Map3k7 (mitogen activated protein kinase kinase kinase 7) - Rat Genome Database

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Gene: Map3k7 (mitogen activated protein kinase kinase kinase 7) Rattus norvegicus
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Symbol: Map3k7
Name: mitogen activated protein kinase kinase kinase 7
RGD ID: 1309438
Description: Enables several functions, including ATP binding activity; enzyme binding activity; and protein kinase activity. Involved in several processes, including positive regulation of cell size; positive regulation of intracellular signal transduction; and positive regulation of vascular associated smooth muscle cell migration. Predicted to be located in plasma membrane and postsynaptic density. Predicted to be part of ATAC complex. Predicted to be active in cytosol and endoplasmic reticulum membrane. Used to study arteriosclerosis. Biomarker of chronic kidney disease and myocardial infarction. Human ortholog(s) of this gene implicated in frontometaphyseal dysplasia; frontometaphyseal dysplasia 2; and prostate cancer. Orthologous to human MAP3K7 (mitogen-activated protein kinase kinase kinase 7); PARTICIPATES IN p38 MAPK signaling pathway; Bone morphogenetic proteins signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC100910771; mitogen-activated protein kinase kinase kinase 7; mitogen-activated protein kinase kinase kinase 7-like; Tak1; TGF-beta activated kinase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8551,149,524 - 51,212,012 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl551,154,352 - 51,212,012 (+)EnsemblGRCr8
mRatBN7.2546,356,973 - 46,415,597 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl546,357,931 - 46,415,597 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx548,494,947 - 48,552,846 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0550,094,119 - 50,152,018 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0550,043,393 - 50,101,289 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd551,267,030 - 51,324,890 (+)NCBI
Lyon_Normotensive552,671,925 - 52,729,785 (+)NCBI
Lyon_Hypertensive552,119,849 - 52,178,021 (+)NCBI
F344_StmMcwi545,986,499 - 46,044,360 (+)NCBI
Rnor_6.0547,183,142 - 47,244,424 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl547,186,558 - 47,244,416 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl9114,022,137 - 114,079,089 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.0551,793,737 - 51,852,677 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4548,252,637 - 48,308,820 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera545,121,067 - 45,178,378 (+)NCBICelera
RGSC_v3.1548,252,815 - 48,309,011 (+)NCBI
Cytogenetic Map5q21NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
arteriosclerosis  (IMP)
benign hypertensive renal disease  (ISO)
brain edema  (ISO)
Brain Hypoxia-Ischemia  (IEP,ISO)
Brain Injuries  (IEP,IMP,ISO)
brain ischemia  (ISO)
Cachexia  (IMP)
Cardiac Fibrosis  (IEP,ISO)
Cardiomegaly  (IEP,ISO)
cardiomyopathy  (ISO)
cardiospondylocarpofacial syndrome  (ISO)
Cardiovascular Abnormalities  (ISO)
cervical cancer  (ISO)
cholangiocarcinoma  (ISO)
chronic kidney disease  (IEP)
chronic lymphocytic leukemia/small lymphocytic lymphoma  (ISO)
chronic obstructive pulmonary disease  (ISO)
clear cell renal cell carcinoma  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
cryptorchidism  (ISO)
Developmental Disabilities  (ISO)
Diabetic Cardiomyopathies  (IEP)
dilated cardiomyopathy  (ISO)
Embryo Loss  (ISO)
esophageal cancer  (ISO)
extrahepatic cholestasis  (ISO)
Familial Pancreatic Carcinoma  (ISO)
Forney Robinson Pascoe Syndrome  (ISO)
frontometaphyseal dysplasia  (ISO)
frontometaphyseal dysplasia 2  (ISO)
genetic disease  (ISO)
Hearing Loss  (ISO)
hepatocellular carcinoma  (ISO)
Hypertelorism  (ISO)
hypertrophic cardiomyopathy  (ISO)
hypertrophic pyloric stenosis  (ISO)
inflammatory bowel disease  (ISS)
Liver Reperfusion Injury  (ISO)
lung cancer  (ISO)
lymphoma  (ISO)
megalocornea  (ISO)
melanoma  (ISO)
microcephaly  (ISO)
Micrognathism  (ISO)
Muscle Hypotonia  (ISO)
myocardial infarction  (IEP)
nonpapillary renal cell carcinoma  (ISO)
nonsyndromic congenital nail disorder 9  (ISO)
Opsismodysplasia  (ISO)
ovarian cancer  (ISO)
ovarian serous cystadenocarcinoma  (ISO)
pancreatic adenocarcinoma  (ISO)
pancreatic ductal carcinoma  (ISO)
prostate cancer  (ISO)
Prostatic Neoplasms  (ISO)
Pulmonary Arterial Hypertension  (IEP)
Retrognathia  (ISO)
sarcoma  (ISO)
stomach cancer  (ISO)
stroke  (ISO)
Subarachnoid Hemorrhage  (IEP)
tetralogy of Fallot  (ISO)
thymoma  (ISO)
Thyroid Carcinoma, Nonmedullary 1  (ISO)
transient cerebral ischemia  (ISO)
uterine carcinosarcoma  (ISO)
uterine corpus endometrial carcinoma  (ISO)
Wolff-Parkinson-White syndrome  (ISS)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-Erythraline  (ISO)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
