Tpmt (thiopurine S-methyltransferase) - Rat Genome Database

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Gene: Tpmt (thiopurine S-methyltransferase) Rattus norvegicus
Analyze
Symbol: Tpmt
Name: thiopurine S-methyltransferase
RGD ID: 1585162
Description: Predicted to enable S-adenosyl-L-methionine binding activity and thiopurine S-methyltransferase activity. Involved in response to testosterone. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; alopecia; leukopenia; and thiopurine S-methyltransferase deficiency. Orthologous to human TPMT (thiopurine S-methyltransferase); PARTICIPATES IN azathioprine pharmacodynamics pathway; mercaptopurine pharmacodynamics pathway; mercaptopurine pharmacokinetics pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC690050; similar to Thiopurine S-methyltransferase (Thiopurine methyltransferase); thiopurine methyltransferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81717,850,308 - 17,868,976 (+)NCBIGRCr8
mRatBN7.21717,644,088 - 17,662,709 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1717,644,173 - 17,662,709 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1717,529,367 - 17,547,810 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01719,133,224 - 19,151,667 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01717,456,484 - 17,474,931 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01718,029,090 - 18,047,716 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1718,029,124 - 18,047,714 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01719,889,509 - 19,908,063 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41723,697,900 - 23,714,173 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1717,356,338 - 17,372,611 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-chloropropane-1,2-diol  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
aconitine  (EXP)
acrylamide  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
bendroflumethiazide  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
cyclosporin A  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
diuron  (EXP)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
furosemide  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
inulin  (ISO)
iodide salt  (EXP)
irinotecan  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
mercaptopurine  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
nickel dichloride  (EXP)
nitrofen  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
parathion  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
propiconazole  (EXP)
Propiverine  (EXP)
purine-6-thiol  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
S-adenosyl-L-methioninate  (ISO)
S-adenosyl-L-methionine  (ISO)
senecionine  (ISO)
silicon dioxide  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP)
theophylline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichlormethiazide  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Thiopurine methyltransferase genotyping in Palestinian childhood acute lymphoblastic leukemia patients. Ayesh BM, etal., BMC Hematol. 2013 Apr 10;13(1):3. doi: 10.1186/2052-1839-13-3.
2. Association of thiopurine methyltransferase status with azathioprine side effects in Chinese patients with systemic lupus erythematosus. Chen D, etal., Clin Rheumatol. 2014 Apr;33(4):499-503. doi: 10.1007/s10067-013-2441-x. Epub 2013 Dec 10.
3. Analysis of thiopurine S-methyltransferase polymorphism in the population of Serbia and Montenegro and mercaptopurine therapy tolerance in childhood acute lymphoblastic leukemia. Dokmanovic L, etal., Ther Drug Monit. 2006 Dec;28(6):800-6.
4. Epistatic interactions between thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) variations determine 6-mercaptopurine toxicity in Indian children with acute lymphoblastic leukemia. Dorababu P, etal., Eur J Clin Pharmacol. 2012 Apr;68(4):379-87. doi: 10.1007/s00228-011-1133-1. Epub 2011 Oct 19.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Thiopurine methyltransferase (TPMT) activity and adverse effects of azathioprine in inflammatory bowel disease: long-term follow-up study of 394 patients. Gisbert JP, etal., Am J Gastroenterol. 2006 Dec;101(12):2769-76. Epub 2006 Oct 6.
7. Thiopurine methyltransferase regulation in rat kidney: immunoprecipitation studies. Hernandez JS, etal., Xenobiotica. 1991 Apr;21(4):451-9.
8. Influences of thiopurine methyltransferase genotype and activity on thiopurine-induced leukopenia in Korean patients with inflammatory bowel disease: a retrospective cohort study. Kim JH, etal., J Clin Gastroenterol. 2010 Nov-Dec;44(10):e242-8. doi: 10.1097/MCG.0b013e3181d6baf5.
9. The impact of thiopurine s-methyltransferase polymorphism on azathioprine-induced myelotoxicity in renal transplant recipients. Kurzawski M, etal., Ther Drug Monit. 2005 Aug;27(4):435-41.
10. TPMT genetic variants are associated with increased rejection with azathioprine use in heart transplantation. Liang JJ, etal., Pharmacogenet Genomics. 2013 Dec;23(12):658-65. doi: 10.1097/FPC.0000000000000005.
