INTERLEUKIN-1 SIGNALING PATHWAY (PW:0000883)

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Description

Interleukin 1 is a member of the interleukin-1 family of cytokines that plays important roles in innate and adaptive immunity and which has been associated with acute and chronic inflammation. Interleukin 1 (alpha and beta) signaling involves the same receptor but there are differences between the localization, processing and function of the two cytokines. Il1b is considered the more potent cytokine while 1a can be active in its precursor form, can be membrane-associated and active and can also

Pathway Diagram:

Ariadne Genomics Inc. NLRP1 inflammasome Myd88 Tollip AIM2 inflammasome NLRP3 inflammasome Map3k7-Tab(s) complex Pellino members Ube2n Il1rap Il1r1 Il-1beta processing cytTraf6 --+> cytMap3k7 cytTraf6 ---- Ube2v1 cytTraf6 ---- Ube2n Pellino members ---> diss-Irak1 diss-Irak1 ---> Pellino members diss-Traf6 ---- Map3k7-Tab(s) complex diss-Irak1 ---- diss-Traf6 diss-Irak1 ---- Map3k7-Tab(s) complex Il1r1 ---- negative regulators Il1rap ---- negative regulators Il1a ---- Il1r1 cytMap3k7 --+> c-Jun N-terminal kinases MAPK signaling pathway cytMap3k7 --+> p38 MAPK signaling pathway cytMap3k7 --+> nuclear factor kappa B signaling pathway Irak1 ---- Myd88 Irak4 ---- Myd88 Irak1 ---- Traf6 Il1r1 ---- Il1rap Il1rap ---- Myd88 Il1r1 ---- Myd88 Il1rap ---- Tollip Il1r1 ---- Tollip Irak4 ---> Irak1 K63-polyubiquitination Irak4 ---> Irak2 Irak4 Traf6 Irak2 Irak1 Ube2v1 Il1a Il1b Il1b ---- Il1r1 diss-Irak1 diss-Traf6 NLRP3 inflammasome ---> Il-1beta processing NLRP1 inflammasome ---> Il-1beta processing AIM2 inflammasome ---> Il-1beta processing p38 MAPK signaling pathway c-Jun N-terminal kinases MAPK signaling pathway nuclear factor kappa B signaling pathway Il-1beta secretion Il-1beta processing ---> Il-1beta secretion cytTraf6 negative regulators ---| Il1rap negative regulators ---| Il1r1 negative regulators cytTab(s) cytMap3k7
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Genes in Pathway:

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interleukin-1 signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aim2 absent in melanoma 2 JBrowse link 13 91,919,834 91,963,080 RGD:5490211
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:5490210
RGD:6484113
RGD:5490211
G Chuk conserved helix-loop-helix ubiquitous kinase JBrowse link 1 263,848,829 263,884,354 RGD:6484113
G Erc1 ELKS/RAB6-interacting/CAST family member 1 JBrowse link 4 152,087,393 152,380,023 RGD:6484113
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:6484113
G Ikbkg inhibitor of nuclear factor kappa B kinase subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:6484113
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:5490209
RGD:6484113
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:5490209
RGD:6484113
G Il1r1 interleukin 1 receptor type 1 JBrowse link 9 46,962,291 47,038,139 RGD:5490209
RGD:6484113
RGD:5130945
G Il1r2 interleukin 1 receptor type 2 JBrowse link 9 46,840,646 46,881,241 RGD:5490209
RGD:6484113
G Il1rap interleukin 1 receptor accessory protein JBrowse link 11 77,456,648 77,593,208 RGD:5490209
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:5490209
RGD:6484113
G Irak1 interleukin-1 receptor-associated kinase 1 JBrowse link X 156,716,469 156,726,367 RGD:5490215
RGD:6484113
RGD:5490218
G Irak2 interleukin-1 receptor-associated kinase 2 JBrowse link 4 145,594,575 145,651,066 RGD:5490215
G Irak3 interleukin-1 receptor-associated kinase 3 JBrowse link 7 64,922,830 64,982,224 RGD:6484113
G Irak4 interleukin-1 receptor-associated kinase 4 JBrowse link 7 135,803,723 135,831,006 RGD:5490215
RGD:6484113
RGD:5490218
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:6484113
G Map2k6 mitogen-activated protein kinase kinase 6 JBrowse link 10 98,707,160 98,823,054 RGD:6484113
G Map3k3 mitogen activated protein kinase kinase kinase 3 JBrowse link 10 94,280,703 94,349,372 RGD:6484113
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:5490215
RGD:6484113
RGD:5490218
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:6484113
G Myd88 myeloid differentiation primary response 88 JBrowse link 8 128,022,512 128,027,462 RGD:5490215
RGD:6484113
RGD:5490218
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:6484113
G Nlrp1a NLR family, pyrin domain containing 1A JBrowse link 10 57,692,474 57,747,608 RGD:5490211
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 10 45,884,324 45,918,290 RGD:5490210
RGD:5490211
G Peli1 pellino E3 ubiquitin protein ligase 1 JBrowse link 14 106,008,086 106,062,566 RGD:5490215
G Peli2 pellino E3 ubiquitin protein ligase family member 2 JBrowse link 15 24,942,218 25,086,350 RGD:5490215
G Peli3 pellino E3 ubiquitin protein ligase family member 3 JBrowse link 1 220,191,209 220,204,032 RGD:5490215
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha JBrowse link 2 118,831,350 118,861,456 RGD:6484113
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:6484113
G Prkci protein kinase C, iota JBrowse link 2 115,941,998 116,002,550 RGD:6484113
G Prkcz protein kinase C, zeta JBrowse link 5 172,658,071 172,769,492 RGD:6484113
G Pycard PYD and CARD domain containing JBrowse link 1 199,438,029 199,439,062 RGD:5490210
RGD:5490211
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6484113
G Sigirr single Ig and TIR domain containing JBrowse link 1 213,898,395 213,907,697 RGD:5490209
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:6484113
G Tab1 TGF-beta activated kinase 1/MAP3K7 binding protein 1 JBrowse link 7 121,350,953 121,382,100 RGD:5490215
RGD:6484113
RGD:5490218
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 JBrowse link 1 1,999,574 2,017,574 RGD:5490215
RGD:6484113
RGD:5490218
G Tab3 TGF-beta activated kinase 1 and MAP3K7 binding protein 3 JBrowse link X 54,035,958 54,090,282 RGD:5490218
G Ticam2 toll-like receptor adaptor molecule 2 JBrowse link 18 40,555,106 40,572,569 RGD:6484113
G Tollip toll interacting protein JBrowse link 1 214,823,993 214,844,861 RGD:5490218
RGD:6484113
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:5490215
RGD:6484113
RGD:5130945
RGD:5490218
G Ube2n ubiquitin-conjugating enzyme E2N JBrowse link 7 36,610,147 36,640,190 RGD:5490215
RGD:6484113
RGD:5490218
G Ube2v1 ubiquitin conjugating enzyme E2 V1 JBrowse link 3 164,343,833 164,366,684 RGD:5490215
RGD:5490218
RGD:6484113

Additional Elements in Pathway:

(includes Gene Groups, Small Molecules, Other Pathways..etc.)
