RGD Reference Report - Diagnostic utility of phosphatase and tensin homolog, beta-catenin, and p53 for endometrial carcinoma by thin-layer endometrial preparations. - Rat Genome Database

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Diagnostic utility of phosphatase and tensin homolog, beta-catenin, and p53 for endometrial carcinoma by thin-layer endometrial preparations.

Authors: Norimatsu, Y  Miyamoto, M  Kobayashi, TK  Moriya, T  Shimizu, K  Yanoh, K  Tsukayama, C  Miyake, Y  Ohno, E 
Citation: Norimatsu Y, etal., Cancer. 2008 Jun 25;114(3):155-64.
RGD ID: 2298525
Pubmed: PMID:18431720   (View Abstract at PubMed)
DOI: DOI:10.1002/cncr.23495   (Journal Full-text)

BACKGROUND: For the current report, the authors examined the characteristic features of morphology and molecular biology of phosphatase and tensin homolog (PTEN), beta-catenin, and p53 immunocytochemistry in endometrial carcinoma by using thin-layer cytologic preparations. METHODS: During a 6-month period, 120 endometrial samples were collected directly by using the Uterobrush, and thin-layer specimens were prepared. Immunocytochemical expression levels of PTEN, beta-catenin, and p53 were investigated by using 40 specimens of endometrial carcinoma (EC), and 30 specimens each of proliferative endometrium, secretory endometrium, and atrophic endometrium. RESULTS: For PTEN immunoreactivity, the a cutoff value of 50% PTEN expression appeared to be useful for the correct diagnosis of EC in endometrial cytology. For beta-catenin immunoreactivity, an increase in cytoplasmic and nuclear beta-catenin expression and a loss of beta-catenin expression appeared to be useful for the correct diagnosis of EC in endometrial cytology and may aid in the stratification of EC into low grade and high grade EC. For p53 immunoreactivity, the application of a cutoff score >or=4 for nuclear p53 expression appeared to be useful for the diagnosis of high-grade EC in endometrial cytology. CONCLUSIONS: Immunocytochemical findings from a combination of PTEN, beta-catenin, and p53, in addition to cytomorphologic features, appeared to be useful for the more accurate diagnosis of EC in endometrial cytology.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TP53Humanendometrial carcinoma severityIEP protein:increased expression:epithelial cell and endometriumRGD 
Tp53Ratendometrial carcinoma severityISOTP53 (Homo sapiens)protein:increased expression:epithelial cell and endometriumRGD 
Trp53Mouseendometrial carcinoma severityISOTP53 (Homo sapiens)protein:increased expression:epithelial cell and endometriumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Tp53  (tumor protein p53)

Genes (Mus musculus)
Trp53  (transformation related protein 53)

Genes (Homo sapiens)
TP53  (tumor protein p53)


Additional Information