Gene: Nrg1 (neuregulin 1) Rattus norvegicus
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Symbol: Nrg1
Name: neuregulin 1
Description: ENCODES a protein that exhibits receptor tyrosine kinase binding; chemorepellent activity (ortholog); ErbB-2 class receptor binding (ortholog); INVOLVED IN memory; negative regulation of corticosterone secretion; positive regulation of axon regeneration; PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; glypican signaling pathway; ASSOCIATED WITH abnormal spatial reference memory; abnormal spatial working memory; increased circulating corticosterone level; ASSOCIATED WITH Diabetic Cardiomyopathies; Diabetic Neuropathies; Hyperalgesia; FOUND IN extracellular space; synapse; apical plasma membrane (ortholog); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1-benzylpiperazine; 1-naphthyl isothiocyanate
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: neuregulin 1 type III beta 3; pro-neuregulin-1, membrane-bound isoform; pro-NRG1
Orthologs:
Homo sapiens (human) : NRG1 (neuregulin 1)  HGNC
Mus musculus (house mouse) : Nrg1 (neuregulin 1)  MGI
Pan paniscus (bonobo/pygmy chimpanzee) : NRG1 (neuregulin 1)
Canis lupus familiaris (dog) : NRG1 (neuregulin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nrg1 (neuregulin 1)
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Allele / Splice: Nrg1Tn(sb-T2/Bart3)2.183Mcwi  
Genetic Models: F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01662,969,573 - 64,065,063 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01662,632,432 - 63,718,738 (+)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.41663,937,796 - 64,126,183 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11663,937,870 - 64,126,262 (+)NCBI
Celera1657,283,140 - 58,311,856 (+)NCBI
Cytogenetic Map16q12.3NCBImapview
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Nrg1
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
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RGD Object Information
RGD ID: 621341
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2017-03-14
Status: ACTIVE