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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2460 Species: Rattus norvegicus RGD Object: Gene Symbol: Cyp1b1 Name: cytochrome P450, family 1, subfamily b, polypeptide 1

Acc ID: CHEBI:6980 Term: monocrotaline Definition: A pyrrolizidine alkaloid that has formula C16H23NO6. CasRN: 315-22-0 Chemical ID: MESH:D016686

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:10439	6480464	CTD	[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of CYP1B1 mRNA	PMID:21224054