11. Effect of S-adenosylhomocysteine on sulfhydryl xenobiotic transmethylases in rat liver. Loo G and Smith JT, Biochem Biophys Res Commun. 1985 Apr 30;128(2):965-71.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:657528   PMID:9539138   PMID:10548451   PMID:11751462   PMID:11810420   PMID:11845325   PMID:11958524   PMID:12477932   PMID:15056293   PMID:15489334   PMID:18484748   PMID:19535798  
PMID:23376485  


Genomics

Comparative Map Data
Tpmt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81717,850,308 - 17,868,976 (+)NCBIGRCr8
mRatBN7.21717,644,088 - 17,662,709 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1717,644,173 - 17,662,709 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1717,529,367 - 17,547,810 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01719,133,224 - 19,151,667 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01717,456,484 - 17,474,931 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01718,029,090 - 18,047,716 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1718,029,124 - 18,047,714 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01719,889,509 - 19,908,063 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41723,697,900 - 23,714,173 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1717,356,338 - 17,372,611 (+)NCBICelera
Cytogenetic Map17p14NCBI
TPMT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38618,128,311 - 18,155,169 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl618,128,311 - 18,155,077 (-)EnsemblGRCh38hg38GRCh38
GRCh37618,128,542 - 18,155,400 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36618,236,521 - 18,263,353 (-)NCBINCBI36Build 36hg18NCBI36
Build 34618,059,377 - 18,263,263NCBI
Celera619,366,550 - 19,393,384 (-)NCBICelera
Cytogenetic Map6p22.3NCBI
HuRef618,072,922 - 18,099,749 (-)NCBIHuRef
CHM1_1618,131,149 - 18,157,981 (-)NCBICHM1_1
T2T-CHM13v2.0618,000,482 - 18,027,339 (-)NCBIT2T-CHM13v2.0
Tpmt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391347,175,463 - 47,196,833 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1347,175,958 - 47,198,213 (-)EnsemblGRCm39 Ensembl
GRCm381347,021,987 - 47,043,338 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1347,022,482 - 47,044,737 (-)EnsemblGRCm38mm10GRCm38
MGSCv371347,118,912 - 47,138,586 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361347,036,149 - 47,054,175 (-)NCBIMGSCv36mm8
Celera1348,108,353 - 48,127,836 (-)NCBICelera
Cytogenetic Map13A5NCBI
cM Map1324.5NCBI
Tpmt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554838,052,849 - 8,072,764 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554838,052,867 - 8,072,235 (+)NCBIChiLan1.0ChiLan1.0
TPMT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2532,789,158 - 32,814,471 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1628,774,422 - 28,799,772 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0617,977,544 - 18,002,839 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1618,330,000 - 18,355,201 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl618,330,000 - 18,355,157 (-)Ensemblpanpan1.1panPan2
TPMT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13516,928,991 - 16,953,891 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3516,929,240 - 16,953,229 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3516,879,116 - 16,902,874 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03517,035,847 - 17,060,453 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3517,035,872 - 17,060,446 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13516,849,193 - 16,872,898 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03516,906,511 - 16,930,057 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03518,237,408 - 18,261,325 (-)NCBIUU_Cfam_GSD_1.0
Tpmt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049467,813,141 - 7,831,506 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365523,897,375 - 3,917,772 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365523,899,445 - 3,917,774 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TPMT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl713,820,866 - 13,846,012 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1713,821,656 - 13,846,107 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2714,563,347 - 14,587,813 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TPMT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11753,987,561 - 54,012,647 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1753,987,559 - 54,014,650 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604418,353,974 - 18,379,216 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tpmt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247568,511,315 - 8,531,745 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247568,511,275 - 8,532,100 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tpmt
62 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:30
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000022085
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)17429913021293263Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
1582199Insul5Insulin level QTL 53.40.0119blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)17920136523653323Rat
1582208Kidm32Kidney mass QTL 323.90.0018kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17920136523653323Rat
