Gene: Ace (angiotensin I converting enzyme) Rattus norvegicus
Symbol: Ace
Name: angiotensin I converting enzyme
Description: ENCODES a protein that exhibits drug binding; metallopeptidase activity; peptide binding; INVOLVED IN aging; angiogenesis involved in coronary vascular morphogenesis; bradykinin catabolic process; PARTICIPATES IN angiotensin (1-7) signaling pathway; renin-angiotensin cascade pathway; angiotensin II signaling pathway; ASSOCIATED WITH decreased angiotensin I-converting enzyme activity; increased angiotensin I-converting enzyme activity; ASSOCIATED WITH Acute Kidney Injury; Alzheimer Disease; Arthritis, Experimental; FOUND IN basal plasma membrane; brush border membrane; extracellular space; INTERACTS WITH (S)-colchicine; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: angiotensin 1 converting enzyme; angiotensin 1 converting enzyme 1; angiotensin converting enzyme; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I converting enzyme 1; angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1); angiotensin-converting enzyme; Dcp1; Dipeptidyl carboxypeptidase 1; Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme); dipeptidyl carboxypeptidase I; kininase II; StsRR92
Orthologs:
Allele / Splice: Aceem1Mcwi   Aceem2Mcwi  
Is Marker For: QTLs:   Bp9   Bw57   Bp342   Bw102  
Latest Assembly: RGSC Genome Assembly v3.4
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
MapChrPositionStrandSource
RGSC Genome Assembly v6.01094,170,766 - 94,213,831+NCBI
Rat Cytogenetic Map10q32.1 NCBI
RGSC Genome Assembly v5.01093,922,062 - 93,965,127+NCBI
RGSC Genome Assembly v3.41095,361,338 - 95,381,455+NCBI
Rat Celera Assembly1089,588,544 - 89,608,666+NCBI
Genome Assembly 3.11095,375,707 - 95,395,825+NCBI
Model

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Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (RGSC Genome Assembly v3.4)
Related Rat Strains

Sequence

Nucleotide Sequences
Protein Sequences
Protein Structures

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ace
Entrez Gene
Ensembl Gene
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RGD Object Information
RGD ID: 2493
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2014-09-10
Status: ACTIVE