MAP3K7 (mitogen-activated protein kinase kinase kinase 7) - Rat Genome Database

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Gene: MAP3K7 (mitogen-activated protein kinase kinase kinase 7) Chlorocebus sabaeus
Analyze
Symbol: MAP3K7
Name: mitogen-activated protein kinase kinase kinase 7
RGD ID: 18599404
Description: ENCODES a protein that exhibits ATP binding (ortholog); DNA-binding transcription factor binding (ortholog); histone kinase activity (ortholog); INVOLVED IN angiogenesis (ortholog); anoikis (ortholog); apoptotic signaling pathway (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH arteriosclerosis (ortholog); benign hypertensive renal disease (ortholog); brain edema (ortholog); FOUND IN ATAC complex (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11315,284,927 - 15,360,539 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1315,284,923 - 15,360,832 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040191,671,798 - 191,744,917 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
anoikis  (ISO)
apoptotic process  (IEA)
apoptotic signaling pathway  (ISO)
bone development  (ISO)
canonical NF-kappaB signal transduction  (ISO)
cellular response to angiotensin  (ISO)
cellular response to hypoxia  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
defense response to bacterium  (ISO)
immune response  (IEA)
inflammatory response  (ISO)
interleukin-1-mediated signaling pathway  (ISO)
interleukin-17A-mediated signaling pathway  (ISO)
interleukin-33-mediated signaling pathway  (ISO)
JNK cascade  (IEA,ISO)
MAPK cascade  (IEA,ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of necroptotic process  (ISO)
negative regulation of reactive oxygen species metabolic process  (ISO)
negative regulation of ripoptosome assembly involved in necroptotic process  (ISO)
negative regulation of voltage-gated calcium channel activity  (ISO)
neural tube formation  (ISO)
osteoblast differentiation  (ISO)
p38MAPK cascade  (ISO)
positive regulation of autophagy  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of cell cycle  (ISO)
positive regulation of cell size  (ISO)
positive regulation of cGAS/STING signaling pathway  (ISO)
positive regulation of interleukin-2 production  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of macroautophagy  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (ISO)
positive regulation of T cell cytokine production  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
protein phosphorylation  (ISO)
regulation of reactive oxygen species metabolic process  (ISO)
response to angiotensin  (ISO)
response to hypoxia  (ISO)
signal transduction  (IEA)
stress-activated MAPK cascade  (ISO)
toll-like receptor 4 signaling pathway  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:19385034   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MAP3K7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11315,284,927 - 15,360,539 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1315,284,923 - 15,360,832 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040191,671,798 - 191,744,917 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
MAP3K7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38690,513,579 - 90,587,072 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl690,513,573 - 90,587,086 (-)EnsemblGRCh38hg38GRCh38
GRCh37691,223,298 - 91,296,791 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36691,282,074 - 91,353,628 (-)NCBINCBI36Build 36hg18NCBI36
Celera691,646,249 - 91,717,462 (-)NCBICelera
Cytogenetic Map6q15NCBI
HuRef688,442,517 - 88,515,844 (-)NCBIHuRef
CHM1_1691,320,725 - 91,394,113 (-)NCBICHM1_1
T2T-CHM13v2.0691,725,183 - 91,798,324 (-)NCBIT2T-CHM13v2.0
Map3k7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39431,963,659 - 32,023,470 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl431,964,097 - 32,023,467 (+)EnsemblGRCm39 Ensembl
GRCm38431,963,492 - 32,023,470 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl431,964,097 - 32,023,467 (+)EnsemblGRCm38mm10GRCm38
MGSCv37432,051,082 - 32,110,442 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36432,292,735 - 32,349,405 (+)NCBIMGSCv36mm8
Celera431,710,402 - 31,768,496 (+)NCBICelera
Cytogenetic Map4A5NCBI
cM Map413.91NCBI
Map3k7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8551,149,524 - 51,212,012 (+)NCBIGRCr8
mRatBN7.2546,356,973 - 46,415,597 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl546,357,931 - 46,415,597 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx548,494,947 - 48,552,846 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0550,094,119 - 50,152,018 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0550,043,393 - 50,101,289 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0547,183,142 - 47,244,424 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl547,186,558 - 47,244,416 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl9114,022,137 - 114,079,089 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0551,793,737 - 51,852,677 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4548,252,637 - 48,308,820 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1548,252,815 - 48,309,011 (+)NCBI
Celera545,121,067 - 45,178,378 (+)NCBICelera
Cytogenetic Map5q21NCBI
Map3k7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541117,177,335 - 17,229,957 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541117,177,335 - 17,229,957 (-)NCBIChiLan1.0ChiLan1.0
MAP3K7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25110,603,908 - 110,680,269 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16108,504,996 - 108,581,339 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0688,398,329 - 88,470,926 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1691,664,263 - 91,737,468 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl691,664,263 - 91,737,468 (-)Ensemblpanpan1.1panPan2
MAP3K7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11249,669,849 - 49,740,039 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1249,672,389 - 49,739,850 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1249,477,606 - 49,546,370 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01250,481,094 - 50,549,843 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1250,481,149 - 50,549,837 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11249,798,234 - 49,867,173 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01249,697,121 - 49,766,116 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01249,887,662 - 49,956,849 (-)NCBIUU_Cfam_GSD_1.0
Map3k7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494684,634,746 - 84,697,875 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365101,772,971 - 1,837,765 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365101,772,971 - 1,836,075 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP3K7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl158,481,956 - 58,548,057 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1158,482,046 - 58,548,087 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2165,479,754 - 65,542,430 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Map3k7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247993,554,678 - 3,622,289 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247993,554,644 - 3,623,317 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 34 4 52
Low 2 16 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000015365   ⟹   ENSCSAP00000013306
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1315,284,923 - 15,360,832 (-)Ensembl
RefSeq Acc Id: XM_008006642   ⟹   XP_008004833
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11315,284,927 - 15,360,539 (-)NCBI
Vero_WHO_p1.0NW_023666040191,671,798 - 191,744,894 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008006643   ⟹   XP_008004834
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11315,284,927 - 15,360,539 (-)NCBI
Vero_WHO_p1.0NW_023666040191,672,323 - 191,744,894 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038002266   ⟹   XP_037858194
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_023666040191,673,918 - 191,744,917 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008004833 (Get FASTA)   NCBI Sequence Viewer  
  XP_008004834 (Get FASTA)   NCBI Sequence Viewer  
  XP_037858194 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000013306
  ENSCSAP00000013306.1
Reference Protein Sequences
RefSeq Acc Id: XP_008004834   ⟸   XM_008006643
- Peptide Label: isoform X2
RefSeq Acc Id: XP_008004833   ⟸   XM_008006642
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RXG7 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000013306   ⟸   ENSCSAT00000015365
RefSeq Acc Id: XP_037858194   ⟸   XM_038002266
- Peptide Label: isoform X3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000017272 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000015365.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  MAP3K7 UniProtKB/TrEMBL
  MAPKKK7 UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report csab:103240115 UniProtKB/TrEMBL
NCBI Gene MAP3K7 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7 UniProtKB/TrEMBL
  PTHR46716 UniProtKB/TrEMBL
Pfam Pkinase_Tyr UniProtKB/TrEMBL
PIRSF MAPKKK7 UniProtKB/TrEMBL
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0D9RXG7 ENTREZGENE, UniProtKB/TrEMBL