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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:1353787 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PKD2 mRNA | CTD | PMID:22079256 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1353787 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PKD2 mRNA | CTD | PMID:20106945 PMID:21632981 | 5-aza-2'-deoxycytidine | increases expression | ISO | RGD:1353787 | 6480464 | decitabine results in increased expression of PKD2 mRNA | CTD | PMID:19194470 | amiloride | multiple interactions | ISO | RGD:1353787 | 6480464 | Amiloride results in decreased activity of [PKD2 protein binds to PKD2 protein]; more ... | CTD | PMID:19193631 | benzo[a]pyrene | increases expression | ISO | RGD:1558338 | 6480464 | Benzo(a)pyrene results in increased expression of PKD2 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | decreases expression | ISO | | 6480464 | Benzo(a)pyrene results in decreased expression of PKD2 mRNA | CTD | PMID:19770486 | benzo[a]pyrene | increases expression | ISO | | 6480464 | Benzo(a)pyrene results in increased expression of PKD2 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | increases expression | ISO | RGD:1353787 | 6480464 | Benzo(a)pyrene results in increased expression of PKD2 mRNA | CTD | PMID:22316170 | benzo[a]pyrene | decreases expression | ISO | RGD:1558338 | 6480464 | Benzo(a)pyrene results in decreased expression of PKD2 mRNA | CTD | PMID:19770486 | calcium atom | multiple interactions | ISO | | 6480464 | IFT88 protein affects the reaction [PKD2 protein results in increased uptake of Calcium] | CTD | PMID:16396941 | calcium atom | increases transport | ISO | RGD:1353787 | 6480464 | PKD2 protein results in increased transport of Calcium | CTD | PMID:15100357 | calcium atom | multiple interactions | ISO | RGD:1353787 | 6480464 | PKD2 protein promotes the reaction [PAFAH1B1 protein results in increased abundance of Calcium] | CTD | PMID:15001556 | calcium atom | multiple interactions | ISO | RGD:1558338 | 6480464 | IFT88 protein affects the reaction [PKD2 protein results in increased uptake of Calcium] | CTD | PMID:16396941 | calcium(0) | increases transport | ISO | RGD:1353787 | 6480464 | PKD2 protein results in increased transport of Calcium | CTD | PMID:15100357 | calcium(0) | multiple interactions | ISO | RGD:1353787 | 6480464 | PKD2 protein promotes the reaction [PAFAH1B1 protein results in increased abundance of Calcium] | CTD | PMID:15001556 | calcium(0) | multiple interactions | ISO | RGD:1558338 | 6480464 | IFT88 protein affects the reaction [PKD2 protein results in increased uptake of Calcium] | CTD | PMID:16396941 | calcium(0) | multiple interactions | ISO | | 6480464 | IFT88 protein affects the reaction [PKD2 protein results in increased uptake of Calcium] | CTD | PMID:16396941 | capecitabine | decreases response to substance | ISO | RGD:1353787 | 6480464 | PKD2 protein results in decreased susceptibility to capecitabine | CTD | PMID:16734730 | cobalt dichloride | decreases expression | ISO | RGD:1353787 | 6480464 | cobaltous chloride results in decreased expression of PKD2 mRNA | CTD | PMID:19376846 | copper atom | multiple interactions | ISO | | 6480464 | [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of PKD2 mRNA | CTD | PMID:15467011 | copper atom | multiple interactions | ISO | RGD:1558338 | 6480464 | [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of PKD2 mRNA | CTD | PMID:15467011 | copper(0) | multiple interactions | ISO | RGD:1558338 | 6480464 | [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of PKD2 mRNA | CTD | PMID:15467011 | copper(0) | multiple interactions | ISO | | 6480464 | [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of PKD2 mRNA | CTD | PMID:15467011 | hydrogen chloride | multiple interactions | ISO | RGD:1353787 | 6480464 | Hydrochloric Acid results in decreased activity of [PKD2 protein binds to PKD2 protein] | CTD | PMID:19193631 | paclitaxel | increases response to substance | ISO | RGD:1353787 | 6480464 | PKD2 protein results in increased susceptibility to Paclitaxel | CTD | PMID:16734730 | phenobarbital | decreases expression | ISO | | 6480464 | Phenobarbital results in decreased expression of PKD2 mRNA | CTD | PMID:19482888 | phenobarbital | multiple interactions | ISO | | 6480464 | NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of PKD2 mRNA] | CTD | PMID:19482888 | phenobarbital | decreases expression | ISO | RGD:1558338 | 6480464 | Phenobarbital results in decreased expression of PKD2 mRNA | CTD | PMID:19482888 | phenobarbital | multiple interactions | ISO | RGD:1558338 | 6480464 | NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of PKD2 mRNA] | CTD | PMID:19482888 | pirinixic acid | decreases expression | ISO | RGD:1558338 | 6480464 | pirinixic acid results in decreased expression of PKD2 mRNA | CTD | PMID:20059764 | pirinixic acid | decreases expression | ISO | | 6480464 | pirinixic acid results in decreased expression of PKD2 mRNA | CTD | PMID:20059764 | pirinixic acid | multiple interactions | ISO | | 6480464 | PPARA protein promotes the reaction [pirinixic acid results in decreased expression of PKD2 mRNA] | CTD | PMID:20059764 | pirinixic acid | multiple interactions | ISO | RGD:1558338 | 6480464 | PPARA protein promotes the reaction [pirinixic acid results in decreased expression of PKD2 mRNA] | CTD | PMID:20059764 | succimer | multiple interactions | ISO | RGD:1558338 | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PKD2 mRNA | CTD | PMID:21641980 | succimer | multiple interactions | ISO | | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of PKD2 mRNA | CTD | PMID:21641980 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsDisease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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References - curated| 1. |
