Btc (betacellulin) - Rat Genome Database

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Gene: Btc (betacellulin) Rattus norvegicus
Analyze
Symbol: Btc
Name: betacellulin
RGD ID: 620275
Description: Enables epidermal growth factor receptor binding activity and growth factor activity. Involved in several processes, including positive regulation of fibroblast proliferation; positive regulation of mitotic nuclear division; and positive regulation of urine volume. Predicted to be located in membrane. Predicted to be active in extracellular space. Biomarker of otitis media. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human BTC (betacellulin); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: probetacellulin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81416,992,668 - 17,031,178 (+)NCBIGRCr8
mRatBN7.21416,708,447 - 16,746,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1416,707,982 - 16,747,049 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1416,716,086 - 16,754,671 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,035,002 - 18,073,595 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01416,727,133 - 16,765,725 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,231,854 - 18,270,621 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,231,860 - 18,272,484 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,121,506 - 18,182,171 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,194,470 - 18,235,228 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11418,214,004 - 18,235,228 (+)NCBI
Celera1416,107,460 - 16,127,465 (+)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methylcatechol  (EXP)
4-nonylphenol  (ISO)
aflatoxin B1  (EXP)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
CGP 52608  (ISO)
Chorionic gonadotropin  (ISO)
chromium atom  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dibutyl phthalate  (ISO)
gentamycin  (EXP)
griseofulvin  (ISO)
indometacin  (EXP)
lidocaine  (EXP)
LY294002  (EXP)
nickel atom  (ISO)
nicotinic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
protoporphyrins  (ISO)
rac-lactic acid  (ISO)
senecionine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirolimus  (EXP)
sodium arsenite  (ISO)
sotorasib  (ISO)
temozolomide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
extracellular space  (IBA,ISO)
membrane  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology An JZ, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2005 May;21(3):284-6.
2. Purification and molecular characterization of recombinant rat betacellulin. Dunbar AJ, etal., J Mol Endocrinol. 2001 Oct;27(2):239-47.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Betacellulin promotes growth of the gastrointestinal organs and effects a diuresis in normal rats. Howarth GS, etal., Growth Factors. 2003 Jun;21(2):79-86.
6. Cloning of rat betacellulin and characterization of its expression in the gastrointestinal tract. Kallincos NC, etal., Growth Factors 2000;18(3):203-13.
7. Genomic structure and promoter characterization of the gene encoding the ErbB ligand betacellulin. Lawson J, etal., Biochim Biophys Acta 2002 Jun 7;1576(1-2):183-90.
8. Activin A and betacellulin: effect on regeneration of pancreatic beta-cells in neonatal streptozotocin-treated rats. Li L, etal., Diabetes 2004 Mar;53(3):608-15.
9. Coexpression of Pdx1 and betacellulin in mesenchymal stem cells could promote the differentiation of nestin-positive epithelium-like progenitors and pancreatic islet-like spheroids. Li L, etal., Stem Cells Dev. 2008 Aug;17(4):815-23.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Immunohistochemical localization of betacellulin, a new member of the EGF family, in normal human pancreas and islet tumor cells. Miyagawa J, etal., Endocr J. 1999 Dec;46(6):755-64.
12. A functional variant in the human betacellulin gene promoter is associated with type 2 diabetes. Nakano Y, etal., Diabetes. 2005 Dec;54(12):3560-6.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. Growth factors and their receptors in the middle ear mucosa during otitis media. Palacios SD, etal., Laryngoscope. 2002 Mar;112(3):420-3.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Comprehensive gene review and curation RGD comprehensive gene curation
21. Remission of diabetes by beta-cell regeneration in diabetic mice treated with a recombinant adenovirus expressing betacellulin. Shin S, etal., Mol Ther. 2008 May;16(5):854-61. Epub 2008 Mar 18.
22. The exon 1 Cys7Gly polymorphism within the betacellulin gene is associated with type 2 diabetes in African Americans. Silver K, etal., Diabetes. 2005 Apr;54(4):1179-84.
