Gene: Rapgef4 (Rap guanine nucleotide exchange factor 4) Rattus norvegicus
Symbol: Rapgef4
Name: Rap guanine nucleotide exchange factor 4
Description: ENCODES a protein that exhibits cAMP binding; guanyl-nucleotide exchange factor activity; protein complex binding; INVOLVED IN brain development; cellular response to nerve growth factor stimulus; ganglion development; ASSOCIATED WITH Burns; Autistic Disorder (ortholog); FOUND IN apical plasma membrane; axon; basolateral plasma membrane; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; benzene
Type: protein-coding
RefSeq Status: MODEL
Also known as: CAMP-GEFII; cAMP-regulated guanine nucleotide exchange factor II; CAMPS; Cgef2; epac 2; Epac2; exchange factor directly activated by cAMP 2; exchange protein directly activated by cAMP 2; Rap guanine nucleotide exchange factor (GEF) 4
Homo sapiens (human) : RAPGEF4 (Rap guanine nucleotide exchange factor 4)  HGNC
Mus musculus (house mouse) : Rapgef4 (Rap guanine nucleotide exchange factor (GEF) 4)  MGI
Pan paniscus (bonobo/pygmy chimpanzee) : RAPGEF4 (Rap guanine nucleotide exchange factor 4)
Canis lupus familiaris (dog) : RAPGEF4 (Rap guanine nucleotide exchange factor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rapgef4 (Rap guanine nucleotide exchange factor 4)
more info ...
Allele / Splice: Rapgef4Tn(sb-T2/Bart3)2.314Mcwi  
Genetic Models: F344-Rapgef4Tn(sb-T2/Bart3)2.314Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0358,632,338 - 58,925,127 (+)NCBIRnor6.0rn6Rnor6.0
Rnor_5.0365,122,705 - 65,409,814 (+)NCBIRnor5.0rn5Rnor5.0
RGSC_v3.4354,396,312 - 54,717,148 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1354,578,917 - 54,613,517 (+)NCBI
Celera356,352,070 - 56,643,335 (+)NCBI
Cytogenetic Map3q23NCBImapview
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Rapgef4
Ensembl Gene
JBrowse: rn5 rn6
NCBI Map Viewer
Vista + UCSC

RGD Object Information
RGD ID: 621886
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2017-03-14
Status: ACTIVE