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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of DMBT1 mRNA | CTD | PMID:12655037 more ... | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of DMBT1 mRNA | CTD | PMID:12655037 more ... | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of DMBT1 mRNA | CTD | PMID:17557909 more ... | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of DMBT1 mRNA | CTD | PMID:15834898 more ... | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of DMBT1 mRNA | CTD | PMID:15834898 more ... | 17beta-estradiol | multiple interactions | ISO | RGD:735357 | 6480464 | ESR1 protein promotes the reaction [Estradiol results in increased expression of DMBT1 mRNA] | CTD | PMID:15564322 | 17beta-estradiol | multiple interactions | ISO | RGD:735357 | 6480464 | [Estradiol binds to ESR2 protein] which results in decreased expression of DMBT1 mRNA | CTD | PMID:20404318 | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of DMBT1 mRNA | CTD | PMID:15564322 | 17beta-estradiol | multiple interactions | ISO | RGD:735357 | 6480464 | [Progesterone co-treated with Estradiol] results in decreased expression of DMBT1 mRNA | CTD | PMID:17404688 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:735357 | 6480464 | [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DMBT1 mRNA | CTD | PMID:14761676 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:62276 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of DMBT1 mRNA | CTD | PMID:21889950 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of DMBT1 mRNA | CTD | PMID:21346803 | 2-nitrofluorene | increases expression | EXP | | 6480464 | 2-nitrofluorene results in increased expression of DMBT1 mRNA | CTD | PMID:23052194 | 3,3',5-triiodo-L-thyronine | multiple interactions | ISO | RGD:735357 | 6480464 | [Triiodothyronine co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DMBT1 mRNA | CTD | PMID:14761676 | 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one | increases expression | EXP | | 6480464 | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DMBT1 mRNA | CTD | PMID:23052194 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of DMBT1 mRNA | CTD | PMID:23052194 | alachlor | increases expression | EXP | | 6480464 | alachlor results in increased expression of DMBT1 mRNA | CTD | PMID:12419858 | all-trans-retinoic acid | affects expression | ISO | RGD:735357 | 6480464 | Tretinoin affects the expression of DMBT1 mRNA | CTD | PMID:15498508 | anthracen-2-amine | increases expression | EXP | | 6480464 | 2-anthramine results in increased expression of DMBT1 mRNA | CTD | PMID:23038007 | bis(2-chloroethyl) sulfide | increases expression | ISO | RGD:62276 | 6480464 | Mustard Gas results in increased expression of DMBT1 mRNA | CTD | PMID:15674844 | ciguatoxin CTX1B | affects expression | ISO | RGD:62276 | 6480464 | Ciguatoxins affects the expression of DMBT1 mRNA | CTD | PMID:18353800 | cisplatin | affects response to substance | ISO | RGD:735357 | 6480464 | DMBT1 protein affects the susceptibility to Cisplatin | CTD | PMID:16217747 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of DMBT1 mRNA | CTD | PMID:21266533 | estrone | increases expression | EXP | | 6480464 | Estrone results in increased expression of DMBT1 mRNA | CTD | PMID:15564322 | estrone | multiple interactions | EXP | | 6480464 | fulvestrant inhibits the reaction [Estrone results in increased expression of DMBT1 mRNA] | CTD | PMID:15564322 | ethanol | multiple interactions | EXP | | 6480464 | [Fish Oils co-treated with Ethanol] results in increased expression of DMBT1 mRNA | CTD | PMID:17347304 | fulvestrant | increases expression | ISO | RGD:735357 | 6480464 | fulvestrant results in increased expression of DMBT1 mRNA | CTD | PMID:15564322 | fulvestrant | multiple interactions | EXP | | 6480464 | fulvestrant inhibits the reaction [Estrone results in increased expression of DMBT1 mRNA] | CTD | PMID:15564322 | fumonisin B1 | decreases expression | ISO | RGD:62276 | 6480464 | fumonisin B1 results in decreased expression of DMBT1 mRNA | CTD | PMID:16221962 | indole-3-methanol | affects expression | EXP | | 6480464 | indole-3-carbinol affects the expression of DMBT1 mRNA | CTD | PMID:21396975 | lead diacetate | increases expression | ISO | RGD:62276 | 6480464 | lead acetate results in increased expression of DMBT1 mRNA | CTD | PMID:20542052 | lead diacetate | decreases expression | ISO | RGD:62276 | 6480464 | lead acetate results in decreased expression of DMBT1 mRNA | CTD | PMID:22609695 | N-methyl-N-nitrosurea | increases expression | ISO | RGD:62276 | 6480464 | Methylnitrosourea results in increased expression of DMBT1 mRNA | CTD | PMID:15240709 | N-nitrosodiethylamine | increases expression | EXP | | 6480464 | Diethylnitrosamine results in increased expression of DMBT1 mRNA | CTD | PMID:19638242 | N-nitrosodiethylamine | multiple interactions | EXP | | 6480464 | [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DMBT1 mRNA | CTD | PMID:18164116 | ozone | decreases expression | ISO | RGD:62276 | 6480464 | Ozone results in decreased expression of DMBT1 mRNA | CTD | PMID:12763052 | pirinixic acid | decreases expression | ISO | RGD:62276 | 6480464 | pirinixic acid results in decreased expression of DMBT1 mRNA | CTD | PMID:16221962 | progesterone | multiple interactions | ISO | RGD:735357 | 6480464 | [Progesterone co-treated with Estradiol] results in decreased expression of DMBT1 mRNA | CTD | PMID:17404688 | raloxifene | increases expression | ISO | RGD:735357 | 6480464 | Raloxifene results in increased expression of DMBT1 mRNA | CTD | PMID:15564322 | raloxifene | increases expression | EXP | | 6480464 | Raloxifene results in increased expression of DMBT1 mRNA; more ... | CTD | PMID:15564322 | tamibarotene | affects expression | ISO | RGD:735357 | 6480464 | Am 80 affects the expression of DMBT1 mRNA; more ... | CTD | PMID:15498508 | tamoxifen | increases expression | ISO | RGD:735357 | 6480464 | Tamoxifen results in increased expression of DMBT1 mRNA | CTD | PMID:15564322 | tamoxifen | increases expression | EXP | | 6480464 | Tamoxifen results in increased expression of DMBT1 mRNA; more ... | CTD | PMID:15564322 | titanium dioxide | increases expression | ISO | RGD:62276 | 6480464 | titanium dioxide results in increased expression of DMBT1 mRNA | CTD | PMID:23409001 | zearalenone | increases expression | EXP | | 6480464 | Zearalenone results in increased expression of DMBT1 mRNA | CTD | PMID:17557909 | zinc atom | increases expression | ISO | RGD:62276 | 6480464 | Zinc deficiency results in increased expression of DMBT1 mRNA | CTD | PMID:20857495 | zinc(0) | increases expression | ISO | RGD:62276 | 6480464 | Zinc deficiency results in increased expression of DMBT1 mRNA | CTD | PMID:20857495 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Salivary secretion |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Salivary secretion |
References - curated| 1. |
Bisgaard HC, etal., Am J Pathol 2002 Oct;161(4):1187-98. |
| 2. |
Elkahloun AG, etal., Ann N Y Acad Sci. 2006 Aug;1073:290-9. |
| 3. |
Genter MB, etal., Physiol Genomics. 2002 Dec 26;12(1):35-45. |
| 4. |
Hikita C, etal., J Cell Biol. 2000 Dec 11;151(6):1235-46. |
| 5. |
Li XJ and Snyder SH, J Biol Chem 1995 Jul 28;270(30):17674-9. |
| 6. |
MGD data from the GO Consortium |
| 7. |
Mollenhauer J, etal., Nat Genet. 1997 Sep;17(1):32-9. |
| 8. |
RGD automated import pipeline for gene-chemical interactions |
| 9. |
RGD comprehensive gene curation |
| 10. |
Tentative Sequence Data IDs. TIGR Gene Index, Rat Data |
| 11. |
Tynan S, etal., Endocrinology. 2005 Mar;146(3):1066-73. Epub 2004 Nov 24. |
RGD Disease Portals| Dmbt1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Dmbt1 (Rattus norvegicus) |
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| DMBT1 (Homo sapiens) |
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| Dmbt1 (Mus musculus) |
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Position Markers| D1Rat110 |
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| D1Rat470 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_022849 | (Get FASTA) | Search GEO for Microarray Profiles |
| XM_003748997 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR06008957 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06008958 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06008959 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06008960 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06008961 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06008962 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06008997 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06008998 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06008999 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06009000 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AABR06009001 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01008666 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01008667 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01008668 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01008669 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF540887 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AY548057 | (Get FASTA) | Search GEO for Microarray Profiles | |