Object TypePathway ObjectPathway Object Description
ComplexMap3k7-Tab(s) complexa pre-formed complex at the membrane consisting of Map3k7 and members of Tab family
Proteindiss-Irak1Irak1 dissociated from the receptor complex
ProteincytMap3k7Map3k7 translocated to the cytoplasm in the Traf6-Map3k7-Tab(s) complex
Pathwaynuclear factor kappa B signalingnf-kappaB signaling plays essential role in the proper functioning of the immune system
Pathwayp38 MAPK signaling pathwayone of the two stress activated MAPK cascades that responds to inflammatory cytokines and various stresses
Pathwayc-Jun N-terminal kinases MAPK signaling pathwayone of the two stress activated MAPK cascades that responds to inflammatory cytokines and various stresses
Functional Classnegative regulatorsspecific and broad negative regulators of interleukin-1 signaling
ProteincytTab(s)Tab(s) translocated to the cytoplasm in the Traf6-Map3k7-Tab(s) complex
ComplexAIM2 inflammasomethe AIM2 inflammasome that processes Il-1beta
Functional ClassPellino membersthe members of E3 ubiqutin ligase Pellino family
ComplexNLRP1 inflammasomethe NLRP1 inflammasome complex that processes Il-1beta
ComplexNLRP3 inflammasomethe NLRP3 inflammasome complex that processes Il-1beta
ProteincytTraf6Traf6 translocated to the the cytoplasm in the Traf6-Map3k7-Tab(s) complex
Proteindiss-traf6Traf6 dissociated from the receptor complex

Pathway Gene Annotations

Disease Annotations Associated with Genes in the interleukin-1 signaling pathway
Disease TermsGene Symbols
Abnormalities, MultipleChuk
Abortion, SpontaneousIl1b
AbscessIl1rn
Acute Kidney InjuryCasp1 , Il1a , Il1b , Il1rn
Acute Lung InjuryIl1b , Il1rn
Acyl-CoA Dehydrogenase Family, Member 9, Deficiency ofPik3ca
AdenocarcinomaIl1b , Nfkb1 , Pik3ca , Pycard
Adenocarcinoma of EsophagusPik3ca
Adenocarcinoma of LungPik3ca
ADENOCARCINOMA OF STOMACHPik3ca
Adenocarcinoma, ColorectalJun , Mapk8
Adenocarcinoma, ProstaticPik3ca
Adenoma, ColorectalJun , Mapk8
Adrenocortical CarcinomaPik3ca
Agammaglobulinemia 7, Autosomal RecessivePik3r1
Aggressive PeriodontitisIl1r2
AgranulocytosisIl1b
AIDS Dementia ComplexIl1b
AlbuminuriaCasp1 , Il1b , Pycard
Alopecia AreataIl1rn
Alveolitis, Extrinsic AllergicIl1a , Il1b
Alzheimer DiseaseIkbkb , Il1a , Il1b , Mapk8 , Pik3r1
AmnesiaIl1a
Amphetamine-Related DisordersRela
Amyotrophic Lateral SclerosisSqstm1
Amyotrophic Lateral Sclerosis 1Casp1
AnaphylaxisNlrp3
AnemiaIl1b
Anemia, Nonspherocytic Hemolytic, due to G6pd DeficiencyIkbkg
AnorexiaIl1a , Il1b , Il1rn
AnthracosisIl1a , Il1b , Il1rn
Anti-Glomerular Basement Membrane DiseaseIl1b , Il1rn , Mapk8
Aortic Aneurysm, AbdominalMapk8
Arsenic PoisoningIl1a , Il1b , Il1rn , Peli1
ArteriosclerosisIl1b , Rela
Arthritis, ExperimentalIkbkb , Ikbkg , Il1a , Il1b , Il1rn , Myd88
Arthritis, JuvenileIl1a , Il1rn , Jun
Arthritis, PsoriaticIrak1
Arthritis, RheumatoidIl1a , Il1b , Il1rn , Irak1 , Traf6
AsbestosisNlrp3
Aspergillosis, Allergic BronchopulmonaryIl1a
AsphyxiaJun
AsthmaCasp1 , Chuk , Il1a , Il1b , Il1rn
Asthma-Related Traits, Susceptibility To, 5Irak3
AtherosclerosisIl1b
AtrophyIl1rn
Atypical Mycobacteriosis, Familial, X-Linked 1Ikbkg
Autistic DisorderIl1rn
AUTOINFLAMMATION WITH ARTHRITIS AND DYSKERATOSISNlrp1a
Bacterial Infections and MycosesIrak4
Bacterial KeratitisIl1r1 , Myd88
Barrett EsophagusRela
Behcet SyndromeIkbkg , Il1b , Il1rn
Beta-ThalassemiaIl1a
bladder urothelial carcinomaPik3ca
Bone Diseases, DevelopmentalChuk
Brain DeathMap2k6
Brain InfarctionIl1b
Brain InjuriesCasp1 , Il1a , Il1b , Il1r1 , Il1rn , Jun , Rela , Ticam2
Brain IschemiaIl1a , Il1b , Il1rn , Irak1 , Irak4 , Jun , Mapk8 , Nfkb1 , Rela
Brain NeoplasmsRela
Breast AdenocarcinomaPik3ca
breast cancerPik3ca
Breast NeoplasmsIkbkb , Il1b , Jun , Pik3ca , Pik3r1 , Prkci , Rela
Bronchial HyperreactivityIl1b , Il1rn
BronchiectasisIl1b
BronchiolitisIl1b , Il1rn
Bronchiolitis ObliteransIl1rn
Bronchiolitis, ViralCasp1 , Il1rn
Bronchopulmonary DysplasiaIl1b , Il1rn
Burkitt LymphomaPik3r1
BurnsIl1a , Il1b
Burns, ChemicalIl1a , Il1b , Il1r1
CachexiaIl1b , Il1rn
CalcinosisIl1b , Pycard
CarcinomaPik3r1
Carcinoma in SituCasp1
Carcinoma, Adenoid CysticPik3ca
