NEFL (neurofilament light) - Rat Genome Database
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Gene: NEFL (neurofilament light) Sus scrofa
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Symbol: NEFL
Name: neurofilament light
RGD ID: 14285052
Description: ENCODES a protein that exhibits identical protein binding (ortholog); phospholipase binding (ortholog); protein C-terminus binding (ortholog); INVOLVED IN anterograde axonal transport (ortholog); axonal transport of mitochondrion (ortholog); cerebral cortex development (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Anti-N-Methyl-D-Aspartate Receptor Encephalitis (ortholog); autosomal dominant distal hereditary motor neuronopathy (ortholog); FOUND IN neurofilament; axon (ortholog); cholinergic synapse (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 68 kDa neurofilament protein; neurofilament light polypeptide; Neurofilament triplet L protein; neurofilament, light polypeptide; NF-L
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl148,990,750 - 8,997,300 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1148,991,321 - 8,996,900 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21410,087,492 - 10,093,071 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:3920075   PMID:8634266   PMID:8889548   PMID:14681463   PMID:17145712   PMID:17407547  


Genomics

Comparative Map Data
NEFL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl148,990,750 - 8,997,300 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1148,991,321 - 8,996,900 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21410,087,492 - 10,093,071 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NEFL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl824,950,955 - 24,956,721 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl824,950,955 - 24,957,110 (-)EnsemblGRCh38hg38GRCh38
GRCh38824,950,955 - 24,956,612 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37824,808,468 - 24,814,383 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh37824,808,468 - 24,814,126 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36824,864,385 - 24,870,043 (-)NCBINCBI36hg18NCBI36
Build 34824,866,239 - 24,869,946NCBI
Celera823,772,893 - 23,778,556 (-)NCBI
Cytogenetic Map8p21.2NCBI
HuRef823,353,235 - 23,359,150 (-)NCBIHuRef
CHM1_1825,010,797 - 25,016,712 (-)NCBICHM1_1
Nefl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391468,321,312 - 68,326,544 (+)NCBIGRCm39mm39
GRCm381468,083,863 - 68,089,095 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1468,083,863 - 68,089,095 (+)EnsemblGRCm38mm10GRCm38
MGSCv371468,701,941 - 68,705,802 (+)NCBIGRCm37mm9NCBIm37
MGSCv361467,037,214 - 67,041,075 (+)NCBImm8
Celera1465,851,013 - 65,854,872 (+)NCBICelera
Cytogenetic Map14D1NCBI
Nefl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21542,301,920 - 42,305,793 (+)NCBI
Rnor_6.0 Ensembl1544,799,334 - 44,804,574 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01544,799,378 - 44,803,251 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01546,793,526 - 46,797,399 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41547,636,303 - 47,640,176 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11547,652,082 - 47,655,956 (+)NCBI
Celera1541,961,053 - 41,964,926 (+)NCBICelera
Cytogenetic Map15p12NCBI
Nefl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540347,946,353 - 47,952,026 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540347,946,413 - 47,951,734 (-)NCBIChiLan1.0ChiLan1.0
NEFL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1821,134,533 - 21,140,694 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl821,134,533 - 21,140,694 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0824,218,510 - 24,224,627 (-)NCBIMhudiblu_PPA_v0panPan3
NEFL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2532,463,452 - 32,467,224 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12532,463,361 - 32,468,965 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Nefl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049367571,642,122 - 1,646,499 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NEFL
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1823,077,085 - 23,083,213 (-)NCBI
ChlSab1.1 Ensembl823,077,086 - 23,083,222 (-)Ensembl
Nefl
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475820,063,109 - 20,068,459 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system hemolymphoid system nervous system reproductive system respiratory system
High
Medium 3 23
Low 8 2
Below cutoff 2 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000010578   ⟹   ENSSSCP00000010302
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl148,991,326 - 8,997,112 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000049084   ⟹   ENSSSCP00000058100
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl148,990,750 - 8,997,300 (-)Ensembl
RefSeq Acc Id: NM_001244331   ⟹   NP_001231260
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1148,991,321 - 8,996,900 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001231260 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABF59810 (Get FASTA)   NCBI Sequence Viewer  
  P02547 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001231260   ⟸   NM_001244331
- UniProtKB: F1RJU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000058100   ⟸   ENSSSCT00000049084
RefSeq Acc Id: ENSSSCP00000010302   ⟸   ENSSSCT00000010578
Protein Domains
IF rod


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000009649 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070023528 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000010302 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000058100 UniProtKB/TrEMBL
  ENSSSCP00070039545 UniProtKB/TrEMBL
  ENSSSCP00070039550 UniProtKB/TrEMBL
  ENSSSCP00070039555 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000010578 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000049084 UniProtKB/TrEMBL
  ENSSSCT00070046880 UniProtKB/TrEMBL
  ENSSSCT00070046884 UniProtKB/TrEMBL
  ENSSSCT00070046889 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.1160 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro IF_conserved UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_rod_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_rod_dom_coil1B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Intermed_filament_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NF-L UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report ssc:100521224 UniProtKB/TrEMBL
NCBI Gene NEFL ENTREZGENE
PANTHER PTHR45652:SF8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Filament_head UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IF_ROD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Filament UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A287BNA7_PIG UniProtKB/TrEMBL
  A0A4X1VCX8_PIG UniProtKB/TrEMBL
  A0A4X1VDT6_PIG UniProtKB/TrEMBL
  A0A4X1VDU1_PIG UniProtKB/TrEMBL
  F1RJU4 ENTREZGENE, UniProtKB/TrEMBL
  NFL_PIG UniProtKB/Swiss-Prot, ENTREZGENE
VGNC ID VGNC:90670 ENTREZGENE