GHSR (growth hormone secretagogue receptor) - Rat Genome Database

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Gene: GHSR (growth hormone secretagogue receptor) Sus scrofa
Analyze
Symbol: GHSR
Name: growth hormone secretagogue receptor (Ensembl:TNF superfamily member 10)
RGD ID: 13929728
Description: ENCODES a protein that exhibits G protein-coupled receptor activity; growth hormone secretagogue receptor activity; growth hormone-releasing hormone receptor activity; INVOLVED IN G protein-coupled receptor signaling pathway; hormone-mediated signaling pathway; actin polymerization or depolymerization (ortholog); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; ghrelin system pathway; ASSOCIATED WITH alcohol use disorder (ortholog); Cardiac Fibrosis (ortholog); Digestive System Neoplasms (ortholog); FOUND IN cell surface; glutamatergic synapse (ortholog); membrane raft (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GH-releasing peptide receptor; ghrelin receptor; GHRP; GHS-R; growth hormone secretagogue receptor type 1; growth hormone secretagogue receptor type 1b
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13110,983,298 - 111,038,324 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113110,981,465 - 111,006,149 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213119,917,068 - 119,929,590 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin polymerization or depolymerization  (IEA,ISS)
adult feeding behavior  (IEA)
cellular response to insulin stimulus  (IEA,ISO)
cellular response to insulin-like growth factor stimulus  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to thyroid hormone stimulus  (ISO)
decidualization  (IEA,ISS)
female pregnancy  (ISO)
G protein-coupled receptor signaling pathway  (IBA,IDA,IEA,ISO,ISS)
ghrelin secretion  (ISO)
growth hormone secretion  (IEA,ISO)
hormone-mediated signaling pathway  (IBA,IDA,IEA,ISS)
immune response  (IEA)
insulin-like growth factor receptor signaling pathway  (IEA,ISO)
learning or memory  (ISO)
negative regulation of appetite  (ISO)
negative regulation of inflammatory response  (IEA,ISS)
negative regulation of insulin secretion  (ISO)
negative regulation of interleukin-1 beta production  (IEA,ISS)
negative regulation of interleukin-6 production  (IEA,ISS)
negative regulation of locomotion involved in locomotory behavior  (ISO)
negative regulation of macrophage apoptotic process  (ISO)
negative regulation of norepinephrine secretion  (ISO)
negative regulation of tumor necrosis factor production  (IEA,ISO,ISS)
positive regulation of appetite  (IEA)
positive regulation of eating behavior  (ISO)
positive regulation of fatty acid metabolic process  (ISO)
positive regulation of growth  (ISO)
positive regulation of insulin-like growth factor receptor signaling pathway  (IEA,ISO)
positive regulation of multicellular organism growth  (IEA,ISS)
positive regulation of small intestinal transit  (ISO)
positive regulation of small intestine smooth muscle contraction  (ISO)
positive regulation of sprouting angiogenesis  (ISO)
positive regulation of vascular endothelial cell proliferation  (ISO)
postsynaptic modulation of chemical synaptic transmission  (ISO)
regulation of feeding behavior  (ISO)
regulation of gastric motility  (ISO)
regulation of growth hormone secretion  (ISO)
regulation of hindgut contraction  (ISO)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (ISO)
regulation of postsynapse organization  (ISO)
regulation of synapse assembly  (IEA,ISO)
regulation of transmission of nerve impulse  (ISO)
response to dexamethasone  (ISO)
response to estradiol  (ISO)
response to follicle-stimulating hormone  (ISO)
response to food  (IEA,ISO)
response to growth hormone  (ISO)
response to hormone  (IEA,ISS)
response to monosodium glutamate  (ISO)
signal transduction  (IEA)
spermatogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:8688086   PMID:18809347   PMID:33857472  


Genomics

Comparative Map Data
