Gem (GTP binding protein overexpressed in skeletal muscle)

Gene: Gem (GTP binding protein overexpressed in skeletal muscle) Rattus norvegicus

Analyze

Symbol:

Gem

Name:

GTP binding protein overexpressed in skeletal muscle

RGD ID:

1307386

Description:

Predicted to enable GTPase activity; guanyl ribonucleotide binding activity; and magnesium ion binding activity. Predicted to be involved in chromosome organization; metaphase chromosome alignment; and mitotic cell cycle. Predicted to be located in several cellular components, including cytoplasmic side of plasma membrane; midbody; and spindle. Biomarker of glaucoma. Orthologous to human GEM (GTP binding protein overexpressed in skeletal muscle); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

GTP binding protein (gene overexpressed in skeletal muscle); GTP-binding protein GEM; LOC297902

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	30,011,641 - 30,022,554 (+)	NCBI		GRCr8
mRatBN7.2	5	25,214,309 - 25,225,222 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	25,214,309 - 25,225,222 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	27,339,200 - 27,350,185 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	28,931,944 - 28,942,929 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	28,874,165 - 28,885,140 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	25,339,479 - 25,353,661 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	25,349,928 - 25,353,661 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	30,050,664 - 30,062,666 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	25,809,543 - 26,008,249 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	26,004,470 - 26,008,270 (+)	NCBI
Celera	5	24,546,414 - 24,557,484 (+)	NCBI		Celera
Cytogenetic Map	5	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

glaucoma (IEP)

megacolon (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

(S)-nicotine (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

15-acetyldeoxynivalenol (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-hydroxypropanoic acid (ISO)

2-methylcholine (ISO)

2-palmitoylglycerol (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-fluorouracil (ISO)

acetaldehyde (ISO)

acrylamide (ISO)

aflatoxin B1 (EXP,ISO)

albendazole (ISO)

aldehydo-D-glucose (ISO)

amiodarone (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

bromobenzene (EXP)

butanal (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP)

calcitriol (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloroprene (ISO)

choline (ISO)

cisplatin (EXP,ISO)

cocaine (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

crotonaldehyde (ISO)

CU-O LINKAGE (ISO)

cyclophosphamide (ISO)

cyclosporin A (ISO)

D-glucose (ISO)

dexamethasone (ISO)

diallyl trisulfide (ISO)

dibutyl phthalate (EXP,ISO)

dioxygen (ISO)

disulfiram (ISO)

dorsomorphin (ISO)

doxorubicin (EXP,ISO)

doxycycline (ISO)

endosulfan (EXP)

folic acid (ISO)

formaldehyde (ISO)

gentamycin (EXP)

glucose (ISO)

Heliotrine (ISO)

hydrogen peroxide (ISO)

indometacin (ISO)

inulin (ISO)

irinotecan (EXP)

iron dichloride (ISO)

isoprenaline (ISO)

ivermectin (ISO)

L-methionine (ISO)

lead(0) (ISO)

Licochalcone B (ISO)

methamphetamine (EXP)

methotrexate (ISO)

methyl methanesulfonate (ISO)

methylisothiazolinone (ISO)

methylmercury chloride (ISO)

N-Nitrosopyrrolidine (ISO)

nickel atom (ISO)

nicotine (ISO)

O-methyleugenol (ISO)

ozone (EXP,ISO)

paracetamol (ISO)

paraquat (EXP)

pentanal (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pioglitazone (ISO)

potassium chromate (ISO)

progesterone (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

SB 431542 (ISO)

SCH 23390 (EXP)

senecionine (ISO)

Senkirkine (ISO)

silicon dioxide (ISO)

sirolimus (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dodecyl sulfate (ISO)

Soman (EXP)

sunitinib (ISO)

tamoxifen (ISO)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloroethene (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

torcetrapib (ISO)

tributylstannane (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

triptonide (ISO)

troglitazone (ISO)

urethane (ISO)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chromosome organization (ISO)

metaphase chromosome alignment (ISO)

mitotic cell cycle (ISO)

