Tbx1 (T-box 1) - Rat Genome Database

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Gene: Tbx1 (T-box 1) Mus musculus
Analyze
Symbol: Tbx1
Name: T-box 1
RGD ID: 1317101
MGI Page MGI
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; positive regulation of cell population proliferation; and vasculature development. Localizes to nucleus. Is expressed in several structures, including alimentary system; brain; branchial arch; ear; and heart. Used to study DiGeorge syndrome; autism spectrum disorder; otitis media; and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in DiGeorge syndrome; tetralogy of Fallot; and velocardiofacial syndrome. Orthologous to human TBX1 (T-box transcription factor 1); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3-isobutyl-1-methyl-7H-xanthine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: nmf21; nmf219; T-box protein 1; T-box transcription factor TBX1; testis-specific T-box protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391618,399,729 - 18,409,421 (-)NCBIGRCm39mm39
GRCm39 Ensembl1618,399,729 - 18,409,421 (-)Ensembl
GRCm381618,580,979 - 18,590,671 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1618,580,979 - 18,590,671 (-)EnsemblGRCm38mm10GRCm38
MGSCv371618,581,806 - 18,587,062 (-)NCBIGRCm37mm9NCBIm37
MGSCv361618,495,276 - 18,500,532 (-)NCBImm8
Celera1619,155,983 - 19,161,240 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.51NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IMP)
anterior/posterior pattern specification  (IGI,IMP)
aorta morphogenesis  (IGI,IMP)
artery morphogenesis  (IGI,IMP)
blood vessel development  (IGI,IMP)
blood vessel morphogenesis  (IMP)
blood vessel remodeling  (IGI)
branching involved in blood vessel morphogenesis  (TAS)
cell fate specification  (IBA,IGI,IMP)
cell population proliferation  (IDA)
cellular response to fibroblast growth factor stimulus  (IMP)
cellular response to retinoic acid  (IEP)
cochlea morphogenesis  (IGI,IMP)
coronary artery morphogenesis  (IMP,TAS)
determination of left/right symmetry  (IMP)
ear morphogenesis  (IMP)
embryonic cranial skeleton morphogenesis  (IMP)
embryonic viscerocranium morphogenesis  (ISO,ISS)
enamel mineralization  (IMP)
epithelial cell differentiation  (IMP)
face morphogenesis  (IMP)
hard palate development  (IMP)
heart development  (IGI,IMP,ISO,ISS)
heart morphogenesis  (IMP)
inner ear morphogenesis  (IMP)
lymph vessel development  (IMP)
mesenchymal cell apoptotic process  (IMP)
mesoderm development  (IMP)
middle ear morphogenesis  (IMP)
multicellular organism development  (IEA)
muscle cell fate commitment  (IMP)
muscle organ development  (IMP)
muscle organ morphogenesis  (IGI)
muscle tissue morphogenesis  (IMP)
negative regulation of cell differentiation  (IMP)
negative regulation of mesenchymal cell apoptotic process  (IGI)
negative regulation of transcription by RNA polymerase II  (IMP)
neural crest cell migration  (IMP)
odontogenesis of dentin-containing tooth  (IMP)
otic vesicle morphogenesis  (IMP)
outer ear morphogenesis  (IMP)
outflow tract morphogenesis  (IGI,IMP)
outflow tract septum morphogenesis  (IMP)
parathyroid gland development  (ISO,ISS)
pattern specification process  (IGI,IMP)
pharyngeal system development  (IGI,IMP,ISO,ISS)
positive regulation of cell population proliferation  (IMP)
positive regulation of epithelial cell proliferation  (IMP)
positive regulation of MAPK cascade  (IMP)
positive regulation of mesenchymal cell proliferation  (IMP)
positive regulation of protein phosphorylation  (IMP)
positive regulation of secondary heart field cardioblast proliferation  (IDA)
positive regulation of tongue muscle cell differentiation  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,IMP)
positive regulation of transcription, DNA-templated  (IDA,ISO)
regulation of animal organ morphogenesis  (IGI,IMP)
