NTRK3 (neurotrophic receptor tyrosine kinase 3) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: NTRK3 (neurotrophic receptor tyrosine kinase 3) Sus scrofa
Analyze
Symbol: NTRK3
Name: neurotrophic receptor tyrosine kinase 3
RGD ID: 14067959
Description: ENCODES a protein that exhibits GPI-linked ephrin receptor activity (ortholog); p53 binding (ortholog); INVOLVED IN activation of GTPase activity (ortholog); activation of MAPK activity (ortholog); activation of protein kinase B activity (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); endometriosis (ortholog); Experimental Diabetes Mellitus (ortholog); FOUND IN cytoplasm (ortholog); glutamatergic synapse (ortholog); integral component of postsynaptic membrane (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: gp145-trkC; neurotrophic tyrosine kinase, receptor, type 3; NT-3 growth factor receptor; trk-C; TRKC; trkC tyrosine kinase; tyrosine kinase receptor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1191,535,300 - 191,925,353 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11191,535,262 - 191,941,675 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21212,938,371 - 213,258,768 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of GTPase activity  (ISO)
activation of MAPK activity  (ISO)
activation of protein kinase B activity  (ISO)
cell differentiation  (IEA)
cellular response to nerve growth factor stimulus  (IBA)
cellular response to retinoic acid  (ISO)
circadian rhythm  (ISO)
cochlea development  (ISO)
heart development  (ISS)
lens fiber cell differentiation  (ISO)
mechanoreceptor differentiation  (ISO)
modulation by virus of host transcription  (ISO)
multicellular organism development  (IBA)
myelination in peripheral nervous system  (ISO)
negative regulation of astrocyte differentiation  (ISO)
negative regulation of cell death  (ISO)
negative regulation of protein phosphorylation  (ISO)
nervous system development  (IEA)
neuron fate specification  (ISO)
neuron migration  (ISO)
neuronal action potential propagation  (ISO)
neurotrophin signaling pathway  (IEA)
peptidyl-tyrosine phosphorylation  (IEA)
positive regulation of actin cytoskeleton reorganization  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of axon extension involved in regeneration  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IBA)
positive regulation of gene expression  (ISO)
positive regulation of kinase activity  (IBA)
positive regulation of MAPK cascade  (IBA)
positive regulation of neuron projection development  (IBA)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (IBA)
positive regulation of positive chemotaxis  (ISO)
positive regulation of synapse assembly  (ISO)
regulation of postsynaptic density assembly  (ISO)
regulation of presynapse assembly  (ISO)
regulation of protein kinase B signaling  (IBA)
response to axon injury  (ISO)
response to corticosterone  (ISO)
response to ethanol  (ISO)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA,IEA)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:1653651   PMID:14681463   PMID:17407547  


Genomics

Comparative Map Data
NTRK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1191,535,300 - 191,925,353 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11191,535,262 - 191,941,675 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21212,938,371 - 213,258,768 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NTRK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1587,859,751 - 88,256,768 (-)EnsemblGRCh38hg38GRCh38
GRCh381587,859,749 - 88,256,796 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371588,419,948 - 88,800,026 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361586,220,992 - 86,600,665 (-)NCBINCBI36hg18NCBI36
Build 341586,220,991 - 86,600,665NCBI
Celera1564,821,267 - 65,200,916 (-)NCBI
Cytogenetic Map15q25.3NCBI
HuRef1564,532,241 - 64,911,404 (-)NCBIHuRef
CHM1_11588,261,800 - 88,641,816 (-)NCBICHM1_1
Ntrk3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39777,825,711 - 78,228,865 (-)NCBIGRCm39mm39
GRCm38778,179,986 - 78,581,034 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl778,175,959 - 78,738,012 (-)EnsemblGRCm38mm10GRCm38
MGSCv37785,337,000 - 85,722,724 (-)NCBIGRCm37mm9NCBIm37
MGSCv36778,066,072 - 78,451,488 (-)NCBImm8
Celera775,610,791 - 75,991,488 (-)NCBICelera
Cytogenetic Map7D2NCBI
cM Map744.01NCBI
Ntrk3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01139,890,537 - 140,262,503 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1139,890,560 - 140,262,503 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01140,868,261 - 141,239,954 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41133,925,530 - 134,302,139 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11134,003,872 - 134,380,482 (-)NCBI
Celera1124,206,109 - 124,576,015 (-)NCBICelera
Cytogenetic Map1q31NCBI
Ntrk3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541616,652,791 - 17,018,188 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541616,652,931 - 17,018,188 (+)NCBIChiLan1.0ChiLan1.0
NTRK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11585,776,819 - 86,157,209 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1585,776,832 - 86,157,204 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01566,566,219 - 66,953,279 (-)NCBIMhudiblu_PPA_v0panPan3
NTRK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl351,138,751 - 51,513,024 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1351,131,470 - 51,491,112 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ntrk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493648313,912,904 - 14,291,881 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NTRK3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl296,447,256 - 6,830,526 (-)Ensembl
ChlSab1.1296,441,824 - 6,831,029 (-)NCBI
Ntrk3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476815,239,111 - 15,619,979 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 15
