RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: Spinal Cord Injuries
Accession: DOID:9000039
browse the term
Definition: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
Synonyms: exact_synonym: Post Traumatic Myelopathy; Post-Traumatic Myelopathies; Spinal Cord Contusion; Spinal Cord Contusions; Spinal Cord Injury; Spinal Cord Laceration; Spinal Cord Lacerations; Spinal Cord Transection; Spinal Cord Transections; Spinal Cord Trauma; Spinal Cord Traumas; Traumatic Myelopathies; Traumatic Myelopathy
narrow_synonym: acute spinal cord injury
primary_id: MESH:D013119 ; RDO:0006597
xref: EFO:1001919
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ABCC8
ATP binding cassette subfamily C member 8
treatment
ISO
mRNA:increased expression:spinal cord
RGD
PMID:20410530 PMID:25763638
RGD:12790978 RGD:12791993
NCBI chr 2:41,666,974...41,754,624
Ensembl chr 2:41,666,909...41,754,620
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ACAN
aggrecan
ISO
protein:altered expression:spinal cord (rat)
RGD
PMID:14769391
RGD:2315837
NCBI chr 7:54,449,830...54,520,606
Ensembl chr 7:54,449,816...54,519,194
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ADARB1
adenosine deaminase RNA specific B1
ISO
RGD
PMID:20456005
RGD:10755338
NCBI chr13:207,746,915...207,791,809
Ensembl chr13:207,691,174...207,791,802
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ADCYAP1
adenylate cyclase activating polypeptide 1
ISO
protein:altered expression:spinal cord,dorsal root ganglion, urinary bladder
RGD
PMID:15698618 PMID:15913892
RGD:2325306 RGD:2325309
NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,631...105,422,294
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ADIPOQ
adiponectin, C1Q and collagen domain containing
ISO
protein:increased expression:serum
RGD
PMID:16213239
RGD:5686719
NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,685...124,646,646
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ADORA1
adenosine A1 receptor
ISO
protein:decreased expression:spinal cord
RGD
PMID:17853654 PMID:18289533 PMID:20065990
RGD:4890369 RGD:5129094 RGD:5129096
NCBI chr 9:113,835,279...113,875,899
Ensembl chr 9:113,835,921...113,872,365
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ADORA2A
adenosine A2a receptor
ISO
RGD
PMID:17559837
RGD:4890378
NCBI chr14:49,467,186...49,485,845
Ensembl chr14:49,468,877...49,485,850
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ADRA1A
adrenoceptor alpha 1A
ISO
mRNA:increased expression:aorta
RGD
PMID:16524515
RGD:5688371
NCBI chr14:10,623,391...10,733,378
Ensembl chr14:10,626,293...10,733,068
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AGER
advanced glycosylation end-product specific receptor
ISO
protein:increased expression:spinal cord (rat)
RGD
PMID:20195207
RGD:2325645
NCBI chr 7:24,218,116...24,221,162
Ensembl chr 7:24,218,120...24,221,162
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AIF1
allograft inflammatory factor 1
ISO
protein:altered expression:spinal cord dorsal horn (rat)
RGD
PMID:17158026
RGD:2313037
NCBI chr 7:23,711,752...23,731,191
Ensembl chr 7:23,726,787...23,731,671
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AKT1
AKT serine/threonine kinase 1
ISO
RGD
PMID:20678995
RGD:10040962
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AKT1S1
AKT1 substrate 1
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:17457363
NCBI chr 6:54,881,581...54,890,917
Ensembl chr 6:54,881,588...54,890,641
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AMBRA1
autophagy and beclin 1 regulator 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29793971
NCBI chr 2:15,935,354...16,119,082
Ensembl chr 2:15,935,375...16,119,079
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ANKRD1
ankyrin repeat domain 1
ISO
mRNA:increased expression:spinal cord, dorsal root ganglion, neuron
RGD
PMID:17610582
RGD:5133279
NCBI chr14:102,603,777...102,612,857
Ensembl chr14:102,603,777...102,612,839
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ANP32B
acidic nuclear phosphoprotein 32 family member B
ISO
RGD
PMID:25034417
RGD:10401137
NCBI chr 1:239,842,062...239,868,404
Ensembl chr 1:239,842,067...239,868,403
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ANXA1
annexin A1
treatment
ISO
mRNA,protein:increased expression:neuron,glial cell
RGD
PMID:15248295 PMID:17917587
RGD:10053688 RGD:2306891
NCBI chr 1:226,414,200...226,431,963
Ensembl chr 1:226,414,306...226,432,279
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ANXA2
annexin A2
ISO
mRNA,protein:increased expression:neuron,glial cell
RGD
PMID:15248295
RGD:10053688
NCBI chr 1:111,588,721...111,635,064
Ensembl chr 1:111,588,306...111,635,059
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ANXA5
annexin A5
ISO
mRNA,protein:increased expression:neuron,glial cell
RGD
PMID:15248295
RGD:10053688
NCBI chr 8:102,387,833...102,420,868
Ensembl chr 8:102,388,103...102,425,750
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APAF1
apoptotic peptidase activating factor 1
ISO
RGD
PMID:21748659
RGD:10053608
NCBI chr 5:85,166,616...85,258,751
Ensembl chr 5:85,166,628...85,258,364
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APEX1
apurinic/apyrimidinic endodeoxyribonuclease 1
ISO
mRNA:increased expression:spinal cord
RGD
PMID:18637713
RGD:2315670
NCBI chr 7:78,451,845...78,454,938
Ensembl chr 7:78,451,851...78,454,938
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APOE
apolipoprotein E
ISO
DNA:polymorphism:exon:
RGD
PMID:18581664 PMID:30036659
RGD:13703128 RGD:7771551
NCBI chr 6:51,373,113...51,375,333
Ensembl chr 6:51,372,292...51,375,330
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AQP1
aquaporin 1 (Colton blood group)
ISO
protein:increased expression:spinal cord, neuron, astrocyte CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:18248364 PMID:21092735
RGD:2307072 RGD:5148013
NCBI chr18:42,063,482...42,076,741
Ensembl chr18:42,063,485...42,076,746
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AQP4
aquaporin 4
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:20517941 PMID:21092735 PMID:21280976
RGD:5148013 RGD:5148027 RGD:5148035
NCBI chr 6:111,407,632...111,422,169
Ensembl chr 6:111,407,639...111,422,109
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ATF4
activating transcription factor 4
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29793971
NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368
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ATG5
autophagy related 5
ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:axon
CTD RGD
PMID:25040536 PMID:29793971
RGD:11553820
NCBI chr 1:72,343,950...72,520,402
Ensembl chr 1:72,270,799...72,520,396
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ATG7
autophagy related 7
ISO
protein:increased expression:axon
RGD
PMID:25040536
RGD:11553820
NCBI chr13:67,301,756...67,699,141
Ensembl chr13:67,417,938...67,707,654
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ATM
ATM serine/threonine kinase
ISO
protein:increased expression:spinal cord
RGD
PMID:21748659
RGD:10053608
NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,658...36,759,552