regulation of transcription by RNA polymerase II  (IBA,IGI)
regulation of transcription, DNA-templated  (IEA)
retinoic acid receptor signaling pathway  (IMP)
semicircular canal morphogenesis  (IGI)
sensory perception of sound  (IMP)
social behavior  (IMP)
soft palate development  (ISO,ISS)
thymus development  (IMP,ISO,ISS)
thyroid gland development  (IGI,IMP)
tongue morphogenesis  (IMP)
vagus nerve morphogenesis  (IMP)

Cellular Component
nucleus  (IDA,ISO,ISS)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
aberrant origin of the right subclavian artery  (IAGP)
abnormal accessory nerve morphology  (IAGP)
abnormal aortic arch development  (IAGP)
abnormal aortic arch morphology  (IAGP)
abnormal arcus anterior morphology  (IAGP)
abnormal artery development  (IAGP)
abnormal atrioventricular valve morphology  (IAGP)
abnormal auditory brainstem response  (IEA)
abnormal blood vessel morphology  (IAGP)
abnormal cardiac neural crest cell migration  (IAGP)
abnormal cardiac outflow tract development  (IAGP)
abnormal cardiovascular development  (IAGP)
abnormal cardiovascular system morphology  (IAGP)
abnormal cervical atlas morphology  (IAGP)
abnormal cervical axis morphology  (IAGP)
abnormal cervical vertebrae morphology  (IAGP)
abnormal cochlea morphology  (IAGP)
abnormal cochlear ganglion morphology  (IAGP)
abnormal common crus morphology  (IAGP)
abnormal conotruncus morphology  (IAGP)
abnormal conotruncus septation  (IAGP)
abnormal coronary vessel morphology  (IAGP)
abnormal cranial nerve morphology  (IAGP)
abnormal cranial neural crest cell migration  (IAGP)
abnormal craniofacial bone morphology  (IAGP)
abnormal craniofacial development  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal cranium morphology  (IAGP)
abnormal crista ampullaris morphology  (IAGP)
abnormal dorsal aorta morphology  (IAGP)
abnormal ear development  (IAGP)
abnormal ear morphology  (IAGP)
abnormal ear shape  (IAGP)
abnormal endolymphatic duct morphology  (IAGP)
abnormal external auditory canal morphology  (IAGP)
abnormal facial morphology  (IAGP)
abnormal facial nerve morphology  (IAGP)
abnormal fetal atrioventricular canal morphology  (IAGP)
abnormal fourth pharyngeal arch artery morphology  (IAGP)
abnormal fourth pharyngeal arch morphology  (IAGP)
abnormal fourth pharyngeal pouch morphology  (IAGP)
abnormal glossopharyngeal ganglion morphology  (IAGP)
abnormal glossopharyngeal nerve morphology  (IAGP)
abnormal heart and great vessel attachment  (IAGP)
abnormal heart development  (IAGP)
abnormal heart morphology  (IAGP)
abnormal heart shape  (IAGP)
abnormal heart ventricle morphology  (IAGP)
abnormal hyoid bone morphology  (IAGP)
abnormal hypoglossal cord morphology  (IAGP)
abnormal incus morphology  (IAGP)
abnormal inner ear morphology  (IAGP)
abnormal interventricular septum morphology  (IAGP)
abnormal laryngeal muscle morphology  (IAGP)
abnormal lateral semicircular canal morphology  (IAGP)
abnormal lymphangiogenesis  (IAGP)
abnormal lymphatic vessel morphology  (IAGP)
abnormal malleus morphology  (IAGP)
abnormal mandibular nerve branching  (IAGP)
abnormal mesenchyme morphology  (IAGP)
abnormal middle ear morphology  (IAGP)
abnormal middle ear ossicle morphology  (IAGP)
abnormal motor capabilities/coordination/movement  (IAGP)
abnormal myogenesis  (IAGP)
abnormal neural crest cell migration  (IAGP)
abnormal neuron differentiation  (IAGP)
abnormal organ of Corti supporting cell differentiation  (IAGP)
abnormal organ of Corti supporting cell morphology  (IAGP)
abnormal otic capsule morphology  (IAGP)
abnormal outer ear morphology  (IAGP)
abnormal palatal shelf fusion at midline  (IAGP)
abnormal palate morphology  (IAGP)
abnormal pharyngeal arch artery morphology  (IAGP)
abnormal pharyngeal arch morphology  (IAGP)
abnormal pharyngeal muscle morphology  (IAGP)
