CDC42 (cell division cycle 42) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: CDC42 (cell division cycle 42) Sus scrofa
Analyze
Symbol: CDC42
Name: cell division cycle 42
RGD ID: 14215573
Description: ENCODES a protein that exhibits GTP binding (ortholog); mitogen-activated protein kinase kinase kinase binding (ortholog); Rho GDP-dissociation inhibitor binding (ortholog); INVOLVED IN actin filament branching (ortholog); actin filament organization (ortholog); adherens junction organization (ortholog); PARTICIPATES IN adenosine signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; E-cadherin signaling pathway; ASSOCIATED WITH 3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency (ortholog); Adrenal Gland Neoplasms (ortholog); Alzheimer's disease (ortholog); FOUND IN cell leading edge (ortholog); glutamatergic synapse (ortholog); Golgi membrane (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cell division control protein 42 homolog; cell division cycle 42 (GTP binding protein, 25kDa)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl680,035,123 - 80,089,233 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1680,035,034 - 80,089,243 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2674,057,184 - 74,116,824 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA)
actin filament branching  (ISO)
actin filament organization  (IBA,IEA,ISO,ISS)
adherens junction organization  (IEA,ISO)
anatomical structure morphogenesis  (IEA)
cardiac conduction system development  (IEA,ISO)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (IEA)
Cdc42 protein signal transduction  (IBA,IEA)
cell differentiation  (IEA)
cell division  (IEA)
cell junction assembly  (IEA,ISS)
cellular response to type II interferon  (IEA,ISO)
dendritic cell migration  (IEA,ISO)
dendritic spine morphogenesis  (IEA,ISS)
embryonic heart tube development  (IEA)
endocytosis  (IBA,IEA,ISO)
endothelin receptor signaling pathway involved in heart process  (IEA)
establishment of epithelial cell apical/basal polarity  (IEA,ISS)
establishment of Golgi localization  (ISO)
establishment of localization in cell  (IEA,ISO)
establishment or maintenance of apical/basal cell polarity  (IEA,ISO)
establishment or maintenance of cell polarity  (IBA,IEA)
filopodium assembly  (IEA,ISO)
Golgi organization  (ISO)
heart contraction  (IEA,ISO)
heart process  (IEA)
integrin-mediated signaling pathway  (IEA)
modification of synaptic structure  (IEA)
modulation by host of viral process  (IEA)
negative regulation of protein-containing complex assembly  (IEA)
nervous system development  (IEA)
neuron fate determination  (IEA,ISO)
neuropilin signaling pathway  (IEA)
nuclear migration  (IEA,ISO)
nucleus localization  (IEA,ISO)
organelle transport along microtubule  (ISO)
phagocytosis, engulfment  (IEA,ISS)
positive regulation of catalytic activity  (ISO)
positive regulation of cell growth  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cellular component organization  (IEA)
positive regulation of cytokinesis  (IEA,ISS)
positive regulation of DNA replication  (ISO)
positive regulation of epithelial cell proliferation involved in lung morphogenesis  (IEA)
positive regulation of filopodium assembly  (IEA,ISS)
positive regulation of intracellular protein transport  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of lamellipodium assembly  (IEA)
positive regulation of MAPK cascade  (IEA,ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,ISO)
positive regulation of pinocytosis  (IEA,ISS)
positive regulation of pseudopodium assembly  (IEA)
positive regulation of stress fiber assembly  (IEA)
positive regulation of substrate adhesion-dependent cell spreading  (IEA,ISS)
positive regulation of synapse structural plasticity  (ISO)
protein localization  (IEA,ISO)
regulation of actin cytoskeleton organization  (IEA)
regulation of attachment of spindle microtubules to kinetochore  (IEA,ISS)
regulation of filopodium assembly  (IBA,IEA,ISS)
regulation of lamellipodium assembly  (IEA)
regulation of mitotic nuclear division  (IEA,ISO)
regulation of modification of postsynaptic structure  (ISO)
regulation of postsynapse organization  (IEA)
regulation of stress fiber assembly  (IEA)
small GTPase-mediated signal transduction  (IEA)
sprouting angiogenesis  (ISO)
submandibular salivary gland formation  (ISO)
