Annotation (Toggle Detail/Summary View) Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | decreases expression | ISO | RGD:731515 | 6480464 | epigallocatechin gallate results in decreased expression of NRG1 mRNA | CTD | PMID:20346928 | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:731515 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NRG1 mRNA | CTD | PMID:22079256 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of NRG1 mRNA | CTD | PMID:20068009 | 2,2',4,4',5,5'-hexachlorobiphenyl | multiple interactions | ISO | RGD:735609 | 6480464 | 2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NRG1 mRNA] | CTD | PMID:21851831 | 2,2',4,4',5,5'-hexachlorobiphenyl | decreases expression | ISO | RGD:731515 | 6480464 | 2,4,5,2',4',5'-hexachlorobiphenyl results in decreased expression of NRG1 mRNA | CTD | PMID:23146750 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:735609 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of NRG1 mRNA | CTD | PMID:19933214 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:731515 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of NRG1 mRNA | CTD | PMID:23152189 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of NRG1 mRNA | CTD | PMID:19692669 more ... | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:735609 | 6480464 | Tetrachlorodibenzodioxin affects the expression of NRG1 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of NRG1 mRNA | CTD | PMID:19692669 PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of NRG1 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:735609 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of NRG1 mRNA | CTD | PMID:19770486 more ... | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:735609 | 6480464 | 2,4,5,2',4',5'-hexachlorobiphenyl promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NRG1 mRNA] | CTD | PMID:21851831 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:735609 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of NRG1 mRNA | CTD | PMID:19770486 PMID:19933214 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of NRG1 mRNA | CTD | PMID:19692669 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:735609 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of NRG1 mRNA | CTD | PMID:19933214 PMID:19770486 | 2,4,6-trinitrotoluene | affects expression | EXP | | 6480464 | Trinitrotoluene affects the expression of NRG1 mRNA | CTD | PMID:21346803 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of NRG1 mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of NRG1 mRNA | CTD | PMID:21346803 | 2-nitrofluorene | increases expression | EXP | | 6480464 | 2-nitrofluorene results in increased expression of NRG1 mRNA | CTD | PMID:15890375 PMID:14600272 | 2-nitrofluorene | increases expression | EXP | | 6480464 | 2-nitrofluorene results in increased expression of NRG1 mRNA | CTD | PMID:14600272 more ... | 2-nitrofluorene | increases expression | EXP | | 6480464 | 2-nitrofluorene results in increased expression of NRG1 mRNA | CTD | PMID:14600272 more ... | 2-nitrofluorene | increases expression | EXP | | 6480464 | 2-nitrofluorene results in increased expression of NRG1 mRNA | CTD | PMID:14600272 PMID:15890375 | 3,3',4,4',5-pentachlorobiphenyl | increases expression | EXP | | 6480464 | 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NRG1 mRNA | CTD | PMID:19692669 | 3,3',4,4',5-pentachlorobiphenyl | increases expression | EXP | | 6480464 | 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NRG1 mRNA | CTD | PMID:19692669 PMID:20959002 | 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one | increases expression | EXP | | 6480464 | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of NRG1 mRNA | CTD | PMID:14600272 PMID:15890375 | 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one | increases expression | EXP | | 6480464 | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of NRG1 mRNA | CTD | PMID:14600272 more ... | 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one | increases expression | EXP | | 6480464 | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of NRG1 mRNA | CTD | PMID:15890375 PMID:14600272 | 5-fluorouracil | affects response to substance | ISO | RGD:731515 | 6480464 | NRG1 protein affects the susceptibility to Fluorouracil | CTD | PMID:16217747 | AACOCF3 | multiple interactions | ISO | RGD:731515 | 6480464 | arachidonyltrifluoromethane