RGD Reference Report - Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1. - Rat Genome Database

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Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1.

Authors: Fan, Huizhen  Jiang, Chunyan  Zhong, Baoyuan  Sheng, Jianwen  Chen, Ting  Chen, Qingqing  Li, Jingtao  Zhao, Hongchuan 
Citation: Fan H, etal., J Immunol Res. 2018 Jan 10;2018:5408324. doi: 10.1155/2018/5408324. eCollection 2018.
RGD ID: 14995449
Pubmed: PMID:29546074   (View Abstract at PubMed)
PMCID: PMC5818890   (View Article at PubMed Central)
DOI: DOI:10.1155/2018/5408324   (Journal Full-text)

Matrine may be protective against colorectal cancer (CRC), but how it may work is unclear. Thus, we explored the underlying mechanisms of matrine in CRC. Matrine-related proteins and CRC-related genes and therapeutic targets of matrine in CRC were predicted using a network pharmacology approach. Five targets, including interleukin 6 (IL-6), the 26S proteasome, tumor necrosis factor alpha (TNF-α), transforming growth factor beta 1 (TGF-β1) and p53, and corresponding high-mobility group box 1 (HMGB1) signaling and T helper cell differentiation were thought to be associated with matrine's mechanism. Expression of predicted serum targets were verified in a 1,2-dimethylhydrazine dihydrochloride-induced CRC model rats that were treated with matrine (ip) for 18 weeks. Data show that matrine suppressed CRC growth and decreased previously elevated expression of IL-6, TNF-α, p53, and HMGB1. Matrine may have had a therapeutic effect on CRC via inhibition of HMGB1 signaling, and this occurred through downregulation of IL-6, TNF-α, and HMGB1.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
TP53Humancolorectal cancer treatmentISOTp53 (Rattus norvegicus) RGD 
Tp53Ratcolorectal cancer treatmentIEP  RGD 
Trp53Mousecolorectal cancer treatmentISOTp53 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tp53  (tumor protein p53)

Genes (Mus musculus)
Trp53  (transformation related protein 53)

Genes (Homo sapiens)
TP53  (tumor protein p53)


Additional Information