abnormal pharyngeal pouch morphology  (IAGP)
abnormal posterior semicircular canal morphology  (IAGP)
abnormal response to novel object  (IAGP)
abnormal second pharyngeal arch artery morphology  (IAGP)
abnormal semicircular canal ampulla morphology  (IAGP)
abnormal semicircular canal morphology  (IAGP)
abnormal semilunar valve morphology  (IAGP)
abnormal sixth pharyngeal arch artery morphology  (IAGP)
abnormal sixth pharyngeal arch morphology  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal social/conspecific interaction  (IAGP)
abnormal spatial working memory  (IAGP)
abnormal stapes morphology  (IAGP)
abnormal stria vascularis morphology  (IAGP)
abnormal strial marginal cell morphology  (IAGP)
abnormal subclavian artery morphology  (IAGP)
abnormal temporal bone morphology  (IAGP)
abnormal third pharyngeal arch artery morphology  (IAGP)
abnormal third pharyngeal arch morphology  (IAGP)
abnormal thymus development  (IAGP)
abnormal thyroid cartilage morphology  (IAGP)
abnormal trigeminal nerve morphology  (IAGP)
abnormal truncus arteriosus septation  (IAGP)
abnormal tympanic ring morphology  (IAGP)
abnormal upper incisor morphology  (IAGP)
abnormal vagus ganglion morphology  (IAGP)
abnormal vagus nerve morphology  (IAGP)
abnormal vascular smooth muscle physiology  (IAGP)
abnormal vertebral arch morphology  (IAGP)
abnormal vestibular saccule morphology  (IAGP)
abnormal vestibulocochlear ganglion morphology  (IAGP)
abnormal vestibulocochlear nerve morphology  (IAGP)
abnormal zygomatic arch morphology  (IAGP)
absent arcus anterior  (IAGP)
absent cochlea  (IAGP)
absent facial muscle  (IAGP)
absent fourth pharyngeal arch  (IAGP)
absent fourth pharyngeal arch artery  (IAGP)
absent inner ear  (IAGP)
absent inner ear vestibule  (IAGP)
absent lateral semicircular canal  (IAGP)
absent mandibular coronoid process  (IAGP)
absent masseter muscle  (IAGP)
absent middle ear ossicles  (IAGP)
absent outer ear  (IAGP)
absent parathyroid glands  (IAGP)
absent pharyngeal arch arteries  (IAGP)
absent pharyngeal arches  (IAGP)
absent pterygoid muscle  (IAGP)
absent second pharyngeal arch  (IAGP)
absent semicircular canals  (IAGP)
absent sixth pharyngeal arch  (IAGP)
absent sixth pharyngeal arch artery  (IAGP)
absent stapes  (IAGP)
absent strial marginal cells  (IAGP)
absent third pharyngeal arch  (IAGP)
absent third pharyngeal arch artery  (IAGP)
absent tubotympanic recess  (IAGP)
absent tympanic ring  (IAGP)
absent ultimobranchial body  (IAGP)
absent upper incisors  (IAGP)
absent vertebral body  (IAGP)
absent zygomatic arch  (IAGP)
anomalous pulmonary venous connection  (IAGP)
anotia  (IAGP)
athymia  (IAGP)
atrial septal defect  (IAGP)
bidirectional circling  (IAGP)
cervical aortic arch  (IAGP)
chylous ascites  (IAGP)
circling  (IAGP)
cleft palate  (IAGP)
cleft secondary palate  (IAGP)
cochlear ganglion degeneration  (IAGP)
collapsed Reissner membrane  (IAGP)
common atrioventricular valve  (IAGP)
curly tail  (IAGP)
cyanosis  (IAGP)
deafness  (IAGP)
decreased embryo size  (IAGP)
decreased mitotic index  (IAGP)
decreased prepulse inhibition  (IAGP)
decreased tympanic ring size  (IAGP)
decreased vocalization  (IAGP)
dehydration  (IAGP)
dilated endolymphatic duct  (IAGP)
double aortic arch  (IAGP)
double outlet right ventricle  (IAGP)
ear lobe hypoplasia  (IAGP)
ectopic thymus  (IAGP)
edema  (IEA)
fourth pharyngeal arch artery hypoplasia  (IAGP)
fourth pharyngeal arch hypoplasia  (IAGP)
fusion of basioccipital and basisphenoid bone  (IAGP)
fusion of glossopharyngeal and vagus nerve  (IAGP)
fusion of vertebral bodies  (IAGP)
glossopharyngeal nerve hypoplasia  (IAGP)
head bobbing  (IEA)
head tilt  (IAGP)
hydrops fetalis  (IAGP)
hyoid bone hypoplasia  (IAGP)
hyperactivity  (IAGP)
increased apoptosis  (IAGP)
increased or absent threshold for auditory brainstem response  (IAGP)
increased susceptibility to otitis media  (IAGP)
