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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 11-deoxycorticosterone | multiple interactions | EXP | | 6480464 | [Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of NOX1 protein | CTD | PMID:22431579 | 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol] | multiple interactions | EXP | | 6480464 | nebivolol inhibits the reaction [AGT protein results in increased expression of NOX1 protein] | CTD | PMID:16940222 | amlodipine | multiple interactions | EXP | | 6480464 | Amlodipine promotes the reaction [candesartan results in decreased expression of NOX1] | CTD | PMID:21107329 | arachidonic acid | multiple interactions | ISO | RGD:732308 | 6480464 | Arachidonic Acid results in increased cleavage of and results in increased secretion of NOX1 protein; more ... | CTD | PMID:20832062 | arsenic atom | increases expression | ISO | RGD:732308 | 6480464 | Arsenic results in increased expression of NOX1 protein | CTD | PMID:22552367 | arsenic atom | increases expression | ISO | RGD:732309 | 6480464 | Arsenic results in increased expression of NOX1 protein | CTD | PMID:22552367 | calcitriol | increases expression | ISO | RGD:732308 | 6480464 | Calcitriol results in increased expression of NOX1 mRNA | CTD | PMID:21592394 | calcitriol | multiple interactions | ISO | RGD:732308 | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of NOX1 mRNA | CTD | PMID:21592394 | candesartan | multiple interactions | EXP | | 6480464 | Amlodipine promotes the reaction [candesartan results in decreased expression of NOX1]; more ... | CTD | PMID:21107329 | candesartan | decreases expression | EXP | | 6480464 | candesartan results in decreased expression of NOX1 | CTD | PMID:21107329 | carvedilol | multiple interactions | EXP | | 6480464 | carvedilol inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA] | CTD | PMID:16213474 | chromium(6+) | increases expression | ISO | RGD:732308 | 6480464 | chromium hexavalent ion results in increased expression of NOX1 protein | CTD | PMID:21742780 | chromium(6+) | increases expression | ISO | RGD:732308 | 6480464 | chromium hexavalent ion results in increased expression of NOX1 protein | CTD | PMID:21742780 PMID:22552367 | chromium(6+) | increases expression | ISO | RGD:732309 | 6480464 | chromium hexavalent ion results in increased expression of NOX1 protein | CTD | PMID:22552367 | cobalt dichloride | increases expression | ISO | RGD:732309 | 6480464 | cobaltous chloride results in increased expression of NOX1 mRNA; more ... | CTD | PMID:16507596 | doxorubicin | multiple interactions | EXP | | 6480464 | Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA]; more ... | CTD | PMID:16213474 | doxorubicin | increases expression | EXP | | 6480464 | Doxorubicin results in increased expression of NOX1 mRNA | CTD | PMID:16213474 | ethanol | increases expression | ISO | RGD:732308 | 6480464 | Ethanol results in increased expression of NOX1 protein | CTD | PMID:22872060 | ethanol | multiple interactions | ISO | RGD:732308 | 6480464 | sodium arsenite promotes the reaction [Ethanol results in increased expression of NOX1 protein]; more ... | CTD | PMID:22872060 | hydrogen chloride | affects response to substance | ISO | RGD:732309 | 6480464 | NOX1 protein affects the susceptibility to Hydrochloric Acid | CTD | PMID:21339339 | L-ascorbic acid | increases expression | ISO | RGD:732309 | 6480464 | Ascorbic Acid results in increased expression of NOX1 protein | CTD | PMID:21570463 | LY294002 | multiple interactions | ISO | RGD:732309 | 6480464 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of NOX1 mRNA] | CTD | PMID:19293636 | menadione | increases expression | ISO | RGD:732309 | 6480464 | Vitamin K 3 results in increased expression of NOX1 protein; more ... | CTD | PMID:16507596 | mercury dichloride | increases expression | EXP | | 6480464 | Mercuric Chloride results in increased expression of NOX1 mRNA | CTD | PMID:21232032 | miconazole | decreases expression | EXP | | 6480464 | Miconazole results in decreased expression of NOX1 mRNA | CTD | PMID:22262564 | N-acetyl-L-cysteine | multiple interactions | EXP | | 6480464 | Acetylcysteine inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA] | CTD | PMID:16213474 | nitroglycerin | decreases expression | EXP | | 6480464 | Nitroglycerin results in decreased expression of NOX1 mRNA | CTD | PMID:17493633 | razoxane | multiple interactions | EXP | | 6480464 | Razoxane inhibits the reaction [Doxorubicin results in increased expression of NOX1 mRNA] | CTD | PMID:16213474 | resveratrol | multiple interactions | ISO | RGD:732309 | 6480464 | resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOX1 mRNA] | CTD | PMID:19293636 | resveratrol | decreases expression | EXP | | 6480464 | resveratrol results in decreased expression of NOX1 mRNA | CTD | PMID:20081535 | silver atom | increases expression | ISO | RGD:732309 | 6480464 | Silver results in increased expression of NOX1 mRNA | CTD | PMID:19429238 | silver(0) | increases expression | ISO | RGD:732309 | 6480464 | Silver results in increased expression of NOX1 mRNA | CTD | PMID:19429238 | sodium chloride | multiple interactions | EXP | | 6480464 | [Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of NOX1 protein | CTD | PMID:22431579 | tacrolimus hydrate | increases expression | EXP | | 6480464 | Tacrolimus results in increased expression of NOX1 mRNA | CTD | PMID:17085464 | testosterone | increases expression | ISO | RGD:732308 | 6480464 | Testosterone results in