Annotation (Toggle Detail/Summary View) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,3-dinitrobenzene | increases expression | EXP | | 6480464 | 3-dinitrobenzene results in increased expression of C3AR1 mRNA | CTD | PMID:21983209 | 17alpha-ethynylestradiol | affects expression | EXP | | 6480464 | Ethinyl Estradiol affects the expression of C3AR1 mRNA | CTD | PMID:17351261 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of C3AR1 mRNA | CTD | PMID:22298810 | 5-azacytidine | increases expression | ISO | RGD:1353843 | 6480464 | Azacitidine results in increased expression of C3AR1 mRNA | CTD | PMID:19194470 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of C3AR1 mRNA | CTD | PMID:16483693 | arsenite(3-) | decreases expression | ISO | RGD:731620 | 6480464 | arsenite results in decreased expression of C3AR1 mRNA | CTD | PMID:18191166 | choline | multiple interactions | ISO | RGD:731620 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of C3AR1 mRNA | CTD | PMID:20938992 | cytarabine | increases expression | ISO | RGD:1353843 | 6480464 | Cytarabine results in increased expression of C3AR1 mRNA | CTD | PMID:19194470 | folic acid | multiple interactions | ISO | RGD:731620 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of C3AR1 mRNA | CTD | PMID:20938992 | indinavir | multiple interactions | ISO | RGD:731620 | 6480464 | [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of C3AR1 mRNA | CTD | PMID:16931933 | L-methionine | multiple interactions | ISO | RGD:731620 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of C3AR1 mRNA | CTD | PMID:20938992 | lamivudine | multiple interactions | ISO | RGD:731620 | 6480464 | [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of C3AR1 mRNA; more ... | CTD | PMID:16931933 | leflunomide | increases expression | ISO | RGD:731620 | 6480464 | leflunomide results in increased expression of C3AR1 mRNA | CTD | PMID:19751817 | paracetamol | decreases expression | ISO | RGD:1353843 | 6480464 | Acetaminophen results in decreased expression of C3AR1 mRNA | CTD | PMID:21420995 | pirinixic acid | decreases expression | ISO | RGD:731620 | 6480464 | pirinixic acid results in decreased expression of C3AR1 mRNA | CTD | PMID:16985257 | saquinavir | multiple interactions | ISO | RGD:731620 | 6480464 | [Zidovudine co-treated with Lamivudine co-treated with Saquinavir] results in increased expression of C3AR1 mRNA | CTD | PMID:16931933 | silicon dioxide | increases expression | ISO | RGD:731620 | 6480464 | Silicon Dioxide results in increased expression of C3AR1 mRNA | CTD | PMID:19073995 | tetrachloromethane | affects expression | EXP | | 6480464 | Carbon Tetrachloride affects the expression of C3AR1 mRNA | CTD | PMID:12734012 | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of C3AR1 protein | CTD | PMID:12629582 | titanium dioxide | increases expression | ISO | RGD:731620 | 6480464 | titanium dioxide results in increased expression of C3AR1 mRNA | CTD | PMID:21259345 | zidovudine | multiple interactions | ISO | RGD:1353843 | 6480464 | [Zidovudine co-treated with IFNA1 protein] results in increased expression of C3AR1 mRNA | CTD | PMID:20370541 | zidovudine | multiple interactions | ISO | RGD:731620 | 6480464 | [Zidovudine co-treated with Lamivudine co-treated with Indinavir] results in increased expression of C3AR1 mRNA; more ... | CTD | PMID:16931933 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Complement and coagulation cascades |
| Neuroactive ligand-receptor interaction | |
| Staphylococcus aureus infection | |
Disease Annotations
|
|
|
Gene-Chemical Interaction Annotations
|
|
|
Gene Ontology Annotations
|
|
|
|
Molecular Pathway Annotations
|
|
| External Database Links | |
| KEGG Pathway | Complement and coagulation cascades |
| Neuroactive ligand-receptor interaction | |
| Staphylococcus aureus infection | |
References - curated| 1. |
Benard M, etal., J Biol Chem. 2004 Oct 15;279(42):43487-96. Epub 2004 Aug 2. |
| 2. |
Benard M, etal., Mol Immunol. 2008 Aug;45(14):3767-74. Epub 2008 Jul 16. |
| 3. |
Fregonese L, etal., J Allergy Clin Immunol. 2005 Jun;115(6):1148-54. |
| 4. |
Fukuoka Y, etal., Biochem Biophys Res Commun 1998 Jan 26;242(3):663-8. |
| 5. |
Hasegawa K, etal., Hum Genet. 2004 Sep;115(4):295-301. |
| 6. |
Jun SW, etal., J Allergy Clin Immunol. 2008 Jul;122(1):119-25. Epub 2008 Jun 5. |