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ATP2A1
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
ISO
protein:decreased expression:tail, skeletal muscle
RGD
PMID:21930674
RGD:13782071
NCBI chr 3:18,545,064...18,568,312
Ensembl chr 3:18,545,071...18,568,310
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ATP2A2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
ISO
protein:decreased expression:tail, skeletal muscle
RGD
PMID:21930674
RGD:13782071
NCBI chr14:31,674,659...31,744,981
Ensembl chr14:31,674,757...31,744,969
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BAMBI
BMP and activin membrane bound inhibitor
ISO
mRNA,protein:decreased expression:spinal cord:
RGD
PMID:28035406
RGD:14390163
NCBI chr10:40,053,368...40,058,590
Ensembl chr10:40,053,355...40,060,319
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BAX
BCL2 associated X, apoptosis regulator
treatment
ISO
RGD
PMID:27256506
RGD:13792677
NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140
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BCAN
brevican
treatment
ISO
RGD
PMID:15016081
RGD:9589823
NCBI chr 4:93,432,331...93,450,895
Ensembl chr 4:93,432,330...93,450,831
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BCL2
BCL2 apoptosis regulator
treatment
ISO
RGD
PMID:27256506
RGD:13792677
NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879
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BDNF
brain derived neurotrophic factor
treatment
ISO
RGD
PMID:16022868 PMID:19203225 PMID:24551172
RGD:10059354 RGD:4891066 RGD:4891112
NCBI chr 2:32,623,668...32,679,293
Ensembl chr 2:32,624,048...32,679,765
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BECN1
beclin 1
treatment
ISO
CTD Direct Evidence: marker/mechanism protein:increased expression:spinal cord
CTD RGD
PMID:21806471 PMID:23852559 PMID:24559459 PMID:29793971
RGD:11561918 RGD:11561922 RGD:6483100
NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373
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BMP2
bone morphogenetic protein 2
ISO
RGD
PMID:23770801
RGD:9068404
NCBI chr17:15,750,487...15,762,982
Ensembl chr17:15,749,835...15,761,195
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BMP4
bone morphogenetic protein 4
treatment
ISO
RGD
PMID:18803859 PMID:23770801
RGD:9068404 RGD:9068437
NCBI chr 1:183,415,989...183,422,888
Ensembl chr 1:183,416,146...183,422,637
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BNIP3
BCL2 interacting protein 3
ISO
protein:increased expression:spinal cord
RGD
PMID:23637053
RGD:11564330
NCBI chr14:140,362,123...140,371,951
Ensembl chr14:140,362,127...140,371,907
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BNIP3L
BCL2 interacting protein 3 like
ISO
protein:increased expression:spinal cord
RGD
PMID:23637053
RGD:11564330
NCBI chr14:10,318,688...10,345,689
Ensembl chr14:10,318,732...10,345,679
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BRCA2
BRCA2 DNA repair associated
ISO
mRNA,protein:increased expression:spinal cord:
RGD
PMID:21748659
RGD:10053608
NCBI chr11:8,805,950...8,858,128
Ensembl chr11:8,805,953...8,858,418
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C1QB
complement C1q B chain
ISO
mRNA:increased expression
RGD
PMID:16345062
RGD:1599510
NCBI chr 6:80,601,680...80,606,076
Ensembl chr 6:80,601,665...80,607,471
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CAPN1
calpain 1
treatment
ISO
RGD
PMID:23102374
RGD:13792496
NCBI chr 2:6,997,513...7,024,410
Ensembl chr 2:6,997,985...7,022,684
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CAPZB
capping actin protein of muscle Z-line subunit beta
ISO
protein:decreased expression:spinal cord
RGD
PMID:20141154
RGD:9685028
NCBI chr 6:77,780,682...77,912,653
Ensembl chr 6:77,780,682...77,912,617
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CASP1
caspase 1, apoptosis-related cysteine peptidase
ISO
protein:increased expression, increased activation:spinal cord
RGD
PMID:18367607
RGD:2315889
NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328
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CASP3
caspase 3
treatment
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:14588118 PMID:18378144 PMID:21748659 PMID:27256506 PMID:27339639
RGD:10053608 RGD:13782345 RGD:13792677 RGD:2293322
NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213
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CASP9
caspase 9
treatment
ISO
RGD
PMID:21748659 PMID:27339639
RGD:10053608 RGD:13782345
NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007
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CAV1
caveolin 1
ISO
protein:increased phosphorylation:spinal cord
RGD
PMID:17275798
RGD:2289124
NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465
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CCL5
C-C motif chemokine ligand 5
ISO
mRNA:increased expression:spinal cord segment (mouse)
RGD
PMID:20478301
RGD:4889905
NCBI chr12:39,652,731...39,659,121
Ensembl chr12:39,648,598...39,659,118
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CCND3
cyclin D3
ISO
protein:increased expression:spinal cord
RGD
PMID:18008145
RGD:2316019
NCBI chr 7:37,087,336...37,182,462
Ensembl chr 7:37,082,097...37,181,366
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CCNE1
cyclin E1
ISO
protein:increased expression:spinal cord
RGD
PMID:16759516
RGD:2289281
NCBI chr 6:39,919,541...39,933,224
Ensembl chr 6:39,919,624...39,933,363
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CCNH
cyclin H
ISO
mRNA, protein:increased expression:spinal cord
RGD
PMID:21710280
RGD:9590263
NCBI chr 2:94,980,938...95,019,053
Ensembl chr 2:94,980,941...95,018,634
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CCR1
C-C motif chemokine receptor 1
ISO
RGD
PMID:21332278
RGD:5688138
NCBI chr13:29,227,218...29,233,862
Ensembl chr13:29,227,222...29,233,960
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CCR2
C-C motif chemokine receptor 2
ISO
protein:increased expression:spinal cord
RGD
PMID:18338959
RGD:4144888
NCBI chr13:29,368,735...29,374,564
Ensembl chr13:29,285,012...29,376,343
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CD274
CD274 molecule
ISO
mRNA:increased expression:microglial cell
RGD
PMID:29665726
RGD:40886268
NCBI chr 1:216,646,378...216,792,731
Ensembl chr 1:216,660,041...216,792,724
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CDC42
cell division cycle 42
ISO
mRNA:increased expression:spinal cord
RGD
PMID:15736231
RGD:5688276
NCBI chr 6:80,035,034...80,089,243
Ensembl chr 6:80,035,123...80,089,233
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CDK1
cyclin dependent kinase 1
ISO
protein:increased expression:spinal cord dura mater (rat)
RGD
PMID:19672039
RGD:2316488
NCBI chr14:64,233,945...64,255,290
Ensembl chr14:64,233,987...64,372,197
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CDK19
cyclin dependent kinase 19
ISO
mRNA, protein:increased expression:spinal cord
RGD
PMID:18008145
RGD:2316019
NCBI chr 1:76,589,050...76,793,476
Ensembl chr 1:76,589,052...76,793,278
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CDKN1B
