RGD Reference Report - The effects of a polyphenol present in olive oil, oleuropein aglycone, in an experimental model of spinal cord injury in mice. - Rat Genome Database

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The effects of a polyphenol present in olive oil, oleuropein aglycone, in an experimental model of spinal cord injury in mice.

Authors: Impellizzeri, D  Esposito, E  Mazzon, E  Paterniti, I  Di Paola, R  Bramanti, P  Morittu, VM  Procopio, A  Perri, E  Britti, D  Cuzzocrea, S 
Citation: Impellizzeri D, etal., Biochem Pharmacol. 2012 Feb 8.
RGD ID: 5688774
Pubmed: PMID:22342994   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bcp.2012.02.001   (Journal Full-text)

Several olive oil phenolic compounds, such us oleuropein have attracted considerable attention because of their antioxidant activity, anti-atherosclerotic and anti-inflammatory properties. The aim of this experimental study was to determine the effect of oleuropein aglycone, a hydrolysis product of oleuropein, in the inflammatory response, in particular in the secondary injury associated with the mouse model of spinal cord trauma. The injury was induced by application of vascular clips to the dura via a four-level T5-T8 laminectomy in mice. Oleuropein aglycone was administered in mice (100mug/kg, 40mug/kg, 20mug/kg, 10% ethanol, i.p.) 1h and 6h after the trauma. The treatment with oleuropein aglycone significantly decreased: (1) histological damage, (2) motor recovery, (3) nuclear factor (NF)-kappaB expression and IKB-alpha degradation, (4) protein kinase A (PKA) activity and expression, (5) pro-inflammatory cytokines production such as tumor necrosis factor (TNF-alpha) and interleukin-1beta (IL-1beta), 6) inducible nitric oxide synthase (iNOS) expression, (7) neutrophil infiltration, (8) lipid peroxidation, (9) nitrotyrosine and poly-ADP-ribose (PAR) formation, (10) glial cell-derived neurotrophic factor (GDNF) levels, (11) apoptosis (TUNEL staining, FAS ligand expression, Caspase 3, Bax and Bcl-2 expression). Thus, we propose that olive oil phenolic constituents such as oleuropein aglycone may be useful in the treatment of various inflammatory diseases.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Spinal Cord Injuries  ISOGdnf (Mus musculus)5688774; 5688774 RGD 
Spinal Cord Injuries  IDA 5688774 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gdnf  (glial cell derived neurotrophic factor)

Genes (Mus musculus)
Gdnf  (glial cell line derived neurotrophic factor)

Genes (Homo sapiens)
GDNF  (glial cell derived neurotrophic factor)


Additional Information