 Heart rate 4 111754988 172369380 Rat 1549832 Bss3 Bone structure and strength QTL 3 11 Bone structure Femoral midshaft cortical area 4 112039347 157039347 Rat 7207480 Bss105 Bone structure and strength QTL 105 8.1 Bone structure Femoral midshaft moment of inertia 4 112039347 157039347 Rat 6478760 Anxrr45 Anxiety related response QTL 45 .06717 Anxiety response response in light-dark box 4 113136999 158136999 Rat 6478763 Anxrr46 Anxiety related response QTL 46 .07428 Anxiety response response in light-dark box 4 113136999 158136999 Rat 1331802 Srn5 Serum renin concentration QTL 5 3.045 Renin concentration serum 4 115896404 160896404 Rat 1300116 Hrtrt5 Heart rate QTL 5 3.76 Heart rate salt-loaded 4 117887605 154283969 Rat 724535 Cm18 Cardiac mass QTL 18 2.6 Cardiac mass 4 121375269 166375269 Rat 2293840 Kiddil9 Kidney dilation QTL 9 2.9 Renal pathology kidney dilation 4 122550935 151158853 Rat 631683 Bp116 Blood pressure QTL 116 .0001 Blood pressure salt-loaded systolic 4 127060280 172060280 Rat 6478778 Anxrr51 Anxiety related response QTL 51 .25384 Anxiety response open field inner locomotion 4 127547983 172547983 Rat 61451 Ciaa4 CIA Autoantibody QTL 4 3.1 Anti-type II collagen autoantibody titer 4 128179957 171204531 Rat