23. Association of a polymorphism in the betacellulin gene with type 1 diabetes mellitus in two populations. Silver KD, etal., J Mol Med. 2006 Jul;84(7):616-23. Epub 2006 May 9.
24. Autocrine, paracrine and juxtacrine signaling by EGFR ligands. Singh AB and Harris RC, Cell Signal. 2005 Oct;17(10):1183-93.
25. Molecular cloning and expression of rat betacellulin cDNA. Tada H, etal., Biochim Biophys Acta 2000 Jun 21;1492(1):285-8.
26. Gene Therapy with Neurogenin 3 and Betacellulin Reverses Major Metabolic Problems in Insulin-Deficient Diabetic Mice. Yechoor V, etal., Endocrinology. 2009 Oct 9.
Additional References at PubMed
PMID:18656477   PMID:25401376  


Genomics

Comparative Map Data
Btc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81416,992,668 - 17,031,178 (+)NCBIGRCr8
mRatBN7.21416,708,447 - 16,746,961 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1416,707,982 - 16,747,049 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1416,716,086 - 16,754,671 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01418,035,002 - 18,073,595 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01416,727,133 - 16,765,725 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01418,231,854 - 18,270,621 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1418,231,860 - 18,272,484 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01418,121,506 - 18,182,171 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41418,194,470 - 18,235,228 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11418,214,004 - 18,235,228 (+)NCBI
Celera1416,107,460 - 16,127,465 (+)NCBICelera
Cytogenetic Map14p22NCBI
BTC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38474,744,759 - 74,794,523 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl474,744,759 - 74,794,523 (-)EnsemblGRCh38hg38GRCh38
GRCh37475,669,969 - 75,719,733 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36475,890,472 - 75,938,853 (-)NCBINCBI36Build 36hg18NCBI36
Build 34476,028,626 - 76,077,008NCBI
Celera472,966,514 - 73,015,096 (-)NCBICelera
Cytogenetic Map4q13.3NCBI
HuRef471,418,290 - 71,466,739 (-)NCBIHuRef
CHM1_1475,647,936 - 75,696,367 (-)NCBICHM1_1
T2T-CHM13v2.0478,084,851 - 78,134,624 (-)NCBIT2T-CHM13v2.0
Btc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39591,505,120 - 91,550,853 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl591,505,120 - 91,550,853 (-)EnsemblGRCm39 Ensembl
GRCm38591,357,261 - 91,402,994 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl591,357,261 - 91,402,994 (-)EnsemblGRCm38mm10GRCm38
MGSCv37591,786,287 - 91,831,939 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36592,432,461 - 92,478,113 (-)NCBIMGSCv36mm8
Celera589,495,391 - 89,540,704 (-)NCBICelera
Cytogenetic Map5E2NCBI
cM Map544.78NCBI
Btc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955474895,573 - 946,894 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955474895,573 - 946,152 (-)NCBIChiLan1.0ChiLan1.0
BTC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2355,275,033 - 55,330,494 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1455,464,444 - 55,519,925 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0449,329,413 - 49,462,891 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1455,242,885 - 55,296,894 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl455,242,899 - 55,298,773 (+)Ensemblpanpan1.1panPan2
BTC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11564,133,051 - 64,159,155 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1564,135,920 - 64,158,970 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1564,312,700 - 64,355,835 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01564,987,534 - 65,030,737 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1564,987,299 - 65,028,910 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11564,211,939 - 64,255,151 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01564,205,431 - 64,248,581 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01564,595,864 - 64,639,083 (+)NCBIUU_Cfam_GSD_1.0