cyclin dependent kinase inhibitor 1B
ISO
protein:decreased expression, altered localization:spinal cord, neuron, microglial cell
RGD
PMID:18319192
RGD:2293615
NCBI chr 5:59,731,224...59,735,831
Ensembl chr 5:59,731,206...59,735,831
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CHL1
cell adhesion molecule L1 like
ISO
protein:increased expression:spinal cord (rat)
RGD
PMID:21337374
RGD:6483045
NCBI chr13:56,804,309...57,034,191
Ensembl chr13:56,804,555...57,034,181
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CNR1
cannabinoid receptor 1
ISO
RGD
PMID:18930143
RGD:2316199
NCBI chr 1:56,466,022...56,493,275
Ensembl chr 1:56,467,835...56,492,602
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CNR2
cannabinoid receptor 2
ISO
RGD
PMID:18930143
RGD:2316199
NCBI chr 6:81,659,162...81,692,550
Ensembl chr 6:81,659,169...81,692,550
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CRH
corticotropin releasing hormone
ISO
protein:altered expression:spinal cord (rat)
RGD
PMID:20458328
RGD:5490964
NCBI chr 4:68,481,696...68,486,122
Ensembl chr 4:68,484,053...68,486,121
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CRP
C-reactive protein, pentraxin-related
ISO
RGD
PMID:22404382
RGD:6903321
NCBI chr 4:90,793,361...90,801,020
Ensembl chr 4:90,793,350...90,805,218
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CSF2
colony stimulating factor 2
treatment
ISO
RGD
PMID:15658127
RGD:10449531
NCBI chr 2:134,354,724...134,357,155
Ensembl chr 2:134,354,724...134,357,155
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CSF3
colony stimulating factor 3
treatment
ISO
RGD
PMID:21953623
RGD:10450511
NCBI chr12:22,333,445...22,335,949
Ensembl chr12:22,333,449...22,338,753
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CSPG4
chondroitin sulfate proteoglycan 4
ISO
RGD
PMID:19604403 PMID:22042562 PMID:22243800
RGD:5686844 RGD:5686848 RGD:5686859
NCBI chr 7:57,949,182...57,988,602
Ensembl chr 7:57,949,455...57,988,335
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CTSS
cathepsin S
ISO
RGD
PMID:16344894
RGD:2303423
NCBI chr 4:98,415,273...98,442,952
Ensembl chr 4:98,417,883...98,442,950
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CXCL10
C-X-C motif chemokine ligand 10
ISO
RGD
PMID:19170890
RGD:2311365
NCBI chr 8:71,693,641...71,695,948
Ensembl chr 8:71,693,339...71,695,948
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CYBA
cytochrome b-245 alpha chain
ISO
mRNA:increased expression:spinal cord
RGD
PMID:16345062
RGD:1599510
NCBI chr 6:1,015,212...1,021,422
Ensembl chr 6:1,015,162...1,021,420
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DAB2
DAB adaptor protein 2
ISO
protein:increased expression:spinal cord
RGD
PMID:17317100
RGD:7243246
NCBI chr16:24,590,638...24,776,937
Ensembl chr16:24,590,645...24,646,122
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DCC
DCC netrin 1 receptor
ISO
RGD
PMID:16998900
RGD:2314373
NCBI chr 1:101,518,629...103,087,021
Ensembl chr 1:101,846,100...103,083,096
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DDIT3
DNA damage inducible transcript 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29793971
NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829
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DUSP1
dual specificity phosphatase 1
treatment
ISO
protein:decreased expression:spinal cord
RGD
PMID:18630599 PMID:19383246
RGD:7771572 RGD:7771580
NCBI chr16:51,457,924...51,461,095
Ensembl chr16:51,458,020...51,461,086
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EFNB2
ephrin B2
ISO
mRNA,protein:increased expression:fibroblast, astrocyte protein:increased phosporylation:spinal cord
RGD
PMID:12944508 PMID:33794069
RGD:127285659 RGD:127285804
NCBI chr11:74,188,337...74,232,768
Ensembl chr11:74,186,640...74,233,354
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EGFR
epidermal growth factor receptor
ISO
protein:increased phosphorylation:spinal cord, astrocyte (rat)
RGD
PMID:20869112 PMID:21402118
RGD:5131454 RGD:5131525
NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,475,589
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EIF5A
eukaryotic translation initiation factor 5A
ISO
mRNA, protein:increased expression:gastrocnemius
RGD
PMID:23238062
RGD:10395360
NCBI chr12:52,659,040...52,664,686
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ENDOG
endonuclease G
ISO
RGD
PMID:16689664
RGD:8655990
NCBI chr 1:269,153,955...269,157,789
Ensembl chr 1:269,154,090...269,157,788
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ENO2
enolase 2
ISO
protein:increased expression:serum, cerebrospinal fluid
RGD
PMID:18343116
RGD:2293743
NCBI chr 5:63,799,927...63,809,067
Ensembl chr 5:63,799,930...63,809,410
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ENSA
endosulfine alpha
ISO
mRNA:decreased expression:spinal cord
RGD
PMID:16344894
RGD:2303423
NCBI chr 4:98,527,902...98,535,647
Ensembl chr 4:98,527,907...98,542,959
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EPHA3
EPH receptor A3
ISO
RGD
PMID:16083359
RGD:2301766
NCBI chr13:166,592,492...166,942,791
Ensembl chr13:166,592,493...166,942,767
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EPHA4
EPH receptor A4
ISO
RGD
PMID:17418490 PMID:17970742 PMID:21931787
RGD:5688750 RGD:5688764 RGD:5688782
NCBI chr15:123,350,867...123,501,872
Ensembl chr15:123,352,816...123,503,126
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EPHA7
EPH receptor A7
ISO
mRNA:increased expression:spinal cord
RGD
PMID:16983667
RGD:2301957
NCBI chr 1:60,771,567...60,944,092
Ensembl chr 1:60,771,572...60,944,038
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EPHB2
EPH receptor B2
ameliorates
ISO
RGD
PMID:12944508 PMID:33794069
RGD:127285659 RGD:127285804
NCBI chr 6:80,649,098...80,849,979
Ensembl chr 6:80,650,740...80,843,567
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EPO
erythropoietin
treatment
ISO
RGD
PMID:22196867
RGD:10401074
NCBI chr 3:8,620,508...8,622,936
Ensembl chr 3:8,620,508...8,622,936
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ERBB3
erb-b2 receptor tyrosine kinase 3
ISO
mRNA, protein:increased expression:spinal cord
RGD
PMID:11797086
RGD:2289967
NCBI chr 5:21,474,218...21,495,040
Ensembl chr 5:21,474,475...21,495,038
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ESR1
estrogen receptor 1
ISO
RGD
PMID:25105782
RGD:10045844
NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363
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ESR2
estrogen receptor 2
ISO
RGD
PMID:25105782
RGD:10045844
NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,829,560...193,906,565
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F2
coagulation factor II, thrombin
ISO
RGD
PMID:16344894
RGD:2303423
NCBI chr 2:15,793,257...15,819,151
Ensembl chr 2:15,791,455...15,819,137
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FADD
Fas associated via death domain
treatment
ISO
RGD
PMID:23574812
RGD:11344882
NCBI chr 2:3,191,718...3,194,820
Ensembl chr 2:3,185,675...3,194,818
G
FAS
Fas cell surface death receptor
ISO
protein:increased expression:cervical spinal cord
RGD