increased thigmotaxis  (IAGP)
inner ear hypoplasia  (IAGP)
interrupted aortic arch  (IAGP)
interrupted aortic arch, type b  (IAGP)
kinked tail  (IAGP)
kyphosis  (IAGP)
lowered ear position  (IAGP)
lymphangiectasis  (IAGP)
malleus hypoplasia  (IAGP)
micrognathia  (IAGP)
muscular ventricular septal defect  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
neonatal lethality, incomplete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
organ of Corti degeneration  (IAGP)
otic capsule hypoplasia  (IAGP)
otic vesicle hypoplasia  (IAGP)
palatal shelves fail to meet at midline  (IAGP)
perimembraneous ventricular septal defect  (IAGP)
persistent truncus arteriosis  (IAGP)
pharynx hypoplasia  (IAGP)
pharynx stenosis  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
respiratory failure  (IAGP)
retroesophageal right subclavian artery  (IAGP)
right aortic arch  (IAGP)
second pharyngeal arch hypoplasia  (IAGP)
sensorineural hearing loss  (IAGP)
short mandible  (IAGP)
short neck  (IAGP)
skin edema  (IAGP)
small cricoid cartilage  (IAGP)
small ears  (IAGP)
small otic vesicle  (IAGP)
small pharyngeal arch  (IAGP)
small scala media  (IAGP)
small second pharyngeal arch  (IAGP)
small thymus  (IAGP)
small thyroid cartilage  (IAGP)
small thyroid gland  (IAGP)
supravalvar pulmonary trunk stenosis  (IAGP)
temporal bone hypoplasia  (IAGP)
thin malleus neck  (IAGP)
thymus hypoplasia  (IAGP)
utricular degeneration  (IAGP)
vascular smooth muscle hypoplasia  (IAGP)
ventricular septal defect  (IAGP)
vestibular saccular degeneration  (IAGP)
References

Additional References at PubMed
PMID:7920656   PMID:8585934   PMID:8853987   PMID:8878690   PMID:9060415   PMID:9119393   PMID:9250875   PMID:9268629   PMID:9337409   PMID:9405660   PMID:9521878   PMID:9740669  
PMID:9774969   PMID:10337614   PMID:10349636   PMID:10704284   PMID:10963672   PMID:11024289   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11239417   PMID:11242049   PMID:11412027  
PMID:11709542   PMID:11804793   PMID:11971873   PMID:12223415   PMID:12223416   PMID:12223417   PMID:12231626   PMID:12441304   PMID:12464426   PMID:12466851   PMID:12477932   PMID:12533514  
PMID:12539040   PMID:12617845   PMID:12810603   PMID:12812790   PMID:12858556   PMID:12913075   PMID:12915323   PMID:12950083   PMID:14614146   PMID:14975726   PMID:15064766   PMID:15084464  
PMID:15175244   PMID:15190012   PMID:15385444   PMID:15469978   PMID:15581866   PMID:15618518   PMID:15652707   PMID:15778864   PMID:15789410   PMID:15817220   PMID:15843409   PMID:15882861  
PMID:15996652   PMID:16109395   PMID:16141072   PMID:16141073   PMID:16141220   PMID:16221730   PMID:16258075   PMID:16284121   PMID:16365290   PMID:16399080   PMID:16444712   PMID:16452092  
PMID:16452098   PMID:16530750   PMID:16556915   PMID:16586352   PMID:16600992   PMID:16602821   PMID:16684884   PMID:16687132   PMID:16696966   PMID:16720879   PMID:16783635   PMID:16839542  
PMID:16914493   PMID:17000704   PMID:17047027   PMID:17074316   PMID:17097888   PMID:17107996   PMID:17117436   PMID:17164259   PMID:17238155   PMID:17286298   PMID:17321697   PMID:17344228  
PMID:17382312   PMID:17384148   PMID:17442300   PMID:17515859   PMID:17526730   PMID:17610275   PMID:17652354   PMID:17683524   PMID:17825816   PMID:17916582   PMID:18039967   PMID:18082678  
PMID:18231833   PMID:18287559   PMID:18328475   PMID:18332117   PMID:18334251   PMID:18356246   PMID:18572158   PMID:18583714   PMID:18703040   PMID:18816853   PMID:18816858   PMID:18848976  
PMID:19178302   PMID:19198652   PMID:19233155   PMID:19235731   PMID:19247433   PMID:19253341   PMID:19299468   PMID:19389367   PMID:19476657   PMID:19531352   PMID:19700621   PMID:19745164  
PMID:19805316   PMID:19855134   PMID:20110535   PMID:20122914   PMID:20129917   PMID:20214979   PMID:20215350   PMID:20299672   PMID:20346939   PMID:20439995   PMID:20463296   PMID:20501333  