5Z-7-oxozeaenol  (ISO)
actinomycin D  (ISO)
aflatoxin B1  (ISO)
AICA ribonucleotide  (EXP)
albiflorin  (ISO)
alpha-Chaconine  (ISO)
angiotensin II  (ISO)
antirheumatic drug  (ISO)
arjunolic acid  (EXP)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
cisplatin  (EXP,ISO)
corn oil  (ISO)
corticosterone  (EXP)
cortisol  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
desloratadine  (EXP)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dihydrolipoic acid  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
ethanol  (ISO)
fasudil  (ISO)
filipin III  (EXP)
flavokawain B  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
genistein  (EXP)
hexadecanoic acid  (EXP)
hypochlorous acid  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
iron(2+) sulfate (anhydrous)  (EXP)
kaempferol  (ISO)
L-glutamic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
maneb  (ISO)
manganese(II) chloride  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
methylparaben  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monocrotaline  (EXP)
myricetin  (ISO)
N-phosphocreatine  (EXP)
nickel dichloride  (EXP)
nonanoic acid  (ISO)
o-anisidine  (ISO)
oligomycin  (EXP)
olmesartan  (EXP)
omega-3 fatty acid  (EXP)
oxazepam  (ISO)
oxidised LDL  (ISO)
paclitaxel  (ISO)
paeoniflorin  (EXP)
paracetamol  (ISO)
paraquat  (EXP,ISO)
Pentoxifylline  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
pirinixic acid  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rosmarinic acid  (EXP)
satavaptan  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (EXP)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
sulfates  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
anoikis  (IEA,ISO)
bone development  (IEA,ISO)
canonical NF-kappaB signal transduction  (IEA,ISO)
cellular response to angiotensin  (IDA)
cellular response to hypoxia  (IEP)
cellular response to transforming growth factor beta stimulus  (IDA,IEA,IEP)
cellular response to tumor necrosis factor  (IDA)
chromatin remodeling  (IEA)
defense response to bacterium  (IEA,ISO)
I-kappaB phosphorylation  (ISO,ISS)
immune response  (IBA)
inflammatory response  (IEA,ISO)
interleukin-1-mediated signaling pathway  (IEA,ISO)
interleukin-17A-mediated signaling pathway  (IEA,ISO)
interleukin-33-mediated signaling pathway  (IEA,ISO)
JNK cascade  (IBA,IEA,ISO,ISS)
MAPK cascade  (IDA,IEA,ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of gene expression  (IMP)
negative regulation of necroptotic process  (IEA,ISO)
negative regulation of reactive oxygen species metabolic process  (IEA,ISO)
negative regulation of ripoptosome assembly involved in necroptotic process  (ISO)
negative regulation of voltage-gated calcium channel activity  (IMP)
neural tube formation  (ISO)
osteoblast differentiation  (IEA,ISO)
p38MAPK cascade  (IEA,ISO)
positive regulation of autophagy  (IEA,IMP)
positive regulation of canonical NF-kappaB signal transduction  (IBA,IEA,IMP,ISO)
positive regulation of cell cycle  (IMP)
positive regulation of cell size  (IMP)
positive regulation of cGAS/STING signaling pathway  (ISO)
positive regulation of interleukin-2 production  (IEA,ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of JUN kinase activity  (ISO,ISS)
positive regulation of macroautophagy  (IEA,ISO)
positive regulation of MAPK cascade  (IDA,IEA)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of T cell cytokine production  (IEA,ISO)
positive regulation of vascular associated smooth muscle cell migration  (IMP)
positive regulation of vascular associated smooth muscle cell proliferation  (IMP)
protein phosphorylation  (IDA,ISO)
regulation of MAPK cascade  (IEA,ISO)
regulation of reactive oxygen species metabolic process  (ISO)
response to angiotensin  (IEP)
response to hypoxia  (IEP)
signal transduction  (IEA)
stress-activated MAPK cascade  (IEA,ISO)
toll-like receptor 4 signaling pathway  (IEA,ISO)
transforming growth factor beta receptor signaling pathway  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Arjunolic acid, a peroxisome proliferator-activated receptor α agonist, regresses cardiac fibrosis by inhibiting non-canonical TGF-β signaling. Bansal T, etal., J Biol Chem. 2017 Oct 6;292(40):16440-16462. doi: 10.1074/jbc.M117.788299. Epub 2017 Aug 18.
2. Tripartite Motif 8 Contributes to Pathological Cardiac Hypertrophy Through Enhancing Transforming Growth Factor β-Activated Kinase 1-Dependent Signaling Pathways. Chen L, etal., Hypertension. 2017 Feb;69(2):249-258. doi: 10.1161/HYPERTENSIONAHA.116.07741. Epub 2016 Dec 12.
3. Mechanisms and functions of p38 MAPK signalling. Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
4. p38 MAP-kinases pathway regulation, function and role in human diseases. Cuenda A and Rousseau S, Biochim Biophys Acta. 2007 Aug;1773(8):1358-75. Epub 2007 Mar 24.