Cellular Component

cytoplasmic side of plasma membrane (ISO)

midbody (ISO)

mitotic spindle (ISO)

nucleus (ISO)

plasma membrane (TAS)

spindle midzone (ISO)

Molecular Function

calcium channel regulator activity (IEA)

calmodulin binding (IEA)

GDP binding (ISO)

GTP binding (ISO)

GTPase activity (ISO)

magnesium ion binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Integrated microarray analysis provided novel insights to the pathogenesis of glaucoma.	Wang J, etal., Mol Med Rep. 2017 Dec;16(6):8735-8746. doi: 10.3892/mmr.2017.7711. Epub 2017 Oct 4.

Additional References at PubMed

PMID:7912851	PMID:12477932	PMID:15860732	PMID:17052716	PMID:17107948	PMID:18480465	PMID:22964304	PMID:23076376	PMID:23602967	PMID:24948002

Genomics

Comparative Map Data

Gem
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	30,011,641 - 30,022,554 (+)	NCBI		GRCr8
mRatBN7.2	5	25,214,309 - 25,225,222 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	25,214,309 - 25,225,222 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	27,339,200 - 27,350,185 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	28,931,944 - 28,942,929 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	28,874,165 - 28,885,140 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	25,339,479 - 25,353,661 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	25,349,928 - 25,353,661 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	30,050,664 - 30,062,666 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	25,809,543 - 26,008,249 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	26,004,470 - 26,008,270 (+)	NCBI
Celera	5	24,546,414 - 24,557,484 (+)	NCBI		Celera
Cytogenetic Map	5	q13	NCBI

GEM
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	8	94,249,253 - 94,262,319 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	8	94,249,253 - 94,262,350 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	8	95,261,481 - 95,274,547 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	95,330,657 - 95,343,733 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	95,330,662 - 95,343,733	NCBI
Celera	8	91,447,594 - 91,460,660 (-)	NCBI		Celera
Cytogenetic Map	8	q22.1	NCBI
HuRef	8	90,470,565 - 90,483,631 (-)	NCBI		HuRef
CHM1_1	8	95,301,787 - 95,314,853 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	8	95,374,122 - 95,387,192 (-)	NCBI		T2T-CHM13v2.0

Gem
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	11,702,379 - 11,714,993 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	11,704,457 - 11,714,752 (+)	Ensembl		GRCm39 Ensembl
GRCm38	4	11,704,447 - 11,714,993 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	11,704,457 - 11,714,752 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	11,631,594 - 11,642,140 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	11,631,604 - 11,641,899 (+)	NCBI		MGSCv36	mm8
Celera	4	11,515,538 - 11,526,084 (+)	NCBI		Celera
Cytogenetic Map	4	A1	NCBI
cM Map	4	5.34	NCBI

Gem
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955417	10,475,822 - 10,487,825 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955417	10,475,967 - 10,486,879 (-)	NCBI	ChiLan1.0	ChiLan1.0

GEM
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	7	111,582,105 - 111,595,278 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	8	87,119,098 - 87,132,234 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	8	90,872,855 - 90,885,969 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	8	92,817,028 - 92,830,133 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	8	92,817,028 - 92,830,133 (-)	Ensembl	panpan1.1		panPan2

GEM
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	29	39,016,543 - 39,037,761 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	29	39,025,483 - 39,037,403 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	29	39,177,842 - 39,199,013 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	29	39,220,477 - 39,241,164 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	29	39,229,312 - 39,239,841 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	29	39,234,088 - 39,255,249 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	29	39,229,276 - 39,250,433 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	29	39,670,894 - 39,692,020 (-)	NCBI		UU_Cfam_GSD_1.0

