Ext1 (exostosin glycosyltransferase 1) - Rat Genome Database

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Gene: Ext1 (exostosin glycosyltransferase 1) Rattus norvegicus
Analyze
Symbol: Ext1
Name: exostosin glycosyltransferase 1
RGD ID: 1587375
Description: Predicted to enable UDP-glycosyltransferase activity and protein dimerization activity. Predicted to contribute to glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Predicted to be involved in glycosaminoglycan biosynthetic process; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; and ossification. Predicted to act upstream of or within with a positive effect on several processes, including cell surface receptor signaling pathway; embryonic morphogenesis; and podocyte differentiation. Predicted to act upstream of or within several processes, including cell surface receptor signaling pathway; extracellular matrix organization; and skeletal system development. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of catalytic complex. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in chondrosarcoma and hereditary multiple exostoses. Orthologous to human EXT1 (exostosin glycosyltransferase 1); PARTICIPATES IN heparan sulfate biosynthetic pathway; INTERACTS WITH 6-propyl-2-thiouracil; amitrole; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: exostoses (multiple) 1; exostosin 1; exostosin-1; LOC299907; similar to Ext1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8786,265,651 - 86,544,488 (-)NCBIGRCr8
mRatBN7.2784,375,769 - 84,654,625 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl784,375,784 - 84,655,357 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx786,286,761 - 86,565,626 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0788,487,951 - 88,766,801 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0788,293,436 - 88,572,286 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0792,605,008 - 92,881,392 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl792,605,728 - 92,882,068 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0793,245,551 - 93,521,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4789,392,837 - 89,671,523 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera781,215,848 - 81,493,311 (-)NCBICelera
Cytogenetic Map7q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-cotinine  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dibutyl phthalate  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
ethanol  (ISO)
fenthion  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methylseleninic acid  (ISO)
nimesulide  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
picoxystrobin  (ISO)
propiconazole  (EXP)
protein kinase inhibitor  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
senecionine  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antigen processing and presentation  (ISO)
axon guidance  (ISO)
basement membrane organization  (ISO)
blood vessel remodeling  (ISO)
BMP signaling pathway  (ISO)
bone growth  (ISO)
bone morphogenesis  (ISO)
bone resorption  (ISO)
brain development  (ISO)
canonical Wnt signaling pathway  (ISO)
cartilage development involved in endochondral bone morphogenesis  (ISO)
cell adhesion  (ISO)
cell adhesion mediated by integrin  (ISO)
cell fate commitment  (ISO)
cell morphogenesis  (ISO)
cell population proliferation  (ISO)
cell surface receptor signaling pathway  (ISO)
cellular response to BMP stimulus  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to virus  (ISO)
chondrocyte differentiation  (ISO)
chondrocyte hypertrophy  (ISO)
chondrocyte proliferation  (ISO)
chondroitin sulfate metabolic process  (ISO)
collagen fibril organization  (ISO)
cranial skeletal system development  (ISO)
dendrite self-avoidance  (ISO)
dendritic cell migration  (ISO)
developmental growth involved in morphogenesis  (ISO)
embryonic morphogenesis  (ISO)
embryonic skeletal joint development  (ISO)
endochondral bone growth  (ISO)
endochondral bone morphogenesis  (ISO)
endochondral ossification  (ISO)
endoderm development  (ISO)
epithelial tube branching involved in lung morphogenesis  (ISO)
epithelium development  (ISO)
fear response  (ISO)
fibroblast growth factor receptor signaling pathway  (ISO)
fluid transport  (ISO)