| U32681 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | XM_001080554 | ||||||||||
| RefSeq Status: | |||||||||||
| Type: | CODING | ||||||||||
| Position: |
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| RefSeq Acc Id: | XM_002728779 | ||||||||||
| RefSeq Status: | |||||||||||
| Type: | CODING | ||||||||||
| Position: |
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| RefSeq Acc Id: | XM_003748997 | ||||||||||
| RefSeq Status: | |||||||||||
| Type: | CODING | ||||||||||
| Protein Acc Id: | XP_003749045 | ||||||||||
| Position: |
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| RefSeq Acc Id: | NM_022849 | ||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||
| Type: | CODING | ||||||||||
| Protein Acc Id: | NP_074040 | ||||||||||
| Peptide Label: | precursor | ||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_074040 | (Get FASTA) |
| XP_003749045 | (Get FASTA) | |
| GenBank Protein | AAC52248 | (Get FASTA) |
| AAN16473 | (Get FASTA) | |
| AAS46613 | (Get FASTA) | |
| Q8CIZ5 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000020560 | UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000051793 | UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000054910 | UniProtKB/TrEMBL |
| Entrez Gene | 170568 | ENTREZGENE |
| Gene3D-CATH | CUB | UniProtKB/Swiss-Prot |
| Germonline | ENSRNOG00000020560 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 68990 | ENTREZGENE |
| InterPro | CUB | UniProtKB/Swiss-Prot |
| Endoglin/CD105 | UniProtKB/Swiss-Prot | |
| Endoglin/CD105_CS | UniProtKB/Swiss-Prot | |
| Srcr_rcpt | UniProtKB/Swiss-Prot | |
| Srcr_rcpt-rel | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:170568 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | CUB | UniProtKB/Swiss-Prot |
| SRCR | UniProtKB/Swiss-Prot | |
| Zona_pellucida | UniProtKB/Swiss-Prot | |
| PRINTS | SPERACTRCPTR | UniProtKB/Swiss-Prot |
| PROSITE | CUB | UniProtKB/Swiss-Prot |
| SRCR_1 | UniProtKB/Swiss-Prot | |
| SRCR_2 | UniProtKB/Swiss-Prot | |
| ZP_1 | UniProtKB/Swiss-Prot | |
| ZP_2 | UniProtKB/Swiss-Prot | |
| SMART | CUB | UniProtKB/Swiss-Prot |
| SM00202 | UniProtKB/Swiss-Prot | |
| SM00241 | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | CUB | UniProtKB/Swiss-Prot |
| Srcr_receptor | UniProtKB/Swiss-Prot | |
| TIGR | TC207016 | |
| UniGene | Rn.10107 | ENTREZGENE |
| UniProt | D3ZZV0_RAT | UniProtKB/TrEMBL |
| DMBT1_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2013-04-17 | Dmbt1 | deleted in malignant brain tumors 1 | LOC691969 | similar to deleted in malignant brain tumors 1 isoform a precursor | Data Merged | 9333 | PROVISIONAL |
| 2013-04-17 | Dmbt1 | deleted in malignant brain tumors 1 | LOC100361701 | deleted in malignant brain tumors 1 | Data Merged | 9333 | PROVISIONAL |
| 2010-05-05 | LOC100361701 | deleted in malignant brain tumors 1 | Symbol and Name status set to provisional | 1724 | PROVISIONAL | ||
| 2006-11-20 | LOC691969 | similar to deleted in malignant brain tumors 1 isoform a precursor | Symbol and Name status set to provisional | 1724 | PROVISIONAL | ||
| 2002-06-10 | Dmbt1 | deleted in malignant brain tumors 1 | Name updated | 1488 | APPROVED | ||
| 2001-12-06 | Dmbt1 | deleted in malignant brain tumors 1 | Symbol and Name updated to reflect Human and Mouse nomenclature | 915 | APPROVED |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_domains | extracellular region contains a number of repeated domains with homology to the scavenger receptor cysteine-rich domain and to a repeated domain of bone morphogenetic protein-I | 61559 |
| gene_expression | expressed in secretory duct epithelial cells of von Ebner's glands (VEG) | 61559 |
| gene_protein | 1290 amino acids | 61559 |
| More on Dmbt1 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 61984 |
| Created: | 2001-04-11 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.