Carcinoma, Basal CellPik3ca
Carcinoma, BronchogenicIl1rn
Carcinoma, HepatocellularIl1b , Jun , Pik3ca , Pycard
Carcinoma, Intraductal, NoninfiltratingRela
Carcinoma, Large CellPycard
Carcinoma, Non-Small-Cell LungIl1a , Il1b , Il1rn , Pik3ca , Pycard , Rela
Carcinoma, Renal CellIl1rn , Jun , Pik3ca , Rela
Carcinoma, Small CellPycard
Carcinoma, Squamous CellIrak1 , Pik3ca , Pycard
Carcinoma, Squamous Cell of Head and NeckPik3ca
Carcinoma, Transitional CellPik3ca
CardiomegalyIl1b , Map2k6 , Mapk8 , Rela
CardiomyopathiesIl1a , Il1b , Irak1
Cardiomyopathy, RestrictiveMap2k6
Carotid Artery InjuriesIl1rn
Cell Transformation, NeoplasticJun , Mapk8 , Myd88 , Nfkb1 , Rela
Cerebral HemorrhageIl1rn , Nfkb1 , Rela , Sqstm1
Cervical Intraepithelial NeoplasiaRela
Chemical and Drug Induced Liver InjuryIl1a , Il1b , Il1r2
CholestasisIl1a , Rela
CholesteatomaIl1a , Il1b
Cholesteatoma, Middle EarIl1a , Il1r1 , Rela
Chondrosarcoma, MesenchymalIl1a
ChorioamnionitisIl1a
Choroidal NeovascularizationIkbkb
Chronic Lymphoid LeukemiaMyd88
Chronic RhinosinusitisIl1rn
Chronic UveitisIl1rn
Cleft PalateChuk
Cocoon SyndromeChuk
Cognition DisordersIrak1
Cognitive DysfunctionIl1b
ColitisChuk , Ikbkb , Il1b , Rela
Colitis, ExperimentalIl1rn
colon cancerPik3ca
Colonic NeoplasmsIkbkb , Il1b , Il1rn , Jun , Map2k6 , Mapk8 , Nfkb1 , Pik3ca , Pik3r1 , Rela
colorectal cancerPik3ca
Colorectal NeoplasmsPik3ca , Pik3r1 , Pycard
Common ColdIl1a , Il1b , Il1rn
Common Variable ImmunodeficiencyNfkb1
Congenital Heart Defects, Multiple Types, 2Tab2
Congenital Lipomatous Overgrowth, Vascular Malformations, and Epidermal NeviPik3ca
Conjunctivitis, AllergicIl1b , Il1rn
Contrast-Induced NephropathyIl1b
Corneal EdemaIl1a
Corneal Graft RejectionIl1rn
Corneal NeovascularizationIl1rn
Coronary Artery DiseaseIl1b , Irak1 , Traf6
Coronary DiseaseIl1b
COWDEN SYNDROME 5Pik3ca
Craniocerebral TraumaIl1a
Creutzfeldt-Jakob SyndromeIl1a
Crohn DiseaseNlrp3
Cryopyrin-Associated Periodic SyndromesIl1rn , Nlrp3
CryptorchidismRela
Currarino TriadPik3ca
Cystic FibrosisIl1a , Il1b , Il1rn
CystitisIl1b , Rela
DacryocystitisIl1rn
Deficiency of Interleukin-1 Receptor AntagonistIl1rn
Dementia, VascularIl1b
Depressive DisorderIl1b , Il1rn , Jun
DermatitisIkbkb
Dermatitis, Allergic ContactIl1a
Dermatitis, AtopicIl1b , Mapk8
DermatomyositisIl1a , Il1b
Diabetes Mellitus, ExperimentalCasp1 , Ikbkb , Il1a , Il1b , Il1rn , Map2k6 , Pik3r1 , Prkci , Rela
Diabetes Mellitus, Insulin-Dependent, 5Tab2
Diabetes Mellitus, Type 1Il1a , Il1b , Il1r1 , Il1rn
Diabetes Mellitus, Type 2Ikbkb , Il1b , Il1rn , Nfkb1 , Pik3r1 , Rela
Diabetic AngiopathiesRela
Diabetic NephropathiesIl1b , Il1rn , Rela
Diabetic NeuropathiesIl1b
Diabetic RetinopathyIl1a , Il1b
DiarrheaIl1a , Il1rn
Dilatation, PathologicCasp1
Disease Models, AnimalIl1b , Mapk8
Drug HypersensitivityNlrp3
Drug Hypersensitivity SyndromeIl1b , Il1rn
Drug-induced agranulocytosisIl1b , Il1rn
Drug-Induced Immune ThrombocytopeniaIl1a , Il1b
Drug-induced NeutropeniaIl1a
Dry Eye SyndromesIl1b , Il1rn
Dyskinesia, Drug-InducedRela
Eales DiseaseIl1b
Ectodermal Dysplasia, Anhidrotic, with Immunodeficiency, Osteopetrosis, and LymphedemaIkbkg
Ectodermal Dysplasia, Hypohidrotic, with Immune DeficiencyIkbkg
EdemaIl1b , Map2k6
Embryo LossUbe2n
EncephalitisIl1b , Il1rn , Rela
Encephalomyelitis, Autoimmune, ExperimentalIl1rn
Endometrial NeoplasmsJun , Pik3ca
EndometriosisIl1r1
EndometritisIl1a
EndophthalmitisIl1b
EndotoxemiaCasp1 , Il1a , Il1b , Il1rn
Endotoxin-Induced UveitisIl1rn
EntamoebiasisIl1b
EnterocolitisIl1a , Il1b
Enterocolitis, NecrotizingIkbkg , Il1b
Enterocolitis, NeutropenicIl1b
EosinophiliaMyd88
Epidermal NevusPik3ca
Esophageal NeoplasmsMap3k3 , Pik3ca
Extravasation of Diagnostic and Therapeutic MaterialsIl1rn
Eye BurnsIl1b
Eye ManifestationsIl1rn
Fabry DiseaseIl1a
Facial AsymmetryPik3ca
Familial cold autoinflammatory syndrome 1Nlrp3
Familial Mediterranean FeverIl1b
Familial Paget's Disease of BoneSqstm1
Fatty LiverIl1b , Mapk8 , Nfkb1 , Rela
Femoral FracturesIl1a
Fetal DiseasesChuk
Fetal Growth RetardationIl1a
FeverIl1a , Il1b , Il1rn , Nlrp3
FibromyalgiaIl1rn
FibrosisIl1b , Il1rn
Food HypersensitivityNlrp3
