TP53 (tumor protein p53) - Rat Genome Database

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Gene: TP53 (tumor protein p53) Sus scrofa
Analyze
Symbol: TP53
Name: tumor protein p53
RGD ID: 14013963
Description: ENCODES a protein that exhibits 14-3-3 protein binding (ortholog); ATP-dependent DNA/DNA annealing activity (ortholog); copper ion binding (ortholog); INVOLVED IN negative regulation of progesterone secretion; regulation of peptide hormone secretion; regulation of prostaglandin secretion; PARTICIPATES IN altered p53 signaling pathway; endometrial cancer pathway; non-small cell lung carcinoma pathway; ASSOCIATED WITH Acute Erythroleukemia (ortholog); acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN nucleus; centrosome (ortholog); chromatin (ortholog); INTERACTS WITH 3-methyladenine; alpha-mangostin; arsenous acid
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cellular tumor antigen p53; P53; tumor suppressor p53
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,939,644 - 52,953,818 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,939,643 - 52,953,786 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,220,545 - 55,234,668 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap12q12-q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
TP53Pigacute myeloid leukemia disease_progressionISOTP53 (Homo sapiens)9068941 RGDPMID:25412846 and REF_RGD_ID:11057925
TP53Pigacute myeloid leukemia treatmentISOTP53 (Homo sapiens)9068941DNA:mutations: :RGDPMID:25573287 and REF_RGD_ID:11075071
TP53Pigacute myeloid leukemia disease_progressionISOTP53 (Homo sapiens)9068941DNA:mutation: :RGDPMID:24836762 and REF_RGD_ID:11073714
TP53Pigadenoid cystic carcinoma disease_progressionISOTP53 (Homo sapiens)9068941 RGDPMID:16249115 and REF_RGD_ID:8547828
TP53PigAdrenal Cortex Neoplasms  ISOTP53 (Homo sapiens)9068941DNA:missense mutation::p.R337H (human)RGDPMID:28387921 and REF_RGD_ID:14995484
TP53PigAlzheimer's disease  ISOTrp53 (Mus musculus)9068941 RGDPMID:17581637 and REF_RGD_ID:2290573
TP53Pigangiosarcoma  ISOTrp53 (Mus musculus)9068941DNA:mutation:multiple (human)RGDPMID:26440310 and REF_RGD_ID:151665099
TP53Pigatherosclerosis amelioratesISOTrp53 (Mus musculus)9068941 RGDPMID:31757932 and REF_RGD_ID:242905202
TP53PigB-Cell Chronic Lymphocytic Leukemia disease_progressionISOTP53 (Homo sapiens)9068941DNA:deletion: :RGDPMID:10867151 and REF_RGD_ID:11075074
TP53PigB-lymphoblastic leukemia/lymphoma disease_progressionISOTP53 (Homo sapiens)9068941DNA:mutations: :RGDPMID:22699455 and REF_RGD_ID:11075072
TP53PigBone Marrow Neoplasms disease_progressionISOTP53 (Homo sapiens)9068941 RGDPMID:24761810 and REF_RGD_ID:11073734
TP53PigBreast Neoplasms susceptibilityISOTP53 (Homo sapiens)9068941DNA:missense mutation: :p.R72PRGDPMID:18230179 and REF_RGD_ID:2290534
TP53Pigbronchiolo-alveolar adenocarcinoma  ISOTp53 (Rattus norvegicus)9068941DNA:mutations:exons:RGDPMID:26059825 and REF_RGD_ID:11075076
TP53Pigbronchiolo-alveolar adenocarcinoma  ISOTrp53 (Mus musculus)9068941DNA:mutations:exons:RGDPMID:26059825 and REF_RGD_ID:11075076
TP53Pigbronchopulmonary dysplasia  ISOTp53 (Rattus norvegicus)9068941 RGDPMID:26431790 and REF_RGD_ID:11537057
TP53Pigcataract  ISOTrp53 (Mus musculus)9068941 RGDPMID:21504908 and REF_RGD_ID:8547757
TP53Pigcervical adenocarcinoma disease_progressionISOTP53 (Homo sapiens)9068941 RGDPMID:17354237 and REF_RGD_ID:2298527
TP53Pigcervical squamous cell carcinoma disease_progressionISOTP53 (Homo sapiens)9068941 RGDPMID:17969407 and REF_RGD_ID:2298526
TP53PigChemotherapy-Induced Febrile Neutropenia susceptibilityISOTP53 (Homo sapiens)9068941associated with Breast Neoplasms and DNA:SNP:cds: p.R72P(rs1042522)(human)RGDPMID:21706156 and REF_RGD_ID:11073725
TP53Pigcholesteatoma of middle ear  ISOTP53 (Homo sapiens)9068941protein:increased expression:tympanic membrane and skin:RGDPMID:9455944 and REF_RGD_ID:8547787
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Original Reference(s)
TP53Pigacute megakaryocytic leukemia  ISOTP53 (Homo sapiens)8554872ClinVar Annotator: match by term: Acute megakaryocytic leukemiaClinVarPMID:11370630 more ...