PMID:17518537 PMID:17703359 PMID:29738767
RGD:13792580 RGD:2290176 RGD:2290177
NCBI chr14:100,927,305...100,954,781
Ensembl chr14:100,927,089...100,956,716
G
FGF1
fibroblast growth factor 1
ISO
Human FGF1 used in rat model of spinal cord injury
RGD
PMID:8662542 PMID:18482974 PMID:20488178 PMID:21663406
RGD:2317692 RGD:5509875 RGD:5509876 RGD:5509877
NCBI chr 2:144,133,846...144,241,345
Ensembl chr 2:144,133,392...144,241,323
G
FGF2
fibroblast growth factor 2
treatment
ISO
RGD
PMID:24968269
RGD:40924652
NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,885...101,343,916
G
FIS1
fission, mitochondrial 1
treatment
ISO
RGD
PMID:26079325
RGD:12437066
NCBI chr 3:8,938,250...8,942,102
Ensembl chr 3:8,937,453...8,946,955
G
FKBP1B
FKBP prolyl isomerase 1B
ISO
RGD
PMID:27998200
RGD:329853757
NCBI chr 3:114,623,529...114,636,200
Ensembl chr 3:114,623,532...114,634,628
G
FLT1
fms related receptor tyrosine kinase 1
ISO
mRNA:increased expression:spinal cord, astrocyte, macrophage
RGD
PMID:17409380
RGD:5684414
NCBI chr11:5,620,698...5,797,095
Ensembl chr11:5,621,212...5,795,264
G
FN1
fibronectin 1
ISO
RGD
PMID:20347014
RGD:7205459
NCBI chr15:117,658,158...117,737,145
Ensembl chr15:117,658,099...117,731,014
G
FOXO3
forkhead box O3
ISO
protein:decreased expression:spinal cord,neuron, astrocyte:
RGD
PMID:22930444
RGD:10402202
NCBI chr 1:74,626,673...74,760,323
Ensembl chr 1:74,628,218...74,760,325
G
FOXP3
forkhead box P3
treatment
ISO
RGD
PMID:30287503
RGD:38549580
NCBI chr X:43,303,777...43,328,164
Ensembl chr X:43,303,785...43,322,968
G
GAP43
growth associated protein 43
treatment
ISO
RGD
PMID:24968269
RGD:40924652
NCBI chr13:144,364,314...144,458,136
Ensembl chr13:144,364,317...144,629,174
G
GAPDH
glyceraldehyde-3-phosphate dehydrogenase
treatment
ISO
RGD
PMID:27256506
RGD:13792677
NCBI chr 5:64,129,678...64,135,194
Ensembl chr 5:64,129,679...64,133,991
G
GDNF
glial cell derived neurotrophic factor
ISO
RGD
PMID:22342994
RGD:5688774
NCBI chr16:22,936,602...22,965,929
Ensembl chr16:22,936,604...22,966,536
G
GFAP
glial fibrillary acidic protein
treatment
ISO
protein:increased expression:spinal cord
RGD
PMID:10225952 PMID:21250919 PMID:24968269
RGD:40924652 RGD:6480471 RGD:6480511
NCBI chr12:18,456,268...18,466,594
Ensembl chr12:18,456,263...18,466,592
G
GHSR
growth hormone secretagogue receptor
ISO
RGD
PMID:25261791
RGD:12907564
NCBI chr13:110,981,465...111,006,149
Ensembl chr13:110,983,298...111,038,324
G
GJA1
gap junction protein alpha 1
treatment
ISO
RGD
PMID:23403365 PMID:24183749
RGD:8662431 RGD:8662460
NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,528...41,002,156
G
GJC2
gap junction protein gamma 2
treatment
ISO
RGD
PMID:26415641
RGD:13208513
NCBI chr 2:51,257,623...51,267,969
Ensembl chr 2:51,258,207...51,267,962
G
GOT2
glutamic-oxaloacetic transaminase 2
ISO
protein:increased expression:spinal cord (rat)
RGD
PMID:27150525
RGD:13506243
NCBI chr 6:20,407,203...20,431,849
Ensembl chr 6:20,407,200...20,432,067
G
GP91-PHOX
NADPH oxidase heavy chain subunit
ISO
mRNA,protein:increased expression:microglia:
RGD
PMID:20679217
RGD:11040629
NCBI chr X:33,654,656...33,678,346
Ensembl chr X:33,643,648...33,680,580
G
GPER1
G protein-coupled estrogen receptor 1
ISO
RGD
PMID:22975889
RGD:8552988
NCBI chr 3:711,427...715,982
Ensembl chr 3:712,160...715,980
G
GPX3
glutathione peroxidase 3
ISO
protein:increased expression:cerebrospinal fluid
RGD
PMID:21559420
RGD:40907059
NCBI chr16:71,980,467...71,989,011
Ensembl chr16:71,980,475...71,989,026
G
GRK6
G protein-coupled receptor kinase 6
ISO
protein:increased expression:spinal cord, neuron, microglial cell (rat)
RGD
PMID:23359120
RGD:13792782
NCBI chr 2:80,496,105...80,527,208
Ensembl chr 2:80,508,979...80,527,210
G
GRN
granulin precursor
ISO
mRNA, protein:increased expression:spinal cord:
RGD
PMID:19946692
RGD:5509603
NCBI chr12:18,893,772...18,900,444
Ensembl chr12:18,893,770...18,900,446
G
GSTA4
glutathione S-transferase alpha 4
ISO
mRNA:increased expression:lumbar segment of spinal cord (rat)
RGD
PMID:22160604
RGD:5687769
NCBI chr 7:46,635,903...46,656,491
Ensembl chr 7:46,635,902...46,656,450
G
HGF
hepatocyte growth factor
treatment
ISO
mRNA,protein:increased expression:spinal cord:
RGD
PMID:17549731 PMID:22140459
RGD:2317487 RGD:8548666
NCBI chr 9:98,437,771...98,513,573
Ensembl chr 9:98,438,143...98,513,564
G
HIF1A
hypoxia inducible factor 1 subunit alpha
ISO
protein:increased expression:spinal cord CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:21092735
RGD:5148013
NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845
G
HMGB1
high mobility group box 1
ISO
mRNA:increased expression:spinal cord
RGD
PMID:20195207
RGD:2325645
NCBI chr11:7,195,556...7,321,071
G
HMOX1
heme oxygenase 1
treatment
ISO
RGD
PMID:23943397
RGD:10766443
G
HRH3
histamine receptor H3
ISO
RGD
PMID:16671478
RGD:1626425
NCBI chr17:61,622,865...61,627,278
Ensembl chr17:61,622,938...61,627,278
G
HSP90AB1
heat shock protein 90 alpha family class B member 1
ISO
protein:decreased expression:spinal cord (rat)
RGD
PMID:24499940
RGD:10445836
NCBI chr 7:39,237,299...39,250,479
Ensembl chr 7:39,244,458...39,250,481
G
HSPA5
heat shock protein family A (Hsp70) member 5
ISO
mRNA: increased expression
RGD
PMID:21933012
RGD:5685666
NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
G
HSPB1
heat shock protein family B (small) member 1
treatment
ISO
mRNA,protein:increased expression:spinal cord:
RGD
PMID:12098653 PMID:30287503
RGD:10402749 RGD:38549580
NCBI chr 3:10,038,074...10,039,441
Ensembl chr 3:10,037,949...10,039,704
G
ICAM1
intercellular adhesion molecule 1
treatment
ISO
RGD
PMID:8627308
RGD:11522712
NCBI chr 2:69,097,136...69,107,722
Ensembl chr 2:69,097,122...69,108,205
G
ID1
inhibitor of DNA binding 1
ISO
mRNA:increased expression:spinal cord (rat)
RGD
PMID:11746449
RGD:9686138
NCBI chr17:35,316,518...35,317,742
Ensembl chr17:35,316,514...35,317,736
G
ID2
inhibitor of DNA binding 2
ISO
mRNA:increased expression:spinal cord (rat)
RGD
PMID:11746449
RGD:9686138
NCBI chr 3:127,500,759...127,503,207
Ensembl chr 3:127,500,763...127,503,257
G
ID3
inhibitor of DNA binding 3
ISO
mRNA:increased expression:spinal cord (rat)
RGD
PMID:11746449
RGD:9686138
NCBI chr 6:81,422,541...81,424,169
Ensembl chr 6:81,422,546...81,424,075
G
IFNB1
interferon beta 1
ameliorates
ISO
RGD
PMID:17426631 PMID:20109445
RGD:401854235 RGD:401854241
NCBI chr 1:201,850,935...201,851,495
Ensembl chr 1:201,850,935...201,851,495
G
IL10
interleukin 10
treatment
ISO
RGD
PMID:29691718
RGD:14975124
NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378
G
IL18
interleukin 18
treatment
ISO
RGD
PMID:18367607 PMID:23140983
RGD:2315889 RGD:8655974
NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219
G
IL1R1
interleukin 1 receptor type 1
ISO
mRNA,protein:increased expression:spinal cord
RGD
PMID:16456668
RGD:7207035
NCBI chr 3:52,192,912...52,334,734
Ensembl chr 3:52,192,915...52,288,485
G
IL1RN
interleukin 1 receptor antagonist
ISO
protein:increased expression:serum (human)
RGD
PMID:16038625 PMID:17964877
RGD:1626673 RGD:6907102
G
IL4
interleukin 4
ISO
RGD
PMID:20623539
RGD:5128562
NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365
G
IL4R
interleukin 4 receptor
ISO
mRNA:increased expression:spinal cord
RGD
PMID:20623539
RGD:5128562
NCBI chr 3:19,526,343...19,576,792
Ensembl chr 3:19,523,564...19,576,544
G
IL6
interleukin 6
treatment
ISO
RGD
PMID:27085942 PMID:29691718
RGD:11062150 RGD:14975124
NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
G
IRF1
interferon regulatory factor 1
ISO
RGD
PMID:11723173
RGD:2298928
NCBI chr 2:134,776,122...134,783,646
Ensembl chr 2:134,776,129...134,783,801
G
IRF5
interferon regulatory factor 5
treatment
ISO
RGD
PMID:24968269
RGD:40924652
NCBI chr18:19,678,377...19,691,154
Ensembl chr18:19,678,687...19,691,243
G
ITIH4
inter-alpha-trypsin inhibitor heavy chain 4
severity
ISO
protein:decreased expression:cerebrospinal fluid
RGD
PMID:21559420
RGD:40907059
NCBI chr13:34,928,455...34,948,250
Ensembl chr13:34,928,439...34,948,229
G
JAK2
Janus kinase 2
treatment
ISO
RGD
PMID:23274522
RGD:10411896
NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,689...217,002,148
G
JUN
Jun proto-oncogene, AP-1 transcription factor subunit
ISO
protein:increased phosphorylation:neuron
RGD
PMID:21132399
RGD:4889994
NCBI chr 6:153,686,425...153,687,635
Ensembl chr 6:153,685,682...153,687,636
G
KCNJ10
potassium inwardly rectifying channel subfamily J member 10
ISO
protein:decreased expression:spinal cord
RGD
PMID:20375134
RGD:8662905
NCBI chr 4:90,421,956...90,457,406
Ensembl chr 4:90,422,025...90,457,406
G
KCNK2
potassium two pore domain channel subfamily K member 2
treatment
ISO
RGD
PMID:22425721
RGD:9831183
NCBI chr 9:128,429,232...128,659,662
Ensembl chr 9:128,429,092...128,661,639
G
KCNN4
potassium calcium-activated channel subfamily N member 4
ISO
RGD
PMID:24606313
RGD:329955563
NCBI chr 6:50,580,016...50,593,518
Ensembl chr 6:50,580,022...50,593,544
G
KDM6B
lysine demethylase 6B
ISO
mRNA:increased expression:spinal cord (rat)
RGD
PMID:22578249
RGD:9587821
NCBI chr12:53,087,072...53,108,949
Ensembl chr12:53,098,964...53,108,214
G
KDR
kinase insert domain receptor
ISO
mRNA:increased expression:spinal cord, astrocyte, macrophage
RGD
PMID:17409380
RGD:5684414
NCBI chr 8:41,809,116...41,856,379
Ensembl chr 8:41,809,122...41,856,336
G
KIF3B
kinesin family member 3B
ISO
protein:increased expression:spinal cord
RGD
PMID:23093447
RGD:11049594
NCBI chr17:35,914,214...35,962,332
Ensembl chr17:35,914,246...35,961,522
G
KLK6
kallikrein related peptidase 6
ISO
protein:increased expression:spinal cord
RGD
PMID:16987227
RGD:2314866
NCBI chr 6:55,629,983...55,639,215
Ensembl chr 6:55,629,991...55,638,080
G
KMO
kynurenine 3-monooxygenase
ISO
mRNA,protein:increased expression:spinal cord:
RGD
PMID:26524415
RGD:13703043
NCBI chr10:12,442,877...12,489,417
Ensembl chr10:12,434,769...12,490,409
G
LEP
leptin
ISO
RGD
PMID:19777863
RGD:5128780
NCBI chr18:20,106,867...20,124,071
Ensembl chr18:20,106,868...20,123,323
G
LOC110258578
interleukin-1 beta-like
treatment
ISO
mRNA, protein:increased expression:spinal cord
RGD
PMID:16038625 PMID:23209732 PMID:29691718
RGD:14975124 RGD:1626673 RGD:7175523
G
LRP1
LDL receptor related protein 1
treatment
ISO
RGD
PMID:23867460
RGD:13800520
NCBI chr 5:22,435,636...22,519,276
G
LRP5
LDL receptor related protein 5
treatment
ISO
RGD
PMID:24090150
RGD:12798566
NCBI chr 2:4,533,721...4,653,997
Ensembl chr 2:4,533,614...4,653,944
G
LUM
lumican
ISO
protein:increased expression:spinal cord
RGD
PMID:18482974
RGD:2317692
NCBI chr 5:91,748,871...91,756,381
Ensembl chr 5:91,748,885...91,757,598
G
MAP1B
microtubule associated protein 1B
ISO
protein:increased phosphorylation:spinal cord, neuron
RGD
PMID:17880387
RGD:2304007
NCBI chr16:48,403,338...48,501,453
Ensembl chr16:48,403,568...48,498,885
G
MAP1LC3A
microtubule associated protein 1 light chain 3 alpha
treatment
ISO
protein:increased expression:spinal cord
RGD
PMID:23637053 PMID:23852559 PMID:24559459
RGD:11561918 RGD:11561922 RGD:11564330
NCBI chr17:37,957,830...37,959,505
Ensembl chr17:37,957,507...37,959,505
G
MAP1LC3B
microtubule associated protein 1 light chain 3 beta
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29793971
NCBI chr 6:1,919,879...1,941,069
Ensembl chr 6:1,915,387...1,941,069
G
MAP2
microtubule associated protein 2
ISO
RGD
PMID:21704982
RGD:6483323
NCBI chr15:112,156,578...112,462,932
Ensembl chr15:112,236,119...112,462,929
G
MAP3K5
mitogen-activated protein kinase kinase kinase 5
ISO
protein:increased expression:white matter and grey matter:
RGD
PMID:10331432
RGD:10412645
NCBI chr 1:27,380,143...27,600,500
Ensembl chr 1:27,380,142...27,600,493
G
MAPT
microtubule associated protein tau
treatment
ISO
RGD
PMID:22052241
RGD:8158113
NCBI chr12:17,098,259...17,211,483
Ensembl chr12:17,095,587...17,211,373
G
MDM2
MDM2 proto-oncogene
ISO
protein:increased expression:spinal cord
RGD
PMID:23595775
RGD:10412063
NCBI chr 5:33,105,717...33,137,602
Ensembl chr 5:33,105,759...33,137,739
G
MET
MET proto-oncogene, receptor tyrosine kinase
ISO
mRNA, protein:increased expression:spinal cord (rat)
RGD
PMID:17549731
RGD:2317487
NCBI chr18:29,426,044...29,541,526
Ensembl chr18:29,426,048...29,541,512
G
MFN1
mitofusin 1
treatment
ISO
protein:altered expression:spinal cord, mitochondrion (rat)
RGD
PMID:26079325 PMID:26981103
RGD:12437066 RGD:12910837
NCBI chr13:117,404,637...117,441,750
Ensembl chr13:117,404,699...117,442,481
G
MFN2
mitofusin 2
treatment
ISO
protein:increased expression:spinal cord (rat)
RGD
PMID:26079325 PMID:28404953
RGD:12437066 RGD:12910735
NCBI chr 6:72,026,512...72,056,439
Ensembl chr 6:72,028,499...72,056,438
G
MIF
macrophage migration inhibitory factor
ISO
mRNA:increased expression:spinal cord, microglial cell
RGD
PMID:15067555
RGD:1641997
NCBI chr14:49,840,303...49,841,063
Ensembl chr14:49,840,305...49,841,068
G
MIR21
microRNA mir-21
exacerbates
ISO
RGD
PMID:31102912
RGD:41410823
NCBI chr12:36,065,267...36,065,358
Ensembl chr12:36,065,267...36,065,358
G
MIR214
microRNA mir-214
treatment
ISO
RGD
PMID:30287503
RGD:38549580
NCBI chr 9:114,527,992...114,528,101
Ensembl chr 9:114,527,990...114,528,101
G
MMP2
matrix metallopeptidase 2
treatment
ISO
RGD
PMID:24436993
RGD:8657106
NCBI chr 6:30,059,247...30,087,031
Ensembl chr 6:30,058,595...30,086,982
G
MMP9
matrix metallopeptidase 9
treatment
ISO
RGD
PMID:25763638
RGD:12791993
NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,179,671...48,186,788
G
MPO
myeloperoxidase
ISO
protein:increased activity:spinal cord
RGD
PMID:22986158
RGD:6909148
NCBI chr12:34,557,031...34,570,091
Ensembl chr12:34,556,408...34,567,904
G
MRC1
mannose receptor C-type 1
treatment
ISO
RGD
PMID:24968269
RGD:40924652
NCBI chr10:44,107,926...44,226,734
Ensembl chr10:44,107,072...44,226,733
G
MT-ND3
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3
ISO
RGD
PMID:20438613
RGD:5687694
NCBI chr MT:10,653...10,998
Ensembl chr MT:10,653...10,998
G
MTOR
mechanistic target of rapamycin kinase
treatment
ISO
RGD
PMID:20678995
RGD:10040962
NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888
G
MYRF
myelin regulatory factor
ameliorates
ISO
RGD
PMID:27370227
RGD:213230157
NCBI chr 2:9,761,230...9,795,873
G
