Gene: Prkdc (protein kinase, DNA activated, catalytic polypeptide) Rattus norvegicus
Symbol: Prkdc
Name: protein kinase, DNA activated, catalytic polypeptide
Description: ENCODES a protein that exhibits DNA-dependent protein kinase activity (ortholog); double-stranded DNA binding (ortholog); enzyme binding (ortholog); INVOLVED IN immunoglobulin production; negative regulation of cellular senescence; negative regulation of immunoglobulin production; PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; phosphatidylinositol 3-kinase-Akt signaling pathway; ASSOCIATED WITH decreased body weight; decreased immunoglobulin level; spleen hypoplasia; ASSOCIATED WITH MHC class II deficiency; Severe Combined Immunodeficiency; severe combined immunodeficiency; FOUND IN DNA-dependent protein kinase-DNA ligase 4 complex (ortholog); extracellular matrix (ortholog); membrane (ortholog); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; bisphenol A; dibutyl phthalate
Type: protein-coding
RefSeq Status: MODEL
Also known as: DNA-dependent protein kinase catalytic subunit; LOC360748; MGC189093
Allele / Splice: Prkdcem1Kyo   Prkdcem2Kyo   Prkdcem4Kyo  
Genetic Models: TM-Prkdcem4KyoIl2rgem5Kyo F344-Prkdcem2KyoIl2rgem6Kyo F344-Prkdcem1Kyo
Is Marker For: Strains:   F344-Prkdcem1Kyo   F344-Prkdcem2KyoIl2rgem6Kyo   TM-Prkdcem4KyoIl2rgem5Kyo   SD-Prkdcem1Sage  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01189,293,547 - 89,510,948 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01192,347,175 - 92,565,022 (-)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.41186,951,420 - 87,169,229 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11186,992,362 - 87,209,825 (-)NCBI
Celera1183,781,535 - 83,998,574 (-)NCBI
Cytogenetic Map11q23NCBImapview
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
More on Prkdc
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 1308982
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2017-06-13
Status: ACTIVE