Gem
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	40,516,800 - 40,530,076 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936544	7,262,629 - 7,275,910 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936544	7,262,629 - 7,275,860 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GEM
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	42,458,466 - 42,471,929 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	42,458,591 - 42,471,941 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	45,876,630 - 45,889,986 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GEM
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	8	89,219,484 - 89,232,788 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	8	89,218,782 - 89,232,753 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666039	51,615,735 - 51,629,058 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gem
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624763	1,654,130 - 1,666,540 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624763	1,654,369 - 1,666,538 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Gem
47 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	108
Count of miRNA genes:	85
Interacting mature miRNAs:	99
Transcripts:	ENSRNOT00000020826
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331756	Rf34	Renal function QTL 34	4.16275		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	1	90450412	Rat
70212	Niddm25	Non-insulin dependent diabetes mellitus QTL 25	3.54		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	5	1	131345958	Rat
1331771	Rf35	Renal function QTL 35	4.36965		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	5	729470	86724018	Rat
2312562	Pur18	Proteinuria QTL 18	2.6	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	5	2138965	32656739	Rat
1576314	Eutr1	Estrogen induced uterine response QTL 1			uterus integrity trait (VT:0010575)	pyometritis severity score (CMO:0002009)	5	2138965	166875058	Rat
8662454	Vetf3	Vascular elastic tissue fragility QTL 3	27.4		artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	5	2282226	69540447	Rat
2313085	Bss59	Bone structure and strength QTL 59	2.9	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	5	3844018	26141981	Rat
1300117	Hrtrt8	Heart rate QTL 8	3.49		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	5	3844018	47869213	Rat
61462	Niddm10	Non-insulin dependent diabetes mellitus QTL 10	3.9	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	5	5112159	47171491	Rat
2293666	Bmd38	Bone mineral density QTL 38	4.4		femur size trait (VT:1000369)	femoral neck cortical cross-sectional area (CMO:0001702)	5	8948228	53948228	Rat
7394712	Emca13	Estrogen-induced mammary cancer QTL 13			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	9823266	99753708	Rat
1641903	Alcrsp3	Alcohol response QTL 3			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	5	12689285	57689285	Rat
634305	Mamtr1	Mammary tumor resistance QTL 1		0.0001	mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	12789751	113558310	Rat
1600358	Mamtr5	Mammary tumor resistance QTL 5			mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	5	18873947	63873947	Rat
1358353	Srcrtb2	Stress Responsive Cort Basal QTL 2	3.48	0.003	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	5	18873947	74251464	Rat
8552954	Pigfal14	Plasma insulin-like growth factor 1 level QTL 14	9		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	5	21226744	66226744	Rat
1549901	Neudeg2	Neurodegradation QTL 2	4	0	nervous system integrity trait (VT:0010566)	mononuclear cell count (CMO:0002119)	5	24838710	44045280	Rat

Markers in Region

RH140150

Rat Assembly	Chr	Position (strand)	Source	JBrowse
RGSC_v3.4	5	25,857,958 - 25,858,142	UniSTS	RGSC3.4
Celera	5	24,403,129 - 24,403,313	UniSTS
RH 3.4 Map	5	138.5	UniSTS
Cytogenetic Map	5	q13	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	26	8						10		23	3
Low		17	34	26	19	26	8	11	64	35	18	8	8
Below cutoff			15	15		15

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106637	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC168988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473962	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000005	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000020826 ⟹ ENSRNOP00000020826

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	5	25,214,309 - 25,225,222 (+)	Ensembl
Rnor_6.0 Ensembl	5	25,349,928 - 25,353,661 (+)	Ensembl

RefSeq Acc Id:

NM_001106637 ⟹ NP_001100107

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	5	30,011,641 - 30,022,554 (+)	NCBI
mRatBN7.2	5	25,214,309 - 25,225,222 (+)	NCBI
Rnor_6.0	5	25,339,479 - 25,353,661 (+)	NCBI
Rnor_5.0	5	30,050,664 - 30,062,666 (+)	NCBI
RGSC_v3.4	5	25,809,543 - 26,008,249 (+)	RGD
Celera	5	24,546,414 - 24,557,484 (+)	RGD