PMID:20534536   PMID:20549734   PMID:20685737   PMID:20699298   PMID:20736290   PMID:20807528   PMID:20807544   PMID:20807701   PMID:20816801   PMID:20843830   PMID:20939858   PMID:21107579  
PMID:21123999   PMID:21145505   PMID:21149574   PMID:21173260   PMID:21177346   PMID:21267068   PMID:21364285   PMID:21382375   PMID:21438027   PMID:21512031   PMID:21664901   PMID:21757651  
PMID:21821099   PMID:21831920   PMID:21873635   PMID:21908517   PMID:22116936   PMID:22164283   PMID:22207710   PMID:22219655   PMID:22275070   PMID:22318627   PMID:22367967   PMID:22371266  
PMID:22381690   PMID:22396765   PMID:22438823   PMID:22495305   PMID:22629441   PMID:22674535   PMID:22842189   PMID:22921202   PMID:22972661   PMID:22982415   PMID:23011393   PMID:23077214  
PMID:23093675   PMID:23112163   PMID:23261931   PMID:23606270   PMID:23642587   PMID:23797856   PMID:23934214   PMID:23945394   PMID:23971992   PMID:24009395   PMID:24068957   PMID:24335256  
PMID:24356861   PMID:24357327   PMID:24564535   PMID:24680892   PMID:24705356   PMID:24727668   PMID:24797903   PMID:24812002   PMID:24821700   PMID:24924197   PMID:24996922   PMID:25053428  
PMID:25178196   PMID:25190705   PMID:25197075   PMID:25209980   PMID:25220152   PMID:25242040   PMID:25249461   PMID:25336743   PMID:25371366   PMID:25410658   PMID:25452432   PMID:25452572  
PMID:25556186   PMID:25605943   PMID:25670795   PMID:25912687   PMID:25915623   PMID:25997579   PMID:26284287   PMID:26295701   PMID:26382615   PMID:26387456   PMID:26577899   PMID:26689739  
PMID:26708418   PMID:26755698   PMID:27005988   PMID:27022145   PMID:27256596   PMID:27633995   PMID:28105375   PMID:28172500   PMID:28173146   PMID:28346476   PMID:28357999   PMID:28438970  
PMID:28687930   PMID:28754980   PMID:28838968   PMID:28884822   PMID:29217752   PMID:29367466   PMID:29409032   PMID:29509905   PMID:29534062   PMID:29866044   PMID:29956664   PMID:30008200  
PMID:30016433   PMID:30087351   PMID:30121012   PMID:30154444   PMID:30166330   PMID:30408103   PMID:30504125   PMID:30543152   PMID:30578278   PMID:30787001   PMID:30933971   PMID:31180501  
PMID:31341279   PMID:31412026   PMID:31422678   PMID:31444215   PMID:31535973   PMID:31550482   PMID:31562240   PMID:31758944   PMID:31776260   PMID:32014863   PMID:32041892   PMID:32105214  
PMID:32107392   PMID:32442036   PMID:32467237   PMID:32866472   PMID:32901292   PMID:33066956  


Genomics

Comparative Map Data
Tbx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391618,399,729 - 18,409,421 (-)NCBIGRCm39mm39
GRCm39 Ensembl1618,399,729 - 18,409,421 (-)Ensembl
GRCm381618,580,979 - 18,590,671 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1618,580,979 - 18,590,671 (-)EnsemblGRCm38mm10GRCm38
MGSCv371618,581,806 - 18,587,062 (-)NCBIGRCm37mm9NCBIm37
MGSCv361618,495,276 - 18,500,532 (-)NCBImm8
Celera1619,155,983 - 19,161,240 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.51NCBI
TBX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2219,756,703 - 19,783,593 (+)EnsemblGRCh38hg38GRCh38
GRCh382219,756,703 - 19,783,593 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372219,744,226 - 19,771,116 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,124,226 - 18,151,116 (+)NCBINCBI36hg18NCBI36
Build 342218,118,779 - 18,129,409NCBI
Celera223,596,280 - 3,623,183 (+)NCBI
Cytogenetic Map22q11.21NCBI
HuRef223,364,192 - 3,390,621 (+)NCBIHuRef
CHM1_12219,744,073 - 19,770,823 (+)NCBICHM1_1
Tbx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21182,409,275 - 82,419,058 (+)NCBI
Rnor_6.0 Ensembl1186,552,022 - 86,560,969 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01186,552,022 - 86,561,647 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01189,651,955 - 89,661,553 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41184,400,980 - 84,410,631 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11184,445,104 - 84,451,228 (+)NCBI