GHSR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13110,983,298 - 111,038,324 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113110,981,465 - 111,006,149 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213119,917,068 - 119,929,590 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GHSR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383172,443,291 - 172,448,456 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl3172,443,291 - 172,448,456 (-)EnsemblGRCh38hg38GRCh38
GRCh373172,161,081 - 172,166,246 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363173,645,645 - 173,648,897 (-)NCBINCBI36Build 36hg18NCBI36
Build 343173,648,035 - 173,648,905NCBI
Celera3170,559,676 - 170,564,839 (-)NCBICelera
Cytogenetic Map3q26.31NCBI
HuRef3169,531,507 - 169,536,581 (-)NCBIHuRef
CHM1_13172,123,965 - 172,129,130 (-)NCBICHM1_1
T2T-CHM13v2.03175,228,381 - 175,233,536 (-)NCBIT2T-CHM13v2.0
Ghsr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39327,425,500 - 27,433,384 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl327,425,500 - 27,432,159 (+)EnsemblGRCm39 Ensembl
GRCm38327,371,351 - 27,379,235 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl327,371,351 - 27,378,010 (+)EnsemblGRCm38mm10GRCm38
MGSCv37327,270,273 - 27,276,932 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36327,562,424 - 27,569,083 (+)NCBIMGSCv36mm8
Celera327,331,821 - 27,338,480 (+)NCBICelera
Cytogenetic Map3A3NCBI
Ghsr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22110,268,489 - 110,271,865 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2110,268,489 - 110,271,865 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2116,922,519 - 116,925,893 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02115,035,078 - 115,038,452 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02109,749,447 - 109,752,824 (+)NCBIRnor_WKY
Rnor_6.02113,065,953 - 113,071,265 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2113,066,885 - 113,070,261 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02132,784,207 - 132,789,319 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42113,269,623 - 113,272,999 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12113,214,584 - 113,217,961 (+)NCBI
Celera2105,470,925 - 105,474,301 (+)NCBICelera
Cytogenetic Map2q24NCBI
Ghsr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554202,478,877 - 2,487,215 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554202,483,173 - 2,486,414 (-)NCBIChiLan1.0ChiLan1.0
GHSR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13177,633,039 - 177,638,202 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3177,633,039 - 177,638,202 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03169,448,217 - 169,458,602 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
GHSR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13436,691,132 - 36,694,304 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3436,690,224 - 36,694,312 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3445,703,894 - 45,707,255 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03436,775,648 - 36,779,007 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3436,774,740 - 36,779,009 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13436,714,573 - 36,717,930 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03436,683,080 - 36,686,432 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03436,941,135 - 36,944,502 (-)NCBIUU_Cfam_GSD_1.0
Ghsr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602103,348,347 - 103,353,683 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936593268,350 - 277,229 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936593268,736 - 273,623 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GHSR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11517,008,185 - 17,013,504 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1517,009,369 - 17,012,618 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606325,770,911 - 25,777,537 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ghsr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473050,488,887 - 50,492,405 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473050,484,763 - 50,492,443 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: NM_214180   ⟹   NP_999345