Forney Robinson Pascoe SyndromeMap3k7
Frontometaphyseal DysplasiaMap3k7
Frontometaphyseal Dysplasia 2Map3k7
Frontotemporal Dementia and/or Amyotrophic Lateral Sclerosis 3Sqstm1
Gallbladder NeoplasmsIl1b
Gastritis, AtrophicIl1b
Gastrointestinal NeoplasmsPik3ca
Genetic Predisposition to DiseaseIl1b
GlioblastomaIl1b , Pik3ca , Pik3r1
GliomaPik3ca
GlomerulonephritisIl1a , Il1b , Il1r1 , Il1rn
Glomerulonephritis, CrescenticIl1b , Il1rn
Glomerulonephritis, IGAIl1a , Il1b , Il1rn
Glomerulonephritis, MembranoproliferativeIl1b
Glomerulonephritis, MembranousIl1b
GlomerulosclerosisIl1b
Glomerulosclerosis, Focal SegmentalIl1b
Glucosephosphate Dehydrogenase DeficiencyIkbkg
GoutIl1b , Il1rn
Graft vs Host DiseaseIl1a , Il1rn
Gram-Negative Bacterial InfectionsIl1b
Graves DiseaseIl1b
Graves OphthalmopathyIl1a , Il1rn
Growth DisordersPik3ca
Head and Neck NeoplasmsPik3ca
Heart FailureCasp1 , Il1b
Heart InjuriesIl1b
Heart Valve DiseasesIl1b , Pycard
Heat StrokeIl1a , Il1b , Jun , Nfkb1 , Rela
HemangiosarcomaJun
HemimegalencephalyPik3ca
Hemolytic-Uremic SyndromeIl1a , Il1b , Il1rn
HemorrhageIl1a
Hepatitis CIl1b
Hirschsprung Disease 1Irak3
HIV Wasting SyndromeIl1a , Il1b
Hodgkin DiseaseJun
Huntington DiseaseNfkb1
HydronephrosisIl1b
Hyper-IgM Immunodeficiency, X-Linked, with Ectodermal Dysplasia, HypohidroticIkbkg
HyperalgesiaIl1a , Il1b , Il1r1 , Il1rn , Mapk8
HypercholesterolemiaIl1b
HyperemiaIl1b
HyperglycemiaIl1a , Il1b , Il1rn , Prkcz
HyperhomocysteinemiaCasp1 , Il1b , Pycard
HyperoxaluriaNfkb1
HyperoxiaIrak4
HyperplasiaIkbkb , Pik3ca
HypersensitivityCasp1 , Il1b , Il1r1 , Il1r2 , Map2k6
HypertensionIkbkb , Il1b , Il1rn , Jun , Mapk8 , Myd88 , Pik3r1 , Rela , Sqstm1
Hypertension, PortalIl1b , Pik3r1
Hypertension, PulmonaryIl1b , Il1rn , Rela
Hypertension, RenovascularRela
Hypertrophy, Left VentricularPrkcz , Rela
Hypoglossal Nerve InjuriesIl1r1
HypoglycemiaIl1b , Pik3r1
HypolipoproteinemiasIl1b
HypotensionIl1a , Il1b
Hypoxia-Ischemia, BrainIl1b , Irak1 , Irak4
Immunodeficiency 15Ikbkb
Immunodeficiency 36Pik3r1
Immunodeficiency without Anhidrotic Ectodermal DysplasiaIkbkg
Immunodeficiency, common variable, 12Nfkb1
Incontinentia pigmenti, familial male-lethal typeIkbkg
Infarction, Middle Cerebral ArteryIkbkb , Il1b , Il1rn
InflammationCasp1 , Chuk , Il1a , Il1b , Il1rn , Myd88 , Nlrp3
Inflammatory Bowel Disease 11Il1b , Il1rn
Inflammatory Bowel DiseasesIkbkb , Il1rn
Influenza, HumanCasp1 , Il1a , Il1b , Il1rn
Insulin ResistanceCasp1 , Ikbkb , Il1b , Pik3r1 , Prkcz , Rela
Intestinal NeoplasmsMapk8
Intestinal PolypsJun
Invasive Pneumococcal Disease, Recurrent Isolated, 1Irak4
Invasive Pneumococcal Disease, Recurrent Isolated, 2Ikbkg
Invasive Pulmonary AspergillosisIl1a , Il1b
IRAK4 DeficiencyIrak4
IridocyclitisIl1a
Irritable Bowel SyndromeIkbkg
Ischemic Attack, TransientIkbkb , Il1b , Il1rn , Nfkb1
Kearns-Sayre SyndromeIl1a , Il1b
Keratitis, HerpeticIl1b , Il1rn
KeratoconusIl1a , Il1b , Il1rn
Keratosis, SeborrheicPik3ca
Kidney DiseasesCasp1 , Il1rn , Pycard
Kidney Failure, ChronicIl1a , Il1b , Il1rn , Nfkb1 , Rela
Kidney NeoplasmsJun
Kidney Reperfusion InjuryIkbkb , Il1b , Il1rn
Learning DisordersIkbkg , Il1b , Il1rn
Leishmaniasis, CutaneousIl1b
Leishmaniasis, VisceralIl1b
LeptospirosisIl1b
LethargyIl1b
LeukemiaPrkcz
Leukemia, ExperimentalIl1a
Leukemia, Hairy CellIl1rn
Leukemia, Lymphocytic, Chronic, B-CellIl1a , Il1b , Il1rn , Myd88
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveIl1b , Il1rn
Leukemia, Myeloid, AcuteIl1a
LeukocytosisIl1b , Il1rn
Lichen Planus, OralIl1a
Lichen Sclerosus et AtrophicusIl1rn
Limb Deformities, CongenitalChuk
ListeriosisIl1rn
liver cancerPik3ca
Liver Cirrhosis, AlcoholicRela
Liver Cirrhosis, BiliaryNfkb1
Liver Cirrhosis, ExperimentalCasp1 , Il1b , Pycard , Rela
Liver DiseasesIl1r2 , Il1rap , Nfkb1
Liver Diseases, AlcoholicIl1b
Liver Failure, AcuteIl1rn , Mapk8
Liver NeoplasmsJun , Pik3ca
Liver Reperfusion InjuryIkbkg , Il1a , Il1b , Il1rn , Mapk8
lung cancerPik3ca
Lung DiseasesCasp1 , Il1a , Il1b
Lung Diseases, InterstitialIl1a , Il1rn
Lung NeoplasmsIkbkg , Il1b , Jun , Pik3ca , Pycard
Lung Reperfusion InjuryIl1b
Lupus Erythematosus, SystemicIl1b , Il1rn