NAPEPLD
N-acyl phosphatidylethanolamine phospholipase D
ISO
mRNA:increased expression:spinal cord
RGD
PMID:18930143
RGD:2316199
NCBI chr 9:103,210,655...103,309,018
Ensembl chr 9:103,210,748...103,262,910
G
NCAM1
neural cell adhesion molecule 1
treatment
ISO
RGD
PMID:28529158
RGD:40924632
NCBI chr 9:40,628,602...40,960,605
Ensembl chr 9:40,628,631...40,960,591
G
NCF2
neutrophil cytosolic factor 2
ISO
protein:increased expression:spinal cord
RGD
PMID:14644473
RGD:2314450
NCBI chr 9:124,776,516...124,813,358
Ensembl chr 9:124,776,534...124,812,923
G
NEFH
neurofilament heavy chain
treatment
ISO
RGD
PMID:18772508 PMID:32168135
RGD:27226888 RGD:9698443
NCBI chr14:46,559,698...46,568,686
Ensembl chr14:46,559,860...46,568,088
G
NEFL
neurofilament light chain
treatment
ISO
RGD
PMID:18772508
RGD:9698443
NCBI chr14:8,991,321...8,996,900
Ensembl chr14:8,991,331...8,997,112
G
NEFM
neurofilament medium chain
treatment
ISO
RGD
PMID:18772508
RGD:9698443
NCBI chr14:8,955,346...8,967,211
G
NFE2L2
NFE2 like bZIP transcription factor 2
treatment
ISO
RGD
PMID:24747453
RGD:10412730
NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183
G
NFKBIA
NFKB inhibitor alpha
treatment
ISO
RGD
PMID:21134362
RGD:10413867
NCBI chr 7:64,508,119...64,510,754
Ensembl chr 7:64,507,822...64,511,277
G
NGF
nerve growth factor
ISO
RGD
PMID:12499054 PMID:16915089
RGD:5144069 RGD:5144073
NCBI chr 4:105,256,691...105,307,843
Ensembl chr 4:105,256,749...105,307,837
G
NGFR
nerve growth factor receptor
treatment
ISO
mRNA:increased expression:spinal cord
RGD
PMID:11223160 PMID:23748892
RGD:10414079 RGD:5144100
NCBI chr12:25,699,410...25,720,355
Ensembl chr12:25,699,427...25,720,356
G
NKX6-1
NK6 homeobox 1
ISO
RGD
PMID:18687784
RGD:2311166
NCBI chr 8:134,137,064...134,143,524
Ensembl chr 8:134,138,097...134,144,254
G
NLK
nemo like kinase
ISO
protein:increased expression:grey matter:
RGD
PMID:24395089
RGD:12791278
NCBI chr12:44,402,990...44,553,527
Ensembl chr12:44,403,021...44,553,518
G
NOG
noggin
treatment
ISO
RGD
PMID:18221366
RGD:10429192
NCBI chr12:32,891,321...32,892,206
Ensembl chr12:32,891,321...32,892,206
G
NOS1
nitric oxide synthase 1
ISO
protein:increased expression:spinal cord
RGD
PMID:19291395 PMID:20633123
RGD:5131936 RGD:5132595
NCBI chr14:35,112,898...35,299,297
Ensembl chr14:35,113,184...35,295,944
G
NOS2
nitric oxide synthase 2
ISO
mRNA:altered expression:thoracic aorta
RGD
PMID:17287083
RGD:4891407
NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146
G
NOS3
nitric oxide synthase 3
ISO
RGD
PMID:17287083
RGD:4891407
NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
G
NOX4
NADPH oxidase 4
ISO
mRNA,protein:increased expression:gastrocnemius muscle
RGD
PMID:27998200
RGD:329853757
NCBI chr 9:22,622,105...22,776,691
Ensembl chr 9:22,624,212...22,776,534
G
NQO1
NAD(P)H quinone dehydrogenase 1
treatment
ISO
protein:increased expression:spinal cord (rat)
RGD
PMID:24747453 PMID:28881715
RGD:10412730 RGD:13434916
NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590
G
NRG1
neuregulin 1
exacerbates ameliorates
ISO
RGD
PMID:20734425 PMID:26993800
RGD:11056189 RGD:405650600
NCBI chr15:52,625,550...53,688,003
Ensembl chr15:52,630,679...52,839,505
G
NTF3
neurotrophin 3
ISO
RGD
PMID:16022868
RGD:4891112
NCBI chr 5:65,052,608...65,122,645
Ensembl chr 5:65,052,519...65,123,788
G
NTRK1
neurotrophic receptor tyrosine kinase 1
ISO
mRNA:decreased expression:spinal cord
RGD
PMID:18585435
RGD:2308892
NCBI chr 4:93,219,509...93,237,944
Ensembl chr 4:93,219,516...93,255,981
G
NTRK2
neurotrophic receptor tyrosine kinase 2
ISO
RGD
PMID:20597685 PMID:22027236
RGD:5684547 RGD:5684898
NCBI chr10:30,030,050...30,429,938
Ensembl chr10:30,033,405...30,429,882
G
NTRK3
neurotrophic receptor tyrosine kinase 3
ISO
mRNA:decreased expression:spinal cord
RGD
PMID:18585435
RGD:2308892
NCBI chr 1:191,535,262...191,941,675
Ensembl chr 1:191,535,301...191,925,327
G
OLIG2
oligodendrocyte transcription factor 2
treatment
ISO
RGD
PMID:22173726 PMID:28452182
RGD:40902836 RGD:40902844
NCBI chr13:196,596,838...196,602,197
Ensembl chr13:196,599,822...196,600,793
G
P2RX7
purinergic receptor P2X 7
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:15258577
NCBI chr14:31,415,188...31,476,502
Ensembl chr14:31,415,193...31,476,472
G
PARP1
poly(ADP-ribose) polymerase 1
ISO
CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:15696051 PMID:21748659
RGD:10053608
NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,160...14,241,196
G
PDCD1
programmed cell death 1
treatment
ISO
RGD
PMID:29665726
RGD:40886268
NCBI chr15:140,337,353...140,347,493
Ensembl chr15:140,336,258...140,347,478
G
PDCD1LG2
programmed cell death 1 ligand 2
ISO
mRNA:increased expression:microglial cell
RGD
PMID:29665726
RGD:40886268
NCBI chr 1:216,564,428...216,600,333
Ensembl chr 1:216,553,105...216,657,170
G
PDGFB
platelet derived growth factor subunit B
ISO
RGD
PMID:21568693
RGD:6482306
Ensembl chr 5:8,986,462...9,007,435
G
PLA2G2A
phospholipase A2 group IIA
ISO
protein:increased expression:spinal cord
RGD
PMID:19306380 PMID:21868473
RGD:6482718 RGD:6482721
NCBI chr 6:78,327,728...78,339,546
Ensembl chr 6:78,327,319...78,330,699
G
PLA2G6
phospholipase A2 group VI
ISO
protein:increased expression:spinal cord
RGD
PMID:21868473
RGD:6482718
NCBI chr 5:9,713,809...9,777,921
Ensembl chr 5:9,713,873...9,777,918
G
PLAU
plasminogen activator, urokinase
ISO
RGD
PMID:21573723
RGD:6483797
NCBI chr14:76,629,313...76,635,173
Ensembl chr14:76,629,299...76,635,172
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PLAUR
plasminogen activator, urokinase receptor
ISO
RGD
PMID:21573723
RGD:6483797
NCBI chr 6:50,489,773...50,505,453
Ensembl chr 6:50,489,777...50,505,418
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PON1
paraoxonase 1
treatment
ISO
RGD
PMID:12897486
RGD:8547682
NCBI chr 9:74,943,646...74,974,720
Ensembl chr 9:74,926,048...74,974,723
G
PPARD
peroxisome proliferator activated receptor delta
ISO
RGD
PMID:20058304
RGD:2324875
NCBI chr 7:31,222,533...31,295,221
Ensembl chr 7:31,222,585...31,295,211
G
PPARGC1A
PPARG coactivator 1 alpha
ISO
RGD
PMID:22208735
RGD:6484263
NCBI chr 8:17,841,844...18,527,953
Ensembl chr 8:17,841,844...17,946,992
G
PPP1CC
protein phosphatase 1 catalytic subunit gamma
ISO
protein:increased expression:spinal cord, astrocyte, microglial cell
RGD
PMID:29033188
RGD:13514047
NCBI chr14:32,071,472...32,091,267
Ensembl chr14:32,070,545...32,091,499
G
PPP1R15A
protein phosphatase 1 regulatory subunit 15A
ISO
mRNA:increased expression:spinal cord (rat) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:17578450 PMID:29793971
RGD:9999410
NCBI chr 6:54,172,038...54,175,461
Ensembl chr 6:54,172,050...54,175,463
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PRKCG
protein kinase C gamma
ISO
protein:decreased expression:spinal cord (mouse)
RGD
PMID:10501452
RGD:28867228
NCBI chr 6:56,213,479...56,235,683
Ensembl chr 6:56,213,480...56,234,210
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PTEN
phosphatase and tensin homolog
ISO
mRNA:increased expression:spinal cord:
RGD
PMID:28601045
RGD:156420142
NCBI chr14:99,929,590...100,021,619
