BAX (BCL2 associated X, apoptosis regulator) - Rat Genome Database
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Gene: BAX (BCL2 associated X, apoptosis regulator) Sus scrofa
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Symbol: BAX
Name: BCL2 associated X, apoptosis regulator
RGD ID: 14023413
Description: ENCODES a protein that exhibits BH domain binding (ortholog); BH3 domain binding (ortholog); chaperone binding (ortholog); INVOLVED IN activation of cysteine-type endopeptidase activity involved in apoptotic process (ortholog); activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (ortholog); activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (ortholog); PARTICIPATES IN ceramide signaling pathway; intrinsic apoptotic pathway; syndecan signaling pathway; ASSOCIATED WITH abdominal obesity-metabolic syndrome 1 (ortholog); acute kidney failure (ortholog); Acute Lung Injury (ortholog); FOUND IN BAK complex (ortholog); BAX complex (ortholog); Bcl-2 family protein complex (ortholog); INTERACTS WITH 2-deoxy-D-glucose; 3-methyladenine; antimycin A
Type: protein-coding
RefSeq Status: MODEL
Also known as: apoptosis regulator BAX; BAX-ALPHA; BCL2-associated X protein
Orthologs:
Homo sapiens (human) : BAX (BCL2 associated X, apoptosis regulator)  HGNC  Alliance
Mus musculus (house mouse) : Bax (BCL2-associated X protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Bax (BCL2 associated X, apoptosis regulator)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bax (BCL2 associated X, apoptosis regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : BAX (BCL2 associated X, apoptosis regulator)
Canis lupus familiaris (dog) : BAX (BCL2 associated X, apoptosis regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bax (BCL2 associated X, apoptosis regulator)
Chlorocebus sabaeus (African green monkey) : BAX (BCL2 associated X, apoptosis regulator)
Heterocephalus glaber (naked mole-rat) : Bax (BCL2 associated X, apoptosis regulator)
more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,187,260 - 54,228,144 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,222,341 - 54,228,150 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,100,514 - 50,106,337 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome 1  (ISO)
acute kidney failure  (ISO)
Acute Lung Injury  (ISO)
acute lymphoblastic leukemia  (ISO)
Adrenal Insufficiency  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
ataxia telangiectasia  (ISO)
brain glioma  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Bronchopulmonary Dysplasia  (ISO)
Burns  (ISO)
Cerebral Hemorrhage  (ISO)
cervical squamous cell carcinoma  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Intermittent Hypoxia  (ISO)
clear cell renal cell carcinoma  (ISO)
colon adenocarcinoma  (ISO)
colon carcinoma  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congestive heart failure  (ISO)
cutaneous T cell lymphoma  (ISO)
dementia  (ISO)
dilated cardiomyopathy  (ISO)
endometriosis  (ISO)
Endotoxemia  (ISO)
Esophageal Neoplasms  (ISO)
Experimental Arthritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Fetal Growth Retardation  (ISO)
Gastrointestinal Hemorrhage  (ISO)
glaucoma  (ISO)
heart disease  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Huntington's disease  (ISO)
Hyperplasia  (ISO)
hypertension  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
impotence  (ISO)
intermittent claudication  (ISO)
intestinal disease  (ISO)
Intestinal Neoplasms  (ISO)
ischemia  (ISO)
Kashin-Beck Disease  (ISO)
Kidney Reperfusion Injury  (ISO)
Knee Osteoarthritis  (ISO)
leiomyoma  (ISO)
Liver Reperfusion Injury  (ISO)
Lung Reperfusion Injury  (ISO)
macular degeneration  (ISO)
male infertility  (ISO)
Mammary Neoplasms, Experimental  (ISO)
mental depression  (ISO)
Microsatellite Instability  (ISO)
middle cerebral artery infarction  (ISO)
morphine dependence  (ISO)
Multi-Infarct Dementia  (ISO)
myocardial infarction  (ISO)
Myocardial Ischemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Metastasis  (ISO)
Nerve Degeneration  (ISO)
Optic Nerve Injuries  (ISO)
osteoarthritis  (ISO)
osteoporosis  (ISO)
polycystic ovary syndrome  (ISO)
post-traumatic stress disorder  (ISO)
pre-malignant neoplasm  (ISO)
Premature Aging  (ISO)
prion disease  (ISO)
prostate cancer  (ISO)
prostate carcinoma  (ISO)
Prostatic Neoplasms  (ISO)
Reperfusion Injury  (ISO)
Retina Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
Sarcopenia  (ISO)
scrapie  (ISO)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
T-cell acute lymphoblastic leukemia  (ISO)
teratoma  (ISO)
Testis Reperfusion Injury  (ISO)
thyroiditis  (ISO)
toxoplasmosis  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c  (ISO)
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  (ISO)