TP53Pigacute myeloid leukemia  ISOTP53 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10089074 more ...
TP53Pigacute myeloid leukemia  ISOTP53 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10089074 more ...
TP53Pigacute myeloid leukemia  ISOTP53 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10089074 more ...
TP53Pigacute myeloid leukemia  ISOTP53 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:30720243 more ...
TP53Pigacute myeloid leukemia  ISOTP53 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10089074 more ...
TP53Pigacute myeloid leukemia  ISOTP53 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:30840781 more ...
TP53Pigacute myeloid leukemia  ISOTP53 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:30840781 more ...
TP53Pigacute myeloid leukemia  ISOTP53 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10089074 more ...
TP53Pigacute myeloid leukemia  ISOTP53 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10089074 more ...
TP53Pigacute myeloid leukemia  ISOTP53 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:29025599 more ...
TP53Pigadenocarcinoma  ISOTP53 (Homo sapiens)8554872ClinVar Annotator: match by term: AdenocarcinomaClinVarPMID:10519380 more ...
TP53Pigadenoid cystic carcinoma  ISOTP53 (Homo sapiens)8554872ClinVar Annotator: match by term: Adenocystic carcinomaClinVarPMID:10713666 more ...
TP53Pigadrenocortical carcinoma  ISOTP53 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10064694 more ...
TP53Piganaplastic astrocytoma  ISOTP53 (Homo sapiens)8554872ClinVar Annotator: match by term: Astrocytoma and anaplasticClinVarPMID:10519380 more ...
TP53Piganaplastic thyroid carcinoma  ISOTP53 (Homo sapiens)8554872ClinVar Annotator: match by term: Thyroid gland undifferentiated (anaplastic) carcinomaClinVarPMID:10864200 more ...
TP53Pigatypical teratoid rhabdoid tumor  ISOTP53 (Homo sapiens)8554872ClinVar Annotator: match by term: Atypical teratoid/rhabdoid tumorClinVarPMID:10519380 more ...
TP53PigAutosomal Recessive Dyskeratosis Congenita  ISOTP53 (Homo sapiens)8554872ClinVar Annotator: match by term: Dyskeratosis Congenita and RecessiveClinVarPMID:25741868 and PMID:28492532
TP53Pigautosomal recessive dyskeratosis congenita 3  ISOTP53 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:17683073 more ...
TP53PigB-Cell Chronic Lymphocytic Leukemia  ISOTP53 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10432928 more ...
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Original Reference(s)
TP53PigAcute Erythroleukemia  ISOTP53 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:30926971
TP53Pigacute kidney failure  ISOTP53 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:20603111
TP53Pigacute lymphoblastic leukemia  ISOTP53 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:23334668
TP53Pigadenoma  ISOTP53 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:21946351
TP53PigAdrenal Gland Neoplasms  ISOTP53 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:24747643
TP53Pigamyotrophic lateral sclerosis  ISOTP53 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:17434459
TP53Pigangiosarcoma  ISOTrp53 (Mus musculus)9068941CTD Direct Evidence: marker/mechanismCTDPMID:10930038 more ...