gastrulation  (ISO)
gene expression  (ISO)
glandular epithelial cell differentiation  (ISO)
glomerular basement membrane development  (ISO)
glycosaminoglycan biosynthetic process  (ISO)
hair cycle process  (ISO)
hair follicle morphogenesis  (ISO)
heart contraction  (ISO)
heart field specification  (ISO)
hematopoietic progenitor cell differentiation  (ISO)
hematopoietic stem cell differentiation  (ISO)
hematopoietic stem cell homeostasis  (ISO)
hematopoietic stem cell migration to bone marrow  (ISO)
heparan sulfate proteoglycan biosynthetic process  (ISO)
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process  (ISO)
heparin biosynthetic process  (ISO)
heparin metabolic process  (ISO)
hypersensitivity  (ISO)
leukocyte tethering or rolling  (ISO)
limb joint morphogenesis  (ISO)
lymphocyte adhesion to endothelial cell of high endothelial venule  (ISO)
lymphocyte migration into lymphoid organs  (ISO)
mesenchymal cell differentiation involved in bone development  (ISO)
mesenchyme development  (ISO)
mesoderm development  (ISO)
motor behavior  (ISO)
multicellular organism growth  (ISO)
multicellular organismal-level water homeostasis  (ISO)
neural crest cell differentiation  (ISO)
neuron projection development  (ISO)
olfactory bulb development  (ISO)
optic nerve development  (ISO)
ossification  (ISO)
ossification involved in bone maturation  (ISO)
perichondral bone morphogenesis  (ISO)
podocyte differentiation  (ISO)
polysaccharide biosynthetic process  (ISO)
protein catabolic process  (ISO)
protein glycosylation  (IEA)
protein-containing complex assembly  (ISO)
proteoglycan biosynthetic process  (ISO)
regulation of blood pressure  (ISO)
regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
response to growth factor  (ISO)
response to heparin  (ISO)
response to leukemia inhibitory factor  (ISO)
response to light intensity  (ISO)
response to virus  (ISO)
sebaceous gland development  (ISO)
smoothened signaling pathway  (ISO)
smoothened signaling pathway involved in lung development  (ISO)
social behavior  (ISO)
sodium ion homeostasis  (ISO)
stem cell division  (ISO)
stomach development  (ISO)
sulfation  (ISO)
sweat gland development  (ISO)
synaptic transmission, glutamatergic  (ISO)
tight junction organization  (ISO)
vacuole organization  (ISO)
vasodilation  (ISO)
vocalization behavior  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Novel EXT1 mutation identified in a pedigree with hereditary multiple exostoses. Cao L, etal., Oncol Rep. 2014 Feb;31(2):713-8. doi: 10.3892/or.2013.2891. Epub 2013 Dec 2.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Decreased EXT expression and intracellular accumulation of heparan sulphate proteoglycan in osteochondromas and peripheral chondrosarcomas. Hameetman L, etal., J Pathol. 2007 Mar;211(4):399-409.
4. Hereditary multiple exostoses (EXT): mutational studies of familial EXT1 cases and EXT-associated malignancies. Hecht JT, etal., Am J Hum Genet. 1997 Jan;60(1):80-6.
5. [Novel mutation of Y271H in EXT1 gene causes multiple exostoses]. Li W, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007 Aug;32(4):546-50.
6. Identification of a novel EXT1 mutation in patients with hereditary multiple exostosis by exome sequencing. Liu H, etal., Oncol Rep. 2015 Feb;33(2):547-52. doi: 10.3892/or.2014.3610. Epub 2014 Nov 21.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Genetic analysis of hereditary multiple exostoses in Tunisian families: a novel frame-shift mutation in the EXT1 gene. Sfar S, etal., Mol Biol Rep. 2009 Apr;36(4):661-7. doi: 10.1007/s11033-008-9226-3. Epub 2008 Mar 11.
14. Expression of Ext1, Ext2, and heparanase genes in brain of senescence-accelerated OXYS rats in early ontogenesis and during development of neurodegenerative changes. Shevelev OB, etal., Biochemistry (Mosc). 2012 Jan;77(1):56-61. doi: 10.1134/S0006297912010063.
15. Mutation screening of the EXT genes in patients with hereditary multiple exostoses in Taiwan. Shi YR, etal., Genet Test. 2002 Fall;6(3):237-43.
16. Deletion of exon 8 from the EXT1 gene causes multiple osteochondromas (MO) in a family with three affected members. Zhuang L, etal., Springerplus. 2016 Jan 22;5:71. doi: 10.1186/s40064-016-1695-6. eCollection 2016.
