GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nos3 | decreases activity | EXP | | 6480464 | CTD | Monocrotaline results in decreased activity of NOS3 protein | PMID:16225752 | Nos3 | decreases expression | EXP | | 6480464 | CTD | Monocrotaline results in decreased expression of NOS3 mRNA; Monocrotaline results in decreased expression of NOS3 protein | PMID:25460361 PMID:30466619 | Nos3 | increases expression | EXP | | 6480464 | CTD | Monocrotaline results in increased expression of NOS3 mRNA | PMID:16225752 PMID:22022327 | Nos3 | multiple interactions | EXP | | 6480464 | CTD | 4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in decreased activity of NOS3 protein]; 4-chlorobenzyltetrahydroberberine inhibits the reaction [Monocrotaline results in increased expression of NOS3 mRNA]; magnolol inhibits the reaction [Monocrotaline results in decreased expression of NOS3 protein]; Quercetin inhibits the reaction [Monocrotaline results in decreased expression of NOS3 mRNA]; Simvastatin inhibits the reaction [Monocrotaline results in increased expression of NOS3 mRNA] | PMID:16225752 PMID:22022327 PMID:25460361 PMID:30466619 | |
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