TP53Pigangiosarcoma  ISOTP53 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:10626228
TP53PigAnimal Disease Models  ISOTrp53 (Mus musculus)9068941CTD Direct Evidence: marker/mechanismCTDPMID:23873029
TP53PigArsenic Poisoning  ISOTP53 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:18621066 and PMID:19203779
TP53PigBalkan nephropathy  ISOTP53 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:22071594
TP53Pigbone development disease  ISOTrp53 (Mus musculus)9068941CTD Direct Evidence: marker/mechanismCTDPMID:9493073
TP53Pigbrain ischemia  ISOTP53 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:19095966
TP53PigBrain Neoplasms  ISOTrp53 (Mus musculus)9068941CTD Direct Evidence: marker/mechanismCTDPMID:16860786
TP53PigCalcification of Aortic Valve  ISOTrp53 (Mus musculus)9068941CTD Direct Evidence: marker/mechanismCTDPMID:29358327
TP53PigCalcification of Aortic Valve  ISOTP53 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:29358327
TP53Pigcalcinosis  ISOTP53 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:29358327
TP53Pigcarcinoma  ISOTP53 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:17450239 and PMID:9626339
TP53Pigcardiomyopathy  ISOTP53 (Homo sapiens)9068941CTD Direct Evidence: therapeuticCTDPMID:31618665
TP53Pigcardiomyopathy  ISOTrp53 (Mus musculus)9068941CTD Direct Evidence: marker/mechanismCTDPMID:16013437
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Original Reference(s)
TP53PigCHARGE syndrome  ISOTrp53 (Mus musculus)9068941OMIM:214800MouseDO 
TP53Pigendometrial cancer  ISOTrp53 (Mus musculus)9068941OMIM:608089MouseDO 

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Original Reference(s)
TP53Pig3-methyladenine multiple interactionsEXP 64804643-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the phosphorylation of TP53 protein]]CTDPMID:34811946
TP53Pigalpha-mangostin multiple interactionsEXP 6480464mangostin inhibits the reaction [Cisplatin results in increased expression of TP53]CTDPMID:20603111
TP53Pigarsenous acid increases expressionEXP 6480464Arsenic Trioxide results in increased expression of TP53CTDPMID:13129816
TP53Pigbis(2-chloroethyl) sulfide increases expressionEXP 6480464Mustard Gas results in increased expression of TP53 proteinCTDPMID:9302645
TP53Pigbisphenol A increases expressionEXP 6480464bisphenol A results in increased expression of TP53 proteinCTDPMID:28819136
TP53Pigcisplatin increases expressionEXP 6480464Cisplatin results in increased expression of TP53CTDPMID:12712633 and PMID:20603111
TP53Pigcisplatin multiple interactionsEXP 6480464mangostin inhibits the reaction [Cisplatin results in increased expression of TP53]CTDPMID:20603111
TP53Pigdeoxynivalenol multiple interactionsEXP 6480464[deoxynivalenol co-treated with fumonisin B1] results in increased expression of TP53 mRNA more ...CTDPMID:29109043 and PMID:38104654
TP53Pigdiarsenic trioxide increases expressionEXP 6480464Arsenic Trioxide results in increased expression of TP53CTDPMID:13129816
TP53Pigfumonisin B1 increases expressionEXP 6480464fumonisin B1 results in increased expression of TP53 mRNACTDPMID:29109043
TP53Pigfumonisin B1 multiple interactionsEXP 6480464[deoxynivalenol co-treated with fumonisin B1] results in increased expression of TP53 mRNA more ...CTDPMID:29109043
TP53Pigmalathion multiple interactionsEXP 6480464Melatonin inhibits the reaction [Malathion results in increased expression of TP53 mRNA]CTDPMID:31535366
TP53Pigmalathion increases expressionEXP 6480464Malathion results in increased expression of TP53 mRNACTDPMID:31535366
TP53Pigmelatonin decreases expressionEXP 6480464Melatonin results in decreased expression of TP53 mRNACTDPMID:31535366
TP53Pigmelatonin multiple interactionsEXP 6480464Melatonin inhibits the reaction [Malathion results in increased expression of TP53 mRNA]CTDPMID:31535366
TP53PigN-acetyl-L-cysteine multiple interactionsEXP 6480464Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in increased expression of TP53 mRNA]] more ...CTDPMID:29109043