substantia nigra development  (ISO)

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:18432402   PMID:20016221   PMID:22301074   PMID:24278102   PMID:25281640   PMID:28781348   PMID:30032202  


Genomics

Comparative Map Data
CDC42
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl680,035,123 - 80,089,233 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1680,035,034 - 80,089,243 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2674,057,184 - 74,116,824 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDC42
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38122,052,709 - 22,101,360 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl122,052,627 - 22,101,360 (+)EnsemblGRCh38hg38GRCh38
GRCh37122,379,202 - 22,427,853 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36122,251,707 - 22,292,023 (+)NCBINCBI36Build 36hg18NCBI36
Build 34122,124,487 - 22,164,741NCBI
Celera120,702,109 - 20,742,389 (+)NCBICelera
Cytogenetic Map1p36.12NCBI
HuRef120,622,960 - 20,663,212 (+)NCBIHuRef
CHM1_1122,491,651 - 22,531,931 (+)NCBICHM1_1
T2T-CHM13v2.0121,876,517 - 21,925,101 (+)NCBIT2T-CHM13v2.0
Cdc42
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394137,047,011 - 137,085,007 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4137,047,007 - 137,085,031 (-)EnsemblGRCm39 Ensembl
GRCm384137,319,696 - 137,357,759 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4137,319,696 - 137,357,720 (-)EnsemblGRCm38mm10GRCm38
MGSCv374136,875,611 - 136,913,652 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364136,591,779 - 136,608,205 (-)NCBIMGSCv36mm8
Celera4135,540,002 - 135,577,854 (-)NCBICelera
Cytogenetic Map4D3NCBI
cM Map469.83NCBI
Cdc42
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85154,838,478 - 154,876,629 (-)NCBIGRCr8
mRatBN7.25149,555,069 - 149,593,239 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5149,553,724 - 149,593,111 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5152,253,400 - 152,289,928 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05154,027,699 - 154,064,227 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05154,009,694 - 154,046,226 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05155,690,267 - 155,728,385 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5155,691,390 - 155,728,300 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05159,446,154 - 159,485,163 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45156,106,123 - 156,143,040 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15156,116,164 - 156,153,079 (-)NCBI
Celera5147,953,334 - 147,989,998 (-)NCBICelera
Cytogenetic Map5q36NCBI
Cdc42
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554522,255,117 - 2,299,042 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554522,255,940 - 2,299,042 (+)NCBIChiLan1.0ChiLan1.0
CDC42
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21204,846,790 - 204,887,042 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11203,958,664 - 203,998,887 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0121,245,970 - 21,286,210 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1122,188,722 - 22,228,351 (+)NCBIpanpan1.1PanPan1.1panPan2
LOC403934
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1277,153,276 - 77,169,947 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl277,153,095 - 77,199,211 (-)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.044,445,564 - 4,446,293 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.144,457,005 - 4,457,734 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.044,574,515 - 4,575,244 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.044,796,130 - 4,796,859 (+)NCBIUU_Cfam_GSD_1.0
Cdc42
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505841,731,950 - 41,773,901 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364747,556,765 - 7,598,687 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDC42
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120110,568,004 - 110,608,318 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20110,569,352 - 110,582,562 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660335,689,907 - 5,730,175 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdc42
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247646,874,453 - 6,891,952 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in CDC42