Btc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528512,519,199 - 12,570,403 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936598971,241 - 1,019,121 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936598971,253 - 1,019,043 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BTC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl870,649,317 - 70,697,420 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1870,645,721 - 70,697,538 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2874,799,009 - 74,832,278 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BTC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1723,283,269 - 23,333,373 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl723,281,862 - 23,308,287 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660371,584,706 - 1,636,334 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Btc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624730917,630 - 976,934 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624730917,514 - 975,159 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Btc
300 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:29
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000003686
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14121760616960180Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 14
Low 3 37 17 4 16 4 60 21 30 10
Below cutoff 6 40 37 3 37 8 11 14 7 1 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000003686   ⟹   ENSRNOP00000003686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1416,726,459 - 16,747,049 (+)Ensembl
Rnor_6.0 Ensembl1418,231,860 - 18,272,484 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000109549   ⟹   ENSRNOP00000095979
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1416,707,982 - 16,747,049 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113734   ⟹   ENSRNOP00000082218
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1416,708,128 - 16,747,049 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000116022   ⟹   ENSRNOP00000081813
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1416,708,710 - 16,747,049 (+)Ensembl
RefSeq Acc Id: NM_022256   ⟹   NP_071592
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81416,992,668 - 17,031,178 (+)NCBI
mRatBN7.21416,708,447 - 16,746,961 (+)NCBI
Rnor_6.01418,231,854 - 18,270,621 (+)NCBI
Rnor_5.01418,121,506 - 18,182,171 (+)NCBI
RGSC_v3.41418,194,470 - 18,235,228 (+)RGD
Celera1416,107,460 - 16,127,465 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_071592 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA96731 (Get FASTA)   NCBI Sequence Viewer  
  EDL88582 (Get FASTA)   NCBI Sequence Viewer  
  EDL88583 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003686.7
  ENSRNOP00000081813.1
  ENSRNOP00000082218
  ENSRNOP00000082218.1
  ENSRNOP00000095979.1
Reference Protein Sequences
RefSeq Acc Id: NP_071592   ⟸   NM_022256
- Peptide Label: precursor
- UniProtKB: Q9JJM4 (UniProtKB/TrEMBL),   F1LPG4 (UniProtKB/TrEMBL),   A0A8J8YRH0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003686   ⟸   ENSRNOT00000003686
RefSeq Acc Id: ENSRNOP00000095979   ⟸   ENSRNOT00000109549
RefSeq Acc Id: ENSRNOP00000082218   ⟸   ENSRNOT00000113734
RefSeq Acc Id: ENSRNOP00000081813   ⟸   ENSRNOT00000116022
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JJM4-F1-model_v2 AlphaFold Q9JJM4 1-177 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620275 AgrOrtholog
BioCyc Gene G2FUF-16217 BioCyc
Ensembl Genes ENSRNOG00000002728 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003686.8 UniProtKB/TrEMBL
  ENSRNOT00000109549.1 UniProtKB/TrEMBL
  ENSRNOT00000113734 ENTREZGENE
  ENSRNOT00000113734.1 UniProtKB/TrEMBL
  ENSRNOT00000116022.1 UniProtKB/TrEMBL
Gene3D-CATH Laminin UniProtKB/TrEMBL
InterPro EGF_3 UniProtKB/TrEMBL
KEGG Report rno:64022 UniProtKB/TrEMBL
NCBI Gene 64022 ENTREZGENE
PANTHER PROBETACELLULIN UniProtKB/TrEMBL
  PTHR10740 UniProtKB/TrEMBL
PhenoGen Btc PhenoGen
PRINTS EGFTGF UniProtKB/TrEMBL
PROSITE EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002728 RatGTEx
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
UniProt A0A8I5ZSF9_RAT UniProtKB/TrEMBL
  A0A8I6AQ55_RAT UniProtKB/TrEMBL
  A0A8J8YRH0 ENTREZGENE, UniProtKB/TrEMBL
  A6KKC7_RAT UniProtKB/TrEMBL
  A6KKC8_RAT UniProtKB/TrEMBL
  F1LPG4 ENTREZGENE
  Q9JJM4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1LPG4 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Btc  betacellulin      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Btc  betacellulin      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in kidney 631927