Celera1181,184,983 - 81,193,848 (+)NCBICelera
Cytogenetic Map11q23NCBI
Tbx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544218,319,762 - 18,325,337 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544218,320,674 - 18,327,062 (-)NCBIChiLan1.0ChiLan1.0
TBX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12218,192,954 - 18,213,786 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0222,521,080 - 2,541,267 (+)NCBIMhudiblu_PPA_v0panPan3
TBX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12629,529,071 - 29,533,240 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2629,528,878 - 29,532,784 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2629,486,387 - 29,494,624 (-)NCBI
ROS_Cfam_1.02630,932,031 - 30,939,925 (-)NCBI
UMICH_Zoey_3.12628,979,960 - 28,987,853 (-)NCBI
UNSW_CanFamBas_1.02628,605,398 - 28,613,298 (-)NCBI
UU_Cfam_GSD_1.02629,690,874 - 29,698,814 (-)NCBI
Tbx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118139,083,586 - 139,092,022 (-)NCBI
SpeTri2.0NW_0049366193,662,567 - 3,670,470 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1451,289,143 - 51,296,725 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11451,289,376 - 51,297,110 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TBX1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1195,980,114 - 5,986,313 (-)NCBI
ChlSab1.1 Ensembl195,980,587 - 5,987,244 (-)Ensembl
Tbx1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624747386,763 - 395,515 (+)NCBI

Position Markers
Tbx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371618,583,560 - 18,584,249UniSTSGRCm37
MGSCv371618,584,187 - 18,585,156UniSTSGRCm37
Celera1619,157,738 - 19,158,427UniSTS
Celera1619,158,365 - 19,159,334UniSTS
Cytogenetic Map16A3UniSTS
cM Map1611.35UniSTS
cM Map1611.35UniSTS
Tbx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381618,583,467 - 18,584,156UniSTSGRCm38
MGSCv371618,583,560 - 18,584,249UniSTSGRCm37
Celera1619,157,738 - 19,158,427UniSTS
Cytogenetic Map16A3UniSTS
cM Map1611.35UniSTS
Tbx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16A3UniSTS
Tbx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16A3UniSTS
Tbx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16A3UniSTS
Tbx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381618,584,094 - 18,585,063UniSTSGRCm38
MGSCv371618,584,187 - 18,585,156UniSTSGRCm37
Celera1619,158,365 - 19,159,334UniSTS
Cytogenetic Map16A3UniSTS
Tbx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16A3UniSTS
Tbx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16A3UniSTS
Tbx1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16A3UniSTS
Cytogenetic Map16B1-B3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141060Pbwg19_mpostnatal body weight growth 19 (mouse)Not determined16120963024Mouse
1300632Loca2_mlocomotor activity 2 (mouse)Not determined16122682710Mouse
10043879Adip25_madiposity 25 (mouse)Not determined16122702454Mouse
1301575Tanidd3_mtally ho associated non-insulin dependednt diabetes mellitus 3 (mouse)Not determined16123079875Mouse
1301970Heal11_mwound healing/regeneration 11 (mouse)Not determined16124445989Mouse
4141468Nhdlq10_mnon-HDL QTL 10 (mouse)Not determined16124445989Mouse
1301384Dice1_mdetermination of interleukin 4 commitment 1 (mouse)Not determined16128616494Mouse
10402497Lmr23_mleishmaniasis resistance 23 (mouse)Not determined16129856336Mouse
1301559Bbaa19_mB.burgdorferi-associated arthritis 19 (mouse)Not determined16130249113Mouse