Additional References at PubMed
PMID:7550340   PMID:9620772   PMID:10639137   PMID:10926768   PMID:12477932   PMID:12907669   PMID:14605369   PMID:15161920   PMID:15177029   PMID:17761672   PMID:18337501   PMID:18480751  
PMID:20022960   PMID:20080592   PMID:20404326   PMID:21093315   PMID:21185280   PMID:21743013  


Genomics

Comparative Map Data
Ext1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8786,265,651 - 86,544,488 (-)NCBIGRCr8
mRatBN7.2784,375,769 - 84,654,625 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl784,375,784 - 84,655,357 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx786,286,761 - 86,565,626 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0788,487,951 - 88,766,801 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0788,293,436 - 88,572,286 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0792,605,008 - 92,881,392 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl792,605,728 - 92,882,068 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0793,245,551 - 93,521,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4789,392,837 - 89,671,523 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera781,215,848 - 81,493,311 (-)NCBICelera
Cytogenetic Map7q31NCBI
EXT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388117,794,490 - 118,111,826 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8117,794,490 - 118,111,826 (-)EnsemblGRCh38hg38GRCh38
GRCh378118,806,729 - 119,124,065 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368118,880,783 - 119,193,239 (-)NCBINCBI36Build 36hg18NCBI36
Build 348118,880,786 - 119,193,239NCBI
Celera8115,000,160 - 115,312,582 (-)NCBICelera
Cytogenetic Map8q24.11NCBI
HuRef8114,138,448 - 114,450,830 (-)NCBIHuRef
CHM1_18118,852,044 - 119,165,143 (-)NCBICHM1_1
T2T-CHM13v2.08118,922,893 - 119,240,285 (-)NCBIT2T-CHM13v2.0
Ext1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391552,931,657 - 53,209,579 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1552,927,434 - 53,209,555 (-)EnsemblGRCm39 Ensembl
GRCm381553,068,261 - 53,346,183 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1553,064,038 - 53,346,159 (-)EnsemblGRCm38mm10GRCm38
MGSCv371552,899,816 - 53,177,738 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361552,898,622 - 53,176,027 (-)NCBIMGSCv36mm8
Celera1554,621,498 - 54,903,011 (-)NCBICelera
Cytogenetic Map15CNCBI
cM Map1520.0NCBI
Ext1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541723,798,393 - 24,067,100 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541723,798,044 - 24,067,759 (-)NCBIChiLan1.0ChiLan1.0
EXT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27135,221,067 - 135,535,535 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18110,736,618 - 111,051,056 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08114,489,325 - 114,803,763 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18117,011,571 - 117,325,464 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8117,011,919 - 117,324,851 (-)Ensemblpanpan1.1panPan2
EXT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11317,172,497 - 17,457,084 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1317,172,705 - 17,456,469 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1317,173,248 - 17,457,626 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01317,470,129 - 17,750,747 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1317,470,144 - 17,750,070 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11317,205,173 - 17,489,568 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01317,305,318 - 17,589,066 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01317,549,676 - 17,834,137 (-)NCBIUU_Cfam_GSD_1.0
Ext1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530320,877,114 - 21,140,365 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647028,303,828 - 28,566,118 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647028,303,213 - 28,566,470 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EXT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl420,645,610 - 20,935,540 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1420,645,002 - 20,935,769 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2421,837,627 - 22,128,132 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EXT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18112,435,733 - 112,751,301 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603927,547,084 - 27,862,637 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ext1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476316,126,938 - 16,392,804 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476316,126,582 - 16,393,476 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ext1
1621 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:50
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000037809
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat
61357Bp38Blood pressure QTL 381.60.052arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)741333674119109060Rat
634326Hc3Hypercalciuria QTL 32.1urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)74278731487787314Rat
10053722Scort27Serum corticosterone level QTL 272.410.0083blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)74322875088228750Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)743747012108555253Rat
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)743747099102228765Rat
631504Cm27Cardiac mass QTL 273.45heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)744421311118198041Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)74486753389867533Rat
738030Anxrr8Anxiety related response QTL 84.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)74659007091590070Rat
2293696Bmd32Bone mineral density QTL 325.10.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)74765143992651439Rat
2293707Bss32Bone structure and strength QTL 327.640.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)74765143992651439Rat
2300178Bmd54Bone mineral density QTL 545.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)74765143992651439Rat
2293644Bmd29Bone mineral density QTL 295.40.0001femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)74765143992651439Rat
2293667Bss42Bone structure and strength QTL 427.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)74765143992651439Rat
2293678Bss24Bone structure and strength QTL 246.710.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)74765143992651439Rat
2293685Bmd21Bone mineral density QTL 214.20.0003femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)74765143992651439Rat
1300151Bp181Blood pressure QTL 1813.36arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)753612714103945643Rat
2317035Aia16Adjuvant induced arthritis QTL 162.71joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)759238038104238038Rat
1298528Bp169Blood pressure QTL 1690.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)761074194106074194Rat
1559283Emca4Estrogen-induced mammary cancer QTL 43.7mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)762004452101773158Rat
1576303Ept7Estrogen-induced pituitary tumorigenesis QTL 73.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)762004452101773158Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
2316947Rf58Renal function QTL 587.8kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)768938720113886318Rat
2316952Pur22Proteinuria QTL 225.2urine protein amount (VT:0005160)urine protein level (CMO:0000591)768938720113886318Rat
2316955Stl24Serum triglyceride level QTL 247.1blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)768938720113886318Rat
631540Bw9Body weight QTL 94.5body mass (VT:0001259)body weight (CMO:0000012)769736226117455174Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)773829340130221005Rat
7411654Foco25Food consumption QTL 259.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
7411607Foco15Food consumption QTL 150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)775918751120918751Rat
724537Niddm52Non-insulin dependent diabetes mellitus QTL 520.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)78022129993595843Rat
1641908Teswt1Testicular weight QTL 13.28testis mass (VT:1000644)both testes wet weight (CMO:0000175)78022129994811326Rat
631529Tls2T-lymphoma susceptibility QTL 200.001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)780221299109401111Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)780221299112308525Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331768Kidm10Kidney mass QTL 104.62096kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)780221299125221299Rat
2317052Aia17Adjuvant induced arthritis QTL 172.13joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)781737938126737938Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)783153392128153392Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat

Markers in Region
AW531028  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2784,577,440 - 84,577,596 (+)MAPPERmRatBN7.2
Rnor_6.0792,805,739 - 92,805,894NCBIRnor6.0
Rnor_5.0793,446,282 - 93,446,437UniSTSRnor5.0
RGSC_v3.4789,593,889 - 89,594,044UniSTSRGSC3.4
Celera781,416,613 - 81,416,768UniSTS
RH 3.4 Map7578.2UniSTS
Cytogenetic Map7q31UniSTS
Ext1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2784,376,764 - 84,376,907 (+)MAPPERmRatBN7.2
Rnor_6.0792,606,003 - 92,606,145NCBIRnor6.0
Rnor_5.0793,246,546 - 93,246,688UniSTSRnor5.0
RGSC_v3.4789,393,839 - 89,393,981UniSTSRGSC3.4
Celera781,216,843 - 81,216,985UniSTS
Cytogenetic Map7q31UniSTS
RH138727  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2784,376,611 - 84,376,789 (+)MAPPERmRatBN7.2
Rnor_6.0792,605,850 - 92,606,027NCBIRnor6.0
Rnor_5.0793,246,393 - 93,246,570UniSTSRnor5.0
RGSC_v3.4789,393,686 - 89,393,863UniSTSRGSC3.4
Celera781,216,690 - 81,216,867UniSTS
RH 3.4 Map7583.7UniSTS
Cytogenetic Map7q31UniSTS
RH142054  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2784,380,208 - 84,380,399 (+)MAPPERmRatBN7.2