TP53Pigochratoxin A increases expressionEXP 6480464ochratoxin A results in increased expression of TP53 proteinCTDPMID:28710020 and PMID:32454083
TP53Pigochratoxin A multiple interactionsEXP 6480464NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TP53 protein]CTDPMID:28710020
TP53Pigparacetamol decreases expressionEXP 6480464Acetaminophen results in decreased expression of TP53 proteinCTDPMID:16330492
TP53Pigparaquat multiple interactionsEXP 64804643-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the phosphorylation of TP53 protein]] and Paraquat affects the reaction [MYD88 protein affects the phosphorylation of TP53 protein]CTDPMID:34811946

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Biological Process
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Original Reference(s)
TP53Pigapoptotic process involved_inIEAUniProtKB-KW:KW-0053150520179 UniProtGO_REF:0000043
TP53Pigapoptotic process acts_upstream_ofISOMGI:18579899068941 PMID:17912366MGIPMID:17912366
TP53Pigapoptotic process acts_upstream_of_or_withinIEAUniProtKB:P02340 and ensembl:ENSMUSP00000104298150520179 EnsemblGO_REF:0000107
TP53Pigapoptotic process involved_inIEAInterPro:IPR002117150520179 InterProGO_REF:0000002
TP53Pigapoptotic signaling pathway involved_inISOTp53 (Rattus norvegicus)9068941PMID:17998337UniProtPMID:17998337 and REF_RGD_ID:10047225
TP53Pigautophagy involved_inIEAUniProtKB:P04637 and ensembl:ENSP00000269305150520179 EnsemblGO_REF:0000107
TP53PigB cell lineage commitment acts_upstream_of_or_withinIEAUniProtKB:P02340 and ensembl:ENSMUSP00000104298150520179 EnsemblGO_REF:0000107
TP53Pigbone marrow development involved_inIEAUniProtKB:P04637 and ensembl:ENSP00000269305150520179 EnsemblGO_REF:0000107
TP53Pigcardiac muscle cell apoptotic process acts_upstream_ofIEAUniProtKB:P02340 and ensembl:ENSMUSP00000104298150520179 EnsemblGO_REF:0000107
TP53Pigcardiac septum morphogenesis acts_upstream_of_or_withinIEAUniProtKB:P02340 and ensembl:ENSMUSP00000104298150520179 EnsemblGO_REF:0000107
TP53Pigcell population proliferation acts_upstream_ofIEAUniProtKB:P02340 and ensembl:ENSMUSP00000104298150520179 EnsemblGO_REF:0000107
TP53Pigcellular response to actinomycin D involved_inIEAUniProtKB:P04637 and ensembl:ENSP00000269305150520179 EnsemblGO_REF:0000107
TP53Pigcellular response to gamma radiation acts_upstream_of_or_withinIEAUniProtKB:P02340 and ensembl:ENSMUSP00000104298150520179 EnsemblGO_REF:0000107
TP53Pigcellular response to gamma radiation involved_inIEAUniProtKB:P04637 and ensembl:ENSP00000269305150520179 EnsemblGO_REF:0000107
TP53Pigcellular response to glucose starvation acts_upstream_of_or_withinIEAUniProtKB:P04637 and ensembl:ENSP00000269305150520179 EnsemblGO_REF:0000107
TP53Pigcellular response to glucose starvation involved_inISOTP53 (Homo sapiens)9068941 PMID:21471221UniProtPMID:21471221
TP53Pigcellular response to heat  ISOTp53 (Rattus norvegicus)9068941 RGDPMID:11295070 and REF_RGD_ID:8547793
TP53Pigcellular response to hypoxia  ISOTp53 (Rattus norvegicus)9068941 RGDPMID:17289031 and REF_RGD_ID:9587773
TP53Pigcellular response to hypoxia involved_inIEAUniProtKB:P04637 and ensembl:ENSP00000269305150520179 EnsemblGO_REF:0000107
TP53Pigcellular response to ionizing radiation involved_inIEAUniProtKB:P02340 more ...150520179 EnsemblGO_REF:0000107
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Cellular Component
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Original Reference(s)
TP53Pigcentrosome located_inIEAUniProtKB-SubCell:SL-0048150520179 UniProtGO_REF:0000044
TP53Pigcentrosome located_inIEAUniProtKB:P04637 and ensembl:ENSP00000269305150520179 EnsemblGO_REF:0000107
TP53Pigcentrosome located_inISSUniProtKB:P04637150520179 UniProtGO_REF:0000024
TP53Pigchromatin  ISOTp53 (Rattus norvegicus)9068941 RGDPMID:15632413 and REF_RGD_ID:1643534
TP53Pigchromatin located_inIEAUniProtKB:P04637 and ensembl:ENSP00000269305150520179 EnsemblGO_REF:0000107