Sequence:

show sequence

CAGGAGGCGGCACTGCCAGCGGACATCACACAGCCTTAGACTGCGGAACCCGCATCGGCAGGCG
GCAAGCATTGCAGCAGGCAGCAGGCATTGTCCGGACCGACGGCAAACGCCCACCCAGCGCCCAG
TACAGCCAAGATCCCACAATGACTCTGAATAACGTCACCATGCGCCAAGGCACTGTGGGCATGC
AGCCACAGCAACGCTGGAGCATCCCTGCTGATGGCAGGCATCTGATGGTCCAGAAGGATCCCCA
CCCCTGCAACCCCCACAACCACCACTCCACTGCTCCCGATGACCACTGCCGGCGGAGCTGGTCC
TCCGAGTCCACAGACTCGGTTATCTCTTCCGAGTCAGGAAACACCTACTACCGAGTGGTGCTTA
TTGGGGAGCAAGGAGTGGGCAAGTCCACCCTGGCCAACATCTTTGCAGGTGTACATGACAGCAT
GGACAGCGACTGTGAGGTCTTGGGAGAAGATACATATGAGCGTACCCTGGTCGTTGATGGAGAG
AGTGCAACCATTATCCTACTGGACATGTGGGAAAATAAGGGGGAGAATGAATGGCTCCACGACC
ACTGCATGCAGGTCGGGGACGCCTACCTGATCGTCTACTCCATCACAGACCGGGCGAGCTTTGA
GAAGGCGTCTGAGCTGAGGATCCAGCTCCGCAGGGCCCGGCAGACAGAAGACATTCCTATAATT
TTGGTTGGCAACAAAAGCGACTTAGTGCGGTGTCGAGAAGTGTCTGTGTCAGAAGGGAGAGCTT
GTGCCGTGGTGTTCGACTGCAAATTCATCGAGACCTCTGCAGCCGTGCAGCACAACGTGAAGGA
ACTGTTTGAGGGCATTGTGCGGCAGGTCCGTCTGCGTCGGGACAGCAAGGAAAAGAACGAGAGG
AGGCTGGCCTACCAGAAGAGGCGGGAGAGTATCCCCAGGAAAGCCAGACGCTTCTGGGGCAAAA
TTGTAGCCAAAAACAACAAGAACATGGCTTTCAAGCTCAAGTCAAAATCCTGCCATGACCTGTC
TGTGCTCTAGGCACCCAGTGTCGTCCAGATGTCCCCTTGATGGACGTCGTTGAAGGCTTTTGGG
ACCAGTGATCTATATTAGATTGGATACAGAAGCATTGTTAAGACGCGGCTTCCCCTACTACAGA
TGGGAACCAAGAGGTTAGCCTCATGGGCAACCAAGTGCATGGGTGGCGAAAGATCTCTGTCGAG
AGTCAGTATTTATTTGTAGGAAAAGCTTGACCTGCTATGCTAGATGGATGCCCCAGACTCACTT
AAGGGCACGTTTGGGGTTCACACGAGTTTTTCTCTCCTTTGGGCAGCAGAATATTGAATCTTGT
GAAGAATGCCTAGGACAGAAGTGTTTCATCATTGAAGTTTTGCTCAGTGTTCTGTGTGAATCTG
AGGTCCTTGGGTCATAAAGAAATGTAGGAAAATGGTGTTTATTGGAAGGAGAAGGGCTCTCTGC
AAACTTATACTCCTGGAACTGCAGCTGCGGAACTGGCCTCCTTGCAGTTTTTACTGCTCTATCG
AACTGTGGAGAGAATTGTTAGAATTTGCTAGAAACTGAGGCTTACTGACAGTTTTTGTTTAAAG
ACCACAGAGATTCCTAGACTTAGACGCTGATATGCGTGTACCACTTATAGGTTCAAAAAATTGT
TTACTTATGTGTCTTAGAAGTGTTTATTTTGAGGAAACTATTTTTTTTTTGCCAGATCCTACTT
AGTCAAATCATCTTTTATGTCTTTTTTTTGAAATCATGAAGCTGTCATAAAATATTTTTTTAAA
AAAATCTCAACTATATTGATAACTTGGAGTGCAAAATTTTAAATATAGTCAGAAGCCTGCTTTT
CCCCCCCAAACATAAAGATGCCCCATCCTTTGGGTTGCTCCTTGTACGCCACAGCCGAATTATA
TTTATTATTATTTTGCAAATAACCATTTTAACCTTTGATAAAGCCTATTTATGAGCATATTTCT
TACTGAGAAAAATGTCTGTTTTGTTACCTTTTTTATATTTTTCAAAATATGCAAGTTTTTACCT
ATATGTCTTATAATAAAATAAATAAAATCTTTGAAAAGGAAAGCA