Lupus NephritisIl1b , Il1rn
Lyme NeuroborreliosisIl1b
Lymphatic MetastasisPik3ca , Rela
LymphomaMyd88 , Rela
Lymphoma, FollicularMyd88
Lymphoma, Large B-Cell, DiffuseMyd88 , Pik3ca
Lymphoma, Non-HodgkinMyd88 , Pik3ca
LymphopeniaIl1b
Macular DegenerationSqstm1
Malformations of Cortical DevelopmentPik3ca
Mammary Neoplasms, AnimalMap2k6 , Pik3r1
Mammary Neoplasms, ExperimentalCasp1 , Il1rn , Pik3r1 , Rela
Manganese PoisoningIl1b
MastoiditisRela
MedulloblastomaPik3ca
Megalancephaly Polymicrogyria-Polydactyly Hydrocephalus SyndromePik3ca
Megalencephaly Cutis Marmorata Telangiectatica CongenitaPik3ca
Meibomian Gland DysfunctionIl1rn
MelanomaIl1rn , Nfkb1 , Nlrp3 , Pik3ca , Pik3r1
Melanoma, Cutaneous Malignant, Susceptibility To, 1Nlrp3 , Pik3ca
Melanoma, ExperimentalIkbkb , Il1a , Il1b
MELAS SyndromeIl1a , Il1b
Memory DisordersIl1b
Meningitis, PneumococcalRela
Mercury Poisoning, Nervous SystemJun
MERRF SyndromeIl1a , Il1b
Mesothelioma, MalignantIl1a , Pycard
Microvascular Complications of Diabetes, Susceptibility To, 3Il1rn
MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 4Il1rn
Microvascular Complications of Diabetes, Susceptibility To, 6Il1rn
Microvascular Complications of Diabetes, Susceptibility To, 7Il1rn
Mitochondrial MyopathiesIl1a , Il1b
Mitral Regurgitation, Conductive Deafness, and Fusion of Cervical Vertebrae and of Carpal and Tarsal BonesMap3k7
Mouth NeoplasmsPik3ca
Muckle-Wells syndromeIl1rn , Nlrp3
Mucocutaneous Lymph Node SyndromeIl1b
MucositisIl1b , Il1rn
Multiple Hamartoma SyndromePik3ca
Multiple MyelomaIl1a , Il1b , Il1rn , Myd88 , Pik3ca
Multiple Organ FailureIl1b , Il1rn
Multiple SclerosisCasp1 , Il1b , Il1rn , Nlrp3
Muscular AtrophyChuk , Ikbkb
Muscular DiseasesIl1b
Mycobacterium Infections, NontuberculousIl1r1
MYD88 DeficiencyMyd88
Myelodysplastic SyndromesIl1b
Myocardial InfarctionCasp1 , Il1b , Il1rn , Map2k6
Myocardial IschemiaIl1a , Il1b
Myocardial Reperfusion InjuryCasp1 , Il1a , Il1b , Il1rn , Irak1 , Map2k6 , Mapk8 , Myd88 , Rela
MyocarditisIrak1
Myocarditis, Autoimmune, ExperimentalIl1rn
MyositisIl1rn
Nasal PolypsIl1a , Jun
Nasopharyngeal CarcinomaPik3ca
Nasopharyngeal NeoplasmsPik3ca
NecrosisIl1b , Il1rn
Nematode InfectionsPik3r1
Neoplasm InvasivenessIl1b , Il1rn , Myd88 , Rela
NeoplasmsIl1b , Pik3ca , Pik3r1
Neoplasms, ExperimentalRela
Neoplastic Syndromes, HereditaryPik3ca
NephritisIl1rn
Nephritis, HereditaryIl1b
NephrolithiasisIl1rn
NephrosisIl1b
Nephrotic SyndromeIl1b , Il1rn
Neuritis, Autoimmune, ExperimentalIl1b
NeuroblastomaPik3ca
NEURODEGENERATION WITH ATAXIA, DYSTONIA, AND GAZE PALSY, CHILDHOOD-ONSETSqstm1
NeutropeniaIl1b
Non-alcoholic Fatty Liver DiseaseIkbkg , Il1a
Nonaka MyopathySqstm1
ObesityCasp1 , Ikbkb , Il1b , Il1rn , Pik3r1 , Rela
Obesity, MorbidIl1rn
OligoanuriaIl1rn
Onchocerciasis, OcularIl1r1
Ophthalmoplegia, Chronic Progressive ExternalIl1a , Il1b
Optic Atrophy, Hereditary, LeberIl1a , Il1b
Optic Nerve InjuriesJun
Osteitis DeformansSqstm1
OsteoarthritisIl1a , Il1b
Osteoarthritis, KneeIl1a
Osteomyelitis, Sterile Multifocal, with Periostitis and PustulosisIl1rn
OsteopetrosisJun
OsteoporosisIl1a , Il1b , Il1rn
Osteoporosis, PostmenopausalIl1b
OsteosarcomaJun
Otitis MediaIl1a , Il1b , Rela
Otitis Media with EffusionIl1b
ovarian cancerPik3ca
Ovarian CystsNfkb1
Ovarian NeoplasmsMap2k6 , Pik3ca , Pik3r1 , Prkci , Rela
ovarian serous cystadenocarcinomaPik3ca
Oxygen-Induced RetinopathyMapk8
PainCasp1 , Il1rn
PALMOPLANTAR CARCINOMA, MULTIPLE SELF-HEALINGNlrp1a
Pancreatic AdenocarcinomaPik3ca
Pancreatic CystIl1b
Pancreatic NeoplasmsIl1a , Il1b , Rela
PancreatitisIkbkb , Il1b
Pancreatitis, Acute NecrotizingIl1b , Il1rn , Rela
Pancreatitis, ExperimentalIkbkg
Pancreatitis, Experimental, Chronic Il1b
papillary renal cell carcinoma Pik3ca
Papillary Renal Cell Carcinoma, SporadicPik3ca
Parkinson DiseaseIl1b
Parkinsonian DisordersIl1b , Rela
Pemphigoid, Benign Mucous MembraneIl1rn
Penile NeoplasmsPik3ca
Peptic UlcerIl1b
PeriodontitisIl1a , Il1b , Il1rn
Peripheral Nerve InjuriesIl1b
Peripheral Nervous System DiseasesJun
Pick Disease of the BrainMap2k6
PlagueIl1b
Pleural DiseasesIl1rn
PleurisyIl1b , Il1rn
PneumoniaCasp1 , Ikbkb , Il1a , Il1b , Il1r1 , Il1r2 , Il1rn , Myd88