Hoefele J, etal., Nephrol Dial Transplant. 2011 Jul;26(7):2181-8. Epub 2010 Nov 29. |
| 2. |
Li Q, etal., Hum Mol Genet. 2005 Jun 15;14(12):1587-603. Epub 2005 Apr 20. |
| 3. |
Masyuk AI, etal., Gastroenterology. 2006 Sep;131(3):911-20. |
| 4. |
Obermuller N, etal., J Am Soc Nephrol. 2002 Jul;13(7):1855-64. |
| 5. |
RGD automated import pipeline for gene-chemical interactions |
| 6. |
RGD Automated Pipelines |
| 7. |
Robinson C, etal., BMC Nephrol. 2012 Aug 3;13:79. doi: 10.1186/1471-2369-13-79. |
| 8. |
Rossetti S, etal., Lancet. 2003 Jun 28;361(9376):2196-201. |
| 9. |
Zhao Y, etal., Nephrol Dial Transplant. 2002 Dec;17(12):2138-44. |
References - uncuratedRGD Disease Portals| Pkd2 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Pkd2 (Rattus norvegicus) |
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| PKD2 (Homo sapiens) |
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| Pkd2 (Mus musculus) |
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Position Markers| BI294486 |
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| RH141583 |
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| RH142028 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001191934 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06077419 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01077904 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01077905 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01077906 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH474022 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | XM_001058532 | ||||||||||
| RefSeq Status: | |||||||||||
| Type: | CODING | ||||||||||
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| RefSeq Acc Id: | XM_573552 | ||||||||||
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| Type: | CODING | ||||||||||
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| RefSeq Acc Id: | NM_001191934 | ||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||
| Type: | CODING | ||||||||||
| Protein Acc Id: | NP_001178863 | ||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001178863 | (Get FASTA) |
| GenBank Protein | EDL99486 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000002146 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000002916 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000002916 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 498328 | ENTREZGENE |
| Gene3D-CATH | EF-Hand_type | UniProtKB/TrEMBL |
| HomoloGene Group ID | 20104 | ENTREZGENE |
| InterPro | EF-hand-like_dom | UniProtKB/TrEMBL |
| EF_hand_Ca-bd | UniProtKB/TrEMBL | |
| PKD1_2_channel | UniProtKB/TrEMBL | |
| PKD_2 | UniProtKB/TrEMBL | |
| IPI | IPI00198146 | UniProtKB/TrEMBL |
| KEGG Report | rno:498328 | ENTREZGENE, UniProtKB/TrEMBL |
| Pfam | PKD_channel | UniProtKB/TrEMBL |
| PRINTS | POLYCYSTIN2 | UniProtKB/TrEMBL |
| PROSITE | EF_HAND_2 | UniProtKB/TrEMBL |
| UniGene | Rn.198353 | ENTREZGENE |
| UniProt | D4A5F1_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2012-11-21 | Pkd2 | polycystic kidney disease 2 (autosomal dominant) | Pkd2 | polycystic kidney disease 2 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2012-11-20 | Pkd2 | polycystic kidney disease 2 | Pkd2 | polycystic kidney disease 2 homolog (human) | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-12-15 | Pkd2 | polycystic kidney disease 2 homolog (human) | Pkd2 | polycystic kidney disease 2 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-04-30 | Pkd2 | polycystic kidney disease 2 | Pkd2_predicted | polycystic kidney disease 2 (predicted) | 'predicted' is removed | 24709 | APPROVED |
| 2006-08-30 | Pkd2_predicted | polycystic kidney disease 2 (predicted) | RGD1559992_predicted | similar to polycystic kidney disease 2 (predicted) | Symbol and Name updated to reflect Human and Mouse nomenclature | 10779 | APPROVED |
| 2006-03-07 | RGD1559992_predicted | similar to polycystic kidney disease 2 (predicted) | LOC498328 | similar to polycystic kidney disease 2 | Symbol and Name status set to approved | 10779 | APPROVED |
| 2006-02-09 | LOC498328 | similar to polycystic kidney disease 2 | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
| More on Pkd2 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1559992 |
| Created: | 2006-02-09 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.