TP53Pigcytoplasm located_inISSUniProtKB:P04637150520179 UniProtGO_REF:0000024
TP53Pigcytoplasm located_inIEAUniProtKB-SubCell:SL-0086150520179 UniProtGO_REF:0000044
TP53Pigcytoplasm located_inIEAUniProtKB:P02340 more ...150520179 EnsemblGO_REF:0000107
TP53Pigcytoplasm located_inIEAUniProtKB-KW:KW-0963150520179 UniProtGO_REF:0000043
TP53Pigcytoskeleton located_inIEAUniProtKB-KW:KW-0206150520179 UniProtGO_REF:0000043
TP53Pigcytosol located_inIEAUniProtKB:K7PPA8 more ...150520179 EnsemblGO_REF:0000107
TP53Pigendoplasmic reticulum located_inIEAUniProtKB-KW:KW-0256150520179 UniProtGO_REF:0000043
TP53Pigendoplasmic reticulum located_inIEAUniProtKB-SubCell:SL-0095150520179 UniProtGO_REF:0000044
TP53Piggerm cell nucleus located_inIEAUniProtKB:P02340 and ensembl:ENSMUSP00000104298150520179 EnsemblGO_REF:0000107
TP53Pigmitochondrial matrix located_inIEAUniProtKB:P02340 and ensembl:ENSMUSP00000104298150520179 EnsemblGO_REF:0000107
TP53Pigmitochondrial matrix located_inIEAUniProtKB-SubCell:SL-0170150520179 UniProtGO_REF:0000044
TP53Pigmitochondrion located_inIEAUniProtKB-KW:KW-0496150520179 UniProtGO_REF:0000043
TP53Pigmitochondrion located_inIEAUniProtKB:P02340 more ...150520179 EnsemblGO_REF:0000107
TP53Pigmitochondrion located_inISSUniProtKB:P04637150520179 UniProtGO_REF:0000024
TP53Pignuclear body located_inIEAUniProtKB:P04637 and ensembl:ENSP00000269305150520179 EnsemblGO_REF:0000107
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Molecular Function
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Original Reference(s)
TP53Pig14-3-3 protein binding enablesISOTP53 (Homo sapiens)9068941 PMID:20206173DisProtPMID:20206173
TP53PigATP-dependent DNA/DNA annealing activity enablesIEAUniProtKB:P04637 and ensembl:ENSP00000269305150520179 EnsemblGO_REF:0000107
TP53PigATP-dependent DNA/DNA annealing activity enablesISSUniProtKB:P04637150520179 UniProtGO_REF:0000024
TP53Pigchromatin binding enablesIEAUniProtKB:P02340 more ...150520179 EnsemblGO_REF:0000107
TP53Pigcis-regulatory region sequence-specific DNA binding enablesIEAUniProtKB:P04637 and ensembl:ENSP00000269305150520179 EnsemblGO_REF:0000107
TP53Pigcopper ion binding enablesISSUniProtKB:P04637150520179 UniProtGO_REF:0000024
TP53Pigcopper ion binding enablesIEAUniProtKB:P04637 and ensembl:ENSP00000269305150520179 EnsemblGO_REF:0000107
TP53Pigcore promoter sequence-specific DNA binding enablesIEAUniProtKB:P04637 and ensembl:ENSP00000269305150520179 EnsemblGO_REF:0000107
TP53Pigdisordered domain specific binding enablesIEAUniProtKB:P04637 and ensembl:ENSP00000269305150520179 EnsemblGO_REF:0000107
TP53PigDNA binding enablesIEAInterPro:IPR002117 and InterPro:IPR012346150520179 InterProGO_REF:0000002
TP53PigDNA binding enablesIEAUniProtKB-KW:KW-0238150520179 UniProtGO_REF:0000043
TP53PigDNA binding enablesIEAUniProtKB:P04637 and ensembl:ENSP00000269305150520179 EnsemblGO_REF:0000107
TP53PigDNA binding enablesISSUniProtKB:P04637150520179 UniProtGO_REF:0000024
TP53PigDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:P02340 more ...150520179 EnsemblGO_REF:0000107
TP53PigDNA-binding transcription factor activity enablesIEAUniProtKB:P02340 more ...150520179 EnsemblGO_REF:0000107
TP53PigDNA-binding transcription factor activity enablesIEAInterPro:IPR002117 more ...150520179 InterProGO_REF:0000002
TP53PigDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAMGI:1330810 more ...150520179 GO_CentralGO_REF:0000033
TP53PigDNA-binding transcription factor activity, RNA polymerase II-specific enablesIEAUniProtKB:P04637 and ensembl:ENSP00000269305150520179 EnsemblGO_REF:0000107
TP53PigDNA-binding transcription factor activity, RNA polymerase II-specific enablesISSUniProtKB:P04637150520179 UniProtGO_REF:0000024
TP53PigDNA-binding transcription repressor activity, RNA polymerase II-specific enablesIEAUniProtKB:P04637 and ensembl:ENSP00000269305150520179 EnsemblGO_REF:0000107
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Imported Annotations - SMPDB