Pneumonia, AspirationIl1a
Pneumonia, BacterialChuk , Il1b , Il1rn
Pneumonia, StaphylococcalIl1b
PoisoningIl1a
Polycystic Kidney, Autosomal DominantIl1rn
Polycystic Kidney, Autosomal RecessivePik3ca
Polycystic Ovary SyndromeTab1
PolymyositisIl1a , Il1b
Postoperative Cognitive DysfunctionIl1b , Il1rn
Pre-EclampsiaIl1rn
Precancerous ConditionsMapk8
PresbycusisIl1r2
Presenile and Senile DementiaIl1b
ProctocolitisIl1rn
prostate cancerNlrp1a , Pik3ca , Pik3r1
Prostatic HyperplasiaCasp1 , Rela
Prostatic Intraepithelial NeoplasiaMap2k6 , Rela
Prostatic NeoplasmsCasp1 , Chuk , Il1rn , Irak4 , Jun , Map2k6 , Map3k7 , Nlrp1a , Pik3ca , Pik3r1 , Prkcz , Rela
ProstatitisIl1rn
ProteinuriaIl1rn
Pseudomonas Aeruginosa KeratitisIl1b , Il1rn
Pseudomonas InfectionsIl1b , Il1rn
PsoriasisIkbkb , Il1b , Irak1
Pulmonary Disease, Chronic ObstructiveIl1b , Il1rn , Mapk8
Pulmonary EdemaIl1b
Pulmonary EosinophiliaIl1rn
Pulmonary FibrosisIl1a , Il1b , Il1rn
PulpitisIl1r1
Purpura, Thrombocytopenic, IdiopathicIl1a , Il1rn
PyelonephritisIl1rn
Radiation InjuriesIl1a
Radiation Injuries, ExperimentalIl1b
Radiation PneumonitisIl1a
Rectal NeoplasmsMapk8 , Pik3ca
Renal InsufficiencyIl1b
Renal Insufficiency, ChronicIl1b , Il1rn
Reperfusion InjuryCasp1 , Il1a , Il1b , Irak3 , Jun , Mapk8 , Myd88 , Pik3r1 , Rela
Respiratory Distress Syndrome, AdultIl1b , Il1rn
Respiratory HypersensitivityIl1a , Il1b , Il1rn
Retina Reperfusion InjuryIl1a , Il1b
Retinal Vein OcclusionIl1b
RetinitisIl1b
Retinopathy of PrematurityIl1b
Rett SyndromeIrak1
RhinitisCasp1 , Il1b , Il1rn
Rhinitis, AllergicIl1b
Rhinitis, Allergic, PerennialIl1a , Il1r1
RhinosinusitisIl1b
Sarcoidosis, PulmonaryIl1rn
SarcomaPik3ca
SchizophreniaIl1b
Schizophrenia, ChildhoodRela
Schnitzler SyndromeIl1a , Il1rn
Sciatic NeuropathyIl1b , Il1rn
Scleroderma, SystemicIl1b , Il1r1 , Irak1
SclerosisIl1a , Il1rn
SeizuresCasp1 , Il1b
Seizures, FebrileIl1b , Il1rn
SepsisIl1b , Il1rn , Irak4 , Rela
Septic PeritonitisPik3r1
SerositisIl1rn
Shock, HemorrhagicIl1a , Il1b , Rela
Shock, SepticIl1rn
SHORT SyndromePik3r1
SilicosisIl1b , Il1rn
SinusitisIl1b
Sjogren's SyndromeIl1rn
Skin AbnormalitiesChuk
Skin DiseasesIl1a , Il1b , Il1r1 , Il1rn , Peli1
Skin NeoplasmsIl1a , Rela
Sleep Apnea, ObstructiveIl1b , Rela
Sleep Wake DisordersIl1b
Small Cell Lung CarcinomaPik3ca
Small-For-Size SyndromeIl1b
Smith-Magenis SyndromeMap2k6 , Map3k3
Spinal Cord InjuriesCasp1 , Il1b , Il1r1 , Il1rn , Jun , Rela
Spondylitis, AnkylosingIl1r2 , Irak1
Squamous Cell Carcinoma of the LungPik3ca
Status AsthmaticusIl1b
Status EpilepticusCasp1 , Il1b , Il1rn , Jun , Rela
Stomach NeoplasmsIl1b , Il1rn , Jun , Mapk8 , Pik3ca , Pycard
Stomach UlcerIl1b
StrokeIl1b , Il1rn , Mapk8
Subarachnoid HemorrhageIl1rn
Supranuclear Palsy, ProgressiveMap2k6
Systemic Inflammatory Response SyndromeIl1b
ThalassemiaIl1b
ThrombocytopeniaIl1b
ThrombocytosisIl1b
Thyroid NeoplasmsIl1b
Tibial FracturesCasp1
Tick InfestationsIl1a
Tobacco Use DisorderIl1rn
Transplant RejectionIkbkb , Il1b , Il1rn
Trigeminal NeuralgiaIl1b , Mapk8
Tuberculosis, PleuralIl1b , Il1rn
Tuberculosis, PulmonaryIl1a , Il1b , Il1rn , Jun
ulcerative colitisIl1b , Il1r2 , Rela
Ureteral ObstructionIl1b , Il1rn
Urinary Bladder NeoplasmsIl1b , Il1rn , Rela
Urinary CalculiIl1rn
Urinary Tract InfectionsIl1a , Il1b
UrticariaIl1b , Nlrp3
uterine carcinosarcomaPik3ca , Pik3r1
Uterine Cervical NeoplasmsMap2k6 , Pik3ca , Rela
Uterine NeoplasmsPik3ca , Pik3r1
UveitisIl1a , Il1b , Rela
Uveitis, AnteriorIl1rn
Uveitis, Autoimmune, ExperimentalIl1rn
Uveitis, Chronic AnteriorIl1rn
VaricoceleIl1a , Il1b
Vascular DiseasesIl1rn
Vascular MalformationsPik3ca
Venous ThrombosisIl1a , Il1b , Il1rn
Ventilator-Induced Lung InjuryIl1b , Il1r1 , Il1rn
VitiligoIl1a
Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1Nlrp1a
Vulvar VestibulitisIl1b
Waldenstrom MacroglobulinemiaMyd88
Weight GainPik3ca , Pycard
Wet Macular DegenerationMapk8
Wounds and InjuriesIl1a
X-Linked Adrenal Hypoplasia CongenitaTab3
Pathway Annotations Associated with Genes in the interleukin-1 signaling pathway
Pathway TermsGene Symbols
acute myeloid leukemia pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3r1 , Rela