1582224Epfw4Epididymal fat weight QTL 43.50.0058epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)17920136523653323Rat
1582225Bw67Body weight QTL 676.20.0001body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582226Bw64Body weight QTL 644.20.0017body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582241Bw70Body weight QTL 704.60.0003body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582245Bw73Body weight QTL 734.60.0004body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
1582258Bw76Body weight QTL 764.60.0005body mass (VT:0001259)body weight (CMO:0000012)17920136523653323Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)171398677321975515Rat
1331720Rf43Renal function QTL 432.881kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)171533061323017269Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat

Markers in Region
RH130497  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21717,662,508 - 17,662,688 (+)MAPPERmRatBN7.2
Rnor_6.01718,047,516 - 18,047,695NCBIRnor6.0
Rnor_5.01719,889,530 - 19,889,709UniSTSRnor5.0
RGSC_v3.41723,714,188 - 23,714,367UniSTSRGSC3.4
Celera1717,372,626 - 17,372,805UniSTS
RH 3.4 Map17194.7UniSTS
Cytogenetic Map17p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 49 41 19 41 4 5 66 35 32 11 4
Low 8 8 4 6 8 9 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022085   ⟹   ENSRNOP00000022084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1717,644,173 - 17,662,705 (+)Ensembl
Rnor_6.0 Ensembl1718,029,124 - 18,047,714 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081708   ⟹   ENSRNOP00000072177
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1717,644,173 - 17,662,705 (+)Ensembl
Rnor_6.0 Ensembl1718,031,228 - 18,047,495 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096156   ⟹   ENSRNOP00000081418
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1717,646,197 - 17,662,709 (+)Ensembl
RefSeq Acc Id: NM_001395670   ⟹   NP_001382599
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81717,850,426 - 17,868,976 (+)NCBI
mRatBN7.21717,644,158 - 17,662,709 (+)NCBI
RefSeq Acc Id: XM_039096087   ⟹   XP_038952015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81717,850,308 - 17,860,715 (+)NCBI
mRatBN7.21717,644,088 - 17,655,058 (+)NCBI
RefSeq Acc Id: XM_039096088   ⟹   XP_038952016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81717,850,308 - 17,860,715 (+)NCBI
mRatBN7.21717,644,094 - 17,654,277 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000022084   ⟸   ENSRNOT00000022085
RefSeq Acc Id: ENSRNOP00000072177   ⟸   ENSRNOT00000081708
RefSeq Acc Id: XP_038952015   ⟸   XM_039096087
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038952016   ⟸   XM_039096088
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000081418   ⟸   ENSRNOT00000096156
RefSeq Acc Id: NP_001382599   ⟸   NM_001395670
- UniProtKB: Q9Z0T0 (UniProtKB/Swiss-Prot),   B0BMT6 (UniProtKB/TrEMBL),   A0A0G2K2B6 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z0T0-F1-model_v2 AlphaFold Q9Z0T0 1-240 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700366
Promoter ID:EPDNEW_R10889
Type:multiple initiation site
Name:Tpmt_1
Description:thiopurine S-methyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01718,029,216 - 18,029,276EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1585162 AgrOrtholog
BioCyc Gene G2FUF-9909 BioCyc
Ensembl Genes ENSRNOG00000016468 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022085.7 UniProtKB/TrEMBL
  ENSRNOT00000081708.2 UniProtKB/TrEMBL
  ENSRNOT00000096156 ENTREZGENE
  ENSRNOT00000096156.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro SAM-dependent_MTases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thiopurine_S-MeTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPMT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:690050 UniProtKB/TrEMBL
NCBI Gene 690050 ENTREZGENE
PANTHER THIOPURINE S-METHYLTRANSFERASE UniProtKB/Swiss-Prot
  THIOPURINE S-METHYLTRANSFERASE UniProtKB/Swiss-Prot
  THIOPURINE S-METHYLTRANSFERASE UniProtKB/TrEMBL
  THIOPURINE S-METHYLTRANSFERASE UniProtKB/TrEMBL
Pfam TPMT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB TPMT RGD
PhenoGen Tpmt PhenoGen
PIRSF Thiopurine_S-methyltransferase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SAM_MT_TPMT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016468 RatGTEx
Superfamily-SCOP SSF53335 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K2B6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZSG8_RAT UniProtKB/TrEMBL
  B0BMT6 ENTREZGENE, UniProtKB/TrEMBL
  Q7TP19_RAT UniProtKB/TrEMBL
  Q9Z0T0 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Tpmt  thiopurine S-methyltransferase  LOC681730  similar to Thiopurine S-methyltransferase (Thiopurine methyltransferase)  Data merged from RGD:1591672 1643240 APPROVED
2008-03-03 Tpmt  thiopurine S-methyltransferase  Tpmt  thiopurine methyltransferase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-09-11 Tpmt  thiopurine methyltransferase  LOC690050  similar to Thiopurine S-methyltransferase (Thiopurine methyltransferase)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2006-11-20 LOC681730  similar to Thiopurine S-methyltransferase (Thiopurine methyltransferase)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC690050  similar to Thiopurine S-methyltransferase (Thiopurine methyltransferase)      Symbol and Name status set to provisional 70820 PROVISIONAL