Rnor_6.0792,609,447 - 92,609,637NCBIRnor6.0
Rnor_5.0793,249,990 - 93,250,180UniSTSRnor5.0
RGSC_v3.4789,397,283 - 89,397,473UniSTSRGSC3.4
Celera781,220,287 - 81,220,477UniSTS
RH 3.4 Map7591.4UniSTS
Cytogenetic Map7q31UniSTS
REN13329  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2784,654,438 - 84,654,693 (+)MAPPERmRatBN7.2
Rnor_6.0792,881,206 - 92,881,460NCBIRnor6.0
Rnor_5.0793,521,749 - 93,522,003UniSTSRnor5.0
RGSC_v3.4789,670,637 - 89,670,891UniSTSRGSC3.4
Celera781,493,125 - 81,493,379UniSTS
Cytogenetic Map7q31UniSTS
REN13326  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2784,655,089 - 84,655,317 (+)MAPPERmRatBN7.2
Rnor_6.0792,881,857 - 92,882,084NCBIRnor6.0
Rnor_5.0793,522,400 - 93,522,627UniSTSRnor5.0
RGSC_v3.4789,671,288 - 89,671,515UniSTSRGSC3.4
Cytogenetic Map7q31UniSTS
REN13331  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2784,653,989 - 84,654,236 (+)MAPPERmRatBN7.2
Rnor_6.0792,880,757 - 92,881,003NCBIRnor6.0
Rnor_5.0793,521,300 - 93,521,546UniSTSRnor5.0
RGSC_v3.4789,670,188 - 89,670,434UniSTSRGSC3.4
Celera781,492,676 - 81,492,922UniSTS
Cytogenetic Map7q31UniSTS
ECD12225  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2784,653,960 - 84,654,510 (+)MAPPERmRatBN7.2
Rnor_6.0792,880,728 - 92,881,277NCBIRnor6.0
Rnor_5.0793,521,271 - 93,521,820UniSTSRnor5.0
RGSC_v3.4789,670,159 - 89,670,708UniSTSRGSC3.4
Celera781,492,647 - 81,493,196UniSTS
Cytogenetic Map7q31UniSTS
ECD12830  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2784,654,548 - 84,655,077 (+)MAPPERmRatBN7.2
Rnor_6.0792,881,316 - 92,881,844NCBIRnor6.0
Rnor_5.0793,521,859 - 93,522,387UniSTSRnor5.0
RGSC_v3.4789,670,747 - 89,671,275UniSTSRGSC3.4
Celera781,493,235 - 81,493,763UniSTS
Cytogenetic Map7q31UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 48 35 19 35 2 2 74 35 34 11 2
Low 9 6 6 6 9 7 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000037809   ⟹   ENSRNOP00000031943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl784,375,784 - 84,655,357 (-)Ensembl
Rnor_6.0 Ensembl792,605,728 - 92,882,068 (-)Ensembl
RefSeq Acc Id: NM_001130540   ⟹   NP_001124012
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8786,265,651 - 86,544,488 (-)NCBI
mRatBN7.2784,375,770 - 84,654,625 (-)NCBI
Rnor_6.0792,605,008 - 92,881,392 (-)NCBI
Rnor_5.0793,245,551 - 93,521,935 (-)NCBI
Celera781,215,848 - 81,493,311 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039078770   ⟹   XP_038934698
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8786,266,363 - 86,543,262 (-)NCBI
mRatBN7.2784,375,769 - 84,653,398 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001124012 (Get FASTA)   NCBI Sequence Viewer  
  XP_038934698 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI05840 (Get FASTA)   NCBI Sequence Viewer  
  EDM16269 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000031943
  ENSRNOP00000031943.3
Reference Protein Sequences
RefSeq Acc Id: NP_001124012   ⟸   NM_001130540
- UniProtKB: G3V901 (UniProtKB/TrEMBL),   A6HRF2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000031943   ⟸   ENSRNOT00000037809
RefSeq Acc Id: XP_038934698   ⟸   XM_039078770
- Peptide Label: isoform X1
Protein Domains
Exostosin GT47   Glycosyl transferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V901-F1-model_v2 AlphaFold G3V901 1-746 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695326
Promoter ID:EPDNEW_R5851
Type:initiation region
Name:Ext1_1
Description:exostosin glycosyltransferase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0792,882,041 - 92,882,101EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1587375 AgrOrtholog
BioCyc Gene G2FUF-33410 BioCyc
Ensembl Genes ENSRNOG00000024886 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037809 ENTREZGENE
  ENSRNOT00000037809.5 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7453681 IMAGE-MGC_LOAD
InterPro Exostosin UniProtKB/TrEMBL
  Exostosin_GT47 UniProtKB/TrEMBL
  HexNAc_Trfase_a UniProtKB/TrEMBL
  Nucleotide-diphossugar_trans UniProtKB/TrEMBL
KEGG Report rno:299907 UniProtKB/TrEMBL
MGC_CLONE MGC:125218 IMAGE-MGC_LOAD
NCBI Gene 299907 ENTREZGENE
PANTHER ACETYLGLUCOSAMINYLTRANSFERASE UniProtKB/TrEMBL
  ACETYLGLUCOSAMINYLTRANSFERASE UniProtKB/TrEMBL
Pfam Exostosin UniProtKB/TrEMBL
  Glyco_transf_64 UniProtKB/TrEMBL
PhenoGen Ext1 PhenoGen
RatGTEx ENSRNOG00000024886 RatGTEx
Superfamily-SCOP SSF53448 UniProtKB/TrEMBL
UniProt A6HRF2 ENTREZGENE, UniProtKB/TrEMBL
  G3V901 ENTREZGENE, UniProtKB/TrEMBL
  Q3B8R0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-20 Ext1  exostosin glycosyltransferase 1  Ext1  exostosin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Ext1  exostosin 1  Ext1  exostoses (multiple) 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Ext1  exostoses (multiple) 1  LOC299907  similar to Ext1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC299907  similar to Ext1      Symbol and Name status set to provisional 70820 PROVISIONAL