ACAN (aggrecan) - Rat Genome Database

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Gene: ACAN (aggrecan) Sus scrofa
Analyze
Symbol: ACAN
Name: aggrecan
RGD ID: 14283004
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); INVOLVED IN cartilage condensation (ortholog); cellular response to growth factor stimulus (ortholog); central nervous system development (ortholog); ASSOCIATED WITH Bloom syndrome (ortholog); Brain Injuries (ortholog); colon cancer (ortholog); FOUND IN basement membrane (ortholog); extracellular matrix (ortholog); extracellular space (ortholog); INTERACTS WITH resveratrol
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: AGC1; aggrecan core protein; cartilage aggregating proteoglycan; cartilage-specific proteoglycan core protein; CSPCP
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl754,449,588 - 54,520,153 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1754,449,830 - 54,520,606 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2759,444,443 - 59,484,493 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
resveratrol  (EXP)

References
Additional References at PubMed
PMID:1326552   PMID:1417734   PMID:7827755   PMID:8489521   PMID:8611178   PMID:9550267   PMID:19041721  


Genomics

Comparative Map Data
ACAN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl754,449,588 - 54,520,153 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1754,449,830 - 54,520,606 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2759,444,443 - 59,484,493 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACAN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1588,803,436 - 88,875,353 (+)EnsemblGRCh38hg38GRCh38
GRCh381588,803,436 - 88,875,353 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371589,346,667 - 89,418,584 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361587,147,678 - 87,219,589 (+)NCBINCBI36hg18NCBI36
Build 341587,147,993 - 87,218,832NCBI
Celera1565,748,790 - 65,819,902 (+)NCBI
Cytogenetic Map15q26.1NCBI
HuRef1565,458,891 - 65,530,587 (+)NCBIHuRef
CHM1_11589,188,178 - 89,259,230 (+)NCBICHM1_1
Acan
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39778,702,974 - 78,764,847 (+)NCBIGRCm39mm39
GRCm39 Ensembl778,703,231 - 78,764,847 (+)Ensembl
GRCm38779,053,226 - 79,115,099 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl779,053,483 - 79,115,099 (+)EnsemblGRCm38mm10GRCm38
MGSCv37786,198,369 - 86,259,985 (+)NCBIGRCm37mm9NCBIm37
MGSCv36778,926,996 - 78,988,612 (+)NCBImm8
Celera776,452,812 - 76,514,796 (+)NCBICelera
Cytogenetic Map7D2NCBI
cM Map744.88NCBI
Acan
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21132,981,034 - 133,044,416 (+)NCBI
Rnor_6.0 Ensembl1140,762,758 - 140,824,441 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01140,762,758 - 140,824,441 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01141,732,130 - 141,793,202 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41134,787,341 - 134,848,992 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11134,865,683 - 134,927,335 (+)NCBI
Celera1125,052,984 - 125,114,449 (+)NCBICelera
Cytogenetic Map1q31NCBI
Acan
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541616,125,536 - 16,186,046 (-)NCBIChiLan1.0ChiLan1.0
ACAN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11586,733,853 - 86,771,420 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1586,733,853 - 86,771,420 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01567,492,494 - 67,563,265 (+)NCBIMhudiblu_PPA_v0panPan3
ACAN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1351,995,100 - 52,031,812 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl351,969,779 - 52,031,544 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha354,631,503 - 54,667,931 (+)NCBI
ROS_Cfam_1.0352,389,075 - 52,451,203 (+)NCBI
UMICH_Zoey_3.1351,936,640 - 51,973,031 (+)NCBI
UNSW_CanFamBas_1.0352,147,017 - 52,183,413 (+)NCBI
UU_Cfam_GSD_1.0352,485,855 - 52,522,279 (+)NCBI
Acan
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640131,487,810 - 131,554,134 (-)NCBI
SpeTri2.0NW_00493648314,811,152 - 14,846,305 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACAN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1297,345,350 - 7,416,951 (+)NCBI
Vero_WHO_p1.0NW_02366605939,423,196 - 39,494,914 (-)NCBI
Acan
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476816,093,552 - 16,156,655 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

hemolymphoid system nervous system reproductive system
High
Medium
Low 9 1
Below cutoff 1 11