Imported Annotations - PID (archival)

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Original Reference(s)
TP53Pigp53 signaling pathway   ISOTP53 (Homo sapiens)9068941 PIDPID:200206
PMID:8239076   PMID:10490836   PMID:14681463   PMID:16616078   PMID:17407547   PMID:17437340   PMID:17543094   PMID:18703674   PMID:19124124   PMID:19937136   PMID:22151798   PMID:22301074  
PMID:23677787   PMID:23950944   PMID:25027053   PMID:25499817   PMID:27142766   PMID:29800601   PMID:30032202   PMID:30121649   PMID:30145695   PMID:30473353   PMID:30541630   PMID:30578299  
PMID:32334023   PMID:33603167   PMID:33756342   PMID:34037422  



TP53
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,939,644 - 52,953,818 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,939,643 - 52,953,786 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,220,545 - 55,234,668 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap12q12-q14NCBI
TP53
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,668,421 - 7,687,490 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,661,779 - 7,687,546 (-)EnsemblGRCh38hg38GRCh38
GRCh37177,571,739 - 7,590,808 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,512,445 - 7,531,642 (-)NCBINCBI36Build 36hg18NCBI36
Build 34177,512,463 - 7,531,642NCBI
Celera177,598,099 - 7,617,224 (-)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef177,465,169 - 7,484,283 (-)NCBIHuRef
CHM1_1177,580,866 - 7,600,003 (-)NCBICHM1_1
T2T-CHM13v2.0177,572,544 - 7,591,594 (-)NCBIT2T-CHM13v2.0
Trp53
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,471,174 - 69,482,699 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,471,185 - 69,482,699 (+)EnsemblGRCm39 Ensembl
GRCm381169,580,348 - 69,591,873 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,580,359 - 69,591,873 (+)EnsemblGRCm38mm10GRCm38
MGSCv371169,393,861 - 69,405,375 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361169,396,176 - 69,408,066 (+)NCBIMGSCv36mm8
Celera1176,543,319 - 76,554,788 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.83NCBI
Tp53
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,798,871 - 54,810,300 (+)NCBIGRCr8
mRatBN7.21054,300,070 - 54,311,525 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,300,048 - 54,311,524 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1058,962,496 - 58,973,951 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,451,039 - 58,462,496 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01053,958,739 - 53,970,151 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,186,299 - 56,198,449 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,187,020 - 56,198,449 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01055,932,658 - 55,944,087 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,399,721 - 56,411,150 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11056,413,290 - 56,424,751 (+)NCBI
Celera1053,454,375 - 53,465,803 (+)NCBICelera
Cytogenetic Map10q24NCBI
Tp53
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554679,252,130 - 9,255,928 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554679,241,391 - 9,256,716 (+)NCBIChiLan1.0ChiLan1.0
TP53
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21915,262,550 - 15,280,917 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11717,217,636 - 17,246,939 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,699,449 - 7,717,812 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,687,132 - 7,706,120 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,684,922 - 7,706,120 (-)Ensemblpanpan1.1panPan2
TP53
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,561,406 - 32,565,149 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,560,598 - 32,574,109 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,699,559 - 32,713,071 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,665,395 - 32,678,721 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,665,394 - 32,678,755 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,633,092 - 32,646,601 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,589,339 - 32,602,824 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,768,467 - 32,781,775 (-)NCBIUU_Cfam_GSD_1.0