adenosine signaling pathwayChuk , Ikbkb , Jun , Map2k6 , Mapk8 , Nfkb1 , Pik3ca , Prkcz
aldosterone signaling pathwayPik3ca , Pik3r1
altered phosphatidylinositol 3-kinase signaling pathwayPik3ca
altered phosphatidylinositol 3-kinase-Akt signaling pathwayPik3ca
altered ubiquitin/proteasome degradation pathwayUbe2n
Alzheimer disease pathwayIl1b , Ube2n
amyotrophic lateral sclerosis disease pathwayCasp1 , Map2k6
angiotensin II signaling pathwayPrkcz
apoptotic cell death pathwayChuk , Ikbkb , Ikbkg , Il1a , Il1b , Il1r1 , Il1rap , Irak1 , Irak2 , Irak3 , Irak4 , Myd88 , Nfkb1 , Pik3ca , Pik3r1 , Rela
ataxia telangiectasia-mutated (ATM) signaling pathwayUbe2n
B cell receptor signaling pathwayChuk , Ikbkb , Ikbkg , Jun , Nfkb1 , Pik3ca , Pik3r1 , Rela
Bone morphogenetic proteins signaling pathwayMap3k7 , Tab1 , Tab2
c-Jun N-terminal kinases MAPK signaling pathwayMap3k3 , Map3k7 , Mapk8
ceramide signaling pathwayChuk , Ikbkb , Ikbkg , Mapk8 , Nfkb1 , Pik3ca , Pik3r1 , Prkcz , Rela
chemokine mediated signaling pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3r1 , Prkcz , Rela
chronic myeloid leukemia pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3r1 , Rela
colorectal cancer pathwayJun , Mapk8 , Pik3ca , Pik3r1
cytokine mediated signaling pathwayIl1a , Il1b , Il1r1 , Il1r2 , Il1rap
E-cadherin signaling pathwayPik3ca , Pik3r1
eicosanoid signaling pathwayPrkcz
endocytosis pathwayPrkci , Prkcz , Traf6
endometrial cancer pathwayPik3ca , Pik3r1
Endoplasmic Reticulum-associated degradation pathwayMapk8
endothelin signaling pathwayJun , Mapk8
Entamoeba histolyca infection pathwayIl1b , Il1r1 , Il1r2 , Nfkb1 , Pik3ca , Pik3r1 , Rela
ephrin - ephrin receptor bidirectional signaling axisMap3k7 , Mapk8 , Pik3ca , Pik3r1
epidermal growth factor/neuregulin signaling pathwayJun , Mapk8 , Pik3ca , Pik3r1 , Prkcz
Erk5 MAPK signaling pathwayMap3k3
erythropoietin signaling pathwayMapk8 , Nfkb1 , Pik3r1
FasL mediated signaling pathwayChuk , Ikbkb , Ikbkg , Map2k6 , Mapk8 , Pik3ca , Pik3r1
Fc epsilon receptor mediated signaling pathwayMap2k6 , Mapk8 , Pik3ca , Pik3r1
Fc gamma receptor mediated signaling pathwayPik3ca , Pik3r1
fibroblast growth factor signaling pathwayJun , Pik3ca , Pik3r1
forkhead class A signaling pathwayJun
glioma pathwayPik3ca , Pik3r1
glypican signaling pathwayMapk8
gonadotropin-releasing hormone signaling pathwayJun , Map2k6 , Map3k3 , Mapk8
graft-versus-host disease pathwayIl1a , Il1b
granulocyte-macrophage colony-stimulating factor signaling pathwayIkbkb , Pik3ca , Pik3r1
Hedgehog signaling pathwayPik3ca , Pik3r1
hepatitis C virus infection pathwayChuk , Ikbkb , Ikbkg , Mapk8 , Nfkb1 , Pik3ca , Pik3r1 , Rela , Traf6
hypoxia inducible factor pathwayJun
inflammatory response pathwayMapk8
influenza A virus infection pathwayCasp1 , Ikbkb , Il1a , Il1b , Irak4 , Jun , Map2k6 , Mapk8 , Myd88 , Nfkb1 , Nlrp3 , Pik3ca , Pik3r1 , Pycard , Rela
inositol metabolic pathwayPik3ca
inositol phosphate metabolic pathwayPik3ca
insulin responsive facilitative sugar transporter mediated glucose transport pathwayPrkci , Prkcz
insulin signaling pathwayIkbkb , Mapk8 , Pik3ca , Pik3r1 , Prkci , Prkcz
insulin-like growth factor signaling pathwayPik3ca , Pik3r1 , Prkcz
interleukin-1 signaling pathwayAim2 , Casp1 , Chuk , Erc1 , Ikbkb , Ikbkg , Il1a , Il1b , Il1r1 , Il1r2 , Il1rap , Il1rn , Irak1 , Irak2 , Irak3 , Irak4 , Jun , Map2k6 , Map3k3 , Map3k7 , Mapk8 , Myd88 , Nfkb1 , Nlrp1a , Nlrp3 , Peli1 , Peli2 , Peli3 , Pik3ca , Pik3r1 , Prkci , Prkcz , Pycard , Rela , Sigirr , Sqstm1 , Tab1 , Tab2 , Tab3 , Ticam2 , Tollip , Traf6 , Ube2n , Ube2v1
interleukin-12 signaling pathwayIl1b , Il1r1 , Map2k6 , Nfkb1 , Rela
interleukin-2 signaling pathwayJun , Mapk8 , Pik3ca , Pik3r1
interleukin-23 signaling pathwayIl1b , Nfkb1 , Pik3ca , Pik3r1 , Rela
interleukin-27 signaling pathwayIl1b
interleukin-3 signaling pathwayPik3ca , Pik3r1
interleukin-4 signaling pathwayPik3ca , Pik3r1
interleukin-5 signaling pathwayPik3ca , Pik3r1
interleukin-6 signaling pathwayJun , Map2k6 , Pik3ca , Pik3r1
Jak-Stat signaling pathwayPik3ca , Pik3r1