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113110,986,422 - 110,989,703 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021068541   ⟹   XP_020924200
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113110,981,465 - 111,006,149 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021068542   ⟹   XP_020924201
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.113110,981,465 - 110,992,364 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_999345 (Get FASTA)   NCBI Sequence Viewer  
  XP_020924200 (Get FASTA)   NCBI Sequence Viewer  
  XP_020924201 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC48630 (Get FASTA)   NCBI Sequence Viewer  
  AAC48631 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020924200   ⟸   XM_021068541
- Peptide Label: isoform X1
- UniProtKB: Q95255 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_020924201   ⟸   XM_021068542
- Peptide Label: isoform X1
- UniProtKB: Q95255 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_999345   ⟸   NM_214180
- UniProtKB: Q95255 (UniProtKB/Swiss-Prot),   Q95254 (UniProtKB/Swiss-Prot)
- Sequence:
Protein Domains
G_PROTEIN_RECEP_F1_2   TNF_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000020906 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSSSCG00015076501 UniProtKB/Swiss-Prot
  ENSSSCG00025065336 UniProtKB/Swiss-Prot
  ENSSSCG00030011593 UniProtKB/Swiss-Prot
  ENSSSCG00035013159 UniProtKB/Swiss-Prot
  ENSSSCG00040003174 UniProtKB/Swiss-Prot
  ENSSSCG00045033986 UniProtKB/Swiss-Prot
  ENSSSCG00050033428 UniProtKB/Swiss-Prot
  ENSSSCG00055014215 UniProtKB/Swiss-Prot
  ENSSSCG00060071407 UniProtKB/Swiss-Prot
  ENSSSCG00065044068 UniProtKB/Swiss-Prot
  ENSSSCG00070022444 UniProtKB/Swiss-Prot
Ensembl Protein ENSSSCP00000012525 UniProtKB/Swiss-Prot
  ENSSSCP00000019468.3 UniProtKB/TrEMBL
  ENSSSCP00000050205.2 UniProtKB/TrEMBL
  ENSSSCP00015043090 UniProtKB/Swiss-Prot
  ENSSSCP00025039240 UniProtKB/Swiss-Prot
  ENSSSCP00030007123 UniProtKB/Swiss-Prot
  ENSSSCP00035005755 UniProtKB/Swiss-Prot
  ENSSSCP00040001235 UniProtKB/Swiss-Prot
  ENSSSCP00045040628 UniProtKB/Swiss-Prot
  ENSSSCP00050018415 UniProtKB/Swiss-Prot
  ENSSSCP00055022326 UniProtKB/Swiss-Prot
  ENSSSCP00060042315 UniProtKB/Swiss-Prot
  ENSSSCP00065026114 UniProtKB/Swiss-Prot
  ENSSSCP00070037580 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000012865 UniProtKB/Swiss-Prot
  ENSSSCT00000025711.3 UniProtKB/TrEMBL
  ENSSSCT00000059499.2 UniProtKB/TrEMBL
  ENSSSCT00015103407 UniProtKB/Swiss-Prot
  ENSSSCT00025089656 UniProtKB/Swiss-Prot
  ENSSSCT00030015905 UniProtKB/Swiss-Prot
  ENSSSCT00035016614 UniProtKB/Swiss-Prot
  ENSSSCT00040003967 UniProtKB/Swiss-Prot
  ENSSSCT00045058121 UniProtKB/Swiss-Prot
  ENSSSCT00050044816 UniProtKB/Swiss-Prot
  ENSSSCT00055028026 UniProtKB/Swiss-Prot
  ENSSSCT00060097610 UniProtKB/Swiss-Prot
  ENSSSCT00065060265 UniProtKB/Swiss-Prot
  ENSSSCT00070044601 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.40 UniProtKB/TrEMBL
InterPro 7tmA_GHSR UniProtKB/Swiss-Prot
  GHS-R/MTLR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_CS UniProtKB/TrEMBL
  TNF_dom UniProtKB/TrEMBL
  TNF_ligand_10/11 UniProtKB/TrEMBL
  Tumour_necrosis_fac-like_dom UniProtKB/TrEMBL
KEGG Report ssc:397372 UniProtKB/Swiss-Prot
NCBI Gene GHSR ENTREZGENE
PANTHER PTHR24243:SF7 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF UniProtKB/TrEMBL
PIRSF TNF10_TNF11 UniProtKB/TrEMBL
PRINTS GHSRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_1 UniProtKB/TrEMBL
  TNF_2 UniProtKB/TrEMBL
SMART TNF UniProtKB/TrEMBL
Superfamily-SCOP SSF49842 UniProtKB/TrEMBL
UniProt A0A5K1TVZ8_PIG UniProtKB/TrEMBL
  A0A5S6I229_PIG UniProtKB/TrEMBL
  GHSR_PIG UniProtKB/Swiss-Prot, ENTREZGENE
  Q95255 ENTREZGENE
UniProt Secondary Q95255 UniProtKB/Swiss-Prot