5. Tumor necrosis factor receptor-associated factor-6 and ribosomal S6 kinase intracellular pathways link the angiotensin II AT1 receptor to the phosphorylation and activation of the IkappaB kinase complex in vascular smooth muscle cells. Doyon P and Servant MJ, J Biol Chem. 2010 Oct 1;285(40):30708-18. doi: 10.1074/jbc.M110.126433. Epub 2010 Jul 21.
6. Growth/differentiation factor 15 causes TGFβ-activated kinase 1-dependent muscle atrophy in pulmonary arterial hypertension. Garfield BE, etal., Thorax. 2019 Feb;74(2):164-176. doi: 10.1136/thoraxjnl-2017-211440. Epub 2018 Dec 15.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Erythropoietin Abrogates Post-Ischemic Activation of the NLRP3, NLRC4, and AIM2 Inflammasomes in Microglia/Macrophages in a TAK1-Dependent Manner. Heinisch O, etal., Transl Stroke Res. 2022 Jun;13(3):462-482. doi: 10.1007/s12975-021-00948-8. Epub 2021 Oct 9.
9. Global analysis of the effects of the V2 receptor antagonist satavaptan on protein phosphorylation in collecting duct. Hoffert JD, etal., Am J Physiol Renal Physiol. 2014 Feb 15;306(4):410-21. doi: 10.1152/ajprenal.00497.2013. Epub 2013 Nov 20.
10. FBXW5 acts as a negative regulator of pathological cardiac hypertrophy by decreasing the TAK1 signaling to pro-hypertrophic members of the MAPK signaling pathway. Hui X, etal., J Mol Cell Cardiol. 2021 Feb;151:31-43. doi: 10.1016/j.yjmcc.2020.09.008. Epub 2020 Sep 22.
11. The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signalling. Ji YX, etal., Nat Commun. 2016 Jun 1;7:11267. doi: 10.1038/ncomms11267.
12. The c-jun kinase/stress-activated pathway: regulation, function and role in human disease. Johnson GL and Nakamura K, Biochim Biophys Acta. 2007 Aug;1773(8):1341-8. Epub 2007 Jan 4.
13. Genetic mapping of allelic loss on chromosome 6q within heterogeneous prostate carcinoma. Konishi N, etal., Cancer Sci. 2003 Sep;94(9):764-8.
14. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
15. Modulation of AT-1R/AMPK-MAPK cascade plays crucial role for the pathogenesis of diabetic cardiomyopathy in transgenic type 2 diabetic (Spontaneous Diabetic Torii) rats. Lakshmanan AP, etal., Biochem Pharmacol. 2012 Mar 1;83(5):653-60. doi: 10.1016/j.bcp.2011.11.018. Epub 2011 Nov 28.
16. Heterozygous Mutations in MAP3K7, Encoding TGF-beta-Activated Kinase 1, Cause Cardiospondylocarpofacial Syndrome. Le Goff C, etal., Am J Hum Genet. 2016 Aug 4;99(2):407-13. doi: 10.1016/j.ajhg.2016.06.005. Epub 2016 Jul 14.
17. Farnesoid X receptor activation inhibits TGFBR1/TAK1-mediated vascular inflammation and calcification via miR-135a-5p. Li C, etal., Commun Biol. 2020 Jun 24;3(1):327. doi: 10.1038/s42003-020-1058-2.
18. Dual-specificity phosphatase 14 protects the heart from aortic banding-induced cardiac hypertrophy and dysfunction through inactivation of TAK1-P38MAPK/-JNK1/2 signaling pathway. Li CY, etal., Basic Res Cardiol. 2016 Mar;111(2):19. doi: 10.1007/s00395-016-0536-7. Epub 2016 Feb 18.
19. GCN5-mediated regulation of pathological cardiac hypertrophy via activation of the TAK1-JNK/p38 signaling pathway. Li J, etal., Cell Death Dis. 2022 Apr 30;13(4):421. doi: 10.1038/s41419-022-04881-y.
20. Transforming growth factor beta-activated kinase 1 signaling pathway critically regulates myocardial survival and remodeling. Li L, etal., Circulation. 2014 Dec 9;130(24):2162-72. doi: 10.1161/CIRCULATIONAHA.114.011195. Epub 2014 Oct 2.
21. microRNA-149-5p mediates the PM2.5-induced inflammatory response by targeting TAB2 via MAPK and NF-κB signaling pathways in vivo and in vitro. Li Q, etal., Cell Biol Toxicol. 2021 Jul 31. pii: 10.1007/s10565-021-09638-5. doi: 10.1007/s10565-021-09638-5.
22. Myricetin Alleviates Pathological Cardiac Hypertrophy via TRAF6/TAK1/MAPK and Nrf2 Signaling Pathway. Liao HH, etal., Oxid Med Cell Longev. 2019 Dec 6;2019:6304058. doi: 10.1155/2019/6304058. eCollection 2019.
23. TGF-beta1 induces cardiac hypertrophic responses via PKC-dependent ATF-2 activation. Lim JY, etal., J Mol Cell Cardiol. 2005 Oct;39(4):627-36. doi: 10.1016/j.yjmcc.2005.06.016.