increased expression of NOX1 mRNA | CTD | PMID:21592394 | testosterone | multiple interactions | ISO | RGD:732308 | 6480464 | [Testosterone co-treated with Calcitriol] results in increased expression of NOX1 mRNA | CTD | PMID:21592394 | trans-resveratrol | multiple interactions | ISO | RGD:732309 | 6480464 | resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOX1 mRNA] | CTD | PMID:19293636 | trans-resveratrol | decreases expression | EXP | | 6480464 | resveratrol results in decreased expression of NOX1 mRNA | CTD | PMID:20081535 | zinc atom | decreases expression | ISO | RGD:732308 | 6480464 | Zinc deficiency results in decreased expression of NOX1 mRNA | CTD | PMID:18356318 | zinc(0) | decreases expression | ISO | RGD:732308 | 6480464 | Zinc deficiency results in decreased expression of NOX1 mRNA | CTD | PMID:18356318 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | HIF-1 signaling pathway |
| Leukocyte transendothelial migration | |
| Osteoclast differentiation | |
| Phagosome | |
| Pathway Interaction Database | RAC1 signaling pathway (PID:200222) |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | HIF-1 signaling pathway |
| Leukocyte transendothelial migration | |
| Osteoclast differentiation | |
| Phagosome | |
| Pathway Interaction Database | RAC1 signaling pathway (PID:200222) |
References - curated| 1. |
Ambasta RK, etal., J Biol Chem. 2004 Oct 29;279(44):45935-41. Epub 2004 Aug 18. |
| 2. |
Dai X, etal., Am J Physiol Heart Circ Physiol. 2006 Mar;290(3):H1019-26. Epub 2005 Oct 7. |
| 3. |
Fortuno A, etal., Diabetes. 2006 Jan;55(1):209-15. |
| 4. |
GOA data from the GO Consortium |
| 5. |
Katsuyama M, etal., J Biol Chem 2002 Apr 19;277(16):13438-42. |
| 6. |
MGD data from the GO Consortium |
| 7. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 8. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 9. |
Pleskova M, etal., FASEB J. 2006 Jan;20(1):139-41. Epub 2005 Oct 27. |
| 10. |
RGD automated data pipeline |
| 11. |
RGD automated import pipeline for gene-chemical interactions |
| 12. |
Suh YA, etal., Nature 1999 Sep 2;401(6748):79-82. |
| 13. |
Zou AP, etal., Hypertension 2001 Feb;37(2 Part 2):547-53. |
References - uncurated| PubMed | 14670934 |
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| 16129699 | |
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| 17085464 | |
| 17283869 | |
| 17324585 | |
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| 21419746 | |
| 21505267 | |
| 21537828 | |
| 21660950 | |
| 21814483 | |
| 22098189 | |
| 22203737 | |
| 22431579 | |
| 22433789 | |
| 22566500 | |
| 22636674 | |
| 22738259 | |
| 23087362 |
RGD Disease Portals| Nox1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Nox1 (Rattus norvegicus) |
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| NOX1 (Homo sapiens) |
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| Nox1 (Mus musculus) |
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Nucleotide Sequences| Nucleotide RefSeqs | NM_053683 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06107015 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01113105 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01113106 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01113107 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF152963 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473969 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_053683 | |||||||||||||||
| RefSeq Status: | PROVISIONAL | |||||||||||||||
| Type: | CODING | |||||||||||||||
| Protein Acc Id: | NP_446135 | |||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_446135 | (Get FASTA) |
| GenBank Protein | AAD39542 | (Get FASTA) |
| EDM07036 | (Get FASTA) | |
| EDM07037 | (Get FASTA) | |
| Q9WV87 | (Get FASTA) |
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000048706 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000065995 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000075325 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 114243 | ENTREZGENE |
| InterPro | Cyt_b245_heavy_chain | UniProtKB/Swiss-Prot |
| FAD_bd_8 | UniProtKB/Swiss-Prot | |
| Fd_Rdtase_FAD-bd | UniProtKB/Swiss-Prot | |
| Fe3_reduct_TM_N | UniProtKB/Swiss-Prot | |
| Fe_red_NAD_bd_6 | UniProtKB/Swiss-Prot | |
| Riboflavin_synthase-like_b-brl | UniProtKB/Swiss-Prot | |
| IPI | IPI00204539 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:114243 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | FAD_binding_8 | UniProtKB/Swiss-Prot |
| Ferric_reduct | UniProtKB/Swiss-Prot | |
| NAD_binding_6 | UniProtKB/Swiss-Prot | |
| PRINTS | GP91PHOX | UniProtKB/Swiss-Prot |
| PROSITE | FAD_FR | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | Riboflavin_synthase_like_b-brl | UniProtKB/Swiss-Prot |
| UniGene | Rn.220465 | ENTREZGENE |
| UniProt | M0R934_RAT | UniProtKB/TrEMBL |
| NOX1_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2004-09-10 | Nox1 | NADPH oxidase 1 | NADH/NADPH mitogenic oxidase subunit p65-mox | Name updated | 10779 | APPROVED | |
| 2002-08-07 | Nox1 | NADH/NADPH mitogenic oxidase subunit p65-mox | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_process | may regulate renal medullary blood flow (MBF) and water/sodium excretion | 628559 |
| gene_process | major superoxide-producing enzyme in the renal outer medulla (OM) of kidney | 628559 |
| gene_regulation | expression is induced by PGF(2alpha) | 625378 |
| More on Nox1 | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 620598 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




