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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | decreases expression | ISO | RGD:1353693 | 6480464 | Estradiol results in decreased expression of SERPINA10 mRNA | CTD | PMID:20106945 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:732336 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SERPINA10 mRNA | CTD | PMID:18172886 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:732336 | 6480464 | Tetrachlorodibenzodioxin affects the expression of SERPINA10 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SERPINA10 mRNA | CTD | PMID:15644576 PMID:16054898 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SERPINA10 mRNA | CTD | PMID:16054898 PMID:15644576 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of SERPINA10 mRNA | CTD | PMID:21346803 | 6-propyl-2-thiouracil | affects expression | EXP | | 6480464 | Propylthiouracil affects the expression of SERPINA10 mRNA | CTD | PMID:19483382 | aflatoxin B1 | affects expression | ISO | RGD:1353693 | 6480464 | Aflatoxin B1 affects the expression of SERPINA10 protein | CTD | PMID:20106945 | aflatoxin B1 | increases expression | ISO | RGD:732336 | 6480464 | Aflatoxin B1 results in increased expression of SERPINA10 mRNA | CTD | PMID:19770486 | amiodarone | increases expression | ISO | RGD:1353693 | 6480464 | Amiodarone results in increased expression of SERPINA10 mRNA | CTD | PMID:19774075 | amiodarone | affects expression | EXP | | 6480464 | Amiodarone affects the expression of SERPINA10 mRNA | CTD | PMID:19483382 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of SERPINA10 mRNA | CTD | PMID:16483693 | benzbromarone | affects expression | EXP | | 6480464 | Benzbromarone affects the expression of SERPINA10 mRNA | CTD | PMID:19483382 | ciguatoxin CTX1B | affects expression | ISO | RGD:732336 | 6480464 | Ciguatoxins affects the expression of SERPINA10 mRNA | CTD | PMID:18353800 | clofibrate | affects expression | EXP | | 6480464 | Clofibrate affects the expression of SERPINA10 mRNA | CTD | PMID:19483382 | clofibrate | multiple interactions | ISO | RGD:732336 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of SERPINA10 mRNA; more ... | CTD | PMID:17585979 | copper(2+) sulfate | decreases expression | ISO | RGD:1353693 | 6480464 | Copper Sulfate results in decreased expression of SERPINA10 mRNA | CTD | PMID:19549813 | cyclosporin A | decreases expression | ISO | RGD:1353693 | 6480464 | Cyclosporine results in decreased expression of SERPINA10 mRNA | CTD | PMID:20106945 | cyclosporin A | increases expression | ISO | RGD:732336 | 6480464 | Cyclosporine results in increased expression of SERPINA10 mRNA | CTD | PMID:19770486 | hydrogen peroxide | affects expression | ISO | RGD:1353693 | 6480464 | Hydrogen Peroxide affects the expression of SERPINA10 mRNA | CTD | PMID:20044591 | L-ethionine | affects expression | EXP | | 6480464 | Ethionine affects the expression of SERPINA10 mRNA | CTD | PMID:19483382 | lead(0) | decreases expression | ISO | RGD:1353693 | 6480464 | Lead results in decreased expression of SERPINA10 mRNA | CTD | PMID:19921347 | omeprazole | affects expression | EXP | | 6480464 | Omeprazole affects the expression of SERPINA10 mRNA | CTD | PMID:19483382 | paracetamol | multiple interactions | ISO | RGD:732336 | 6480464 | [Clofibrate co-treated with Acetaminophen] affects the expression of SERPINA10 mRNA; more ... | CTD | PMID:17585979 | paracetamol | decreases expression | ISO | RGD:1353693 | 6480464 | Acetaminophen results in decreased expression of SERPINA10 mRNA | CTD | PMID:21420995 | paracetamol | affects expression | ISO | RGD:732336 | 6480464 | Acetaminophen affects the expression of SERPINA10 mRNA | CTD | PMID:17562736 | perfluorooctane-1-sulfonic acid | decreases expression | EXP | | 6480464 | perfluorooctane sulfonic acid results in decreased expression of SERPINA10 mRNA | CTD | PMID:18692542 | perfluorooctanoic acid | decreases expression | EXP | | 6480464 | perfluorooctanoic acid results in decreased expression of SERPINA10 mRNA | CTD | PMID:19162173 | pirinixic acid | affects expression | EXP | | 6480464 | pirinixic acid affects the expression of SERPINA10 mRNA | CTD | PMID:19483382 | pirinixic acid | multiple interactions | ISO | RGD:732336 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SERPINA10 mRNA | CTD | PMID:19710929 | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of SERPINA10 mRNA | CTD | PMID:19162173 | pregnenolone 16alpha-carbonitrile | increases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in increased expression of SERPINA10 mRNA | CTD | PMID:19162173 | quartz | increases expression | EXP | | 6480464 | Quartz results in increased expression of SERPINA10 mRNA | CTD | PMID:19836432 | quercetin | decreases expression | ISO | RGD:1353693 | 6480464 | Quercetin results in decreased expression of SERPINA10 mRNA | CTD | PMID:21632981 | tamoxifen | decreases expression | ISO | RGD:732336 | 6480464 | Tamoxifen results in decreased expression of SERPINA10 mRNA | CTD | PMID:17555576 | thioacetamide | affects expression | EXP | | 6480464 | Thioacetamide affects the expression of SERPINA10 mRNA | CTD | PMID:19483382 | valproic acid | affects expression | ISO | RGD:732336 | 6480464 | Valproic Acid affects the expression of SERPINA10 mRNA | CTD | PMID:17292431 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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References - curated
References - uncurated
RGD Disease Portals| Serpina10 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Serpina10 (Rattus norvegicus) |
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| SERPINA10 (Homo sapiens) |
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| Serpina10 (Mus musculus) |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| RefSeq Acc Id: | NM_133617 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_598301 | ||||||||||||||||||||
| Peptide Label: | precursor | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_598301 | (Get FASTA) |
| GenBank Protein | AAC52624 | (Get FASTA) |
| AAH88113 | (Get FASTA) | |
| EDL81781 | (Get FASTA) | |
| EDL81782 | (Get FASTA) | |
| Q62975 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000048988 | UniProtKB/Swiss-Prot |
| ENSRNOG00000050761 | ENTREZGENE, UniProtKB/Swiss-Prot | |
| Ensembl Protein | ENSRNOP00000064104 | ENTREZGENE, UniProtKB/Swiss-Prot |
| ENSRNOP00000066602 | UniProtKB/Swiss-Prot | |
| Ensembl Transcript | ENSRNOT00000073709 | ENTREZGENE, UniProtKB/Swiss-Prot |
| ENSRNOT00000075378 | UniProtKB/Swiss-Prot | |
| Entrez Gene | 171154 | ENTREZGENE |
| Germonline | ENSRNOG00000028888 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 9414 | ENTREZGENE |
| IMAGE_CLONE | IMAGE:7326099 | IMAGE-MGC_LOAD |
| InterPro | Prot_inh_Lserp2 | UniProtKB/Swiss-Prot |
| Protease_inhib_I4_serpin | UniProtKB/Swiss-Prot | |
| Sepin_dom | UniProtKB/Swiss-Prot | |
| KEGG Report | rno:100909524 | UniProtKB/Swiss-Prot |
| rno:171154 | ENTREZGENE, UniProtKB/Swiss-Prot | |
| MGC_CLONE | MGC:108600 | IMAGE-MGC_LOAD |
| PANTHER | Prot_inh_serpin | UniProtKB/Swiss-Prot |
| Pfam | Serpin | UniProtKB/Swiss-Prot |
| PRINTS | LEUSERPINII | UniProtKB/Swiss-Prot |
| PROSITE | SERPIN; FALSE_NEG | UniProtKB/Swiss-Prot |
| SMART | SERPIN | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | Prot_inh_serpin | UniProtKB/Swiss-Prot |
| UniGene | Rn.10502 | ENTREZGENE |
| UniProt | ZPI_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2012-10-16 | Serpina10 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 | Serpina10 | serpin peptidase inhibitor, clade A, member 10 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2012-03-05 | Serpina10 | serpin peptidase inhibitor, clade A, member 10 | Serpina10 | serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2006-03-30 | Serpina10 | serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 | serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 | Name updated | 10779 | APPROVED | |
| 2004-09-10 | Serpina10 | serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 | Symbol and Name status set to approved | 10779 | APPROVED | ||
| 2002-08-07 | Serpina10 | serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 | Symbol and Name status set to provisional | 1724 | PROVISIONAL |
RGD Curation Notes| Note Type | Note | Reference |
|---|---|---|
| gene_expression | mRNA is highly expressed in liver and displays increased expession during liver regeneration | 729731 |
| More on Serpina10 | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 621220 |
| Created: | 2002-08-06 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-05-28 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