Leishmania infection pathwayIl1a , Il1b , Irak1 , Irak4 , Jun , Map3k7 , Myd88 , Nfkb1 , Rela , Traf6
measles infection pathwayChuk , Il1a , Il1b , Irak1 , Irak4 , Map3k7 , Myd88 , Nfkb1 , Pik3ca , Pik3r1 , Rela , Traf6
melanoma pathwayPik3ca , Pik3r1
mitochondrial autophagy pathwaySqstm1
mitogen activated protein kinase signaling pathwayChuk , Ikbkb , Ikbkg , Il1a , Il1b , Il1r1 , Il1r2 , Jun , Map2k6 , Map3k3 , Map3k7 , Mapk8 , Nfkb1 , Rela , Traf6
mTOR signaling pathwayIkbkb , Pik3ca , Pik3r1
Mycobacterium tuberculosis infection pathwayIl1a , Il1b , Irak1 , Irak2 , Irak4 , Mapk8 , Myd88 , Nfkb1 , Rela , Traf6
N-cadherin signaling pathwayMapk8 , Pik3ca , Pik3r1
neurotrophic factor signaling pathwayIkbkb , Irak1 , Irak2 , Irak3 , Irak4 , Jun , Map3k3 , Mapk8 , Nfkb1 , Pik3ca , Pik3r1 , Rela , Traf6
NOD-like receptor signaling pathwayCasp1 , Chuk , Ikbkb , Ikbkg , Il1b , Map3k7 , Mapk8 , Nfkb1 , Nlrp1a , Nlrp3 , Pycard , Rela , Traf6
non-small cell lung cancer pathwayPik3ca , Pik3r1
nuclear factor kappa B signaling pathwayChuk , Erc1 , Ikbkb , Ikbkg , Map3k7 , Nfkb1 , Pik3ca , Pik3r1 , Rela , Tab1 , Tab2 , Tab3 , Traf6
nuclear factor, erythroid 2 like 2 signaling pathwayIkbkb , Sqstm1
p38 MAPK signaling pathwayMap2k6 , Map3k3 , Map3k7 , Tab1 , Tab2 , Traf6
p53 signaling pathwayMapk8
pancreatic cancer pathwayChuk , Ikbkb , Ikbkg , Mapk8 , Nfkb1 , Pik3ca , Pik3r1 , Rela
phosphatidylinositol 3-kinase class I signaling pathwayPik3ca , Pik3r1
phosphatidylinositol 3-kinase signaling pathwayPik3ca , Pik3r1
phosphatidylinositol 3-kinase-Akt signaling pathwayChuk , Pik3ca , Pik3r1
phosphoinositide metabolic pathwayPik3ca , Pik3r1
Plasmodium infection pathwayIl1b , Myd88
platelet-derived growth factor signaling pathwayJun , Mapk8 , Pik3ca , Pik3r1
primary immunodeficiency disease pathwayIkbkg
prion diseases pathwayIl1a , Il1b
prostate cancer pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3r1 , Rela
protein kinase C (PKC) signaling pathwayPrkci , Prkcz
Reelin signaling pathwayMapk8 , Pik3ca , Pik3r1
renal cell cancer pathwayJun , Pik3ca , Pik3r1
Retinoic acid-inducible gene (RIG) I-like receptor signaling pathwayChuk , Ikbkb , Ikbkg , Map3k7 , Mapk8 , Nfkb1 , Rela , Traf6
rheumatoid arthritis disease pathwayIl1a , Il1b , Jun
Rho/Rac/Cdc42 mediated signaling pathwayJun , Mapk8
scatter factor/hepatocyte growth factor signaling pathwayPik3r1
small cell lung cancer pathwayChuk , Ikbkb , Ikbkg , Nfkb1 , Pik3ca , Pik3r1 , Rela , Traf6
sphingosine 1-phosphate signaling pathwayJun , Mapk8
syndecan signaling pathwayMapk8
T cell receptor signaling pathwayChuk , Ikbkb , Ikbkg , Jun , Map3k7 , Nfkb1 , Pik3ca , Pik3r1 , Rela
Toll-like receptor signaling pathwayChuk , Ikbkb , Ikbkg , Il1b , Irak1 , Irak2 , Irak4 , Jun , Map2k6 , Map3k7 , Mapk8 , Myd88 , Nfkb1 , Pik3ca , Pik3r1 , Rela , Tab1 , Tab2 , Tab3 , Ticam2 , Tollip , Traf6 , Ube2n , Ube2v1
Toxoplasma gondii infection pathwayChuk , Ikbkb , Ikbkg , Irak1 , Irak4 , Map2k6 , Map3k7 , Mapk8 , Myd88 , Nfkb1 , Pik3ca , Pik3r1 , Rela , Traf6
Trail mediated signaling pathwayChuk , Ikbkb , Ikbkg , Mapk8 , Pik3ca , Pik3r1
transforming growth factor-beta Smad dependent signaling pathwayMap3k7 , Tab1 , Tab2
Trypanosoma brucei infection pathwayIl1b , Myd88
Trypanosoma cruzi infection pathwayChuk , Ikbkb , Ikbkg , Il1b , Irak1 , Irak4 , Jun , Mapk8 , Myd88 , Nfkb1 , Pik3ca , Pik3r1 , Rela , Traf6
tumor necrosis factor mediated signaling pathwayChuk , Ikbkb , Ikbkg , Map3k3 , Map3k7 , Nfkb1 , Prkci , Prkcz , Rela , Sqstm1 , Tab1 , Tab2 , Tab3
type 1 diabetes mellitus pathwayIl1a , Il1b
type 2 diabetes mellitus pathwayIkbkb , Mapk8 , Pik3ca , Pik3r1 , Prkcz
type II interferon signaling pathwayCasp1 , Il1b , Pik3ca , Pik3r1
ubiquitin/proteasome degradation pathwayTraf6 , Ube2n
vascular endothelial growth factor signaling pathwayMap2k6 , Pik3ca , Pik3r1 , Prkcz
Wnt signaling pathwayJun , Map3k7 , Mapk8
Wnt signaling, non-canonical pathwayMap3k7 , Mapk8 , Prkcz , Tab1 , Tab2
Phenotype Annotations Associated with Genes in the interleukin-1 signaling pathway

References Associated with the interleukin-1 signaling pathway:

Ontology Path Diagram:

paths to the root

Import into Pathway Studio: