Biological Process
| activation of MAPK activity | | ISO | UniProtKB:O43318 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| activation of MAPKK activity | | ISO | UniProtKB:O43318 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| activation of MAPKK activity | | ISO | RGD:1309438 | 2290270 | MGI:MGI:4417868 | RGD | MGI:MGI:4417868 |
| activation of NF-kappaB-inducing kinase activity | | ISO | UniProtKB:O43318 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| angiogenesis | | IMP | MGI:MGI:3608889 | 2290270 | MGI:MGI:3621089|PMID:16556914 | MGI | MGI:MGI:3621089 PMID:16556914 |
| apoptotic process | | IEA | UniProtKB-KW:KW-0053 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| histone H3 acetylation | | ISO | UniProtKB:O43318 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| I-kappaB phosphorylation | | IGI | MGI:MGI:104798|MGI:MGI:96536 | 2290270 | MGI:MGI:3607973|PMID:16260493 | MGI | MGI:MGI:3607973 PMID:16260493 |
| I-kappaB phosphorylation | | ISO | UniProtKB:O43318 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| JNK cascade | | ISO | UniProtKB:O43318 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| MAPK cascade | | IDA | | 2290270 | MGI:MGI:2668070|PMID:12556533 | MGI | MGI:MGI:2668070 PMID:12556533 |
| MAPK cascade | | ISO | RGD:1309438 | 2290270 | MGI:MGI:4417868 | RGD | MGI:MGI:4417868 |
| negative regulation of apoptotic process | | IGI | MGI:MGI:104798 | 2290270 | MGI:MGI:3607973|PMID:16260493 | MGI | MGI:MGI:3607973 PMID:16260493 |
| negative regulation of apoptotic process | | IMP | | 2290270 | MGI:MGI:3607973|PMID:16260493 | MGI | MGI:MGI:3607973 PMID:16260493 |
| negative regulation of necroptosis | | IMP | | 2290270 | MGI:MGI:5315337|PMID:21052097 | UniProtKB | MGI:MGI:5315337 PMID:21052097 |
| negative regulation of reactive oxygen species metabolic process | | IMP | | 2290270 | MGI:MGI:5315337|PMID:21052097 | UniProtKB | MGI:MGI:5315337 PMID:21052097 |
| neural tube formation | | IMP | | 2290270 | MGI:MGI:3607973|PMID:16260493 | MGI | MGI:MGI:3607973 PMID:16260493 |
| phosphorylation | | IEA | UniProtKB-KW:KW-0418 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| positive regulation of I-kappaB kinase/NF-kappaB cascade | | IGI | MGI:MGI:104798|MGI:MGI:96536|MGI:MGI:2156367 | 2290270 | MGI:MGI:3607973|PMID:16260493 | MGI | MGI:MGI:3607973 PMID:16260493 |
| positive regulation of I-kappaB kinase/NF-kappaB cascade | | ISO | RGD:1309438 | 2290270 | MGI:MGI:4417868 | RGD | MGI:MGI:4417868 |
| positive regulation of I-kappaB kinase/NF-kappaB cascade | | ISO | UniProtKB:O43318 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| positive regulation of interleukin-2 production | | ISO | UniProtKB:O43318 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| positive regulation of JNK cascade | | IGI | MGI:MGI:104798|MGI:MGI:96536|MGI:MGI:96824 | 2290270 | MGI:MGI:3607973|PMID:16260493 | MGI | MGI:MGI:3607973 PMID:16260493 |
| positive regulation of JUN kinase activity | | ISO | UniProtKB:O43318 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| positive regulation of T cell cytokine production | | ISO | UniProtKB:O43318 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| protein phosphorylation | | IDA | | 2290270 | MGI:MGI:2447107|PMID:12464436 | MGI | MGI:MGI:2447107 PMID:12464436 |
| protein phosphorylation | | ISO | RGD:1309438 | 2290270 | MGI:MGI:4417868 | RGD | MGI:MGI:4417868 |
| protein phosphorylation | | IEA | InterPro:IPR008271 | 2290270 | MGI:MGI:2152098 | GOC | MGI:MGI:2152098 |
| protein phosphorylation | | IEA | UniProtKB-KW:KW-0723 | 2290270 | MGI:MGI:1354194 | GOC | MGI:MGI:1354194 |
| regulation of transcription, DNA-dependent | | IEA | UniProtKB-KW:KW-0805 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| response to stress | | IEA | UniProtKB-KW:KW-0346 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| signal transduction | | IEA | InterPro:IPR017421 | 2290270 | MGI:MGI:2152098 | UniProtKB | MGI:MGI:2152098 |
| stress-activated MAPK cascade | | ISO | UniProtKB:O43318 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| transcription, DNA-dependent | | IEA | UniProtKB-KW:KW-0804 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| transforming growth factor beta receptor signaling pathway | | IMP | | 2290270 | MGI:MGI:3607216|PMID:16145668 | MGI | MGI:MGI:3607216 PMID:16145668 |
Cellular Component
| Ada2/Gcn5/Ada3 transcription activator complex | | ISO | UniProtKB:O43318 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| cytoplasm | | IEA | UniProtKB-KW:KW-0963 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| IkappaB kinase complex | colocalizes_with | ISO | UniProtKB:O43318 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| membrane | | IEA | UniProtKB-KW:KW-0472 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| plasma membrane | | IEA | UniProtKB-KW:KW-1003 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
Molecular Function
| ATP binding | | ISO | RGD:1309438 | 2290270 | MGI:MGI:4417868 | RGD | MGI:MGI:4417868 |
| kinase activity | | IEA | UniProtKB-KW:KW-0418 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| magnesium ion binding | | IEA | InterPro:IPR017421 | 2290270 | MGI:MGI:2152098 | UniProtKB | MGI:MGI:2152098 |
| MAP kinase kinase activity | | IDA | | 2290270 | MGI:MGI:2447107|PMID:12464436 | MGI | MGI:MGI:2447107 PMID:12464436 |
| MAP kinase kinase kinase activity | | ISO | UniProtKB:O43318 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| MAP kinase kinase kinase activity | | ISO | RGD:1309438 | 2290270 | MGI:MGI:4417868 | RGD | MGI:MGI:4417868 |
| metal ion binding | | IEA | UniProtKB-KW:KW-0479 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| nucleotide binding | | IEA | UniProtKB-KW:KW-0547 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| protein binding | | IPI | UniProtKB:Q8N5C8|UniProtKB:Q99K90 | 2290270 | MGI:MGI:3708399|PMID:17158449 | IntAct | MGI:MGI:3708399 PMID:17158449 |
| protein binding | | IPI | UniProtKB:Q86Y07-1|UniProtKB:Q9WVI9-2 | 2290270 | MGI:MGI:3843421|PMID:17709393 | IntAct | MGI:MGI:3843421 PMID:17709393 |
| protein kinase activity | | ISO | UniProtKB:O43318 | 2290270 | MGI:MGI:4834177 | MGI | MGI:MGI:4834177 |
| protein serine/threonine kinase activity | | IEA | InterPro:IPR008271 | 2290270 | MGI:MGI:2152098 | UniProtKB | MGI:MGI:2152098 |
| protein serine/threonine kinase activity | | IEA | UniProtKB-KW:KW-0723 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| transferase activity | | IEA | UniProtKB-KW:KW-0808 | 2290270 | MGI:MGI:1354194 | UniProtKB | MGI:MGI:1354194 |
| transferase activity, transferring phosphorus-containing groups | | IEA | InterPro:IPR011009 | 2290270 | MGI:MGI:2152098 | UniProtKB | MGI:MGI:2152098 |
| 4142458 | Spmd2_m | spermatogenesis defect 2 (mouse) | | | Not determined | | 4 | 29492110 | 63492313 | Mouse |
| 1301990 | Arvm1_m | autoimmune renal vasculitis 1 (mouse) | | | Not determined | | 4 | 29345518 | 63345648 | Mouse |
| 4141351 | Elda4_m | ethanol induced low dose activation 4 (mouse) | | | Not determined | | 4 | 29345518 | 63345648 | Mouse |
| 1357877 | Synch1_m | synechia 1 (mouse) | | | Not determined | | 4 | 28722797 | 62722979 | Mouse |
| 1301586 | Stheal3_m | soft tissue heal 3 (mouse) | | | Not determined | | 4 | 28671314 | 62671438 | Mouse |
| 4141110 | Wtlr3_m | weight loss response 3 (mouse) | | | Not determined | | 4 | 26209772 | 60209867 | Mouse |
| 1302184 | Aaom1_m | autoimmune aoritis in MRL mice 1 (mouse) | | | Not determined | | 4 | 24249446 | 46345648 | Mouse |
| 1301697 | Sluc18_m | susceptibility to lung cancer 18 (mouse) | | | Not determined | | 4 | 22320481 | 56320645 | Mouse |
| 1301437 | Scon1_m | sucrose consumption 1 (mouse) | | | Not determined | | 4 | 22320481 | 56320645 | Mouse |
| 1302075 | Bdln6_m | body length 6 (mouse) | | | Not determined | | 4 | 22320481 | 56320645 | Mouse |
| 1300769 | Pcyts2_m | plasmacytoma susceptibility 2 (mouse) | | | Not determined | | 4 | 22058977 | 56059178 | Mouse |
| 1302058 | Hrtfm3_m | heart failure modifier 3 (mouse) | | | Not determined | | 4 | 22058977 | 56059178 | Mouse |
| 1301387 | Chol8_m | cholesterol 8 (mouse) | | | Not determined | | 4 | 19766249 | 53766394 | Mouse |
| 4141555 | Nbwa2_m | NZB and NZW autoimmunity 2 (mouse) | | | Not determined | | 4 | 17839764 | 51839884 | Mouse |
| 1301237 | Alcp7_m | alcohol preference locus 7 (mouse) | | | Not determined | | 4 | 17342409 | 51342539 | Mouse |
| 1301203 | Alcp8_m | alcohol preference locus 8 (mouse) | | | Not determined | | 4 | 17342409 | 51342539 | Mouse |
| 1357576 | Angfq1_m | angiogenesis due to FGF2 QTL 1 (mouse) | | | Not determined | | 4 | 15254939 | 49255074 | Mouse |
| 1302010 | Wta1_m | weight adult 1 (mouse) | | | Not determined | | 4 | 8610387 | 42610576 | Mouse |
| 1302125 | Lxw1_m | lupus BXSB x NZW 1 (mouse) | | | Not determined | | 4 | 8610387 | 42610576 | Mouse |
| 1301473 | Triglq1_m | triglyceride QTL 1 (mouse) | | | Not determined | | 4 | 8610387 | 42610576 | Mouse |
| 1558992 | Ses8_m | salmonella enteritidis susceptibility 8 (mouse) | | | Not determined | | 4 | 8610387 | 42610576 | Mouse |