24. Expanding role of ubiquitination in NF-kappaB signaling. Liu S and Chen ZJ, Cell Res. 2011 Jan;21(1):6-21. Epub 2010 Dec 7.
25. MG53, A Novel Regulator of KChIP2 and Ito,f, Plays a Critical Role in Electrophysiological Remodeling in Cardiac Hypertrophy. Liu W, etal., Circulation. 2019 Apr 30;139(18):2142-2156. doi: 10.1161/CIRCULATIONAHA.118.029413.
26. Deletion of a small consensus region at 6q15, including the MAP3K7 gene, is significantly associated with high-grade prostate cancers. Liu W, etal., Clin Cancer Res. 2007 Sep 1;13(17):5028-33.
27. Leukotriene B4 Inhibits L-Type Calcium Channels via p38 Signaling Pathway in Vascular Smooth Muscle Cells. Liu X, etal., Cell Physiol Biochem. 2015;37(5):1903-13. doi: 10.1159/000438551. Epub 2015 Nov 17.
28. Albiflorin Alleviates Ox-LDL-Induced Human Umbilical Vein Endothelial Cell Injury through IRAK1/TAK1 Pathway. Liu Y, etal., Biomed Res Int. 2022 May 13;2022:6584645. doi: 10.1155/2022/6584645. eCollection 2022.
29. Inhibition of TGFβ-activated kinase 1 promotes inflammation-resolving microglial/macrophage responses and recovery after stroke in ovariectomized female mice. Liu Y, etal., Neurobiol Dis. 2021 Apr;151:105257. doi: 10.1016/j.nbd.2021.105257. Epub 2021 Jan 9.
30. C1q-tumour necrosis factor-related protein-3 exacerbates cardiac hypertrophy in mice. Ma ZG, etal., Cardiovasc Res. 2019 May 1;115(6):1067-1077. doi: 10.1093/cvr/cvy279.
31. Biomechanical signals suppress TAK1 activation to inhibit NF-kappaB transcriptional activation in fibrochondrocytes. Madhavan S, etal., J Immunol. 2007 Nov 1;179(9):6246-54.
32. Activation of TGF-beta1-TAK1-p38 MAPK pathway in spared cardiomyocytes is involved in left ventricular remodeling after myocardial infarction in rats. Matsumoto-Ida M, etal., Am J Physiol Heart Circ Physiol. 2006 Feb;290(2):H709-15. Epub 2005 Sep 23.
33. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
34. TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration. Morioka S, etal., Blood. 2012 Nov 1;120(18):3846-57. doi: 10.1182/blood-2012-03-416198. Epub 2012 Sep 12.
35. BMPR-II deficiency elicits pro-proliferative and anti-apoptotic responses through the activation of TGFβ-TAK1-MAPK pathways in PAH. Nasim MT, etal., Hum Mol Genet. 2012 Jun 1;21(11):2548-58. doi: 10.1093/hmg/dds073. Epub 2012 Mar 2.
36. Acute inhibition of TAK1 protects against neuronal death in cerebral ischemia. Neubert M, etal., Cell Death Differ. 2011 Sep;18(9):1521-30. doi: 10.1038/cdd.2011.29. Epub 2011 Apr 8.
37. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
38. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
39. GOA pipeline RGD automated data pipeline
40. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
41. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
42. Comprehensive gene review and curation RGD comprehensive gene curation
43. Brain endothelial TAK1 and NEMO safeguard the neurovascular unit. Ridder DA, etal., J Exp Med. 2015 Sep 21;212(10):1529-49. doi: 10.1084/jem.20150165. Epub 2015 Sep 7.
44. TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme. Verstrepen L, etal., Cell Mol Life Sci. 2008 Oct;65(19):2964-78.
45. Mutations in MAP3K7 that Alter the Activity of the TAK1 Signaling Complex Cause Frontometaphyseal Dysplasia. Wade EM, etal., Am J Hum Genet. 2016 Aug 4;99(2):392-406. doi: 10.1016/j.ajhg.2016.05.024. Epub 2016 Jul 15.
46. NG25, an inhibitor of transforming growth factor‑β‑activated kinase 1, ameliorates neuronal apoptosis in neonatal hypoxic‑ischemic rats. Wang H, etal., Mol Med Rep. 2018 Jan;17(1):1710-1716. doi: 10.3892/mmr.2017.8024. Epub 2017 Nov 10.
47. Transforming Growth Factor Beta-Activated Kinase 1-Dependent Microglial and Macrophage Responses Aggravate Long-Term Outcomes After Ischemic Stroke. Wang R, etal., Stroke. 2020 Mar;51(3):975-985. doi: 10.1161/STROKEAHA.119.028398. Epub 2020 Feb 12.
48. A direct interaction between TGFbeta activated kinase 1 and the TGFbeta type II receptor: implications for TGFbeta signalling and cardiac hypertrophy. Watkins SJ, etal., Cardiovasc Res. 2006 Feb 1;69(2):432-9. Epub 2005 Dec 19.