G
PTGS1
prostaglandin-endoperoxide synthase 1
ISO
protein:increased expression:microglia, macrophage
RGD
PMID:11063829 PMID:17184185
RGD:5688221 RGD:5688246
NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035
G
PTGS2
prostaglandin-endoperoxide synthase 2
ISO
RGD
PMID:18606213
RGD:5135219
NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884
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PTPRZ1
protein tyrosine phosphatase receptor type Z1
treatment
ISO
RGD
PMID:12895450 PMID:15016081 PMID:18065151
RGD:9589823 RGD:9590113 RGD:9590124
NCBI chr18:25,046,027...25,228,276
Ensembl chr18:25,045,742...25,168,053
G
RAD21
RAD21 cohesin complex component
treatment
ISO
RGD
PMID:33741460
RGD:243065262
NCBI chr 4:21,772,821...21,802,453
Ensembl chr 4:21,772,855...21,802,715
G
RARA
retinoic acid receptor alpha
ISO
RGD
PMID:16420438
RGD:2314291
NCBI chr12:22,047,449...22,085,759
Ensembl chr12:22,047,443...22,085,673
G
RBMX
RNA binding motif protein X-linked
ISO
RGD
PMID:23180094
RGD:10053723
NCBI chr X:111,965,859...111,974,544
Ensembl chr X:111,962,633...111,974,472
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RELA
RELA proto-oncogene, NF-kB subunit
ISO
RGD
PMID:17918744
RGD:2298849
NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469
G
RGMA
repulsive guidance molecule BMP co-receptor a
treatment
ISO
RGD
PMID:16585268
RGD:9850138
NCBI chr 7:85,921,524...85,968,887
Ensembl chr 7:85,921,594...85,968,888
G
RHOA
ras homolog family member A
ISO
mRNA,protein:increased expression:spinal cord:
RGD
PMID:27893610
RGD:243048440
NCBI chr13:31,918,484...31,991,207
Ensembl chr13:31,918,834...31,986,607
G
ROBO1
roundabout guidance receptor 1
ISO
mRNA,protein:increased expression:spinal cord:
RGD
PMID:27893610
RGD:243048440
NCBI chr13:175,348,223...176,479,482
Ensembl chr13:175,348,410...176,479,481
G
RPSA
ribosomal protein SA
ISO
RGD
PMID:19196078
RGD:11041651
NCBI chr13:24,072,551...24,081,536
Ensembl chr13:24,072,527...24,081,541
G
RYR1
ryanodine receptor 1
ISO
protein:hyperoxidation,hypernitrosylation:gastrocnemius muscle
RGD
PMID:27998200
RGD:329853757
NCBI chr 6:47,339,759...47,458,457
Ensembl chr 6:47,343,768...47,458,458
G
SCN3A
sodium voltage-gated channel alpha subunit 3
ISO
RGD
PMID:16109750 PMID:16718433
RGD:2317320 RGD:2317321
NCBI chr15:71,717,330...71,824,190
Ensembl chr15:71,717,334...71,824,160
G
SERPINC1
serpin family C member 1
treatment
ISO
RGD
PMID:15792522
RGD:1599333
NCBI chr 9:116,181,988...116,193,100
Ensembl chr 9:116,181,670...116,193,201
G
SHH
sonic hedgehog signaling molecule
treatment
ISO
RGD
PMID:24837681
RGD:12879409
NCBI chr18:2,546,202...2,555,484
Ensembl chr18:2,545,994...2,555,484
G
SIAH1
siah E3 ubiquitin protein ligase 1
treatment
ISO
RGD
PMID:27256506
RGD:13792677
NCBI chr 6:36,337,770...36,365,784
Ensembl chr 6:36,342,872...36,371,383
G
SLC25A27
solute carrier family 25 member 27
ISO
protein:increased expression:spinal cord
RGD
PMID:18534681
RGD:6482843
NCBI chr 7:41,426,161...41,457,887
Ensembl chr 7:41,426,170...41,457,883
G
SLC7A5
solute carrier family 7 member 5
ISO
protein:increased expression:spinal cord
RGD
PMID:19388351
RGD:151361131
NCBI chr 6:1,545,940...1,574,298
Ensembl chr 6:1,545,944...1,574,285
G
SLIT1
slit guidance ligand 1
ISO
RGD
PMID:16262652
RGD:2316136
NCBI chr14:108,446,003...108,624,508
Ensembl chr14:108,446,004...108,624,302
G
SLIT2
slit guidance ligand 2
ISO
mRNA, protein:increased expression:spinal cord mRNA,protein:decreased expression:spinal cord:
RGD
PMID:19783284 PMID:27893610
RGD:2316127 RGD:243048440
NCBI chr 8:14,758,426...15,149,515
Ensembl chr 8:14,758,335...15,149,510
G
SLIT3
slit guidance ligand 3
ISO
RGD
PMID:16262652
RGD:2316136
NCBI chr16:54,551,536...55,221,427
Ensembl chr16:54,553,426...55,220,296
G
SMURF1
SMAD specific E3 ubiquitin protein ligase 1
ISO
protein:increased expression:spinal cord
RGD
PMID:23595775
RGD:10412063
NCBI chr 3:6,037,732...6,142,569
Ensembl chr 3:6,037,741...6,142,575
G
SOCS2
suppressor of cytokine signaling 2
ISO
RGD
PMID:11723173
RGD:2298928
NCBI chr 5:89,581,081...89,587,424
Ensembl chr 5:89,581,090...89,584,581
G
SOD1
superoxide dismutase 1
treatment
ISO
CTD Direct Evidence: therapeutic human gene in a rat model human protein in a rat model
CTD RGD
PMID:16689664 PMID:17457363 PMID:18722523
RGD:8655939 RGD:8655990
NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729
G
SOX2
SRY-box transcription factor 2
ISO
mRNA, protein:increased expression:spinal cord
RGD
PMID:23169458
RGD:8661675
NCBI chr13:119,668,476...119,669,435
Ensembl chr13:119,668,476...119,669,435
G
SPARC
secreted protein acidic and cysteine rich
ISO
RGD
PMID:17611274
RGD:2300052
NCBI chr16:71,368,164...71,380,972
Ensembl chr16:71,357,586...71,381,161
G
SPP1
secreted phosphoprotein 1
ISO
RGD
PMID:15592854
RGD:6483848
NCBI chr 8:131,077,786...131,085,334
Ensembl chr 8:131,077,786...131,085,340
G
SQSTM1
sequestosome 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29793971
NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938
G
TACR1
tachykinin receptor 1
ISO
RGD
PMID:18945947
RGD:2304258
NCBI chr 3:67,839,367...68,021,733
Ensembl chr 3:67,839,411...68,021,724
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TBP
TATA-box binding protein
ISO
protein:increased expression:spinal cord, astrocyte, microglial cell
RGD
PMID:24710803
RGD:9681729
NCBI chr 1:5,669...23,675
G
TERT
telomerase reverse transcriptase
ISO
mRNA, protein:increased expression:spinal cord
RGD
PMID:15798365 PMID:23793903
RGD:11038671 RGD:2291993
NCBI chr16:79,258,591...79,276,421
Ensembl chr16:79,258,591...79,276,421
G
TGFB1
transforming growth factor beta 1
ISO
RGD
PMID:15145083
RGD:2302103
NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046
G
TGFB2
transforming growth factor beta 2
ISO
RGD
PMID:15145083
RGD:2302103
NCBI chr10:8,306,136...8,435,307
Ensembl chr10:8,305,539...8,390,341
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THBD
thrombomodulin
ISO
RGD
PMID:15307903
RGD:1580060
NCBI chr17:30,219,870...30,223,499
Ensembl chr17:30,217,303...30,224,099
G
THBS1
thrombospondin 1
ISO
protein:increased expression:spinal cord
RGD
PMID:19719963
RGD:2317939
NCBI chr 1:131,728,781...131,746,098
Ensembl chr 1:131,728,784...131,746,115
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TLR1
toll like receptor 1
treatment
ISO
mRNA:increased expression:spinal cord (mouse)
RGD
PMID:21970496
RGD:7246886
NCBI chr 8:30,147,600...30,155,454
Ensembl chr 8:30,147,624...30,155,466
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TLR4
toll like receptor 4
severity
ISO
RGD
PMID:25990044
RGD:14700556
NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970
G
TNC
tenascin C
ISO
mRNA:increased expression:spinal cord
RGD
PMID:11085900
RGD:4889619
NCBI chr 1:255,533,235...255,630,381
Ensembl chr 1:255,533,238...255,630,376
G
TNF
tumor necrosis factor
ISO
RGD
PMID:20633123
RGD:5131936
NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
G
TNFRSF1A
TNF receptor superfamily member 1A
ISO
protein:increased expression:cerebrospinal fluid
RGD
PMID:16083358
RGD:1624185
NCBI chr 5:64,319,349...64,331,876