aging  (ISO)
apoptotic mitochondrial changes  (ISO)
apoptotic process  (IEA)
apoptotic process involved in blood vessel morphogenesis  (ISO)
apoptotic process involved in embryonic digit morphogenesis  (ISO)
apoptotic signaling pathway  (ISO)
B cell apoptotic process  (ISO)
B cell homeostasis  (ISO)
B cell homeostatic proliferation  (ISO)
B cell negative selection  (ISO)
B cell receptor apoptotic signaling pathway  (ISO)
blood vessel remodeling  (ISO)
brain development  (ISO)
cell population proliferation  (ISO)
cellular respiration  (ISO)
cellular response to DNA damage stimulus  (ISO)
cellular response to organic substance  (ISO)
cellular response to UV  (ISO)
cerebral cortex development  (ISO)
development of secondary sexual characteristics  (ISO)
ectopic germ cell programmed cell death  (ISO)
establishment or maintenance of transmembrane electrochemical gradient  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IBA)
extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
fertilization  (ISO)
germ cell development  (ISO)
glial cell apoptotic process  (ISO)
glycosphingolipid metabolic process  (ISO)
homeostasis of number of cells  (ISO)
homeostasis of number of cells within a tissue  (ISO)
hypothalamus development  (ISO)
inner mitochondrial membrane organization  (ISO)
intrinsic apoptotic signaling pathway  (ISO)
intrinsic apoptotic signaling pathway by p53 class mediator  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IBA)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (ISO)
kidney development  (ISO)
leukocyte homeostasis  (ISO)
limb morphogenesis  (ISO)
male gonad development  (ISO)
mitochondrial fragmentation involved in apoptotic process  (ISO)
mitochondrial fusion  (IBA)
mitochondrion morphogenesis  (ISO)
myeloid cell homeostasis  (ISO)
negative regulation of apoptotic signaling pathway  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of endoplasmic reticulum calcium ion concentration  (ISO)
negative regulation of fibroblast proliferation  (ISO)
negative regulation of mitochondrial membrane potential  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of peptidyl-serine phosphorylation  (ISO)
negative regulation of protein binding  (ISO)
nervous system development  (ISO)
neuron apoptotic process  (ISO)
neuron migration  (ISO)
odontogenesis of dentin-containing tooth  (ISO)
outer mitochondrial membrane organization  (ISO)
ovarian follicle development  (ISO)
oxidation-reduction process  (IEA)
positive regulation of apoptotic DNA fragmentation  (ISO)
positive regulation of apoptotic process  (IBA,IEA)
positive regulation of apoptotic process involved in mammary gland involution  (ISO)
positive regulation of B cell apoptotic process  (ISO)
positive regulation of calcium ion transport into cytosol  (ISO)
positive regulation of developmental pigmentation  (ISO)
positive regulation of endoplasmic reticulum unfolded protein response  (ISO)
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
positive regulation of intrinsic apoptotic signaling pathway  (ISO)
positive regulation of mitochondrial membrane permeability involved in apoptotic process  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of release of cytochrome c from mitochondria  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
post-embryonic camera-type eye morphogenesis  (ISO)
post-embryonic development  (ISO)
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway  (ISO)
regulation of cell cycle  (ISO)
regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
regulation of mammary gland epithelial cell proliferation  (ISO)
regulation of mitochondrial membrane permeability involved in apoptotic process  (ISO)
regulation of mitochondrial membrane permeability involved in programmed necrotic cell death  (ISO)
regulation of mitochondrial membrane potential  (ISO)
regulation of neuron apoptotic process  (ISO)
regulation of nitrogen utilization  (ISO)
release of cytochrome c from mitochondria  (IBA)
release of matrix enzymes from mitochondria  (ISO)
response to axon injury  (ISO)
response to cocaine  (ISO)
response to copper ion  (ISO)
response to corticosterone  (ISO)
response to drug  (ISO)
response to gamma radiation  (ISO)
response to ionizing radiation  (ISO)
response to salt stress  (ISO)
response to toxic substance  (ISO)
response to wounding  (ISO)
retina development in camera-type eye  (ISO)
retinal cell programmed cell death  (ISO)
Sertoli cell proliferation  (ISO)
sex differentiation  (ISO)
spermatid differentiation  (ISO)
spermatogenesis  (ISO)
T cell homeostatic proliferation  (ISO)
thymocyte apoptotic process  (ISO)
transmembrane transport  (IEA)
vagina development  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:17344648   PMID:21441714  