49. Interleukin-1 (IL-1) pathway. Weber A, etal., Sci Signal. 2010 Jan 19;3(105):cm1. doi: 10.1126/scisignal.3105cm1.
50. Olmesartan ameliorates pressure overload-induced cardiac remodeling through inhibition of TAK1/p38 signaling in mice. Wu L, etal., Life Sci. 2016 Jan 15;145:121-6. doi: 10.1016/j.lfs.2015.12.034. Epub 2015 Dec 17.
51. CARD3 Promotes Cerebral Ischemia-Reperfusion Injury Via Activation of TAK1. Wu X, etal., J Am Heart Assoc. 2020 May 5;9(9):e014920. doi: 10.1161/JAHA.119.014920. Epub 2020 Apr 30.
52. [Mobilization of Bone Marrow Mesenchymal Stem Cells Inhibits TGF-β Non-classical Pathway Against Myocardial Fibrosis in Rats]. Xia WQ, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2020 May;51(3):344-349. doi: 10.12182/20200560503.
53. Simvastatin ameliorates ventricular remodeling via the TGFbeta1 signaling pathway in rats following myocardial infarction. Xiao X, etal., Mol Med Rep. 2016 Apr 25. doi: 10.3892/mmr.2016.5178.
54. A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway. Xie M, etal., Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17378-83. doi: 10.1073/pnas.0604708103. Epub 2006 Nov 3.
55. A20 prevents obesity-induced development of cardiac dysfunction. Xu W, etal., J Mol Med (Berl). 2018 Feb;96(2):159-172. doi: 10.1007/s00109-017-1608-3. Epub 2017 Nov 16.
56. Sialyltransferase7A promotes angiotensin II-induced cardiomyocyte hypertrophy via HIF-1α-TAK1 signalling pathway. Yan X, etal., Cardiovasc Res. 2020 Jan 1;116(1):114-126. doi: 10.1093/cvr/cvz064.
57. Transforming growth factor β-activated kinase 1 negatively regulates interleukin-1α-induced stromal-derived factor-1 expression in vascular smooth muscle cells. Yang B, etal., Biochem Biophys Res Commun. 2015 Jul 17-24;463(1-2):130-6. doi: 10.1016/j.bbrc.2015.05.047. Epub 2015 May 20.
58. Overexpression of miR-146b-5p Ameliorates Neonatal Hypoxic Ischemic Encephalopathy by Inhibiting IRAK1/TRAF6/TAK1/NF-αB Signaling. Yang G and Zhao Y, Yonsei Med J. 2020 Aug;61(8):660-669. doi: 10.3349/ymj.2020.61.8.660.
59. Cardiomyocyte-Specific RIP2 Overexpression Exacerbated Pathologic Remodeling and Contributed to Spontaneous Cardiac Hypertrophy. Yang JJ, etal., Front Cell Dev Biol. 2021 Oct 18;9:688238. doi: 10.3389/fcell.2021.688238. eCollection 2021.
60. Creg in Hepatocytes Ameliorates Liver Ischemia/Reperfusion Injury in a TAK1-Dependent Manner in Mice. Yang L, etal., Hepatology. 2019 Jan;69(1):294-313. doi: 10.1002/hep.30203.
61. TAK1-AMPK Pathway in Macrophages Regulates Hypothyroid Atherosclerosis. Yang Y, etal., Cardiovasc Drugs Ther. 2021 Jun;35(3):599-612. doi: 10.1007/s10557-020-06996-w.
62. Inhibitory effects of omega-3 fatty acids on early brain injury after subarachnoid hemorrhage in rats: Possible involvement of G protein-coupled receptor 120/β-arrestin2/TGF-β activated kinase-1 binding protein-1 signaling pathway. Yin J, etal., Int J Biochem Cell Biol. 2016 Jun;75:11-22. doi: 10.1016/j.biocel.2016.03.008. Epub 2016 Mar 18.
63. Paeoniflorin attenuates monocrotaline-induced pulmonary arterial hypertension in rats by suppressing TAK1-MAPK/NF-κB pathways. Yu M, etal., Int J Med Sci. 2022 Mar 28;19(4):681-694. doi: 10.7150/ijms.69289. eCollection 2022.
64. RNF207 exacerbates pathological cardiac hypertrophy via post-translational modification of TAB1. Yuan L, etal., Cardiovasc Res. 2022 Mar 30:cvac039. doi: 10.1093/cvr/cvac039.
65. Microglial-specific depletion of TAK1 is neuroprotective in the acute phase after ischemic stroke. Zeyen T, etal., J Mol Med (Berl). 2020 Jun;98(6):833-847. doi: 10.1007/s00109-020-01916-9. Epub 2020 May 7.
66. TGFβ-activated Kinase 1 (TAK1) Inhibition by 5Z-7-Oxozeaenol Attenuates Early Brain Injury after Experimental Subarachnoid Hemorrhage. Zhang D, etal., J Biol Chem. 2015 Aug 7;290(32):19900-9. doi: 10.1074/jbc.M115.636795. Epub 2015 Jun 22.
67. TAK1 is activated in the myocardium after pressure overload and is sufficient to provoke heart failure in transgenic mice. Zhang D, etal., Nat Med. 2000 May;6(5):556-63. doi: 10.1038/75037.