Tp53
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,445,372 - 47,461,208 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936595919,428 - 925,425 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936595919,807 - 935,367 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TP53
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,047,686 - 7,065,567 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl167,045,146 - 7,066,223 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605914,343,255 - 14,361,299 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tp53
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478610,263,518 - 10,271,218 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478610,266,316 - 10,282,664 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in TP53
439 total Variants



alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
10 4 23 3 2 5 14 12 23 3 6 3



Ensembl Acc Id: ENSSSCT00000019534   ⟹   ENSSSCP00000019016
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1252,939,645 - 52,953,818 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000063943   ⟹   ENSSSCP00000050664
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1252,939,644 - 52,944,374 (-)Ensembl
Ensembl Acc Id: ENSSSCT00000098124   ⟹   ENSSSCP00000075884
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1252,940,833 - 52,953,818 (-)Ensembl
RefSeq Acc Id: NM_213824   ⟹   NP_998989
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11252,939,643 - 52,953,786 (-)NCBI
Sequence:
RefSeq Acc Id: NP_998989   ⟸   NM_213824
- UniProtKB: Q9TUB2 (UniProtKB/Swiss-Prot),   A0A1B2TT48 (UniProtKB/TrEMBL),   A0A8D0RRN3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSSCP00000019016   ⟸   ENSSSCT00000019534
Ensembl Acc Id: ENSSSCP00000050664   ⟸   ENSSSCT00000063943
Ensembl Acc Id: ENSSSCP00000075884   ⟸   ENSSSCT00000098124
p53 DNA-binding   p53 tetramerisation   p53 transactivation



1 to 40 of 56 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSSSCG00000017950 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSSSCG00015036126 UniProtKB/Swiss-Prot
  ENSSSCG00035050744 UniProtKB/Swiss-Prot
  ENSSSCG00040016253 UniProtKB/Swiss-Prot
  ENSSSCG00045034213 UniProtKB/Swiss-Prot
  ENSSSCG00050006598 UniProtKB/Swiss-Prot
  ENSSSCG00055015386 UniProtKB/Swiss-Prot
  ENSSSCG00060053915 UniProtKB/Swiss-Prot
  ENSSSCG00065049233 UniProtKB/Swiss-Prot
  ENSSSCG00090006714 UniProtKB/Swiss-Prot
  ENSSSCG00115016173 UniProtKB/Swiss-Prot
  ENSSSCG00130026322 UniProtKB/Swiss-Prot
Ensembl Transcript ENSSSCT00000019534 ENTREZGENE
  ENSSSCT00000019534.5 UniProtKB/Swiss-Prot
  ENSSSCT00015048254.1 UniProtKB/Swiss-Prot
  ENSSSCT00035067627.1 UniProtKB/Swiss-Prot
  ENSSSCT00040021964.1 UniProtKB/Swiss-Prot
  ENSSSCT00045058698.1 UniProtKB/Swiss-Prot
  ENSSSCT00050009065.1 UniProtKB/Swiss-Prot
  ENSSSCT00055030523.1 UniProtKB/Swiss-Prot
  ENSSSCT00060073506.1 UniProtKB/Swiss-Prot
  ENSSSCT00065067435.1 UniProtKB/Swiss-Prot
  ENSSSCT00090011860 UniProtKB/Swiss-Prot
  ENSSSCT00115028337 UniProtKB/Swiss-Prot
  ENSSSCT00130051255 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.720 UniProtKB/Swiss-Prot
  4.10.170.10 UniProtKB/Swiss-Prot
  6.10.50.20 UniProtKB/Swiss-Prot
InterPro p53-like_TF_DNA-bd UniProtKB/Swiss-Prot
  p53/RUNT-type_TF_DNA-bd_sf UniProtKB/Swiss-Prot
  p53_DNA-bd UniProtKB/Swiss-Prot
  p53_tetramer_sf UniProtKB/Swiss-Prot
  p53_tetrameristn UniProtKB/Swiss-Prot
  p53_transactivation_domain UniProtKB/Swiss-Prot
  p53_tumour_suppressor UniProtKB/Swiss-Prot
KEGG Report ssc:397276 UniProtKB/Swiss-Prot
NCBI Gene TP53 ENTREZGENE
PANTHER CELLULAR TUMOR ANTIGEN P53 UniProtKB/Swiss-Prot
  PTHR11447 UniProtKB/Swiss-Prot
Pfam P53 UniProtKB/Swiss-Prot
1 to 40 of 56 rows