Genomics

Comparative Map Data
BAX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,187,260 - 54,228,144 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,222,341 - 54,228,150 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,100,514 - 50,106,337 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BAX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1948,954,815 - 48,961,798 (+)EnsemblGRCh38hg38GRCh38
GRCh381948,954,825 - 48,961,798 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371949,458,117 - 49,465,055 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,149,929 - 54,156,867 (+)NCBINCBI36hg18NCBI36
Build 341954,149,928 - 54,156,866NCBI
Celera1946,325,480 - 46,332,409 (+)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1945,835,055 - 45,841,975 (+)NCBIHuRef
CHM1_11949,460,326 - 49,467,266 (+)NCBICHM1_1
Bax
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,111,119 - 45,116,344 (-)NCBI
GRCm38745,461,695 - 45,466,903 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,461,697 - 45,466,898 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,717,065 - 52,722,268 (-)NCBIGRCm37mm9NCBIm37
MGSCv36745,329,744 - 45,334,864 (-)NCBImm8
Celera740,917,745 - 40,922,946 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.32NCBI
Bax
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01101,451,801 - 101,457,207 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1101,451,802 - 101,457,207 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01102,530,747 - 102,536,153 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,933,023 - 95,938,176 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1196,011,133 - 96,016,287 (-)NCBI
Celera190,195,913 - 90,201,319 (-)NCBICelera
Cytogenetic Map1q22NCBI
Bax
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555591,695,960 - 1,700,244 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555591,695,960 - 1,700,246 (-)NCBIChiLan1.0ChiLan1.0
BAX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11954,793,594 - 54,800,466 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,793,594 - 54,800,468 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01945,955,926 - 45,962,870 (+)NCBIMhudiblu_PPA_v0panPan3
BAX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1107,422,424 - 107,426,464 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11107,423,388 - 107,426,464 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Bax
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366642,968,103 - 2,973,652 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BAX
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,186,028 - 42,193,105 (+)NCBI
Bax
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248325,050,222 - 5,068,565 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 10 2 3 5 1 22 2 3 3
Below cutoff 2 1 1

Sequence


Reference Sequences
RefSeq Acc Id: XM_003127290   ⟹   XP_003127338
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1654,222,341 - 54,228,150 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013998624   ⟹   XP_013854078
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1654,222,375 - 54,228,150 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003127338 (Get FASTA)   NCBI Sequence Viewer  
  XP_013854078 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAE54428 (Get FASTA)   NCBI Sequence Viewer  
  CAJ80412 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003127338   ⟸   XM_003127290
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013854078   ⟸   XM_013998624
- Peptide Label: isoform X2
- Sequence:
Protein Domains
GFO_IDH_MocA   GFO_IDH_MocA_C


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000003144 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070027758 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000003404 UniProtKB/TrEMBL
  ENSSSCP00000003425 UniProtKB/TrEMBL
  ENSSSCP00000034895 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000066789 UniProtKB/TrEMBL
  ENSSSCP00000068217 UniProtKB/TrEMBL
  ENSSSCP00000073747 UniProtKB/TrEMBL
  ENSSSCP00070047298 UniProtKB/TrEMBL
  ENSSSCP00070047300 UniProtKB/TrEMBL
  ENSSSCP00070047302 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000003487 UniProtKB/TrEMBL
  ENSSSCT00000003508 UniProtKB/TrEMBL
  ENSSSCT00000063771 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000072023 UniProtKB/TrEMBL
  ENSSSCT00000085633 UniProtKB/TrEMBL
  ENSSSCT00000090884 UniProtKB/TrEMBL
  ENSSSCT00070055688 UniProtKB/TrEMBL
  ENSSSCT00070055691 UniProtKB/TrEMBL
  ENSSSCT00070055693 UniProtKB/TrEMBL
Gene3D-CATH 1.10.437.10 UniProtKB/TrEMBL
InterPro BAX UniProtKB/TrEMBL
  Bcl2-like UniProtKB/TrEMBL
  Bcl2_BH1_motif_CS UniProtKB/TrEMBL
  Bcl2_BH2_motif_CS UniProtKB/TrEMBL
  Bcl2_BH3_motif_CS UniProtKB/TrEMBL
  Blc2-like_sf UniProtKB/TrEMBL
  Blc2_fam UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  Oxidoreductase_N UniProtKB/TrEMBL
  OxRdtase_C UniProtKB/TrEMBL
KEGG Report ssc:396633 UniProtKB/TrEMBL
NCBI Gene BAX ENTREZGENE
PANTHER PTHR11256 UniProtKB/TrEMBL
  PTHR11256:SF42 UniProtKB/TrEMBL
Pfam Bcl-2 UniProtKB/TrEMBL
  GFO_IDH_MocA UniProtKB/TrEMBL
  GFO_IDH_MocA_C UniProtKB/TrEMBL
PRINTS BCL2FAMILY UniProtKB/TrEMBL
PROSITE BCL2_FAMILY UniProtKB/TrEMBL
  BH1 UniProtKB/TrEMBL
  BH2 UniProtKB/TrEMBL
  BH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
  SSF56854 UniProtKB/TrEMBL
UniGene Ssc.23470 ENTREZGENE
UniProt A0A286ZTT0_PIG UniProtKB/TrEMBL
  A0A4X1VUB8_PIG UniProtKB/TrEMBL
  A0A4X1W035_PIG UniProtKB/TrEMBL
  A0A4X1W1A2_PIG UniProtKB/TrEMBL
  A0A5G2QXW5_PIG UniProtKB/TrEMBL
  A0A5G2R1Z9_PIG UniProtKB/TrEMBL
  A0A5G2RFU3_PIG UniProtKB/TrEMBL
  A0A5S6FWI2_PIG UniProtKB/TrEMBL
  F1RIQ4_PIG UniProtKB/TrEMBL
  Q2A135_PIG UniProtKB/TrEMBL