68. The E3 ubiquitin ligase TRIM31 plays a critical role in hypertensive nephropathy by promoting proteasomal degradation of MAP3K7 in the TGF-β1 signaling pathway. Zhang J, etal., Cell Death Differ. 2022 Mar;29(3):556-567. doi: 10.1038/s41418-021-00874-0. Epub 2021 Sep 28.
69. TAK1 accelerates transplant arteriosclerosis in rat aortic allografts by inducing autophagy in vascular smooth muscle cells. Zheng X, etal., Atherosclerosis. 2022 Feb;343:10-19. doi: 10.1016/j.atherosclerosis.2022.01.009. Epub 2022 Jan 19.
70. USP4 deficiency exacerbates hepatic ischaemia/reperfusion injury via TAK1 signalling. Zhou J, etal., Clin Sci (Lond). 2019 Jan 30;133(2):335-349. doi: 10.1042/CS20180959. Print 2019 Jan 31.
71. Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat. Zhou K, etal., Stroke. 2018 Jan;49(1):175-183. doi: 10.1161/STROKEAHA.117.018593.
72. TRAF3 mediates neuronal apoptosis in early brain injury following subarachnoid hemorrhage via targeting TAK1-dependent MAPKs and NF-κB pathways. Zhou Y, etal., Cell Death Dis. 2021 Jan 7;12(1):10. doi: 10.1038/s41419-020-03278-z.
Additional References at PubMed
PMID:8663074   PMID:9079627   PMID:10094049   PMID:10702308   PMID:11460167   PMID:12464436   PMID:12477932   PMID:12556533   PMID:12969270   PMID:14982987   PMID:15125833   PMID:15831522  
PMID:16145668   PMID:16157589   PMID:16260493   PMID:16556914   PMID:17114649   PMID:17209006   PMID:18293403   PMID:18762249   PMID:18838386   PMID:20538596   PMID:20615388   PMID:20730577  
PMID:21052097   PMID:21630459   PMID:22829592   PMID:23378049   PMID:23751595   PMID:23776175   PMID:23778976   PMID:27012613   PMID:28842570   PMID:29291351   PMID:29348267   PMID:30361391  
PMID:30367484   PMID:31028803   PMID:31953451   PMID:32798288   PMID:35696800   PMID:35842555   PMID:35982795   PMID:36279673   PMID:37329446   PMID:38756773  


Genomics

Comparative Map Data
Map3k7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8551,149,524 - 51,212,012 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl551,154,352 - 51,212,012 (+)EnsemblGRCr8
mRatBN7.2546,356,973 - 46,415,597 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl546,357,931 - 46,415,597 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx548,494,947 - 48,552,846 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0550,094,119 - 50,152,018 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0550,043,393 - 50,101,289 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd551,267,030 - 51,324,890 (+)NCBI
Lyon_Normotensive552,671,925 - 52,729,785 (+)NCBI
Lyon_Hypertensive552,119,849 - 52,178,021 (+)NCBI
F344_StmMcwi545,986,499 - 46,044,360 (+)NCBI
Rnor_6.0547,183,142 - 47,244,424 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl547,186,558 - 47,244,416 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl9114,022,137 - 114,079,089 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.0551,793,737 - 51,852,677 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4548,252,637 - 48,308,820 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera545,121,067 - 45,178,378 (+)NCBICelera
RGSC_v3.1548,252,815 - 48,309,011 (+)NCBI
Cytogenetic Map5q21NCBI
MAP3K7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38690,513,579 - 90,587,072 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl690,513,472 - 90,587,233 (-)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh37691,223,298 - 91,296,791 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36691,282,074 - 91,353,628 (-)NCBIBuild 36Build 36hg18NCBI36
Celera691,646,249 - 91,717,462 (-)NCBICelera
Cytogenetic Map6q15NCBI
HuRef688,442,517 - 88,515,844 (-)NCBIHuRef
CHM1_1691,320,725 - 91,394,113 (-)NCBICHM1_1
T2T-CHM13v2.0691,725,183 - 91,798,324 (-)NCBIT2T-CHM13v2.0
Map3k7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39431,963,659 - 32,023,470 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl431,963,864 - 32,051,628 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38431,963,492 - 32,023,470 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl431,964,097 - 32,023,467 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv37432,051,082 - 32,110,442 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36432,292,735 - 32,349,405 (+)NCBIMGSCv36mm8
Celera431,710,402 - 31,768,496 (+)NCBICelera
Cytogenetic Map4A5NCBI
cM Map413.91NCBI
Map3k7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541117,177,335 - 17,229,957 (-)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_00495541117,177,335 - 17,229,957 (-)NCBIChiLan1.0ChiLan1.0
MAP3K7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25110,603,908 - 110,680,269 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16108,504,996 - 108,581,339 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0688,398,329 - 88,470,926 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1691,664,263 - 91,737,468 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl691,664,263 - 91,737,468 (-)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
MAP3K7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11249,669,849 - 49,740,039 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1249,672,389 - 49,739,850 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1249,477,606 - 49,546,370 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01250,481,094 - 50,549,843 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1250,481,149 - 50,549,837 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11249,798,234 - 49,867,173 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01249,697,121 - 49,766,116 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01249,887,662 - 49,956,849 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Map3k7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap1870,419,018 - 70,483,795 (+)NCBImIctTri1.hap1