inhibits the reaction [NRG1 protein alternative form results in increased phosphorylation of and results in increased activity of MAPK3 protein]; more ... | CTD | PMID:15231676 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of NRG1 mRNA | CTD | PMID:15890375 PMID:14600272 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of NRG1 mRNA | CTD | PMID:14600272 more ... | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of NRG1 mRNA | CTD | PMID:14600272 PMID:15890375 | all-trans-retinoic acid | decreases expression | ISO | RGD:731515 | 6480464 | Tretinoin results in decreased expression of NRG1 mRNA | CTD | PMID:21934132 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of NRG1 mRNA | CTD | PMID:16483693 | arsenic atom | increases expression | ISO | RGD:731515 | 6480464 | Arsenic results in increased expression of NRG1 mRNA | CTD | PMID:19945496 | benzo[a]pyrene | multiple interactions | ISO | RGD:735609 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of NRG1 mRNA | CTD | PMID:21715664 | cadmium dichloride | affects expression | EXP | | 6480464 | Cadmium Chloride affects the expression of NRG1 mRNA | CTD | PMID:22110744 | cadmium dichloride | decreases expression | ISO | RGD:731515 | 6480464 | Cadmium Chloride results in decreased expression of NRG1 mRNA | CTD | PMID:12160620 | cadmium dichloride | decreases methylation | EXP | | 6480464 | Cadmium Chloride results in decreased methylation of NRG1 promoter | CTD | PMID:22457795 | celecoxib | multiple interactions | ISO | RGD:731515 | 6480464 | celecoxib inhibits the reaction [IL1B protein results in increased expression of NRG1 mRNA]; more ... | CTD | PMID:16357062 | choline | multiple interactions | ISO | RGD:735609 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NRG1 mRNA | CTD | PMID:20938992 | clozapine | increases expression | ISO | RGD:731515 | 6480464 | Clozapine results in increased expression of NRG1 mRNA | CTD | PMID:19502011 | clozapine | affects expression | EXP | | 6480464 | Clozapine affects the expression of NRG1 protein | CTD | PMID:18184445 | clozapine | affects response to substance | ISO | RGD:735609 | 6480464 | NRG1 protein affects the susceptibility to Clozapine | CTD | PMID:15706234 | cobalt dichloride | decreases expression | ISO | RGD:731515 | 6480464 | cobaltous chloride results in decreased expression of NRG1 mRNA | CTD | PMID:19320972 | copper(2+) sulfate | increases expression | ISO | RGD:731515 | 6480464 | Copper Sulfate results in increased expression of NRG1 mRNA | CTD | PMID:19549813 | cyclophosphamide | increases expression | ISO | RGD:731515 | 6480464 | Cyclophosphamide results in increased expression of NRG1 mRNA | CTD | PMID:21527772 | cyclosporin A | increases expression | ISO | RGD:731515 | 6480464 | Cyclosporine results in increased expression of NRG1 mRNA | CTD | PMID:20106945 | cyclosporin A | increases expression | ISO | RGD:731515 | 6480464 | Cyclosporine results in increased expression of NRG1 mRNA | CTD | PMID:20106945 PMID:22147139 | D-glucose | multiple interactions | EXP | | 6480464 | MAPK3 protein promotes the reaction [NRG1 protein results in increased transport of Glucose]; more ... | CTD | PMID:14711829 | D-glucose | increases transport | EXP | | 6480464 | NRG1 protein results in increased transport of Glucose | CTD | PMID:14711829 | Delta(9)-tetrahydrocannabinol | multiple interactions | ISO | RGD:735609 | 6480464 | [NRG1 affects the susceptibility to Tetrahydrocannabinol] which affects the expression of FOS protein | CTD | PMID:17905522 | Delta(9)-tetrahydrocannabinol | affects response to substance | ISO | RGD:735609 | 6480464 | NRG1 affects the susceptibility to Tetrahydrocannabinol | CTD | PMID:17333138 more ... | Delta(9)-tetrahydrocannabinol | affects response to substance | ISO | RGD:735609 | 6480464 | NRG1 affects the susceptibility to Tetrahydrocannabinol | CTD | PMID:22226049 more ... | Delta(9)-tetrahydrocannabinol | affects response to substance | ISO | RGD:731515 | 6480464 | NRG1 gene SNP affects the susceptibility to Tetrahydrocannabinol | CTD | PMID:20582876 | diarsenic trioxide | increases expression | ISO | RGD:731515 | 6480464 | arsenic trioxide results in increased expression of NRG1 mRNA | CTD | PMID:22521957 | diethylstilbestrol | increases expression | EXP | | 6480464 | Diethylstilbestrol results in increased expression of NRG1 mRNA | CTD | PMID:15890375 | dimethylarsinic acid | increases expression | ISO | RGD:731515 | 6480464 | Cacodylic Acid results in increased expression of NRG1 mRNA | CTD | PMID:17720352 | disodium selenite | multiple interactions | ISO | RGD:735609 | 6480464 | [ptaquiloside co-treated with Sodium Selenite] results in increased expression of NRG1 mRNA | CTD | PMID:23274088 | disodium selenite | increases expression | ISO | RGD:735609 | 6480464 | Sodium Selenite results in increased expression of NRG1 mRNA | CTD | PMID:23274088 | doxorubicin | multiple interactions | ISO | RGD:735609 | 6480464 | NRG1 protein affects the reaction [Doxorubicin affects the phosphorylation of AKT1 protein]; more ... | CTD | PMID:15833803 | doxorubicin | multiple interactions | EXP | | 6480464 | NRG1 protein alternative form inhibits the reaction [Doxorubicin results in decreased expression of GSR mRNA]; more ... | CTD | PMID:17005195 | doxorubicin | increases expression | EXP | | 6480464 | Doxorubicin results in increased expression of NRG1 protein alternative form | CTD | PMID:17308081 | doxorubicin | multiple interactions | EXP | | 6480464 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP10 protein]]; more ... | CTD | PMID:19801490 | doxorubicin | affects response to substance | ISO | RGD:735609 | 6480464 | NRG1 protein affects the susceptibility to Doxorubicin | CTD | PMID:19801490 | doxorubicin | multiple interactions | ISO | RGD:735609 | 6480464 | NRG1 protein affects the reaction [Doxorubicin results in decreased expression of TNNC1 protein]; more ... | CTD | PMID:19801490 | folic acid | multiple interactions | ISO | RGD:735609 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NRG1 mRNA | CTD | PMID:20938992 | fonofos | increases methylation | ISO | RGD:731515 | 6480464 | Fonofos results in increased methylation of NRG1 promoter | CTD | PMID:22847954 | glucose | multiple interactions | EXP | | 6480464 | MAPK3 protein promotes the reaction [NRG1 protein results in increased transport of Glucose]; more ... | CTD | PMID:14711829 | glucose | increases transport | EXP | | 6480464 | NRG1 protein results in increased transport of Glucose | CTD | PMID:14711829 | haloperidol | increases expression | EXP | | 6480464 | Haloperidol results in increased expression of NRG1 protein | CTD | PMID:18184445 | hydrogen peroxide | multiple interactions | EXP | | 6480464 | NRG1 protein alternative form inhibits the reaction [Hydrogen Peroxide results in decreased expression of ATP2A2 protein] | CTD | PMID:17005195 | indole-3-methanol | affects expression | EXP | | 6480464 | indole-3-carbinol affects the expression of NRG1 mRNA | CTD | PMID:21396975 | ketamine | decreases expression | ISO | RGD:735609 | 6480464 | Ketamine results in decreased expression of NRG1 mRNA | CTD | PMID:20000043 | L-methionine | multiple interactions | ISO | RGD:735609 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of NRG1 mRNA | CTD | PMID:20938992 | LY294002 | multiple interactions | EXP | | 6480464 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP2 protein]]; more ... | CTD | PMID:19801490 | LY294002 | multiple interactions | ISO | RGD:731515 | 6480464 | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LHB protein results in decreased expression of NRG1 mRNA] | CTD | PMID:23071612 | maneb | multiple interactions | ISO | RGD:735609 | 6480464 | [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NRG1 mRNA | CTD | PMID:23017109 | methamphetamine | affects response to substance | ISO | RGD:731515 | 6480464 | NRG1 gene SNP affects the susceptibility to Methamphetamine | CTD | PMID:18316681 | methapyrilene | increases expression | EXP | | 6480464 | Methapyrilene results in increased expression of NRG1 mRNA | CTD | PMID:15890375 | methyl methanesulfonate | increases expression | ISO | RGD:731515 | 6480464 | Methyl Methanesulfonate results in increased expression of NRG1 mRNA | CTD | PMID:21527772 | mono(2-ethylhexyl) phthalate | increases expression | ISO | RGD:735609 | 6480464 | mono-(2-ethylhexyl)phthalate results in increased expression of NRG1 mRNA | CTD | PMID:22401849 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of NRG1 mRNA | CTD | PMID:18164116 | N-nitrosodimethylamine | increases expression | EXP | | 6480464 | Dimethylnitrosamine results in increased expression of NRG1 mRNA | CTD | PMID:15890375 PMID:14600272 | N-nitrosodimethylamine | increases