| 7. |
Lajoie S, etal., Nat Immunol. 2010 Oct;11(10):928-35. Epub 2010 Aug 29. |
| 8. |
Melendi GA, etal., J Virol. 2007 Jan;81(2):991-9. Epub 2006 Nov 1. |
| 9. |
MGD data from the GO Consortium |
| 10. |
Mueller-Ortiz SL, etal., Am J Physiol Lung Cell Mol Physiol. 2006 Aug;291(2):L157-65. Epub 2006 Feb 3. |
| 11. |
NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 12. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 13. |
Proctor LM, etal., Br J Pharmacol. 2004 Jun;142(4):756-64. Epub 2004 May 24. |
| 14. |
Proctor LM, etal., Int Immunopharmacol. 2006 Aug;6(8):1224-32. Epub 2006 Apr 3. |
| 15. |
Proctor LM, etal., Int Immunopharmacol. 2009 Jun;9(6):800-6. Epub 2009 Mar 12. |
| 16. |
Pucheu-Haston CM, etal., Toxicol Appl Pharmacol. 2010 Apr 15;244(2):144-55. Epub 2010 Jan 4. |
| 17. |
RGD automated data pipeline |
| 18. |
RGD automated import pipeline for gene-chemical interactions |
| 19. |
Sohn JH, etal., Nat Med. 2003 Feb;9(2):206-12. Epub 2003 Jan 6. |
| 20. |
Sun S, etal., Am J Respir Cell Mol Biol. 2011 Mar 18. |
| 21. |
Tschernig T, etal., Exp Toxicol Pathol. 2007 Aug;58(6):419-25. Epub 2007 Jun 1. |
RGD Disease Portals| C3ar1 has been annotated in the following RGD Disease Portals. |
|||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
 |
| ||||||
Candidate Gene StatusComparative Map Data| C3ar1 (Rattus norvegicus) |
|
|||||||||||||||||||||||||||||||||||
| C3AR1 (Homo sapiens) |
|
|||||||||||||||||||||||||||||||||||
| C3ar1 (Mus musculus) |
|
Position Markers| D4Got128 |
|
|||||||||||||||||||||||||||||||||||||||||||||
| RH138462 |
|
QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_032060 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06033440 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06033441 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01032769 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01032770 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473964 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U86379 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_032060 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_114449 | ||||||||||||||||||||
| Position: |
|
Protein Sequences| Protein RefSeqs | NP_114449 | (Get FASTA) |
| GenBank Protein | AAC40071 | (Get FASTA) |
| EDM01978 | (Get FASTA) | |
| O55197 | (Get FASTA) |
Strain Sequence Variants
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
|
||||||||||||||||||||
External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000009211 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000012216 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000012216 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 84007 | ENTREZGENE |
| Germonline | ENSRNOG00000009211 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 2992 | ENTREZGENE |
| InterPro | 7TM_GPCR_Rhodpsn | UniProtKB/Swiss-Prot |
| Anphylx_rcpt | UniProtKB/Swiss-Prot | |
| C3A_anaphtx_rcpt | UniProtKB/Swiss-Prot | |
| Formyl_pep_rcpt | UniProtKB/Swiss-Prot | |
| GPCR_Rhodpsn_supfam | UniProtKB/Swiss-Prot | |
| IPI | IPI00196057 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:84007 | ENTREZGENE, UniProtKB/Swiss-Prot |
| PANTHER | PTHR24225 | UniProtKB/Swiss-Prot |
| Pfam | 7tm_1 | UniProtKB/Swiss-Prot |
| PRINTS | ANPHYLATOXNR | UniProtKB/Swiss-Prot |
| C3ANPHYLTXNR | UniProtKB/Swiss-Prot | |
| GPCRRHODOPSN | UniProtKB/Swiss-Prot | |
| PROSITE | G_PROTEIN_RECEP_F1_1 | UniProtKB/Swiss-Prot |
| G_PROTEIN_RECEP_F1_2 | UniProtKB/Swiss-Prot | |
| UniGene | Rn.9772 | ENTREZGENE |
| UniProt | C3AR_RAT | UniProtKB/Swiss-Prot |
| G3V759_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2004-09-10 | C3ar1 | complement component 3a receptor 1 | Symbol and Name status set to approved | 10779 | APPROVED | ||
| 2002-08-07 | C3ar1 | complement component 3a receptor 1 | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_expression | ubiquitously expressed | 724614 |
| gene_process | important mediator of inflammation and potent chemotactic factor for eosinophils and mast cells | 724614 |
| gene_product | member of the G-protein coupled receptor family | 724614 |
| More on C3ar1 | |
|
Entrez Gene |
|
Ensembl Gene |
| Genome Browser |
|
NCBI Map Viewer |
|
Vista |
|
Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 620537 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.