10412289Ppsl_mplasma P-selectin levels (mouse)Not determined16130996708Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16350000040000000Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16350000051600000Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16350000064800000Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16400000064800000Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16450000044700000Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16482756438827664Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16595650239956690Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16595650239956690Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16595650239956690Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16595650239956690Mouse
4141010Bbq1_mbrain and behavior QTL 1 (mouse)Not determined16665914535200846Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16672511565669666Mouse
4142460Nilac10_mnicotine induced locomotor activity 10 (mouse)Not determined16731904229406653Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16840730242407302Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16860000091100000Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined161006288144062881Mouse
1301086Lprm5_mlymphoproliferation modifier 5 (mouse)Not determined161203007246030171Mouse
1301841Lrnx9_mlearning-contextual 9 (mouse)Not determined161240654246406653Mouse
15092082Igly9_mIgG glycosylation 9, GP17b (mouse)161495735920284763Mouse
10045614Rapop6_mradiation-induced apoptosis 6 (mouse)Not determined161498410348984214Mouse
4142236Pstc4_mperiosteal circumference 4 (mouse)Not determined161570409149704294Mouse

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir182mmu-miR-182-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI22381690

Predicted Target Of
Summary Value
Count of predictions:235
Count of miRNA genes:203
Interacting mature miRNAs:221
Transcripts:ENSMUST00000009241
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001285472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001285476 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001373938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_011532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC003066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC003067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC008019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC133488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF326960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF349658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK029096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC139474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U15565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U57327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000009241   ⟹   ENSMUSP00000009241
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1618,581,704 - 18,590,671 (-)Ensembl
RefSeq Acc Id: ENSMUST00000232143   ⟹   ENSMUSP00000155894
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1618,581,804 - 18,586,969 (-)Ensembl
RefSeq Acc Id: ENSMUST00000232335   ⟹   ENSMUSP00000156061
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1618,580,979 - 18,586,969 (-)Ensembl
RefSeq Acc Id: ENSMUST00000232557
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1618,580,980 - 18,583,328 (-)Ensembl
RefSeq Acc Id: ENSMUST00000232589   ⟹   ENSMUSP00000156125
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1618,586,544 - 18,588,808 (-)Ensembl
RefSeq Acc Id: NM_001285472   ⟹   NP_001272401
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391618,400,454 - 18,409,421 (-)NCBI
GRCm381618,581,704 - 18,590,671 (-)NCBI
Celera1619,155,974 - 19,164,943 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001285476   ⟹   NP_001272405
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391618,400,454 - 18,405,719 (-)NCBI
GRCm381618,581,704 - 18,586,969 (-)NCBI
Celera1619,155,974 - 19,164,943 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001373938   ⟹   NP_001360867