1301 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 10 4 3 5 2 23 2 3 3
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSSSCT00000033211   ⟹   ENSSSCP00000029815
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl680,068,939 - 80,089,233 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000034073   ⟹   ENSSSCP00000029701
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl680,035,123 - 80,087,427 (+)Ensembl
RefSeq Acc Id: NM_001078680   ⟹   NP_001072148
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1680,068,991 - 80,086,329 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005656039   ⟹   XP_005656096
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1680,035,035 - 80,089,243 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005656040   ⟹   XP_005656097
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1680,035,034 - 80,087,100 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005656097   ⟸   XM_005656040
- Peptide Label: isoform X2
- UniProtKB: F2Z5W2 (UniProtKB/TrEMBL),   A0A4X1W0S5 (UniProtKB/TrEMBL),   A0A8D0JLD0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005656096   ⟸   XM_005656039
- Peptide Label: isoform X1
- UniProtKB: D1YSL6 (UniProtKB/Swiss-Prot),   Q007T2 (UniProtKB/Swiss-Prot),   A0A8D0JMP9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001072148   ⟸   NM_001078680
- UniProtKB: A0A8D0JLD0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000029701   ⟸   ENSSSCT00000034073
RefSeq Acc Id: ENSSSCP00000029815   ⟸   ENSSSCT00000033211


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000003520 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005028139 UniProtKB/TrEMBL
  ENSSSCG00015058076 UniProtKB/TrEMBL
  ENSSSCG00025066075 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00030046284 UniProtKB/TrEMBL
  ENSSSCG00035080048 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00040071638 UniProtKB/TrEMBL
  ENSSSCG00045031455 UniProtKB/TrEMBL
  ENSSSCG00050075450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00055029308 UniProtKB/TrEMBL
  ENSSSCG00060060565 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00065073552 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00070028168 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000033211 ENTREZGENE
  ENSSSCT00000033211.3 UniProtKB/TrEMBL
  ENSSSCT00000034073 ENTREZGENE
  ENSSSCT00000034073.4 UniProtKB/TrEMBL
  ENSSSCT00005044659.1 UniProtKB/TrEMBL
  ENSSSCT00005044697.1 UniProtKB/TrEMBL
  ENSSSCT00015077587.1 UniProtKB/TrEMBL
  ENSSSCT00025091006.1 UniProtKB/Swiss-Prot
  ENSSSCT00025091150.1 UniProtKB/TrEMBL
  ENSSSCT00030064556.1 UniProtKB/TrEMBL
  ENSSSCT00035109564.1 UniProtKB/Swiss-Prot
  ENSSSCT00035109580.1 UniProtKB/TrEMBL
  ENSSSCT00040098478.1 UniProtKB/TrEMBL
  ENSSSCT00045053657.1 UniProtKB/TrEMBL
  ENSSSCT00050103462.1 UniProtKB/Swiss-Prot
  ENSSSCT00050103464.1 UniProtKB/TrEMBL
  ENSSSCT00055058142.1 UniProtKB/TrEMBL
  ENSSSCT00060082664.1 UniProtKB/Swiss-Prot
  ENSSSCT00060082707.1 UniProtKB/TrEMBL
  ENSSSCT00065101263.1 UniProtKB/Swiss-Prot
  ENSSSCT00065101275.1 UniProtKB/Swiss-Prot
  ENSSSCT00065101298.1 UniProtKB/TrEMBL
  ENSSSCT00070056502.1 UniProtKB/Swiss-Prot
  ENSSSCT00070056506.1 UniProtKB/TrEMBL
  ENSSSCT00070056507.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cdc42 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Small_GTPase_Rho UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:780428 UniProtKB/Swiss-Prot
NCBI Gene CDC42 ENTREZGENE
PANTHER CELL DIVISION CONTROL PROTEIN 42 HOMOLOG UniProtKB/Swiss-Prot
  CELL DIVISION CONTROL PROTEIN 42 HOMOLOG UniProtKB/TrEMBL
  CELL DIVISION CONTROL PROTEIN 42 HOMOLOG UniProtKB/TrEMBL
  PTHR24072 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ras UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART RAB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RAS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A4X1W0S5 ENTREZGENE, UniProtKB/TrEMBL
  A0A5S6GXN2_PIG UniProtKB/TrEMBL
  A0A8D0JLD0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0JMP9 ENTREZGENE, UniProtKB/TrEMBL
  CDC42_PIG UniProtKB/Swiss-Prot
  D1YSL6 ENTREZGENE
  F2Z5W2 ENTREZGENE, UniProtKB/TrEMBL
  Q007T2 ENTREZGENE
UniProt Secondary D1YSL6 UniProtKB/Swiss-Prot
VGNC ID VGNC:110412 ENTREZGENE