Ensembl chr 5:64,319,051...64,331,909
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TP53
tumor protein p53
ISO
protein:increased expression:spinal cord
RGD
PMID:23595775
RGD:10412063
NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818
G
TRAF7
TNF receptor associated factor 7
ISO
mRNA, protein:increased expression:spinal cord
RGD
PMID:30100091
RGD:151356968
NCBI chr 3:39,811,803...39,828,450
Ensembl chr 3:39,810,606...39,828,395
G
TRPA1
transient receptor potential cation channel subfamily A member 1
ISO
mRNA,protein:increased expression:urinary bladder, dorsal root ganglion:
RGD
PMID:21367919
RGD:10043365
NCBI chr 4:63,493,374...63,558,486
Ensembl chr 4:63,508,104...63,558,484
G
TRPM4
transient receptor potential cation channel subfamily M member 4
treatment
ISO
RGD
PMID:19169264 PMID:25763638
RGD:10003030 RGD:12791993
NCBI chr 6:54,342,774...54,377,557
Ensembl chr 6:54,342,784...54,377,155
G
ULK1
unc-51 like autophagy activating kinase 1
ISO
protein:increased expression:neuron, axon
RGD
PMID:25040536
RGD:11553820
NCBI chr14:23,423,693...23,448,130
Ensembl chr14:23,423,698...23,448,136
G
VEGFA
vascular endothelial growth factor A
ISO
protein:increased expression:spinal cord CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:21092735
RGD:5148013
NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366
G
VHL
von Hippel-Lindau tumor suppressor
ISO
RGD
PMID:20125055
RGD:2325181
NCBI chr13:66,334,535...66,342,401
Ensembl chr13:66,334,591...66,342,654
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VIM
vimentin
ISO
protein:increased expression:spinal cord
RGD
PMID:10225952 PMID:21250919
RGD:6480471 RGD:6480511
NCBI chr10:43,516,441...43,526,172
Ensembl chr10:43,517,307...43,526,170
G
VWF
von Willebrand factor
ISO
RGD
PMID:25771801
RGD:13673888
NCBI chr 5:64,516,627...64,655,938
Ensembl chr 5:64,519,186...65,002,452
G
XBP1
X-box binding protein 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29793971
NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,016,526
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XDH
xanthine dehydrogenase
ISO
protein:increased expression:spinal cord
RGD
PMID:1649310
RGD:13209021
NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,987,126...108,053,169
G
XYLT1
xylosyltransferase 1
ISO
RGD
PMID:18765417
RGD:2313145
NCBI chr 3:27,158,438...27,492,629
Ensembl chr 3:27,158,878...27,492,762
G
ADAMTS13
ADAM metallopeptidase with thrombospondin type 1 motif 13
ISO
mRNA, protein:increased expression, increased activity:spinal cord (rat)
RGD
PMID:22425718
RGD:10449098
NCBI chr 1:273,022,014...273,066,916
Ensembl chr 1:273,024,009...273,056,039
G
CCL2
chemokine (C-C motif) ligand 2
ISO
mRNA, protein:increased expression:liver, serum (rat) CTD Direct Evidence: marker/mechanism
RGD CTD
PMID:15135227 PMID:15855648
RGD:11526154
NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026
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CD163
CD163 molecule
disease_progression
ISO
protein:increased expression:gray matter of spinal cord, white matter of spinal cord (rat)
RGD
PMID:23775900
RGD:149735576
NCBI chr 5:63,300,200...63,334,497
Ensembl chr 5:63,300,231...63,334,498
G
CHST14
carbohydrate sulfotransferase 14
exacerbates
ISO
RGD
PMID:26586562
RGD:155663489
NCBI chr 1:130,845,103...130,847,203
Ensembl chr 1:130,845,835...130,846,965
G
EGR1
early growth response 1
ISO
protein:increased expression:spinal cord dorsal horn (rat)
RGD
PMID:20675054
RGD:5131876
NCBI chr 2:140,440,829...140,445,302
Ensembl chr 2:140,441,421...140,445,296
G
ELANE
elastase, neutrophil expressed
treatment
ISO
RGD
PMID:9675307
RGD:10450552
NCBI chr 2:77,513,769...77,516,118
Ensembl chr 2:77,509,344...77,516,027
G
EPO
erythropoietin
ISO
protein:increased expression:neuron, endothelium, glia:
RGD
PMID:15792521
RGD:11041719
NCBI chr 3:8,620,508...8,622,936
Ensembl chr 3:8,620,508...8,622,936
G
EPOR
erythropoietin receptor
ISO
protein:increased expression:neuron, endothelium, glia:
RGD
PMID:15792521
RGD:11041719
NCBI chr 2:70,063,601...70,068,821
Ensembl chr 2:70,063,519...70,068,821
G
FAS
Fas cell surface death receptor
treatment
ISO
human protein in a rat model protein:increased expression:spinal cord:
RGD
PMID:16202410 PMID:16689665 PMID:21490053
RGD:12904017 RGD:1582444 RGD:8663485
NCBI chr14:100,927,305...100,954,781
Ensembl chr14:100,927,089...100,956,716
G
FASLG
Fas ligand
treatment
ISO
protein:increased expression:spinal cord:
RGD
PMID:21490053
RGD:12904017
NCBI chr 9:115,068,314...115,075,147
Ensembl chr 9:115,068,090...115,076,464
G
FGF2
fibroblast growth factor 2
ISO
protein:increased expression:spinal cord
RGD
PMID:17244329
RGD:8655633
NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,885...101,343,916
G
FGFR2
fibroblast growth factor receptor 2
ISO
protein:increased expression:spinal cord (rat)
RGD
PMID:28981091
RGD:155782905
NCBI chr14:131,183,095...131,285,001
Ensembl chr14:131,181,713...131,289,425
G
FIS1
fission, mitochondrial 1
treatment
ISO
RGD
PMID:25595990
RGD:12437079
NCBI chr 3:8,938,250...8,942,102
Ensembl chr 3:8,937,453...8,946,955
G
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1
ISO
protein:decreased expression:spinal cord, thoracic vertebrae (rat)
RGD
PMID:20399821
RGD:2326108
NCBI chr16:27,936,225...27,957,261
Ensembl chr16:27,936,218...27,957,193
G
HSPA4
heat shock protein family A (Hsp70) member 4
ISO
protein:increased expression:spinal cord (mouse)
RGD
PMID:21787762
RGD:6218959
NCBI chr 2:135,345,724...135,391,112
Ensembl chr 2:135,345,867...135,391,108
G
IL6
interleukin 6
ISO
protein:increased expression:cerebrospinal fluid, serum
RGD
PMID:30327453
RGD:14975119
NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
G
L1CAM
L1 cell adhesion molecule
ISO
RGD
PMID:21671795
RGD:6483029
NCBI chr X:124,595,649...124,618,292
Ensembl chr X:124,595,651...124,618,307
G
MIR17
microRNA mir-17
treatment
ISO
RGD
PMID:31115018
RGD:329403058
NCBI chr11:60,734,656...60,734,732
Ensembl chr11:60,734,656...60,734,732
G
MT-2B
metallothionein-2A
ISO
mRNA:increased expression:spinal cord (mouse)
RGD
PMID:15592854
RGD:6483848
NCBI chr 6:18,645,125...18,646,034
Ensembl chr 6:18,645,153...18,646,033
G
NOS3
nitric oxide synthase 3
treatment
ISO
RGD
PMID:29323048
RGD:13504709
NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
G
PLAT
plasminogen activator, tissue type
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12227717
NCBI chr17:11,195,599...11,223,821
Ensembl chr17:11,195,602...11,224,032
G
TNF
tumor necrosis factor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:15135227
NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416
G
TNFRSF1A
TNF receptor superfamily member 1A
ISO
protein:increased expression:spinal cord (rat)
RGD
PMID:21224756
RGD:5130917
NCBI chr 5:64,319,349...64,331,876
Ensembl chr 5:64,319,051...64,331,909
G
TNFRSF1B
TNF receptor superfamily member 1B
ISO
protein:increased expression:spinal cord (rat) human protein in rat model
RGD
PMID:21224756
RGD:5130917
NCBI chr 6:72,195,420...72,231,146
Ensembl chr 6:72,195,435...72,231,147
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