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000002052   ⟹   ENSSSCP00000002003
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl754,449,588 - 54,519,194 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000042657   ⟹   ENSSSCP00000059425
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl754,449,588 - 54,520,153 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000051705   ⟹   ENSSSCP00000059139
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl754,449,588 - 54,513,637 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000064359   ⟹   ENSSSCP00000052661
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl754,449,588 - 54,519,194 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000067012   ⟹   ENSSSCP00000063224
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl754,449,588 - 54,519,194 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000076809   ⟹   ENSSSCP00000067029
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl754,449,588 - 54,504,266 (+)Ensembl
RefSeq Acc Id: NM_001164652   ⟹   NP_001158124
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1754,479,354 - 54,519,194 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021098297   ⟹   XP_020953956
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1754,449,830 - 54,520,606 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021098298   ⟹   XP_020953957
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1754,449,830 - 54,520,606 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021098299   ⟹   XP_020953958
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1754,449,830 - 54,520,606 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020953956   ⟸   XM_021098297
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_020953958   ⟸   XM_021098299
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020953957   ⟸   XM_021098298
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001158124   ⟸   NM_001164652
- Peptide Label: precursor
- UniProtKB: F1SKR0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000052661   ⟸   ENSSSCT00000064359
RefSeq Acc Id: ENSSSCP00000002003   ⟸   ENSSSCT00000002052
RefSeq Acc Id: ENSSSCP00000059139   ⟸   ENSSSCT00000051705
RefSeq Acc Id: ENSSSCP00000059425   ⟸   ENSSSCT00000042657
RefSeq Acc Id: ENSSSCP00000067029   ⟸   ENSSSCT00000076809
RefSeq Acc Id: ENSSSCP00000063224   ⟸   ENSSSCT00000067012
Protein Domains
C-type lectin   EGF-like   Ig-like   Ig-like V-type   Link   Sushi


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000001832 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000002003 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000052661 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000059139 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000059425 UniProtKB/TrEMBL
  ENSSSCP00000063224 UniProtKB/TrEMBL
  ENSSSCP00000067029 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000002052 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000042657 UniProtKB/TrEMBL
  ENSSSCT00000051705 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000064359 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000067012 UniProtKB/TrEMBL
  ENSSSCT00000076809 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/TrEMBL
  CSPG_CTLD UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Link_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/TrEMBL
KEGG Report ssc:397255 UniProtKB/TrEMBL
NCBI Gene ACAN ENTREZGENE
Pfam EGF UniProtKB/TrEMBL
  Lectin_C UniProtKB/TrEMBL
  Sushi UniProtKB/TrEMBL
  V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Xlink UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS LINKMODULE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  C_TYPE_LECTIN_1 UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_MHC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LINK_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LINK_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUSHI UniProtKB/TrEMBL
SMART CCP UniProtKB/TrEMBL
  CLECT UniProtKB/TrEMBL
  EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  IGv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LINK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57535 UniProtKB/TrEMBL
UniProt A0A287B863_PIG UniProtKB/TrEMBL
  A0A287BRK5_PIG UniProtKB/TrEMBL
  A0A287BRZ9_PIG UniProtKB/TrEMBL
  A0A5G2QYD1_PIG UniProtKB/TrEMBL
  A0A5G2R8U4_PIG UniProtKB/TrEMBL
  F1SKR0 ENTREZGENE, UniProtKB/TrEMBL
  PGCA_PIG UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O18833 UniProtKB/Swiss-Prot
  Q7M2W7 UniProtKB/Swiss-Prot