Low 4 2 3 5 8 2 1
Below cutoff 5 2 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000005628   ⟹   ENSSSCP00000005487
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1191,535,688 - 191,925,353 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000040145   ⟹   ENSSSCP00000058161
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1191,535,688 - 191,925,353 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000044043   ⟹   ENSSSCP00000040262
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1191,535,688 - 191,925,353 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000053046   ⟹   ENSSSCP00000044353
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1191,535,300 - 191,823,220 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000057030   ⟹   ENSSSCP00000056080
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1191,535,882 - 191,925,327 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000067108   ⟹   ENSSSCP00000066833
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1191,535,300 - 191,925,353 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000068344   ⟹   ENSSSCP00000072174
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1191,535,688 - 191,925,353 (+)Ensembl
RefSeq Acc Id: NM_214271   ⟹   NP_999436
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11191,535,266 - 191,925,342 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021083214   ⟹   XP_020938873
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11191,535,262 - 191,941,675 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021083220   ⟹   XP_020938879
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11191,535,739 - 191,941,675 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021083229   ⟹   XP_020938888
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11191,535,739 - 191,823,225 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021083231   ⟹   XP_020938890
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11191,535,739 - 191,823,225 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_020938873   ⟸   XM_021083214
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_999436   ⟸   NM_214271
- Peptide Label: precursor
- Sequence:
RefSeq Acc Id: XP_020938879   ⟸   XM_021083220
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_020938888   ⟸   XM_021083229
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_020938890   ⟸   XM_021083231
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSSSCP00000005487   ⟸   ENSSSCT00000005628
RefSeq Acc Id: ENSSSCP00000058161   ⟸   ENSSSCT00000040145
RefSeq Acc Id: ENSSSCP00000040262   ⟸   ENSSSCT00000044043
RefSeq Acc Id: ENSSSCP00000072174   ⟸   ENSSSCT00000068344
RefSeq Acc Id: ENSSSCP00000044353   ⟸   ENSSSCT00000053046
RefSeq Acc Id: ENSSSCP00000056080   ⟸   ENSSSCT00000057030
RefSeq Acc Id: ENSSSCP00000066833   ⟸   ENSSSCT00000067108
Protein Domains
Ig-like   Ig-like C2-type   LRRCT   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000005106 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070030460 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000005487 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000040262 UniProtKB/TrEMBL
  ENSSSCP00000044353 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000056080 UniProtKB/TrEMBL
  ENSSSCP00000058161 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000066833 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000072174 UniProtKB/TrEMBL
  ENSSSCP00070052298 UniProtKB/TrEMBL
  ENSSSCP00070052299 UniProtKB/TrEMBL
  ENSSSCP00070052300 UniProtKB/TrEMBL
  ENSSSCP00070052301 UniProtKB/TrEMBL
  ENSSSCP00070052302 UniProtKB/TrEMBL
  ENSSSCP00070052303 UniProtKB/TrEMBL
  ENSSSCP00070052304 UniProtKB/TrEMBL
  ENSSSCP00070052305 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000005628 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000040145 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000044043 UniProtKB/TrEMBL
  ENSSSCT00000053046 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000057030 UniProtKB/TrEMBL
  ENSSSCT00000067108 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000068344 UniProtKB/TrEMBL
  ENSSSCT00070061350 UniProtKB/TrEMBL
  ENSSSCT00070061351 UniProtKB/TrEMBL
  ENSSSCT00070061352 UniProtKB/TrEMBL
  ENSSSCT00070061353 UniProtKB/TrEMBL
  ENSSSCT00070061354 UniProtKB/TrEMBL
  ENSSSCT00070061355 UniProtKB/TrEMBL
  ENSSSCT00070061356 UniProtKB/TrEMBL
  ENSSSCT00070061357 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NTRK_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kin_neurotrophic_rcpt_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_NGF_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_rcpt_2_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:397511 UniProtKB/Swiss-Prot
NCBI Gene NTRK3 ENTREZGENE
Pfam I-set UniProtKB/TrEMBL
  LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00047 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPKR_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS NTKRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NTKRECEPTOR3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LRRCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRNT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Ssc.16303 ENTREZGENE
UniProt A0A287A8F5_PIG UniProtKB/TrEMBL
  A0A287AK14_PIG UniProtKB/TrEMBL
  A0A287BIA0_PIG UniProtKB/TrEMBL
  A0A287BNG7_PIG UniProtKB/TrEMBL
  A0A4X1W782_PIG UniProtKB/TrEMBL
  A0A4X1WCM2_PIG UniProtKB/TrEMBL
  A0A4X1WCM3_PIG UniProtKB/TrEMBL
  A0A4X1WCM7_PIG UniProtKB/TrEMBL
  A0A4X1WCM8_PIG UniProtKB/TrEMBL
  A0A4X1WCV3_PIG UniProtKB/TrEMBL
  A0A4X1WDT4_PIG UniProtKB/TrEMBL
  A0A4X1WDT7_PIG UniProtKB/TrEMBL
  A0A5G2QPK3_PIG UniProtKB/TrEMBL
  A0A5G2RJR4_PIG UniProtKB/TrEMBL
  F1SRS9_PIG UniProtKB/TrEMBL
  NTRK3_PIG UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A480PUD4 UniProtKB/TrEMBL
VGNC ID VGNC:103142 ENTREZGENE