HiC_Itri_2NW_02440494684,634,746 - 84,697,875 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365101,772,971 - 1,837,765 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365101,772,971 - 1,836,075 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP3K7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl158,481,956 - 58,548,057 (-)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1158,482,046 - 58,548,087 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2165,479,754 - 65,542,430 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP3K7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap11385,166,173 - 85,239,151 (+)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_023666040191,671,798 - 191,744,917 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.11315,284,927 - 15,360,539 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1315,284,923 - 15,360,832 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Map3k7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247993,554,644 - 3,623,317 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_0046247993,554,678 - 3,622,289 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl198,314,576 - 98,382,451 (-)Ensembl
Map3k7
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11111,003,753 - 111,061,041 (-)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in Map3k7
619 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:904
Count of miRNA genes:298
Interacting mature miRNAs:384
Transcripts:ENSRNOT00000007654, ENSRNOT00000007657
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)53275164977751649Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53801167083011670Rat
6907115Mcs29Mammary carcinoma susceptibility QTL 29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)53800433183004331Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)544924861153890773Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)52367149379046465Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)538207390136631402Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5862723052665523Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51757663362576633Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)548523123134369373Rat
1578774Tcas8Tongue tumor susceptibility QTL 83.47tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)51570745160707451Rat
1598807Glom12Glomerulus QTL 122.7kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)53801167083011670Rat
1302786Kidm8Kidney mass QTL 828.15kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)53801167083011670Rat
1331782Rf36Renal function QTL 363.296kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)539019942102105896Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)53331167378311673Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)53275164977751649Rat
1641922Alcrsp8Alcohol response QTL 8alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)51748608062486080Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5862723053627230Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)53998594884985948Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)5692228281330203Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53331167378311673Rat
1576317Eutr2Estrogen induced uterine response QTL 20.01uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)53952692484526924Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51460607859606078Rat
1331773Scl26Serum cholesterol level QTL 263.065blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)54852312391770353Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906491770353Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5706553574335773Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)536460764136631402Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51748608062486080Rat
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)51001906487027358Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52602321171023211Rat
2303577Gluco47Glucose level QTL 473blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51652001961520019Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)52367149368671493Rat

Markers in Region
AU048745  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q32UniSTS
Cytogenetic Map13q24UniSTS
Cytogenetic Map6q32UniSTS
Cytogenetic Map17p12UniSTS
Cytogenetic Map16p14UniSTS
Cytogenetic Map13q26UniSTS
Cytogenetic Map10q22UniSTS
Cytogenetic Map7q11UniSTS
Cytogenetic Map8q24UniSTS
Cytogenetic Map5q21UniSTS
Cytogenetic Map4q24UniSTS
Cytogenetic Map2q11UniSTS
Cytogenetic Map1q54UniSTS
Cytogenetic Map1q36UniSTS
Cytogenetic Map18p11UniSTS
Cytogenetic Map13q13UniSTS
Cytogenetic Map10q24UniSTS
Cytogenetic Map8q31UniSTS
Cytogenetic Map3q21UniSTS
Cytogenetic Map13p13UniSTS
Cytogenetic Map1q21UniSTS
Cytogenetic Map11q23UniSTS
Cytogenetic Map10q31UniSTS
Cytogenetic Map16q12.2UniSTS
Cytogenetic Map3q24UniSTS
Cytogenetic Map5q36UniSTS
Cytogenetic Map3p13UniSTS
BE120532  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2546,391,359 - 46,391,525 (+)MAPPERmRatBN7.2
Rnor_6.0547,220,180 - 47,220,345NCBIRnor6.0
Rnor_6.09114,055,103 - 114,055,268NCBIRnor6.0
Rnor_5.09113,573,073 - 113,573,238UniSTSRnor5.0
Rnor_5.0551,828,433 - 51,828,598UniSTSRnor5.0