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391618,399,729 - 18,407,649 (-)NCBI
GRCm381618,580,979 - 18,588,899 (-)NCBI
RefSeq Acc Id: NM_011532   ⟹   NP_035662
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391618,400,454 - 18,405,719 (-)NCBI
GRCm381618,581,704 - 18,586,969 (-)NCBI
MGSCv371618,581,806 - 18,587,062 (-)RGD
Celera1619,155,974 - 19,164,943 (-)NCBI
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006521978   ⟹   XP_006522041
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391618,400,460 - 18,407,502 (-)NCBI
GRCm381618,581,710 - 18,588,752 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006521979   ⟹   XP_006522042
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391618,400,460 - 18,407,636 (-)NCBI
GRCm381618,581,710 - 18,588,909 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_035662   ⟸   NM_011532
- Peptide Label: isoform 1
- UniProtKB: P70323 (UniProtKB/Swiss-Prot),   B9EII4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001272401   ⟸   NM_001285472
- Peptide Label: isoform 2
- Sequence:
RefSeq Acc Id: NP_001272405   ⟸   NM_001285476
- Peptide Label: isoform 3
- Sequence:
RefSeq Acc Id: XP_006522042   ⟸   XM_006521979
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006522041   ⟸   XM_006521978
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001360867   ⟸   NM_001373938
- Peptide Label: isoform 4
RefSeq Acc Id: ENSMUSP00000009241   ⟸   ENSMUST00000009241
RefSeq Acc Id: ENSMUSP00000155894   ⟸   ENSMUST00000232143
RefSeq Acc Id: ENSMUSP00000156061   ⟸   ENSMUST00000232335
RefSeq Acc Id: ENSMUSP00000156125   ⟸   ENSMUST00000232589

Promoters
RGD ID:6847329
Promoter ID:MM_ACW:20029
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:TBX1.DSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361618,581,561 - 18,582,162 (-)MPROMDB
RGD ID:6827549
Promoter ID:MM_KWN:20398
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:NM_011532
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361618,586,411 - 18,586,911 (-)MPROMDB
RGD ID:8685684
Promoter ID:EPDNEW_M20873
Type:multiple initiation site
Name:Tbx1_1
Description:Mus musculus T-box 1 , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381618,586,994 - 18,587,054EPDNEW
RGD ID:6827550
Promoter ID:MM_KWN:20400
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:UC007YOH.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361618,590,361 - 18,590,861 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:98493 AgrOrtholog
Ensembl Genes ENSMUSG00000009097 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000009241 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000155894 UniProtKB/TrEMBL
  ENSMUSP00000156061 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000156125 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000009241 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000232143 UniProtKB/TrEMBL
  ENSMUST00000232335 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000232589 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T-box_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_T-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_T-box_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21380 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:98493 ENTREZGENE
NCBI Gene 21380 ENTREZGENE
PANTHER PTHR11267 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam T-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tbx1 PhenoGen
PRINTS TBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBOX_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A338P6A8_MOUSE UniProtKB/TrEMBL
  A0A338P6V6_MOUSE UniProtKB/TrEMBL
  B9EII4 ENTREZGENE, UniProtKB/TrEMBL
  F6ZP09_MOUSE UniProtKB/TrEMBL
  P70323 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q60706 UniProtKB/Swiss-Prot
  Q99MP0 UniProtKB/Swiss-Prot
  Q99P22 UniProtKB/Swiss-Prot