expression | EXP | | 6480464 | Dimethylnitrosamine results in increased expression of NRG1 mRNA | CTD | PMID:14600272 PMID:15890375 | N-tosyl-L-phenylalanyl chloromethyl ketone | multiple interactions | EXP | | 6480464 | Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [NRG1 protein results in increased transport of Glucose] | CTD | PMID:14711829 | nickel dichloride | increases expression | ISO | RGD:731515 | 6480464 | nickel chloride results in increased expression of NRG1 mRNA | CTD | PMID:17312168 | ochratoxin A | decreases expression | ISO | RGD:731515 | 6480464 | ochratoxin A results in decreased expression of NRG1 mRNA | CTD | PMID:22124623 | ozone | increases expression | EXP | | 6480464 | Ozone results in increased expression of NRG1 mRNA | CTD | PMID:16716893 | paracetamol | affects expression | ISO | RGD:735609 | 6480464 | Acetaminophen affects the expression of NRG1 mRNA | CTD | PMID:17562736 | paraquat | multiple interactions | ISO | RGD:735609 | 6480464 | [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NRG1 mRNA | CTD | PMID:23017109 | parathion | increases methylation | ISO | RGD:731515 | 6480464 | Parathion results in increased methylation of NRG1 promoter | CTD | PMID:22847954 | perfluorooctanoic acid | increases expression | EXP | | 6480464 | perfluorooctanoic acid results in increased expression of NRG1 mRNA | CTD | PMID:19162173 | phenobarbital | affects expression | ISO | RGD:731515 | 6480464 | Phenobarbital affects the expression of NRG1 mRNA | CTD | PMID:19159669 | phenylephrine | decreases expression | EXP | | 6480464 | Phenylephrine results in decreased expression of NRG1 mRNA; more ... | CTD | PMID:16698793 | piperonyl butoxide | increases expression | EXP | | 6480464 | Piperonyl Butoxide results in increased expression of NRG1 mRNA | CTD | PMID:15890375 | pirinixic acid | decreases expression | ISO | RGD:735609 | 6480464 | pirinixic acid results in decreased expression of NRG1 mRNA | CTD | PMID:17950772 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of NRG1 mRNA | CTD | PMID:19162173 PMID:15890375 | pirinixic acid | increases expression | EXP | | 6480464 | pirinixic acid results in increased expression of NRG1 mRNA | CTD | PMID:15890375 PMID:19162173 | pirinixic acid | multiple interactions | ISO | RGD:735609 | 6480464 | PPARA protein promotes the reaction [pirinixic acid results in decreased expression of NRG1 mRNA] | CTD | PMID:17950772 | prostaglandin E2 | multiple interactions | ISO | RGD:731515 | 6480464 | Dinoprostone inhibits the reaction [celecoxib inhibits the reaction [IL1B protein results in increased expression of NRG1 mRNA]] | CTD | PMID:16357062 | prostaglandin E2 | increases expression | ISO | RGD:731515 | 6480464 | Dinoprostone results in increased expression of NRG1 mRNA | CTD | PMID:16357062 | resveratrol | multiple interactions | ISO | RGD:731515 | 6480464 | resveratrol inhibits the reaction [NRG1 protein alternative form results in increased expression of MMP9 protein]; more ... | CTD | PMID:17651959 | resveratrol | decreases expression | ISO | RGD:731515 | 6480464 | resveratrol results in decreased expression of NRG1 mRNA | CTD | PMID:12002526 | sodium dichromate | increases expression | EXP | | 6480464 | sodium bichromate results in increased expression of NRG1 mRNA | CTD | PMID:22561333 | terbufos | increases methylation | ISO | RGD:731515 | 6480464 | terbufos results in increased methylation of NRG1 promoter | CTD | PMID:22847954 | trans-resveratrol | multiple interactions | ISO | RGD:731515 | 6480464 | resveratrol inhibits the reaction [NRG1 protein alternative form results in increased expression of MMP9 protein]; more ... | CTD | PMID:17651959 | trans-resveratrol | decreases expression | ISO | RGD:731515 | 6480464 | resveratrol results in decreased expression of NRG1 mRNA | CTD | PMID:12002526 | troglitazone | increases expression | ISO | RGD:731515 | 6480464 | troglitazone results in increased expression of NRG1 mRNA | CTD | PMID:19140230 | valproic acid | increases expression | ISO | RGD:731515 | 6480464 | Valproic Acid results in increased expression of NRG1 mRNA | CTD | PMID:19101580 | zinc sulfate | multiple interactions | EXP | | 6480464 | Zinc Sulfate affects the expression of and affects the splicing of NRG1 mRNA | CTD | PMID:10878590 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsBiological Process











