Gene: Nrg1 (neuregulin 1) Rattus norvegicus
Symbol: Nrg1
Name: neuregulin 1
Description: ENCODES a protein that exhibits receptor tyrosine kinase binding; chemorepellent activity (ortholog); ErbB-2 class receptor binding (ortholog); INVOLVED IN memory; negative regulation of corticosterone secretion; positive regulation of axon regeneration; PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; glypican signaling pathway; ASSOCIATED WITH abnormal spatial reference memory; abnormal spatial working memory; increased circulating corticosterone level; ASSOCIATED WITH diabetic autonomic neuropathy; Diabetic Cardiomyopathies; Diabetic Neuropathies; FOUND IN extracellular space; synapse; apical plasma membrane (ortholog); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1-benzylpiperazine; 1-naphthyl isothiocyanate
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: neuregulin 1 type III beta 3; pro-neuregulin-1, membrane-bound isoform; pro-NRG1
Homo sapiens (human) : NRG1 (neuregulin 1)  HGNC
Mus musculus (house mouse) : Nrg1 (neuregulin 1)  MGI
Chinchilla lanigera (long-tailed chinchilla) : Nrg1 (neuregulin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NRG1 (neuregulin 1)
Canis lupus familiaris (dog) : NRG1 (neuregulin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nrg1 (neuregulin 1)
more info ...
Allele / Splice: Nrg1Tn(sb-T2/Bart3)2.183Mcwi  
Genetic Models: F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01662,969,573 - 64,065,063 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.01662,632,432 - 63,718,738 (+)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.41663,937,796 - 64,126,183 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11663,937,870 - 64,126,262 (+)NCBI
Celera1657,283,140 - 58,311,856 (+)NCBI
Cytogenetic Map16q12.3NCBImapview
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Nrg1
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 621341
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2017-06-13
Status: ACTIVE