RGSC_v3.4548,286,051 - 48,286,216UniSTSRGSC3.4
Celera545,154,141 - 45,154,306UniSTS
RH 3.4 Map5263.39UniSTS
Cytogenetic Map5q21UniSTS
RH134828  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8551,211,679 - 51,211,868 (+)Marker Load Pipeline
mRatBN7.2546,415,264 - 46,415,453 (+)MAPPERmRatBN7.2
Rnor_6.0547,244,084 - 47,244,272NCBIRnor6.0
Rnor_6.09114,079,007 - 114,079,204NCBIRnor6.0
Rnor_5.0551,852,337 - 51,852,525UniSTSRnor5.0
Rnor_5.09113,596,977 - 113,597,174UniSTSRnor5.0
RGSC_v3.4548,309,955 - 48,310,143UniSTSRGSC3.4
Celera545,178,034 - 45,178,234UniSTS
RH 3.4 Map5260.4UniSTS
Cytogenetic Map5q21UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
270 149 730 1584 4031 976 1696 133 855 488 837 150 5336 2571 449 3956 38 1383 722 896 160 158

Sequence


Ensembl Acc Id: ENSRNOT00000007654   ⟹   ENSRNOP00000007654
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl551,154,352 - 51,212,012 (+)Ensembl
mRatBN7.2 Ensembl546,357,931 - 46,415,597 (+)Ensembl
Rnor_6.0 Ensembl547,186,558 - 47,244,416 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000007657   ⟹   ENSRNOP00000007657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl551,154,352 - 51,212,012 (+)Ensembl
mRatBN7.2 Ensembl546,357,931 - 46,415,597 (+)Ensembl
Rnor_6.0 Ensembl9114,022,137 - 114,079,089 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098749   ⟹   ENSRNOP00000083011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl551,154,425 - 51,212,011 (+)Ensembl
mRatBN7.2 Ensembl546,357,931 - 46,415,597 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109648   ⟹   ENSRNOP00000090653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl551,154,352 - 51,209,301 (+)Ensembl
mRatBN7.2 Ensembl546,357,931 - 46,412,886 (+)Ensembl
RefSeq Acc Id: NM_001107920   ⟹   NP_001101390
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8551,154,352 - 51,212,012 (+)NCBI
mRatBN7.2546,357,931 - 46,415,597 (+)NCBI
Dahl_SR_JrHsd551,267,030 - 51,324,890 (+)NCBI
Lyon_Normotensive552,671,925 - 52,729,785 (+)NCBI
Lyon_Hypertensive552,119,849 - 52,178,021 (+)NCBI
F344_StmMcwi545,986,499 - 46,044,360 (+)NCBI
Rnor_6.0547,186,558 - 47,244,416 (+)NCBI
Rnor_5.0551,793,737 - 51,852,677 (+)NCBI
RGSC_v3.4548,252,637 - 48,308,820 (+)RGD
Celera545,121,067 - 45,178,378 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006237966   ⟹   XP_006238028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8551,149,524 - 51,212,012 (+)NCBI
mRatBN7.2546,356,973 - 46,413,034 (+)NCBI
Rnor_6.0547,183,142 - 47,244,424 (+)NCBI
Rnor_5.0551,793,737 - 51,852,677 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039109819   ⟹   XP_038965747
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8551,149,524 - 51,185,913 (+)NCBI
mRatBN7.2546,356,973 - 46,389,490 (+)NCBI
RefSeq Acc Id: NP_001101390   ⟸   NM_001107920
- UniProtKB: P0C8E4 (UniProtKB/Swiss-Prot),   A0A8L2Q3A7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238028   ⟸   XM_006237966
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GA73 (UniProtKB/TrEMBL),   A0A8L2Q3A7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000007654   ⟸   ENSRNOT00000007654
RefSeq Acc Id: XP_038965747   ⟸   XM_039109819
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000007657   ⟸   ENSRNOT00000007657
Ensembl Acc Id: ENSRNOP00000090653   ⟸   ENSRNOT00000109648
Ensembl Acc Id: ENSRNOP00000083011   ⟸   ENSRNOT00000098749
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P0C8E4-F1-model_v2 AlphaFold P0C8E4 1-606 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309438 AgrOrtholog
BioCyc Gene G2FUF-41739 BioCyc
Ensembl Genes ENSRNOG00000005724 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000047516 Ensembl
  ENSRNOG00055010068 UniProtKB/Swiss-Prot
  ENSRNOG00060013880 UniProtKB/Swiss-Prot
  ENSRNOG00065005799 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007654 ENTREZGENE
  ENSRNOT00000007654.7 UniProtKB/Swiss-Prot
  ENSRNOT00000098749 ENTREZGENE
  ENSRNOT00055017015 UniProtKB/Swiss-Prot
  ENSRNOT00060023757 UniProtKB/Swiss-Prot
  ENSRNOT00065008681 UniProtKB/Swiss-Prot
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  MAP3K7 UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:313121 UniProtKB/Swiss-Prot
NCBI Gene 313121 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7 UniProtKB/Swiss-Prot
  PTHR46716 UniProtKB/Swiss-Prot
Pfam Map3k7cl UniProtKB/Swiss-Prot
  Pkinase_Tyr UniProtKB/Swiss-Prot
PhenoGen Map3k7 PhenoGen
PIRSF MAPKKK7 UniProtKB/Swiss-Prot
PRINTS TYRKINASE UniProtKB/Swiss-Prot
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005724 RatGTEx
  ENSRNOG00000047516 RatGTEx
  ENSRNOG00055010068 RatGTEx
  ENSRNOG00060013880 RatGTEx
  ENSRNOG00065005799 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I6GA73 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GIE2_RAT UniProtKB/TrEMBL
  A0A8L2Q3A7 ENTREZGENE, UniProtKB/TrEMBL
  M3K7_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Map3k7  mitogen activated protein kinase kinase kinase 7  LOC100910771  mitogen-activated protein kinase kinase kinase 7-like  Data merged from RGD:6496502 737654 PROVISIONAL
2012-07-05 LOC100910771  mitogen-activated protein kinase kinase kinase 7-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Map3k7  mitogen activated protein kinase kinase kinase 7   Map3k7_predicted  mitogen activated protein kinase kinase kinase 7 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Map3k7_predicted  mitogen activated protein kinase kinase kinase 7 (predicted)      Symbol and Name status set to approved 70820 APPROVED