RGD Reference Report - Prognosis of adenocarcinoma of the uterine cervix: p53 expression correlates with higher incidence of mortality. - Rat Genome Database

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Prognosis of adenocarcinoma of the uterine cervix: p53 expression correlates with higher incidence of mortality.

Authors: Baalbergen, A  Ewing-Graham, PC  Eijkemans, MJ  Helmerhorst, TJ 
Citation: Baalbergen A, etal., Int J Cancer. 2007 Jul 1;121(1):106-10.
RGD ID: 2298527
Pubmed: PMID:17354237   (View Abstract at PubMed)
DOI: DOI:10.1002/ijc.22678   (Journal Full-text)

We investigated the significance of prognostic markers-estrogen receptor, progesterone receptor, p53, MIB-1 and bcl-2 - in adenocarcinoma of the uterine cervix. In 101 patients with primary cervical adenocarcinoma, treated from 1989 to 2000, we evaluated clinical parameters in relation to these prognostic markers. Mean age of patients was 45 years. Seventy eight percent of the patients were in FIGO stage I, 16% stage II, 7% stage III and IV. estrogen receptor, progesterone receptor, p53 and bcl-2 immunoreactivity was scored as 0 (up to 5% positive cells), 1+ (5-25% of cells positive), 2+ (26-50% of cells positive), 3+ (51-75% of cells positive) or 4+ (>76% of cells positive). MIB-1 was scored in 10 categories: 0-10, 11-20, 21-30, 31-40, 41-50, 51-60, 61-70, 71-80, 81-90, 91-100. The overall survival rate was 67%. Survival was not influenced by estrogen receptor, progesterone receptor, MIB-1, or bcl-2 strongly positive staining. Only p53 showed significant influence on survival, even when adjusted for stage or tumor grade. In conclusion, it does not seems useful to determine estrogen receptor, progesterone receptor, MIB-1 or bcl-2 in cervical adenocarcinomas as an indication of prognosis: survival is not influenced by presence or absence. However, if p53 staining is strongly positive survival is significantly worse than in tumors scored as negative or weak positive.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TP53Humancervical adenocarcinoma disease_progressionIEP  RGD 
Tp53Ratcervical adenocarcinoma disease_progressionISOTP53 (Homo sapiens) RGD 
Trp53Mousecervical adenocarcinoma disease_progressionISOTP53 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tp53  (tumor protein p53)

Genes (Mus musculus)
Trp53  (transformation related protein 53)

Genes (Homo sapiens)
TP53  (tumor protein p53)


Additional Information