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Protein Sequences


Protein RefSeqs	NP_001100107	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI68988	(Get FASTA)	NCBI Sequence Viewer
	EDL98442	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000020826
	ENSRNOP00000020826.6

RefSeq Acc Id:

NP_001100107 ⟸ NM_001106637

- UniProtKB:

B5DFA6 (UniProtKB/TrEMBL), E9PT99 (UniProtKB/TrEMBL), A0A9K3Y811 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTLNNVTMRQGTVGMQPQQRWSIPADGRHLMVQKDPHPCNPHNHHSTAPDDHCRRSWSSESTDS
VISSESGNTYYRVVLIGEQGVGKSTLANIFAGVHDSMDSDCEVLGEDTYERTLVVDGESATIIL
LDMWENKGENEWLHDHCMQVGDAYLIVYSITDRASFEKASELRIQLRRARQTEDIPIILVGNKS
DLVRCREVSVSEGRACAVVFDCKFIETSAAVQHNVKELFEGIVRQVRLRRDSKEKNERRLAYQK
RRESIPRKARRFWGKIVAKNNKNMAFKLKSKSCHDLSVL

hide sequence

RefSeq Acc Id:

ENSRNOP00000020826 ⟸ ENSRNOT00000020826

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-E9PT99-F1-model_v2	AlphaFold	E9PT99	1-188	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307386	AgrOrtholog
BioCyc Gene	G2FUF-41918	BioCyc
Ensembl Genes	ENSRNOG00000015160	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000020826	ENTREZGENE
	ENSRNOT00000020826.6	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.300	UniProtKB/TrEMBL
InterPro	P-loop_NTPase	UniProtKB/TrEMBL
	Ras_GTPase	UniProtKB/TrEMBL
	Small_GTP-bd_dom	UniProtKB/TrEMBL
	Small_GTPase_GEM/REM/Rad	UniProtKB/TrEMBL
KEGG Report	rno:297902	UniProtKB/TrEMBL
NCBI Gene	297902	ENTREZGENE
PANTHER	GTP-BINDING PROTEIN GEM	UniProtKB/TrEMBL
	RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C	UniProtKB/TrEMBL
Pfam	Ras	UniProtKB/TrEMBL
PhenoGen	Gem	PhenoGen
PIRSF	GTP-binding_GEM	UniProtKB/TrEMBL
PRINTS	RASTRNSFRMNG	UniProtKB/TrEMBL
PROSITE	RAB	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000015160	RatGTEx
SMART	RAB	UniProtKB/TrEMBL
	RAS	UniProtKB/TrEMBL
	RHO	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	A0A9K3Y811	ENTREZGENE, UniProtKB/TrEMBL
	B5DFA6	ENTREZGENE, UniProtKB/TrEMBL
	E9PT99	ENTREZGENE
UniProt Secondary	E9PT99	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-07-16	Gem	GTP binding protein overexpressed in skeletal muscle	Gem	GTP binding protein (gene overexpressed in skeletal muscle)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Gem	GTP binding protein (gene overexpressed in skeletal muscle)	Gem_predicted	GTP binding protein (gene overexpressed in skeletal muscle) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Gem_predicted	GTP binding protein (gene overexpressed in skeletal muscle) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar